Galectin-3 secreted by triple-negative breast cancer cells regulates T cell function by Annat Raiter, Yael Barhum, Julia Lipovetsky, Chen Menachem, Sharona Elgavish, Shmuel Ruppo, Yehudit Birger, Shai Izraeli, Orna Steinberg-Shemer, Rinat Yerushalmi

“…RNA sequencing of T cells from women with TNBC with elevated plasma levels of Gal-3 revealed significantly lower expression of oxidative phosphorylation genes than in T cells from healthy women. …”
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Genome-Wide Identification and Expression Analysis of the <i>GRF</i> and <i>GIF</i> Gene Families in <i>Prunus avium</i> by Hongxu Chen, Yangang Pei, Wanjia Tang, Hongfen Li, Yidi Huang, Yizhe Chu, Guanqiong Kou, Wenyi Niu, Runmei He, Ronggao Gong

“…Transcriptome data revealed that five <i>PavGRFs</i> exhibited elevated expression levels during the green ripening and color conversion stages in <i>P. avium</i>, <i>PavGRF9</i> and <i>PavGIF1</i> displayed higher expression during the full red stage, and gibberellin treatment led to the upregulation of these five <i>PavGRFs</i> and <i>PavGIF1</i> during the full red stage. …”
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Global Mean and Relative Sea-Level Changes Over the Past 66 Myr: Implications for Early Eocene Ice Sheets by K. G. Miller, W. J. Schmelz, J. V. Browning, Y. Rosenthal, A. V. Hess, R. E. Kopp, J. D. Wright

“…Bayesian analysis with Gaussian process priors shows that our BSL estimate shares a component that covaries on the Myr scale with “backstripped” relative sea-level (RSL) estimates (accounting for compaction, loading, and thermal subsidence) from the US Mid-Atlantic Coastal Plain, validating our method and estimates with errors of ±10 m. Peak warmth, elevated GMGSL and BSL, high CO2, and ice-free conditions occurred at times in the Paleocene to Eocene (ca. 64, 57.5, 35 Ma) and in much of the Early Eocene (55–48 Ma). …”
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Sepiolite immobilizes soil Cd to optimize microbial community structure thereby promoting wheat growth and reducing Cd accumulation by Ziqi Li, Xiaoxun Xu, Xin Qi, Changlian Xu, Guiyin Wang, Shirong Zhang, Zhanbiao Yang, Zhang Cheng, Junzhuo Cai, Guochun Lv, Ting Li, Yulin Pu, Yongxia Jia

“…The findings confirm that applying sepiolite in the field enhanced the main yield traits of wheat, significantly elevated soil pH by 0.30–1.04 units, reduced Cd bioavailability by 55.46 % −93.27 % (P < 0.05), and decreased Cd accumulation in wheat by regulating Cd transport and enrichment in different plant organs. …”
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Association between Circulating B-Type Natriuretic Peptide and Diabetic Peripheral Neuropathy: A Cross-Sectional Study of a Chinese Type 2 Diabetic Population by Pijun Yan, Qin Wan, Zhihong Zhang, Yong Xu, Ying Miao, Pan Chen, Chenlin Gao

“…Circulating levels of BNP were significantly elevated in T2DM patients with DPN compared to those without (P=0.001). …”
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Chitosan oligosaccharide alleviates DON-induced liver injury via suppressing ferroptosis in mice by Mengjie Liu, Zhenlin Li, Jie Li, Guorong Yan, Chaoqi Liu, Qingqiang Yin, Yeqiang Liu, Xiaoxiang Xu

“…The results indicated that COS effectively reversed DON-induced weight loss, elevated liver index, and liver hemorrhage and swelling in mice. …”
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TUBA1B as a novel prognostic biomarker correlated with immunosuppressive tumor microenvironment and immunotherapy response by Juntao Qi, Juntao Qi, Mingming Zhou, Na Yang, Huiyun Ma, Min He, Gujie Wu, Chang Ge, Liuyin Jin, Lin Cheng, Wei Liao, Hefei Ren, Caiyun Lei

“…These insights underscore TUBA1B’s multifaceted role in cancer progression and immune response.Conclusion: This study highlights TUBA1B’s potential as a human oncogene with substantial roles in tumorigenesis and immune regulation. Elevated TUBA1B levels are associated with an immunosuppressive tumor microenvironment, impacting cancer progression and treatment outcomes. …”
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How resistant is anammox biofilm against antibiotics: A special insight into anammox response towards fluoroquinolones by Faysal-Al Mamun, Rohit Kumar, Kelvin Ugochukwu Anwuta, Sovik Das, Madis Jaagura, Koit Herodes, Tetyana Kyrpel, Agnieszka Fiszka Borzyszkowska, Anna Zielińska-Jurek, Zane Vincevica-Gaile, Juris Burlakovs, Andrey E. Krauklis, Mohamad Nor Azra, Md Salauddin, Jiexi Zhong, Taavo Tenno, Kai Bester, Ivar Zekker

