Identification and validation of prognostic biomarkers in ccRCC: immune-stromal score and survival prediction by Fang Lyu, Yuxin Zhong, Qingliu He, Wen Xiao, Xiaoping Zhang

“…Immune profiling revealed significant differences in the TME between risk groups, with high-risk patients displaying elevated expression of HLA and immune checkpoints. …”
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Segmental analysis of human hair reveals intra-annual variation in 25(OH)D3 concentrations in modern and archaeological individuals by Kate Britton, Orsolya Czére, Eléa Gutierrez, Linda M. Reynard, Eamon Laird, Gary Duncan, Baukje de Roos

“…For a subset of our cohort (n = 4) isotope analysis highlighted potential relationships between elevated δ 18O values (which can indicate season of hair growth) and 25(OH)D3 concentrations in some individuals, which may reflect seasonally-increased UVB exposure. …”
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Relationship between serum ECP and TIgE levels and the risk of postoperative recurrence in patients with chronic rhinosinusitis with nasal polyps by Qing Zhang, Hui Li, Di Xie, SiJian Fan

“…Significant differences were not observed in any general clinical data.ConclusionThe findings suggest that elevated serum ECP and TIgE levels in patients with CRSwNP can be as good predictors for the risk of recurrence after endoscopic sinus surgery.…”
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Pulmonary and systemic immune alterations in rats exposed to airborne lunar dust by Brian E. Crucian, Heather Quiriarte, Chiu-wing Lam, Mayra Nelman, Audrie A. Colorado, Douglass M. Diak, John T. James

“…By week 4, the peripheral granulocyte percentage was elevated in the treated rats. Plasma cytokine levels were unchanged in all treated rats compared to controls; however, altered mitogen-stimulated cytokine production profiles were observed consisting of increased IL-1β and IL-6 and decreased IL-2. …”
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NKX6.3 modulation of mitotic dynamics and genomic stability in gastric carcinogenesis by Jung Hwan Yoon, Jeong-Kyu Kim, Jung Woo Eun, Hassan Ashktorab, Duane T. Smoot, Suk Woo Nam, Won Sang Park

“…These abnormalities corresponded with elevated levels of genomic instability markers, indicating compromised genomic integrity. …”
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Mesalazine-Induced Acute Pancreatitis in Inflammatory Bowel Disease Patients: A Systematic Review by Pan J, Li Z, Ye C, Zhang X, Yang Q, Zhang X, Zhou Y, Zhang J

“…Common symptoms included abdominal pain (100%), vomiting (38.1%), fever (21.4%), and nausea (21.4%). Most patients had elevated serum amylase and lipase levels, with some showing raised C-reactive protein and erythrocyte sedimentation rate. …”
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Examining the association between child development and parental mental health after preterm birth-related stress: a systematic review of the literature and meta-analysis protocol by Lotte Haverman, Cornelieke S H Aarnoudse-Moens, Joost G Daams, Gerbrich E van den Bosch, Kirsten S Muller, Celina E Henke

“…Simultaneously, adverse child development after preterm birth can (further) elevate parental stress and mental health problems, straining parental behaviour, the parent–infant relationship and child development. …”
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Enhancing Food Security via selecting Superior Camelina (Camelina sativa L.) parents: a positive approach incorporating pheno-morphological traits, fatty acids composition, and Toc... by Amin Ebrahimi, Hamzeh Minaei Chenar, Sajad Rashidi-Monfared, Danial Kahrizi

“…Conversely, in the realm of biochemical traits, lines 35, 66, 47, 30, 65, 135, 83, 27, 4, 77, 62, 81, and 93 stood out for their elevated potential. The gene expression analysis related to the tocopherol biosynthesis pathway revealed distinct expression patterns. …”
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Protective effect and mechanism of Sufentanil on acute lung injury in septic mice by Hongqiao Hou, Bowen Jiang, Aiqing Zhu, Junjun Hou, Zhe Qu, Ruping Liu, Aiqun Li

“…According to the results of animal experiments, compared with the control group, mice in the model group had severe lung tissue injury and elevated expression of relevant inflammatory factors in lung tissue. …”
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Beeswax Alcohol (BWA, Raydel^®) Improved Blood Oxidative Variables and Ameliorated Severe Damage of Zebrafish Kidneys, Testes, and Ovaries Impaired by 24-Week Consumption... by Kyung-Hyun Cho, Ashutosh Bahuguna, Ji-Eun Kim, Yunki Lee, Sang Hyuk Lee, Cheolmin Jeon, Cheol-Hee Kim

“…Results: The HC+Gal-elevated plasma oxidative variables were reverted by the consumption of BWA, marked by the lowest plasma malondialdehyde (MDA) level and highest sulfhydryl content. …”
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Ivermectin as a promising therapeutic option for onchocerciasis‐associated epilepsy by Mohammad Amin Manavi, Razieh Mohammad Jafari, Hamed Shafaroodi, Mohammad Sharifzadeh, Ahmad Reza Dehpour

