Expression and delivery of HA1-M2e antigen using an innovative attenuated Salmonella–mediated delivery system confers promising protection against H9N2 avian influenza challenge by Ram Prasad Aganja, In-Shik Kim, Hyun-Jin Tae, John Hwa Lee

“…The IL-4 and IFN-γ levels were elevated, indicating a balanced Th-1 and Th-2 response. …”
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Different starch sources and amino acid levels on growth performance, starch and amino acids digestion, absorption and metabolism of 0- to 3-week-old broilers fed low protein diet by Caiwei Luo, Jinping Wang, Wei Jiang, Dafei Yin, Gang Meng, Jiwei Wang, Jing Xu, Jianmin Yuan

“…Compared with the corn starch diet, waxy corn starch and tapioca starch diets significantly elevated the AID of Met, Glu, Lys, Arg, Asp, His, Ile, Tyr, Gly, and Val levels (P < 0.05). …”
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NH3 release during the snow evaporation process in typical cities in Northeast China by Xiaoteng Liu, Hongsheng Jia, Yunze Zhao, Yachao Zhang, Haodong Hou, Yingying Xu

“…As particulate matter acts as a condensation nucleus for wet deposition, the NH4 + concentrations in precipitation are typically elevated. During the evaporation process of wet deposition, NH4 + is likely to be re-emitted as a gas (NH3). …”
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Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms by Mariah A. Manter, Kirstin B. Birtwell, James Bath, Nora D. B. Friedman, Christopher J. Keary, Ann M. Neumeyer, Michelle L. Palumbo, Robyn P. Thom, Emily Stonestreet, Hannah Brooks, Kelly Dakin, Jacob M. Hooker, Christopher J. McDougle

“…Autistic individuals face elevated rates of co-occurring medical, psychiatric, and behavioral conditions compared to non-autistic individuals. …”
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New Approach to Improving the Prognosis of Ischemic Stroke by Regulating SCFAs with Acupuncture-Rehabilitation Therapy Based on Gut-Brain Axis by TANG Qiang, LIU Chong, CHAI Fanglei, ZHANG Jinpeng, LI Hongyu, ZHU Luwen

“…The inflammatory reaction has cascade amplification effect, and inflammatory factors can aggravate secondary brain damage, thereby affecting the self-repair of the central nervous system.The elevated levels of inflammatory indicators lead to poor prognosis and a variety of complications. …”
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Integrated Analysis of Cell-Free DNA and Novel Protein Biomarkers for Stratification and Therapy Monitoring in Stage IV Pancreatic Cancer: A Preliminary Study by Saskia Hussung, Maria E. Hess, Elham Bavafaye Haghighi, Uwe A. Wittel, Melanie Boerries, Ralph M. Fritsch

“…<b>Results</b>: <i>KRAS</i>^mut cfDNA was detectable in 37/47 (78.7%) patients throughout the course of study, and CA 19-9 levels were elevated in 40 out of 47 (85.1%) patients. <i>KRAS</i>^mut cfDNA increase at the time of the first follow-up could predict inferior progression-free survival (PFS) (Hazard ratio (HR) = 3.40, <i>p</i> = 0.0003) and overall survival (OS) (HR = 4.91, <i>p</i> < 0.0001). …”
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Gene content of seawater microbes is a strong predictor of water chemistry across the Great Barrier Reef by Marko Terzin, Steven J. Robbins, Sara C. Bell, Kim-Anh Lê Cao, Renee K. Gruber, Pedro R. Frade, Nicole S. Webster, Yun Kit Yeoh, David G. Bourne, Patrick W. Laffy

“…., Rhodospirillaceae, Burkholderiaceae, Flavobacteriaceae, and Rhodobacteraceae) were enriched in reefs with elevated dissolved organic carbon (DOC) and phytoplankton-derived POM, encoding functional genes related to membrane transport, sugar utilization, and energy metabolism. …”
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Inflammatory Indices and MAFLD Prevalence in Hypertensive Patients: A Large-Scale Cross-Sectional Analysis from China by Shen D, Cai X, Hu J, Song S, Zhu Q, Ma H, Zhang Y, Ma R, Zhou P, Yang W, Hong J, Zhang D, Li N