“…Elevated concentrations of pharmaceutically active compounds (PhACs) in the water bodies are posing a serious threat to the aquatic microbiota and other organisms. …”
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Pattern of Disinfection of Root Canal Dentin by Alternated Acid-Base Irrigating Regimen by Janir Alves Soares, Maria Auxiliadora Roque de Carvalho, Suelleng Maria Cunha Santos Soares, Rodrigo Dantas Pereira, Manoel Brito-Júnior, Paula Prazeres Magalhães, Isabel Alessandra Miranda Nunes, Rudys Rodolpho de Jesus Tavarez, Claudia de Castro Rizzi, Rafaela Nogueira Moreira, Luiz de Macêdo Farias, Etevaldo Matos Maia Filho

“…The E. faecalis density (CFU/mg) in log10 was categorized as residual (0 > 0.2), moderate (0.2 ≥ 0.5), or elevated (> 0.5). The prevalence of positive samples in BHI and BHI-A was analyzed by Pearson’s chi-square test. …”
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Pan-cancer and experimental analyses reveal the immunotherapeutic significance of CST2 and its association with stomach adenocarcinoma proliferation and metastasis by Dan Huang, Jing Li, Zhijun He, Wenjing Liang, Likun Zhong, Jun Huang, Yinteng Wu, Shijian Zhao

“…Finally, experimental validation revealed significantly elevated expression of CST2 in STAD, indicating its role as a driver gene in regulating malignant cell proliferation and migration.ConclusionCST2 serves as a potential tumor immune biomarker, playing a critical facilitating role in the proliferation and migration processes of STAD.…”
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Associations between neutrophil-percentage-to-albumin ratio level and all-cause mortality and cardiovascular disease-cause mortality in diabetes population by Geng Shen, Yuting Liu, Can Zhou, Wei Luo, Yun-xiao Yang, Shuai Guo, Jiayi Yi, Lin Wang, Wei Li, Zhao-gong Zhi, Xiu-huan Chen, Chen Li, Yanyan Jin, Hai Gao

“…Conclusions This study identified a significant association between elevated levels of the neutrophil percentage-to-albumin ratio (NPAR) and an increased risk of all-cause mortality among individuals with type 2 diabetes mellitus (T2DM). …”
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Impact of vitamin E and selenium supplementation on growth, reproductive performance, and oxidative stress in dexamethasone-stressed Japanese quail cocks by Ifeanyi Emmanuel Uzochukwu, Luke Chukwudi Ali, Bright Chigozie Amaefule, Chisom C. Okeke, Charles Onochie Osita, Ndubuisi Samuel Machebe, Vesela Yancheva, Dóra Somogyi, Krisztián Nyeste

“…Plasma antioxidant assays showed elevated superoxide dismutase and catalase functions and reduced malondialdehyde levels in G3, G4, and G5 compared to G2, indicating reduced oxidative stress. …”
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RETRACTED: A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice by Shireen Mohammad, Sura Al Zoubi, Sura Al Zoubi, Debora Collotta, Nadine Krieg, Nadine Krieg, Bianka Wissuwa, Bianka Wissuwa, Gustavo Ferreira Alves, Gareth S. D. Purvis, Gareth S. D. Purvis, Giuseppe Danilo Norata, Giuseppe Danilo Norata, Giuseppe Danilo Norata, Andrea Baragetti, Andrea Baragetti, Alberico Luigi Catapano, Alberico Luigi Catapano, Alberico Luigi Catapano, Egle Solito, Egle Solito, Elisabeth Zechendorf, Tobias Schürholz, Wilmar Correa-Vargas, Klaus Brandenburg, Sina M. Coldewey, Sina M. Coldewey, Massimo Collino, Muhammad M. Yaqoob, Lukas Martin, Lukas Martin, Christoph Thiemermann

“…We report here for the first time that patients with T2DM compared to healthy volunteers have elevated plasma levels of LL-37. In a reverse-translational approach, we have investigated the effects of the AMP, peptide 19-2.5, in a murine model of high-fat diet (HFD)-induced insulin-resistance, steatohepatitis and T2DM. …”
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Comparison of Secondary Metabolite Extraction Methods in <i>Hamelia patens</i> Jacq. and Their Inhibitory Effect on <i>Fusarium oxysporum</i> f. sp. <i>radicis-lycopersici</i> by Daniel Jafet Valle Ortiz, Dolores Guadalupe Aguila Muñoz, María del Carmen Cruz López, Diana Verónica Cortés Espinosa, Martha Rosales Castro, Fabiola Eloísa Jiménez Montejo

