Sodium Butyrate: A Multifaceted Modulator in Colorectal Cancer Therapy by Alexandra Laura Mederle, Alexandra Semenescu, George Andrei Drăghici, Cristina Adriana Dehelean, Nicolae-Valentin Vlăduț, Dragoş Vasile Nica

“…However, its precise mechanisms of action and effects at elevated doses remain insufficiently explored. This study investigated the impact of NaB at physiologically relevant doses on key cellular metrics (viability, confluence, cell number, morphology, nuclear integrity) and a comprehensive set of apoptosis and proliferation regulators (including underexplored genes) in colorectal cancer (CRC) cells. …”
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Comparison of Clinical Characteristics and Mortality Outcome in Critical COVID-19 Patients Infected with Alpha and Omicron Variants by Cheng HI, Chang KW, Wu BC, Teo MY, Hung WS, Wu HM, Huang ACC, Lin CW, Lin TY, Lin HC, Chiu CH, Lin SM

“…The independent risk factors for in-hospital mortality, were Charlson Comorbidity Index (CCI) ≥ 3 and higher PT and creatine levels.Conclusion: Our study discovered that CCI ≥ 3, elevated serum creatine levels, and prolonged PT were independently associated with a high mortality rate in patients with critical COVID-19. …”
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Hyperbaric oxygen potentiates platelet-rich plasma composition and accelerates bone healing by Wen-Shuo Chang, Chien-Cheng Huang, Tzu-Hao Chen, Ssu-Han Chao, Cheng-Hsien Lin, Ching-Ping Chang, Chi-Sheng Chien

“…In vivo, hPRP treatment resulted in enhanced bone healing, higher OPG levels in osteoblasts and osteoclasts, and an elevated OPG/RANKL ratio compared to nPRP. Conclusions: HBOP enhances the biological activity of PRP and accelerates bone healing in a closed femur fracture model in rats. …”
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Mechanism of Bone-metastatic LUAD Cells Promoting Angiogenesis 
Through HGF/YAP Signaling Pathway by Yan DENG, Rong QIU, Xingyu LIU, Yingyang SU, Yang XUE, Yuzhen DU

“…Bioinformatics analysis, combined with in vitro experiment, demonstrated that the secretory protein HGF was significantly elevated in BM3 cells and BM3-CM (P<0.05). The addition of HGF neutralizing antibodies to BM3-CM inhibited the promoting effect of BM3-CM on HUVEC (P<0.05), while the addition of recombinant HGF to A549-CM reproduced that promoting effect of BM3-CM on HUVEC (P<0.05). …”
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Semaphorin-4D signaling in recruiting dental stem cells for vascular stabilization by Lili Zhang, Dineshi Sewvandi Thalakiriyawa, Jiawei Liu, Shengyan Yang, Yan Wang, Waruna Lakmal Dissanayaka

“…Mechanistically, Sema4D was found to upregulate the expression of methyltransferases, specifically METTL3, and to elevate the level of m6A modification in HUVECs. This modification was determined to be critical for enhancing PDGF-BB secretion, suggesting that Sema4D activates an epigenetic regulatory mechanism. …”
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Immune Mediator Profile in Aqueous Humor Differs in Patients with Primary Acquired Ocular Toxoplasmosis and Recurrent Acute Ocular Toxoplasmosis by Claudia Thieme, Stephan Schlickeiser, Sylvia Metzner, Claudia Dames, Uwe Pleyer

“…Patients with rOT showed elevated levels of IL-2, IFN-γ, TNF-α, IL-15, IL-4, IL-5, IL-9, IL-17, IL-1Rα, IL-6, IL-1β, and chemokines MIP-1α, IP-10, Eotaxin, IL-8, RANTES, PDGF-bb, G-CSF, and MCP-1 compared to controls (p<0.05). …”
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Predictive role of SLC1A5 in neuroblastoma prognosis and immunotherapy by Jian Cheng, Miaomiao Sun, Xiao Dong, Yang Yang, Xiaohan Qin, Xing Zhou, Yongcheng Fu, Yuanyuan Wang, Jingyue Wang, Da Zhang