“…The diagnostic performance of these indices was analyzed using receiver operating characteristic (ROC) curves and area under the curve (AUC) calculations.Results: Patients with MAFLD exhibited significantly elevated levels of all inflammatory indices compared to those without. …”
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RETRACTED: Long non‐coding RNA Sox2OT promotes coronary microembolization‐induced myocardial injury by mediating pyroptosis by Liying Xuan, Danni Fu, Dong Zhen, Dongsong Bai, Lijun Yu, Guohua Gong

“…Compared with the sham group (1.05 ± 0.32), lncRNA Sox2OT level (4.41 ± 0.67) in the CME group was elevated (P < 0.05). Sox2OT acted as a competitive endogenous RNA (ceRNA) of miR‐23b to regulate TLR4. …”
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Real-world outcomes in patients with melanoma brain metastasis: a US multisite retrospective chart review study of systemic treatments by Ning Ning, Sunandana Chandra, Andriy Moshyk, Divya Patel, Isabella C Glitza Oliva, Jennell Palaia, Leon A Sakkal, Natalia Han, Shardul Odak, Jordana K Schmier

“…Patients receiving nivolumab plus ipilimumab, compared with patients receiving anti-PD-1 monotherapy or BRAF/MEK inhibitors, had favourable baseline prognostic factors, such as younger age, fewer or smaller brain metastases, better Eastern Cooperative Oncology Group performance status and less frequently elevated lactate dehydrogenase. Median follow-up times were 15.4 months (range 0.1 to 37.0), 13.3 months (range 0.3 to 36.6) and 13.9 months (range 1.9 to 36.5), respectively. …”
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Association between the hemoglobin A1c/High-density lipoprotein cholesterol ratio and stroke incidence: a prospective nationwide cohort study in China by Chaojuan Huang, Hongtao You, Yuyang Zhang, Ligang Fan, Xingliang Feng, Naiyuan Shao

“…Consistent associations were observed across most stratified subgroups. Conclusions Elevated baseline and cumulative mean HbA1c/HDL-C levels are significantly associated with an increased risk of stroke among middle-aged and older individuals in China, underscoring the potential of HbA1c/HDL-C as a clinical marker for long-term stroke risk assessment and prevention strategies.…”
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Long-Term Analysis of Recurrence Beyond Milan Criteria Following Ablation of Solitary Early-Stage Hepatocellular Carcinoma &le;3 cm in Potentially Transplantable Patients: A Over 1... by Chen S, Qi H, Tan H, Cao F, Xie L, Huang T, Wu Y, Wen C, Wang Y, Shen L, Fan W

“…Also, cirrhosis, CRP≥ 1.81 mg/L and PLT≤ 80× 109/L were identified as independent risk factors of the occurrence of RBM. Elevated Platelet-CRP Score(PCS), integrating CRP and PLT, correlated significantly with an increased incidence of RBM and a more aggressive phenotype, characterized by vascular invasion or metastatic dissemination (P< 0.05). …”
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Association of preoperative blood biomarkers with postoperative major adverse cardiac events and mortality in major orthopaedic surgery: a systematic review and meta-analysis by Lin Lu, Yi Ren, Zhen Hua, Yanxia Sun, Zhenghao Wen, Suzhen Zhou

“…This study aimed to assess the association between preoperative blood biomarkers and postoperative MACEs as well as all-cause mortality in patients undergoing major orthopaedic surgery.Design A systematic review and meta-analysis.Data sources PubMed, EMBASE, the Cochrane Controlled Trials Register and Cochrane Database of Systematic Reviews from inception to 20 October 2024 were searched.Eligibility criteria Observational or experimental studies reporting the correlation between preoperative blood biomarkers and postoperative MACEs—categorised as short-term (within 3 months) or long-term (beyond 3 months)—and all-cause mortality in patients undergoing major orthopaedic surgery.Data extraction and synthesis Data from studies reporting OR or HR and its 95% CI were pooled for analysis using random-effects model.Results 21 preoperative blood-based biomarkers from 80 studies with 226 468 patients were analysed. Elevated preoperative cardiac biomarkers were correlated with a heightened risk of MACEs within 3 months (natriuretic peptide: OR 3.37, 95% CI 2.07 to 5.47, I2=87.9%; cardiac troponin: OR 4.89, 95% CI 1.52 to 15.75, I2=69.5%) with significant heterogeneity. …”
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Prognostic value of body adipose tissue parameters in cancer patients treated with immune checkpoint inhibitors by Yan Li, Yean Yu, Kun Lv, Rongjuan Ge, Xie Xie

