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7461
Multi-Isotope Geochemical Baseline Study of the Carbon Management Canada Research Institutes CCS Field Research Station (Alberta, Canada), Prior to CO2 Injection
Published 2023-12-01“…Importantly, 4He concentrations in all gas samples lie on a mixing line between the atmosphere and the elevated 4He concentration present in a hydrocarbon well sampled from a reservoir located below the Field Research Station (FRS) implying a diffusive or advective crustal flux of 4He at the site. …”
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7462
The ameliorative effects of melatonin against BDE-47-induced hippocampal neuronal ferroptosis and cognitive dysfunction through Nrf2-Chaperone-mediated autophagy of ACSL4 degradati...
Published 2025-01-01“…Acyl-CoA synthetase long-chain family member 4 (ACSL4), a key lipid metabolism enzyme dictating ferroptosis sensitivity, accompanied by higher MDA and lipid reactive oxygen species (ROS), was remarkably increased under BDE-47 stress, while melatonin supplementation could suppress the elevated ACSL4 in vivo and in vitro. Furthermore, melatonin facilitated lysosomal ACSL4 degradation through enhancing lysosome-associated membrane protein type 2a (LAMP2a) expression and chaperone-mediated autophagy (CMA) activity, while LAMP2a knockdown abrogated the positive effects of melatonin on ACSL4 elimination in BDE-47-treated HT-22 cells. …”
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7463
Effect of different intraoperative blood pressure regulation levels on postoperative myocardial injury in patients undergoing radical mastectomy for breast cancer after receiving n...
Published 2025-01-01“…This study is being conducted to determine whether targeting mean arterial pressure (MAP) to 100%–120% of the patient’s baseline blood pressure reduces the incidence of myocardial injury after non-cardiac surgery (MINS) compared with targeting MAP to 80%–100%. MINS is defined as elevated cardiac troponin levels within 30 days after non-cardiac surgery with or without clinical and electrocardiographic signs of cardiac ischaemia.Methods and analysis The study is a single-centre, single-blind, prospective randomised controlled trial. …”
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7464
Seasonal air concentration variability, gas–particle partitioning, precipitation scavenging, and air–water equilibrium of organophosphate esters in southern Canada
Published 2025-01-01“…Whereas consistent seasonal trends were not observed for OPE concentrations in precipitation or atmospheric particles, gas phase concentrations of several OPEs were elevated during the summer in suburban Toronto and at two remote sites on Canada's eastern and western coast. …”
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7465
Comparison of Different Invasive Devices for the Treatment of Urinary Incontinence after Radical Prostatectomy
Published 2022-01-01“…Results are conditioned by an elevated rate of heterogeneity in part explained with a high variability of consistence in urinary leakage at baseline among populations.…”
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7466
NF-κB-Specific Suppression in Cardiomyocytes Unveils Aging-Associated Responses in Cardiac Tissue
Published 2025-01-01“…Additionally, cardiac fibrosis, senescence-associated β-galactosidase activity, p21 protein expression, and DNA damage (marked by phosphorylated H2A.X) were elevated in aged WT and both young and aged 3M mice. …”
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7467
Pediatric bacterial meningitis in southern China: analysis of 838 cases
Published 2025-02-01“…Most patients initially exhibited typical cerebrospinal fluid (CSF) changes of BM, including elevated white blood cell count, increased protein levels, and decreased glucose concentration. …”
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7468
Correlation between the white blood cell/platelet ratio and 28-day all-cause mortality in cardiac arrest patients: a retrospective cohort study based on machine learning
Published 2025-01-01“…Subgroup analyses indicated that elevated WPR was particularly associated with increased mortality in males, elderly patients, married individuals, and those with chronic pulmonary disease.ConclusionWPR serves as an independent and reliable prognostic biomarker for 28-day mortality in cardiac arrest patients. …”
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7469
Heat shock transcription factor 1 facilitates liver cancer progression by driving super‐enhancer‐mediated transcription of MYCN
Published 2024-09-01“…Results HSF1 expression is elevated in HCC and is linked to poor prognosis in several datasets. …”
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7470
A disintegrin and metallopeptidase domain (ADAM) 12, ADAM 17 mRNA and ADAM10 protein hold potential as biomarkers for detection of early gastric cancer
