Global burden, trends, and disparities in kidney cancer attributable to smoking from 1990 to 2021 by Siyu Han, Shiyu Zhao, Ran Zhong, Peizhe Li, Yuewen Pang, Shuang He, Junyao Duan, Huijie Gong, Jing Shi, Li Liu, Yongji Yan

“…However, significant demographic and geographic disparities persist, with the disease burden remaining higher in older populations and regions with elevated SDI levels. Moreover, while the overall burden is projected to decline annually over the next 15 years, it is expected to remain significantly higher in men. …”
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Oxidative Stress, Antioxidant Capacity, and Inflammatory Markers in Patients with Idiopathic Complete Heart Block by Shobhit Shah, Monika Bhandari, Pravesh Vishwakarma, Wahid Ali, Mohammad Kaleem Ahmad, Abhishek Singh, Ayush Shukla, Akhil Kumar Sharma, Gaurav Chaudhary, Akshyaya Pradhan, Sharad Chandra, Rishi Sethi, S. K. Dwivedi

“…Conclusions: Serum MDA and inflammatory markers were markedly elevated during a CHB. This is particularly the case with IL-5, which was significantly increased in patients with CHB. …”
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Clinicodemographic profile and predictors of poor outcome in hospitalised COVID-19 patients: a single-centre, retrospective cohort study from India by Prashant K Singh, Lokesh Tiwari, Alok Ranjan, Prakriti Gupta, Prabhat Kumar Singh, Yogesh Kumar, Yankappa N, Amrita Banerjee, C M Singh

“…Disease severity on admission (adjusted OR 12.53, 95% CI 4.92 to 31.91, p<0.01), coagulation defect (33.21, 3.85–302.1, p<0.01), CKD (5.67, 1.08–29.64, p=0.04), high urea (11.05, 3.9–31.02, p<0.01), high prothrombin time (3.91, 1.59–9.65, p<0.01) and elevated ferritin (1.02, 1.00–1.03, p=0.02) were associated with poor outcome on multivariate regression. …”
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Electroacupuncture Regulates Disorders of Gut-Brain Interaction by Decreasing Corticotropin-Releasing Factor in a Rat Model of IBS by Ying Chen, Yan Zhao, Dan-ni Luo, Hui Zheng, Ying Li, Si-yuan Zhou

“…Visceral pain threshold, the percentage of time spent in open arms (OT%) in the elevated plus maze test (EPMT), and the sucrose preference (SP%) in the sucrose preference test (SPT) were measured at baseline, day 15, and day 30. …”
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Anatomy, histology, and morphology of fish gills in relation to feeding habits: a comparative review of marine and freshwater species by Mohamed A. M. Alsafy, Hanan H. Abd-Elhafeez, Ahmed M. Rashwan, Atef Erasha, Safwat Ali, Samir A. A. El-Gendy

“…Four transversely raised areas on each side are connected by transverse lines caudal to the base of the tongue (Bagrus bayad) and an elevated part at the level of the third-gill arch (Tilapia zilli). …”
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Conglomerated Imiquimod and Metronidazole Incorporated Biodegradable Nanofibrous Mats for Potential Therapy of Cervical Cancer by Chen YP, Chiu CF, Wang CN, Lin CC, Shen CR, Yao YC, Kuo YH, Liu SJ

“…In vivo, each membrane consistently released elevated concentrations of imiquimod/metronidazole at the intended site in mice over a four-week period, with minimal systemic drug concentration detected in the bloodstream. …”
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EHMT2‐mediated R‐loop formation promotes the malignant progression of prostate cancer via activating Aurora B by Yuyang Zhang, Mingqin Su, Yiming Chen, Li Cui, Wei Xia, Renfang Xu, Dong Xue, Xiansheng Zhang, Xingliang Feng

“…Results EHMT2 was highly expressed in metastatic PCa tissues exhibiting elevated CIN and was strongly associated with adverse clinical outcomes in patients with PCa. …”
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Integrating bulk and single-cell RNA sequencing data: unveiling RNA methylation and autophagy-related signatures in chronic obstructive pulmonary disease patients by Shi-Xia Liao, Lan-Ying Zhang, Ling-Mei Shi, Huai-Yu Hu, Yan-Hui Gu, Ting-Hua Wang, Yao Ouyang, Peng-Peng Sun