“…These areas exhibit elevated rates of epilepsy, underscoring the significant impact of ongoing onchocerciasis on the incidence of epilepsy, particularly within the specified age range. …”
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Socially inclusive valorization of gold mill tailings from the small-scale gold mining sector by R.M. Balanay, R.P. Varela, A. Balbin, M.A. Lavapiez

“…A gap analysis was utilized to pinpoint the methods for enhancing a socially inclusive reuse strategy for the mill tailings.FINDINGS: The characterization of the tailings reveal that some heavy metals like zinc, titanium, copper, barium, and manganese, and hazardous substances like arsenic, mercury, and lead are present. Elevated levels of mercury, lead, and free cyanide were detected in the wastewater, with concentrations of 0.029 milligram per liter, 0.40 milligram per liter, and 1.9 milligram per liter, respectively, surpassing the allowable thresholds. …”
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The effect of SARS-CoV-2 Omicron BA. 5.2 infection on perioperative physiological indicators in orthopedic patients by Hao Wu, JunZhe Yang, YuQin Yan, Xiao Hu, BiXi Li, PengFei Cheng, XiaoYang Song

“…Conclusion Omicron BA. 5.2 Infection affects the perioperative coagulation function of orthopedic patients, thereby inducing a hypercoagulable state characterized by significant elevations in D-dimer and FDP levels and increasing the risk of venous thrombosis. …”
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Effects of Yam Powder Produced by Different Drying Ways on the Quality and Antioxidant Activity of Greek Style Yogurt during Refrigeration by Rongkun MA, Zhongyi ZHANG, Shangzhen CHENG

“…Notably, the solid content of the Y3 group (freeze drying) was significantly elevated compared to both the Y1 group (hot air drying) and the Y2 group (microwave drying) (P<0.05). …”
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The Impact of Complete Revascularization in Symptomatic Severe Left Ventricular Dysfunction between Coronary Artery Bypass Graft and Percutaneous Coronary Intervention by Hsiu-Yu Fang, Yen-Nan Fang, Yin-Chia Chen, Jiunn-Jye Sheu, Wei-Chieh Lee

“…The patients (N = 236) who were diagnosed with dilated cardiomyopathy or valvular heart disease without coronary artery stenosis, those with prior history of CABG or valvular surgery (N = 59), those who presented ST-segment elevated myocardial infarction (STEMI), those with a CAD and SYNTAX score of  ≦ 22 (N = 175), those who received emergent CABG for coronary perforation (N = 3), and those who had NYHA class ≦ 2 (N = 65) were excluded. …”
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Correlation between the Serum Platelet-Derived Growth Factor, Angiopoietin-1, and Severity of Coronary Heart Disease by Sisi Pang, Zhengxian Tao, Xiaoyan Min, Chuanwei Zhou, Dijia Pan, Zhen Cao, Xiangming Wang

“…In peripheral blood, the concentration of the PDGF was significantly elevated in the ACS group than that of the control group. …”
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SUMO modified ETV1 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by facilitating CCL2 transcription in esophageal squamous cell carcinoma ce... by Tianci Han, Xiaoqi Guo, Junwei Xie, Wei Tong, Liang Zhang

“…C–C motif chemokine ligand 2 (CCL2), a key factor inducing M2 macrophage polarization, was also found to be elevated in ESCC tumor tissues. Mechanism study demonstrated that ETV1 facilitated M2 macrophage infiltration via the transcriptional modulation of CCL2. …”
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Inhibition of complement system-related gene ITGB2 attenuates epithelial–mesenchymal transition and inflammation in diabetic nephropathy by Jun Peng, Wenqi Zhao, Lu Zhou, Kun Ding

“…Besides, mRNA and protein expression levels of ITGB2 in HG-treated HK-2 cells were remarkably elevated. Moreover, the viability of HK-2 cells, expression of TNF-α, IL-6, IL-12, α-SMA, E-cadherin and vimentin in HK-2 cells changed by HG administration were reversed by ITGB2-silence. …”
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Blood metal levels predict digestive tract cancer risk using machine learning in a U.S. cohort by Chenyuan Shi, Hanfeng Jiang, Fangzhou Zhao, Yigang Zhang, Haoming Chen

“…Compared to healthy controls, EC patients exhibited significantly higher blood levels of potassium (K, 4.40 vs. 4.00 mmol/L), cadmium (Cd, 12.46 vs. 2.49 µg/L), and lead (Pb, 0.09 vs. 0.05 µg/L). GC patients had elevated Pb levels (0.08 vs. 0.05 µg/L), while CRC patients showed higher concentrations of Cd (3.11 vs. 2.49 µg/L) and Pb (0.06 vs. 0.04 µg/L). …”
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The Plasma Soluble Urokinase Plasminogen Activator Receptor Is Related to Disease Activity of Patients with ANCA-Associated Vasculitis by Fei Huang, Yueqiang Li, Ranran Xu, Anying Cheng, Yongman Lv, Qingquan Liu

“…Furthermore, suPAR was significantly elevated in AAV patients in active stage compared to those in partial remissions (6,492.19±3,689.48 vs. 5,031.86±2,489.01 pg/mL, P=0.039). …”
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