Published 2025-01-01“…In human blood sample analyses, ADAM12 (p = 0.0007), ADAM17 mRNA (p < 0.0001) and ADAM10 (p < 0.0017) protein were significantly elevated in patients with EGC (n = 27 for mRNA and n = 25 for protein) compared to the controls (n = 30 for mRNA and n = 26 for protein). …”
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7471
Identification and validation of immune and diagnostic biomarkers for interstitial cystitis/painful bladder syndrome by integrating bioinformatics and machine-learning
Published 2025-01-01“…Analysis of IC/BPS tissue samples confirmed elevated PLAC8 expression and the presence of immune cell markers in the validation cohorts. …”
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7472
Development of a transportable High-Performance Liquid Chromatograph with Ultraviolet detection and a method for the rapid analysis of 13 carbonyl compounds hydrazones
Published 2025-05-01“…In environments with elevated air pollution, highly reactive aldehydes pose significant health concerns. …”
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7473
Patterns of failure and prognosis in nasopharyngeal carcinoma according to Epstein-Barr virus DNA status
Published 2025-02-01“…While the EBV-DNA positivity rate did not differ significantly between oligometastatic disease and polymetastatic disease (P = 0.493), the levels were significantly elevated in the polymetastatic disease group than the oligometastatic disease group (P < 0.001). …”
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7474
Association between some environmental risk factors and attention-deficit hyperactivity disorder among children in Egypt: a case-control study
Published 2025-01-01“…The logistic regression model revealed that six factors had a significant association with ADHD: using of newspapers to wrap food 3 or more times a week (adjusted odds ratio (AOR) = 105.11, 95% CI: 11.18-988.26), daily TV watching by child for more than 5 h (AOR = 63.96, 95% CI: 2.56-1601.32), child’s eating commercially packed noodles 3 times or more per week (AOR = 57.73, 95% CI: 3.77–593.93), using unpackaged flour in cooking (AOR = 44.47, 95% CI: 1.83–629.80), eating sweets daily by child (AOR = 6.82, 95% CI: 1.23–37.94), and lastly elevated hair Manganese level (AOR = 3.57, 95% CI: 1.24–10.29). …”
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7475
GATA1-mediated macrophage polarization via TrkB/cGMP–PKG signaling pathway to promote the development of preeclampsia
Published 2025-01-01“…In comparison with the control group, the proportion of M2 cells elevated significantly in the sh-GATA1 group (P < 0.001). …”
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7476
Defects at the Posttranscriptional Level Account for the Low TCRζ Chain Expression Detected in Gastric Cancer Independently of Caspase-3 Activity
Published 2020-01-01“…These results further place the defect responsible for the low TCRζ expression in cancer at the posttranscriptional level and suggests contrary to what has been proposed in other pathologies that elevated caspase-3 activity is not the causative agent.…”
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7477
Peripheral blood complement factors C2 and C3 as biomarkers of clinical efficacy in patients with first-episode schizophrenia after aripiprazole treatment
Published 2024-12-01“…Results At baseline, patients with SCZ exhibited significantly elevated levels of C1, C2, C3, C4, and CH50 compared to the control group (P < 0.05). …”
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7478
Prevalence and Determinants of Hypertension Awareness, Treatment, and Control in Botswana: A Nationally Representative Population-Based Survey
Published 2020-01-01“…Hypertension was defined as self-report of use of antihypertensives in the previous two weeks and/or having elevated BP (≥140/90 mmHg). Multivariable logistic regression was employed to explore factors associated with hypertension, awareness (report of previous diagnosis), treatment (antihypertensives), and control (BP < 140/90). …”
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7479
Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies
Published 2025-01-01“…Conclusions This meta-analysis demonstrates that elevated AIP is strongly associated with increased CAD risk, greater severity, and poorer prognosis in populations with and without established CAD. …”
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7480
Diagnostic Potential of CTRP5 and Chemerin for Coronary Artery Disease: A Study by Coronary Computed Tomography Angiography
Published 2025-01-01“…<b>Conclusions</b>: CTRP5 and chemerin were significantly elevated in the CCTA-confirmed CAD group compared to the non-CAD group, with CTRP5 showing greater sensitivity and specificity. …”
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