“…Integrated scRNA-seq analysis demonstrated a marked reduction of macrophages in COPD, with FTO and IGF2BP2 emerging as critical RNA methylation regulators. Macrophages with elevated RNA methylation and autophagy scores had increased interactions with other immune cells. …”
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Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome by Zhixiao Xu, Xiong Lei, Weiwei Chu, Luoqi Weng, Chengshui Chen, Chengshui Chen, Chengshui Chen, Ran Ye

“…The OBS (where a higher OBS signified an increased prevalence of anti- or pro-oxidant exposures) weighed the 20 factors, while the MetS severity score weighed the five factors.ResultsAfter multivariable adjustment, individuals with elevated OBS were found to exhibit a decreased susceptibility to MetS [odds ratio (OR) 0.95; 95% CI 0.94-0.96]. …”
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Exploring the Mechanisms of Iron Overload-Induced Liver Injury in Rats Based on Transcriptomics and Proteomics by Yujia Shu, Xuanfu Wu, Dongxu Zhang, Shuxia Jiang, Wenqiang Ma

“…Excessive iron supplementation may lead to iron overload and elevated reactive oxygen species (ROS) production in animals, causing cellular damage. …”
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Clinicopathological analysis of adrenal intravascular large B-cell lymphoma by LIN Jiaxin, WEI Ran, SHUI Ruohong, LU Hongfen, LI Xiaoqiu, YU Baohua

“…Peripheral blood test showed elevated serum lactate dehydrogenase in 2 cases and adrenal dysfunction in 2 cases. …”
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The Diagnostic Value of Plasma NETs Levels and iCEB in Silent Myocardial Ischemia in Maintenance Hemodialysis Patients by Liu H, Han J, Ni W, Lu Y, Hu X, Wang J, Zhou Y, Wang Z, Cao J, Liu H

“…The SMI group exhibited significantly elevated levels of NETs associated components (dsDNA(37.89± 4.55 vs 31.64± 5.32, P< 0.001), cfDNA(11.27± 2.03 vs 8.91± 1.84, P< 0.001), MPO-DNA(23.69± 4.01 vs 17.52± 3.41, P< 0.001)), as well as higher iCEB compared to the control group(56.45± 7.67 vs 45.89± 6.23, P< 0.001). …”
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CircPRMT5, a Potential Salivary Biomarker, Facilitates the Progression of Head and Neck Squamous Cell Carcinoma via the IGF2BP3-SERPINE1 Pathway by Jiang S, Ou L, Wang Y, Su K, Chen Z, He L, Xu X, Cheng B, Xia J, Fan Z

“…Notably, circPRMT5 levels were significantly elevated in the saliva exosomes of HNSCC patients, exhibiting substantial diagnostic value.Conclusion: CircPRMT5 exhibits significant diagnostic utility through salivary exosomes and plays a crucial role in promoting the progression of HNSCC via the IGF2BP3-SERPINE1 pathway. …”
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Differential impact of TIM-3 ligands on NK cell function by Xin Zhang, Lazar Vujanovic, Riyue Bao, Robert L Ferris, Tullia C Bruno, Aditi Kulkarni, Hridesh Banerjee, Housaiyin Li, Juncheng Wang, Lawrence P Kane, Pragati Upadhyay, Jennifer L Anderson, Onyedikachi Victor Onyekachi, Lidia M R B Arantes

“…Among patients with HNSCC, an elevated intratumoral TIM-3+ NK cell gene signature associates with worse outcomes, specifically in those with human papillomavirus (HPV)+ disease, potentially attributable to higher galectin-9 levels in HPV+ versus HPV− patients.Conclusions Our findings underscore the complex functional impact of TIM-3 ligand signaling, which is consistent with recent clinical trials suggesting that targeting TIM-3 alone is suboptimal as an immunotherapeutic approach for treating malignancies.…”
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Remnant cholesterol and its variability independent of low density lipoprotein cholesterol predict metabolic dysfunction associated steatotic liver disease by Yuting Sun, Xinlei Miao, Manling Hu, Xiaoling Xie, Shuang Liu, Ziping Song, Jiayi Deng, Fei Xu, Meng Li, Yangxuan He, Song Leng