“…CMML showed the highest antifungal activity (IC₅₀ 3.7% <i>w</i>/<i>v</i>), which was associated with elevated levels of these compounds. Significant correlations linked antifungal activity with rutin (HP21) and kaempferol-3-O-β-rutinoside (HP29). …”
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Enhancing broiler growth and carcass quality: impact of diets enriched with Moringa oleifera leaf powder conjugated with zinc nanoparticles by Mohammed M. El-Abbasy, Ahmed K. Aldhalmi, Elwy A. Ashour, Samar S. Bassiony, Mahmoud Kamal, Abdulmohsen H. Alqhtani, Diaa E. Abou-Kassem, Ahmed A. Elolimy, Mohamed E. Abd El-Hack, Ayman A. Swelum

“…Immunoglobulins IgY and IgM, as well as superoxide dismutase (SOD) levels, were elevated. Malondialdehyde (MDA) levels were reduced, indicating improved antioxidant capacity and immune function in the ZnNPs-MLPE-treated groups. …”
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Associations between oxidation balance score and abdominal aortic calcification, and the mediating role of glycohemoglobin: a nationally representative cross-sectional study from N... by Heqian Liu, Yifei Wu, Zhenyu Liu, Hongzhi Ren, Ya Wu, Ya Wu, Yong Liu, Yong Liu, Yong Liu

“…BackgroundAbdominal aortic calcification (AAC) is prevalent among middle-aged and elderly populations, elevating the risk of cardiovascular and cerebrovascular events. …”
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Beyond Dermatological Findings: Multisystem Involvement in Prolidase Deficiency by Ezgi Yalcin Gungoren, Zeynep Meric, Asena Pinar Sefer, Asuman Deveci Ozkan, Salim Can, Royala Babayeva, Nurhan Kasap, Ercan Nain, Esra Ozek Yucel, Ayca Kiykim, Sevgi Bilgic-Eltan, Ayse Deniz Yucelten, Elif Karakoc-Aydiner, Ahmet Ozen, Safa Baris

“…Three patients (75%) had lymphopenia. Two patients had elevated IgE levels. Lymphocyte subgroup analysis showed an inverted CD4/CD8 ratio in all patients. …”
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The impact of uric acid on acute coronary syndrome prognosis in elderly patients by Yifan Li, Tiantian Sang, Naqiang Lv, Jinxing Liu, Yingzhen Gu, Xiaorong Han, Wei Zhang, Aimin Dang

“…Both hyperuricemia and high UA levels were independent risk factors for long-term MACE in advanced-age ACS patients, with HR values of 1.546 (1.049–2.280, p = 0.028) and 1.491 (1.011–2.198, p = 0.044), respectively.Conclusion Elevated UA levels were identified as independent risk factors for MACE in elderly patients with ACS. …”
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Spatiotemporal Assessment of PM2.5 Exposure of a High-risk Occupational Group in a Southeast Asian Megacity by Jarl Tynan Collado, Jose Gabriel Abalos, Imee de los Reyes, Melliza T. Cruz, Gabrielle Frances Leung, Katrina Abenojar, Carlos Rosauro Manalo, Bernell Go, Christine L. Chan, Charlotte Kendra Gotangco Gonzales, James Bernard B. Simpas, Emma E. Porio, John Q. Wong, Shih-Chun Candice Lung, Maria Obiminda L. Cambaliza

“…From all 15-second measurements obtained, the mean concentration of PM2.5 is 36.4 µg m−3, seven times greater than the mean annual guideline value (5.0 µg m−3) set by the World Health Organization (WHO). Elevated levels of PM2.5 were observed at key transportation microenvironments (TMEs) such as a transport terminal and near a shopping mall. …”
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Effect of Massage on the TLR4 Signalling Pathway in Rats with Neuropathic Pain by Qian Wang, Jing Lin, Peng Yang, Yingye Liang, Dongming Lu, Kailong Wang, Wei Gan, Jianping Fu, Zhenbao Gan, Mingchen Ma, Pingting Wu, Fengshi He, Jun Pang, Hongliang Tang

“…The PWTL and PWMT of SNL rats were decreased, while these parameters were elevated after massage. SNL rats showed higher levels of TLR4, IRAK1, TRAF6, IL-6, and TNF-α, and massage effectively lowered the expression levels of these molecules. …”
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