“…Additionally, increased subcutaneous adipose tissue (SAT) levels were associated with significantly better OS (HR: 0.69, 95% CI: 0.58–0.82, p &lt; 0.001) and PFS (HR: 0.82, 95% CI: 0.68–1.00, p = 0.049), and a higher DCR (OR: 1.99, 95% CI: 1.15–3.44, p = 0.014). Elevated total adipose tissue (TAT) levels were also linked to longer OS (HR: 0.73, 95% CI: 0.55–0.97, p = 0.028). …”
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The Impact of Nutritional Status and Tumor-Infiltrating Lymphocytes (CD4+ and CD8+) on Chemotherapy Response in Colorectal Cancer Patients by Lukman K, Septianto R, Rudiman R, Ruchimat T, Sribudiani Y, Nugraha P, Primastari E, Budiman D

“…Nutritional status, levels of CD4+ and CD8+ were significantly associated with chemotherapy responses in CRC patients (p< 0.001).Conclusion: Nutritional status and elevated TIL levels (CD4+/CD8+) positively correlate with better chemotherapy response in CRC patients.Plain Language Summary: Colorectal cancer is the second leading cause of cancer-related deaths worldwide, with 1.9 million new cases reported annually, according to the World Health Organization. …”
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Microfluidic Synthesis of miR-200c-3p Lipid Nanoparticles: Targeting ZEB2 to Alleviate Chondrocyte Damage in Osteoarthritis by Zheng D, Chen T, Yang K, Yin G, Chen Y, Gui J, Xu C, Lv S

“…The ZEB2 expression was greatly elevated following LPS stimulation and dramatically decreased following transfection of miR-200c-3p. …”
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Pre-pregnancy BMI modifies the associations between triglyceride–glucose index in early pregnancy and adverse perinatal outcomes: a 5-year cohort study of 67,936 women in China by Li Li, Yulai Zhou, Huan Li, Juan Li, Lishi Huang, Weibin Wu

“…Conclusions Dose–response relationships were identified between elevated maternal TyG index in early pregnancy and APOs. …”
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Regulation of LPS-Induced Inflammatory Responses in Bovine Mammary Epithelial Cells via TLR4-Mediated NF-κB and MAPK Signaling Pathways by Lactoferrin by Kai Zhang, Ruizhen Zhang, Yuanyuan Zhang, Min Zhang, Hong Su, Feifei Zhao, Daqing Wang, Guifang Cao, Yong Zhang

“…However, when LF was added after the onset of LPS-induced inflammation, inflammatory cytokine expression and phosphorylation levels in the NF-κB/P65 and MAPK/P38/ERK pathways remained elevated, along with high expression of the TLR4 receptor gene (<i>p</i> < 0.05). …”
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Prevalence, Patterns and Factors Associated with Dyslipidemia Among Adult Hypertensive Patients by Muktar Hassan Mohamud, Awil Abdulkadir Abdi, Abishir Mohamud Hirsi, Ibrahim Ahmed Nur, Alina Peris

“…Multivariate analysis revealed that patients with elevated blood pressure, stage 1 hypertension, and stage 2 hypertension had 1.350 (aOR = 1.350, CI = 1.194-1.525, P < 0.001), 1.290 (aOR = 1.290, CI = 1.123-1.482, P < 0.001), and 1.302 (aOR = 1.302, CI = 1.077-1.576, P = 0.007) times higher odds of having dyslipidemia, respectively. …”
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Biologic Therapy and Cardiometabolic Risk in Psoriasis: A Retrospective Review by Annika Smith, Aidin Karahasan, Deborah Yi, Sanjay Yapabandara, James Elhindi, Pablo Fernandez-Penas, Clara Chow, Sarah Zaman

“…Biologic therapy effectively treats the cutaneous inflammatory burden of psoriasis and evolving evidence suggests potential to reduce systemic inflammatory sequalae that can elevate cardiovascular risk. This study aimed to assess the change in cardiometabolic risk markers in a cohort of patients with psoriasis treated with 1 year of continuous biologic treatment. …”
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