“…Results SLC1A5 expression was significantly elevated in high-risk neuroblastoma and correlated with advanced stages and poor prognosis. …”
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Impact of Self-Management Clustered Care on Psychological and Birth Outcomes in Gestational Diabetes by Tang S, Wang S, Wu J, Hu S, Lu T, Zhu M, Li J, Xue F

“…The study group demonstrated an elevated spontaneous delivery rate compared to the control group (χ2=5.168, P< 0.05). …”
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A dehazing and enhancement algorithm for heterogeneous images of underground mining environments in coal mines by Xuhui ZHANG, Yanbin XIE, Wenjuan YANG, Chao ZHANG, Jicheng WAN, Zheng DONG, Yanqun WANG, Jie JIANG, Long LI

“…The results indicate that compared to the above novel and excellent algorithms in terms of their optimal indicators, the proposed algorithm exhibited that: (1) The average gradients were approximately twice those obtained by CEEF, suggesting elevated image clarity. (2) The average information entropy decreased by approximately 1% compared to that of MRP, implying more information preserved. (3) The standard deviation increased by approximately 6% on average compared to OSFD, representing improved image contrast. (4) The average fog aware density evaluator (FADE) value by approximately 23% compared to CEEF, implying an effective reduction in the haze Therefore, the proposed algorithm can effectively improve the visual effects and quality of blurred images of underground mining environments in coal mines, exhibiting high utility in engineering.…”
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Efficacy and safety of PCSK9 inhibitors, potent statins, and their combinations for reducing low-density lipoprotein cholesterol in hyperlipidemia patients: a systematic network me... by Yuhua Jiang, Yingying Wang, Sijia Ma, Linlin Qian, Yeteng Jing, Xi Chen, Jinsheng Yang

“…BackgroundThe objective of this study is to assess the relative efficacy of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, such as alirocumab, evolocumab, and inclisiran, in conjunction with potent statins like atorvastatin and rosuvastatin, in patients presenting with hyperlipidemia or heightened cardiovascular risk attributable to elevated low-density lipoprotein cholesterol (LDL-C).MethodsA systematic search was conducted across databases including PubMed, Embase, and the Cochrane Library to explore lipid-lowering therapies in hyperlipidemia from their inception to 7 November 2023. …”
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Financial crisis and its association with parental stress and children’s mental health in Lebanon by Ramona Nasr, Samantha Abi Saab, Nada Nasr, Chadia Haddad, Eman Swaidan, Sara Abou Ibrahim, Joanne Karam

“…Parental stress was heightened among those with lower education levels, non-Lebanese nationality, and employment in low-wage jobs, with children from these families exhibiting elevated mental health symptoms. Additionally, regional factors and socioeconomic status played a role, as children in urbanized areas and technical schools reported higher distress. …”
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Integrating single-cell RNA-Seq and bulk RNA-Seq data to explore the key role of fatty acid metabolism in hepatocellular carcinoma by Hua Dai, Xin Tao, Yuansen Shu, Fanrong Liu, Xiaoping Cheng, Xiushen Li, Bairui Shu, Hongcheng Luo, XuXiang Chen, Zhaorui Cheng

“…Cellular communication analysis revealed that PTGES3 exhibits the highest communication intensity with T cells, modulating the tumor microenvironment by potentiating the FN1/CD44 + MDK/NCL signaling pathway. Elevated expression of PTGES3 was linked to immunosuppressive cascades, diminished responsiveness to immunotherapy, and inferior overall survival outcomes. …”
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Evaluation of a Guided Chatbot Intervention for Young People in Jordan: Feasibility Randomized Controlled Trial by Anne Marijn de Graaff, Rand Habashneh, Sarah Fanatseh, Dharani Keyan, Aemal Akhtar, Adnan Abualhaija, Muhannad Faroun, Ibrahim Said Aqel, Latefa Dardas, Chiara Servili, Mark van Ommeren, Richard Bryant, Kenneth Carswell