“…In both LDL-C subgroups (≥ 3.4 mmol/L and < 3.4 mmol/L), high baseline RC was associated with elevated MASLD risk (HR 1.208, 95% CI 1.148–1.270, P < 0.001; HR 1.246, 95% CI 1.129–1.374, P < 0.001). …”
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Serum IL-1<mml:math alttext="$eta $"> <mml:mi>&#x03B2;</mml:mi> </mml:math>, IL-2, and IL-6 in Insulin-Dependent Diabetic Children

“…In all stages of diabetes higher levels of IL-1<mml:math alttext="$eta $"> <mml:mi>&#x03B2;</mml:mi> </mml:math> and TNF-<mml:math alttext="$alpha $"> <mml:mi>&#x03B1;</mml:mi> </mml:math> and lower levels of IL-2 and IL-6 were detected. Our data about elevated serum IL-1<mml:math alttext="$eta $"> <mml:mi>&#x03B2;</mml:mi> </mml:math>, TNF-<mml:math alttext="$alpha $"> <mml:mi>&#x03B1;</mml:mi> </mml:math> and decreased IL-2, IL-6 levels in newly diagnosed IDDM patients in comparison with longer standing cases supports an activation of systemic inflammatory process during early phases of IDDM which may be indicative of an ongoing <mml:math alttext="$eta $"> <mml:mi>&#x03B2;</mml:mi> </mml:math>-cell destruction. …”
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Resistance exercise training improves disuse-induced skeletal muscle atrophy in humans: a meta-analysis of randomized controlled trials by Xian Guo, Yanbing Zhou, Xinxin Li, Jinhao Mu

“…Peak power of quadriceps muscles (n = 4, MD = 166.08, 95% CI = 28.44, 303.73, p < 0.05) and calf muscles (n = 2, MD = 176.58, 95% CI = 102.36, 250.79, p < 0.001) were elevated after RET intervention. RET significantly ameliorated the weakening of both concentric and eccentric peak force in quadriceps (concentric: n = 2, MD = 470.95, 95% CI = 355.45, 586.44, p < 0.001; eccentric: n = 1, MD = 351.51, 95% CI = 254.43, 448.58, p < 0.001) and calf muscles (concentric: n = 2, MD = 867.52, 95% CI = 548.18, 1186.86, p < 0.001; eccentric: n = 1, MD = 899.86, 95% CI = 558.17, 1241.55, p < 0.001). …”
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Efficacy and Safety Outcomes of Intravitreal Dexamethasone Implant Therapy for the Treatment of Adult Coats’ Disease by Qingshan Chen, Saying Liang, Xizhen Wang, Chenli Hu, Jieting She, Zi Li

“…For the DEX(−) group, BCVA changed from 0.76 ± 0.74 to 0.96 ± 0.60 logMAR at month 6 (P=0.066), while the CRT from 382.75 ± 17.68 to 412.75 ± 195.53 μm (P=0.525) with no significant difference. IOP was elevated from 13.15 ± 1.74 mmHg at baseline to 18.05 ± 3.57 mmHg at month 6 with a P value of 0.02 for the DEX(+) group and from 14.48 ± 1.70 to 18.83 ± 4.06 mmHg (P=0.076) for the DEX (−) group. …”
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A novel human specific lncRNA MEK6-AS1 regulates adipogenesis and fatty acid biosynthesis by stabilizing MEK6 mRNA by Di Li, Yunhua Chen, Xingyu Zhu, Yanlei Yang, Hongling Li, Robert Chunhua Zhao

“…We also found that MEK6-AS1 was elevated during hepatic steatosis organoid generation. …”
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Hypoxic BMSC-derived exosomal miR-210-3p promotes progression of triple-negative breast cancer cells via NFIX-Wnt/β-catenin signaling axis by Meng Wang, Yi Zheng, Qian Hao, Guochao Mao, Zhijun Dai, Zhen Zhai, Shuai Lin, Baobao Liang, Huafeng Kang, Xiaobin Ma

“…The expression of miR-210-3p in BMSC-derived exosomes is markedly elevated in hypoxic conditions. Exosome-mediated transfer of miR-210-3p from hypoxic BMSCs to TNBC targets NFIX and activates Wnt/β-Catenin signaling in TNBC. …”
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