Extracellular viral microRNAs as biomarkers of virus infection in human cells by Cheryl Chan, Joanne Xin Yi Loh, Wei-Xiang Sin, Denise Bei Lin Teo, Nicholas Kwan Zen Tan, Chandramouli Nagarajan, Yunxin Chen, Francesca Lorraine Wei Inng Lim, Michael E. Birnbaum, Rohan B.H. Williams, Stacy L. Springs

“…Viral exmiR profiling of spent media from EBV- and HHV-8-reactivated B cell models revealed specific signatures of elevated EBV miR-BHRF1-2-3p and HHV-8 miR-K12-10a-3p, miR-K12-10b, and miR-K12-12-3p, respectively, during virus reactivation. …”
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Genetic interaction between oxidative stress and body mass index in a Spanish population by Francisco Lara-Hernández, Rebeca Melero, María Elena Quiroz-Rodríguez, Celeste Moya-Valera, Mariana de Jesús Gallardo-Espinoza, Luis Álvarez, Ingrid Lizeth Valarezo-Torres, Laisa Briongos-Figuero, Jessica Abadía-Otero, Francisco Javier Mena-Martin, Guillermo Saez, Josep Redon, Juan-Carlos Martín-Escudero, Ana-Bárbara García-García, Guillermo Ayala, Felipe Javier Chaves

“…Oxidative stress may act as a contributing factor in the development of an elevated body mass index (BMI). Oxidative stress has the potential to modulate genetic activity at various levels, including gene transcription and protein function regulation. …”
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Potency of Bone Marrow-Derived Mesenchymal Stem Cells and Indomethacin in Complete Freund’s Adjuvant-Induced Arthritic Rats: Roles of TNF-α, IL-10, iNOS, MMP-9, and TGF-β1 by Eman A. Ahmed, Osama M. Ahmed, Hanaa I. Fahim, Tarek M. Ali, Basem H. Elesawy, Mohamed B. Ashour

“…The BM-MSC intravenous injection and IMC oral administration significantly reduced the elevated right hind leg paw diameter and circumference, serum anti-CCP, and ankle joint articular tissue expressions of TNF-α, iNOS, MMP-9, and TGF-β1 while they significantly increased the lowered articular IL-10 expression in CFA-induced arthritic rats. …”
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Exploring the CD3/CD56/TNF-α/Caspase3 pathway in pyrethroid-induced immune dysregulation: curcumin-loaded chitosan nanoparticle intervention by Nawal Alsubaie, Yasmina M. Abd-Elhakim, Amany Abdel-Rahman Mohamed, Tarek Khamis, Tarek Khamis, Mohamed M. M. Metwally, Mohamed M. M. Metwally, Nawal Helmi, Afnan M. Alnajeebi, Badriyah S. Alotaibi, Amirah Albaqami, Wedad Mawkili, Mai A. Samak, Mai A. Samak, Samar A. Eissa

“…FTN exposure significantly upregulated splenic Caspase-3 and increased its immunohistochemical expression, along with elevated TNF-α immunoexpression. However, the alterations in immune function, splenic antioxidant status, blood cell populations, and immune-related gene expression were notably restored in the FTN + CML-CNP-treated group.ConclusionThe findings of this study highlighted the immunosuppressive effects of FTN and suggested the involvement of many CD cell markers as a potential underlying mechanism. …”
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A protocol to study the effect of targeted parental education intervention to identify early childhood development disorder – multisite interventional study by Vadivelan Kanniappan, Prakash Muthuperumal, P. Venkataraman, Anuradha Murugesan, Balaji Chinnasami, Manikumar Muthiah, Subramanian Sethuraman, Abishek J. R., Shrisruthi Suresh, Murali Krishnan Nambirajan, Angeline Grace G., Veeragoudhaman T. S., Kuberan Deivasigamani

“…Maternal unemployment rates are also elevated in such cases. Delayed Developmental Milestones identification, often due to a lack of parental awareness, further compounds these challenges. …”
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Social context affects tissue-specific copper distribution and behaviour of threespine stickleback (Gasterosteus aculeatus) by Sienna L. Overduin, Shaun S. Killen, Alex M. Zimmer, Jenelle D. McCuaig, Lucy Cotgrove, Isabel Aragao, Kelly J. Rozanitis, Kurt O. Konhauser, Daniel S. Alessi, Tamzin A. Blewett