“…MethodsA 2-arm, single-blind, feasibility randomized controlled trial was conducted among 60 young people aged 18 years to 21 years living in Jordan with self-reported elevated levels of psychological distress. Immediately after baseline, participants were randomized 1:1 into the STARS intervention or enhanced care as usual (ECAU). …”
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Myofibrillogenesis Regulator-1 in Smooth Muscle Cells Modulates Inflammation Signaling Pathways via Regulating ROCK1 Ubiquitination and Degradation to Impact Aortic Dissection by Yin H, Li X, Lu D, Zhao X, Yang Z, Wang Z, Xu F, Chen Y, Li C

“…In vitro experiments, human aortic smooth muscle cells were extracted, and an in vitro dissection model was constructed with angiotensin II. siRNA silencing studies were performed to investigate the effects of MR-1 and ROCK1 on the development of AD and their interconnections.Results: Analysis of aortic tissues revealed significantly elevated levels of MR-1 and ROCK1 in AD patients, and meanwhile the inflammatory indexes showed the same trend. …”
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Multiomic characterization, immunological and prognostic potential of SMAD3 in pan-cancer and validation in LIHC by Tao Zhou, Dan Dan Zhang, Jiejing jin, Jinyang Xie, Jianhua Yu, Chao Zhu, Rong Wan

“…Additionally, our analysis of SMAD3 methylation patterns in human cancers unveiled a favorable prognosis linked to elevated DNA methylation levels in pan-cancer. Furthermore, we identified positive associations between SMAD3 expression and RNAm6A methylation-related genes in the majority of cancers. …”
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Decoding gene expression dynamics in planktonic and biofilm cells of Streptococcus mutans: regulation and role of mutanofactin genes in biofilm formation by Muhammad Afzal, Miguel Carda-Diéguez, Susanne Bloch, Susanne Bloch, Leon G. S. Thies, Alex Mira, Christina Schäffer

“…Notably, expression of the muf gene cluster, was elevated in early exponential-phase cells relative to stationary-phase cells. …”
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Going, going, gone: Landscape drying reduces wetland function across the American West by J. Patrick Donnelly, Johnnie N. Moore, John S. Kimball, Kelsey Jencso, Mark Petrie, David E. Naugle

“…Outcomes from this work improve our understanding of environmental change, elevating the urgency of developing adaptive conservation strategies in light of the rapidly evolving trajectory of wetland ecosystems in the western U.S.…”
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Association Between Liver Fibrosis and Risk of Incident Stroke and Mortality: A Large Prospective Cohort Study by Zijie Wang, Zhitao Gong, Jianshang Wen, Shanyu Zhang, Xiao Hu, Wenliang Guo, Yanghua Tian, Qi Li

“…Noninvasive indices of liver fibrosis may serve as an easily accessible marker to detect individuals facing elevated risk of stroke and death in the primary prevention settings.…”
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Un ensemble funéraire de l’Antiquité tardive à dépôt atypique d’âne à Woippy (Moselle) by Gaël Brkojewitsch, Olivier Putelat

“…It also appears that the burial area developed around a hierarchically elevated grave containing the burial (no 1) of a probable young adult male. …”
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Question–Answer Methodology for Vulnerable Source Code Review via Prototype-Based Model-Agnostic Meta-Learning by Pablo Corona-Fraga, Aldo Hernandez-Suarez, Gabriel Sanchez-Perez, Linda Karina Toscano-Medina, Hector Perez-Meana, Jose Portillo-Portillo, Jesus Olivares-Mercado, Luis Javier García Villalba

“…Traditional static and dynamic analysis techniques, although widely used, often exhibit high false-positive rates, elevated costs, and limited interpretability. Machine Learning (ML)-based approaches aim to overcome these limitations but encounter challenges related to scalability and adaptability due to their reliance on large labeled datasets and their limited alignment with the requirements of secure development teams. …”
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