“…If disruption to an animal’s social structure occurs and prevents social buffering, an elevated metabolic rate and thus ventilation frequency and gill permeability are likely. …”
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The Increased Ratio of Blood CD56bright NK to CD56dim NK Is a Distinguishing Feature of Primary Sjögren’s Syndrome by Bingxia Ming, Tong Wu, Shaozhe Cai, Peng Hu, Jungen Tang, Fang Zheng, Cong Ye, Lingli Dong

“…The proportion of CD56bright NK cell subset was increased, and the proportion of CD56dim NK cell subset was decreased among NK cells, resulting in the ratio of CD56bright NK to CD56dim NK which was significantly elevated in pSS patients. ROC analysis indicated that the AUC of CD56bright NK/CD56dim NK ratio was 0.838, and the best diagnostic cut-off point was 0.0487 for pSS patients. …”
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Comparative and synergistic impacts of lime and biochar on soil properties, nitrogen transformation, and microbial function in acidic soils under tobacco cropping by Bianhong Zhang, Lina Tang, Zhicheng Chen, Xiaoyan Chen, Lindong You, Ruixin Pan, Ting Chen, Yifei Liu, Wenxiong Lin, Wenxiong Lin, Jinwen Huang

“…Lime treatments (L, L+B) promoted nitrification potential in rhizosphere soil, whereas biochar application (B, L+B) resulted in elevated nitrate nitrogen content. Microbial functional analysis indicated that lime (L, L+B) enhanced nitrification, while biochar (B, L+B) fostered dissimilatory nitrate reduction, thereby improving nitrogen retention. …”
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Antibiotic-mediated dysbiosis leads to activation of inflammatory pathways by Jemma J. Taitz, Jemma J. Taitz, Jian Tan, Jian Tan, Duan Ni, Duan Ni, Camille Potier-Villette, Camille Potier-Villette, Georges Grau, Georges Grau, Ralph Nanan, Ralph Nanan, Ralph Nanan, Laurence Macia, Laurence Macia, Laurence Macia

“…Non-specific activation of splenocytes ex vivo, however, revealed mice with perturbed microbiota had significantly elevated production of TNF. Thus, this highlights antibiotic-mediated disruption of the gut microbiota may program the host towards dysregulated immune responses, predisposing to the development of TNF-associated autoimmune or chronic inflammatory disease.…”
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Enriched environment rescues bisphenol A induced anxiety-like behavior and cognitive impairment by modulating synaptic plasticity by Jiong Li, Guangyin Yu, Laijian Wang, Wenjun Zhang, Wenya Ke, Yifei Li, Danlei Liu, Keman Xie, Yuanyuan Xu, Caihui Cha, Guoqing Guo, Jifeng Zhang

“…Our research revealed that exposure to BPA results in anxiety-like behavior in open field and elevated-plus maze experiments. Additionally, spatial and learning memory cognitive impairments were observed in Y-maze and water maze tests. …”
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Prediction of implant failure risk due to periprosthetic femoral fracture after primary elective total hip arthroplasty: a simplified and validated model based on 154,519 total hip... by M. A. Alagha, Justin Cobb, Alexander D. Liddle, Henrik Malchau, Ola Rolfson, Maziar Mohaddes

“…Predictive factors for revision and reoperation were identified, with patient features such as increasing age, higher American Society of Anesthesiologists grade (> III), and World Health Organization obesity classes II to III associated with elevated risks. A preoperative diagnosis of idiopathic necrosis increased revision risk. …”
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Long-term outcomes of Fontan palliation; the influence of the dominant ventricle by Abdelmonem M. Helal, Jameel Al-Ata, Nashwa Mostafa Badawy, Ahmed Abdelwahed, Wejdan Khaled Ba-Atiyah, Anhar Ali Baeshen, Abdullah J. Alata, Ahmed F. Elmahrouk, Mohammad S. Shihata, Ahmed A. Jamjoom, Samia Bekheet

“…Factors influencing long-term mortality were older age, right dominance, and elevated pulmonary artery pressure. Conclusions Patients with left dominance exhibited superior survival rates and fewer complications compared to those with right dominance and codominance. …”
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Clinical features and prognostic predictors of C. Psittaci Pneumonia: a systematic review and individual patient meta-analysis by Qingqing Jia, Jibo Sun, Dongguang Wang, Jiao Xu, Xiu Li, Shijie Zhang, Lian Wang, Sitong Liu, Xiang Tong, Hong Fan

“…Patients with chronic cardiovascular disease face a significantly elevated risk of developing severe C. psittaci pneumonia (adjusted odds ratio (aOR) 2.63; 95% confidence interval (CI) 1.05–6.59; P = 0.039). …”
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Association between Virulence Factors and TRAF1/4-1BB/Bcl-xL Expression in Gastric Mucosa Infected with Helicobacter pylori by Fen Wang, Xiang Wu, Zhiying Liu, Guangkui Bu, Xiayu Li, Nanfang Qu, Jin Peng, Canxia Xu, Shourong Shen, Yi Yuan

“…There were more cases of cagA+/vacAs1+/vacAm1+ H. pylori infection in samples with elevated TRAF1, 4-1BB, or Bcl-xL expression (P<0.05). …”
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DEmiRNA-mRNA regulatory network reveals miR‐122-5p as a regulatory factor of arginine metabolism in necrotizing enterocolitis by Zhili Ding, Ting Guo, Qiang Tang, Yaqiang Hong, Zhibao Lv, Li Lu, Wenjun Zhuang

“…In vivo, inhibition of miR-122-5p led to increased expression of PRODH2 and ALDH18A1, along with elevated arginine levels. Following transfection with a miR-122-5p inhibiting adenovirus, the survival rate of NEC mice improved, and intestinal injury was alleviated.ConclusionMiR-122-5p inhibition could impact arginine metabolism by targeting PRODH2 and ALDH18A1, thereby mitigating intestinal injury in NEC.…”
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Long-Term Safety and Efficacy of Lenabasum, a Cannabinoid Receptor Type 2 Agonist, in Patients with Dermatomyositis with Refractory Skin Disease: Follow-Up Data from a 3-Year Open-... by Caroline J. Stone, Geeta Ahuja, Lais Lopes Almeida Gomes, Joy Poroye, Daniella Forman Faden, Lillian Xie, Rui Feng, Barbara White, Victoria P. Werth

“…Background: Dermatomyositis (DM) is a rare autoimmune condition involving skin manifestations often resistant to standard treatments such as immunosuppressants and antimalarials. Biopsies show elevated inflammatory cells such as CD4+ T cells, dendritic cells, and cytokines. …”
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Comparative analysis of the performance, egg quality and ovarian immune function of fast and slow feather strains in tianfu green shell laying hens at various stages of egg product... by Zhi Hu, Hengyong Xu, Zhipeng Zhang, Yuxiang Lu, Yuxin Zhou, Jiajun Zhu, Qingqing Deng, Xi Wang, Yiping Liu, Yao Zhang, Yan Wang

“…Immunologically, EF hens demonstrated elevated peak serum levels of IgA, IgG, and IgM compared to LF hens. …”
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Combined effect of the smartphone addiction and physical activity on the depressive symptoms in secondary school students: a cross sectional study in Shanghai, China by Rui Yang, Shuoyuan Tan, Gulqihra Abdukerima, Ting Lu, Chen Chen, Lixin Song, Bing Ji, Yipeng Lv, Jianwei Shi, Jianwei Shi

“…Joint analysis indicated that combined smartphone addiction and insufficient physical activity significantly increased the risk of depressive symptoms (OR=2.781, 95% CI: 1.627-4.753, P &lt; 0.001).ConclusionThe study identified a high prevalence of severe smartphone addiction, insufficient physical activity, and elevated rates of depressive symptoms among secondary school students. …”
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Are patients with stage III non-small cell lung cancer treated with chemoradiotherapy at risk for cardiac events? Results from a retrospective cohort study by Juliette Degens, D De Ruysscher, Ruud Houben, Bastiaan Kietselaer, Gerben Bootsma, Lizza Hendriks, Ellen Huijbers, Annemie Schols, Anne-Marie C Dingemans

“…The majority of patients did not have pre-existent cardiac comorbidity (n=322). Elevated WHO/International Society of Hypertension score was not identified as a significant predictor for cardiac events.Conclusion One-third of patients with stage III NSCLC treated in daily clinical practice develop a new cardiac event within 5 years after CRT. …”
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Molecular-genetic pathways of hepatitis C virus regulation of the expression of cellular factors PREB and PLA2G4C, which play an important role in virus replication by E. L. Mishchenko, A. A. Makarova, E. A. Antropova, A. S. Venzel, T. V. Ivanisenko, P. S. Demenkov, V. A. Ivanisenko

“…The expression of PREB and PLA2G4C was significantly elevated in the presence of the HCV genome. However, the mechanisms of its regulation by HCV remain unknown. …”
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