Dysfunction of ATP7B Splicing Variant Caused by Enhanced Interaction With COMMD1 in Wilson DiseaseSummary by Donghu Zhou, Huaduan Zi, Xiaoxi Yang, Xiaojin Li, Yanmeng Li, Anjian Xu, Bei Zhang, Wei Zhang, Xiaojuan Ou, Jidong Jia, Jian Huang, Hong You

“…Results: The c.1543+1G>C mutation resulted in the skipping of ATP7B exon 3, and the mutant ATP7B showed a loss of trans-Golgi network localization and was degraded via the ubiquitin-proteasome pathway, facilitated by enhanced interactions with COMMD1. Elevated intercellular copper concentration and reduced survival rate were observed in HuH-7 cells expressing mutant ATP7B. …”
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The expression profile of genes associated with behavior, stress, and adult neurogenesis along the hippocampal dorsoventral axis in tame and aggressive foxes by Yu. V. Alexandrovich, E. V. Antonov, S. G. Shikhevich, A. V. Kharlamova, L. V. Meister, Y. V. Makovka, D. V. Shepeleva, R. G. Gulevich, Yu. E. Herbeck

“…In tame foxes, significantly elevated mRNA levels were recorded for several genes: CYP26B1 for cytochrome P450 26B1 and ADRA1A for α1A adrenergic receptor in the dorsal hippocampus, whereas the level of NR3C2 mRNA for mineralocorticoid receptor was higher in the ventral. …”
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Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis by Wenwen Zhu, Jiali Fang, Chenbo Ji, Hong Zhong, Tianying Zhong, Xianwei Cui

“…Exposure to mixed NEOs during gestation resulted in elevated glucose levels and impaired insulin sensitivity in normal pregnant and GDM mice models. …”
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Primary results from the Japanese Heart Failure and Sudden Cardiac Death Prevention Trial (HINODE) by Kazutaka Aonuma, Kenji Ando, Kengo Kusano, Toru Asai, Koichi Inoue, Yukihiro Inamura, Takanori Ikeda, Takeshi Mitsuhashi, Toyoaki Murohara, Nobuhiro Nishii, Akihiko Nogami, Wataru Shimizu, Caroline Beaudoint, Torri Simon, Torsten Kayser, Hussin Azlan, Ngarmukos Tachapong, Joseph Yat‐Sun Chan, Valentina Kutyifa, Yasushi Sakata, For the HINODE Investigators

“…The ND cohort presented a high crossover rate to ICD therapy (6.1%, n = 7/115), and the CRT‐D cohort showed elevated mortality rates. The pacing cohort revealed that patients implanted with pacemakers had higher mortality (26.0%) than those with CRT‐Pacing (8.4%, P = 0.05). …”
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A study of impulsivity and adverse childhood experiences in a population health setting by Robert W. Read, Karen A. Schlauch, Gai Elhanan, Iva Neveux, Stephanie Koning, Takesha Cooper, Takesha Cooper, Joseph J. Grzymski, Joseph J. Grzymski

“…These results demonstrate that high ACES and elevated impulsivity scores are associated with a range of negative health outcomes and a simple self-assessment of complex traits and life history may significantly impact clinical risk assessments.…”
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The role of natural exosomes from SHED-MSC in immunoregulation of M0/M1 polarized macrophage cells by Ali Fallah, Abasalt Hosseinzadeh Colagar, Ayyoob Khosravi, Ayyoob Khosravi, Azadeh Mohammad-Hasani, Azadeh Mohammad-Hasani, Mohsen Saeidi, Mohsen Saeidi

“…The levels of anti-inflammatory and antioxidant markers, including CD206, Arg-1, IL-10, TGF-β, TAC, CAT, and SOD, which act as immunosuppressive macromolecules, were elevated. In contrast, there was a reduction in pro-inflammatory and pro-oxidant markers, including CD80, CD81, IL-6R, IL-12, TNF-α, MDA, and NO, which act as immunostimulatory macromolecules (P < 0.05).DiscussionThe findings suggest that exosomes derived from SHED-MSC can skew M0/M1 macrophages to the M2 phenotype and inhibit M1 polarization. …”
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Soil warming increases the active antibiotic resistome in the gut of invasive giant African snails by Yiyue Zhang, Hong-Zhe Li, Martin Breed, Zhonghui Tang, Li Cui, Yong-Guan Zhu, Xin Sun

“…Furthermore, we identified elevated biosynthetic gene clusters (BGCs) within these ARG-carrying MAGs, with a third encoding at least one BGC. …”
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Salivary alpha-amylase activity and its association with early childhood caries and rampant caries experience: a cross-sectional study by Vivek Padmanabhan, Md Sofiqul Islam, Muhammed Mustahsen Rahman, Manjunatha B. K. Goud, Latifa Majed Sulaiman Allay Alshehhi, Hebah Mushref Ahmad Hamed, Sheela Haridas, Dileep Sharma

“…Pearson’s correlation coefficients indicated a strong positive correlation between salivary alpha-amylase levels and severity of dental caries in both ECC (r = 0.9891, p < 0.0001) and RC (r = 0.9142, p < 0.0001) groups.ConclusionThe study concludes that elevated salivary alpha-amylase levels, which are statistically significant, are observed in children with ECC and RC. …”
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Gardnerella vaginalis-binding IgA in the urethra of sexually experienced males by Rachel Liu, R. M. Galiwango, Daniel Park, Sanja Huibner, Maliha Aziz, Aggrey Anok, James Nnamutete, Yahaya Isbirye, John Bosco Wasswa, Deo Male, Godfrey Kigozi, Aaron A. R. Tobian, Jessica L. Prodger, Cindy Liu, Bryan Coburn, Rupert Kaul

“…Gardnerella vaginalis-binding IgA was elevated in participants with detectable urethral Gardnerella, with the latter only present in participants who reported prior penile-vaginal sex. …”
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Optimising Growth, Immunity, and Gene Expression in Broiler Chickens Through Dietary Threonine Levels and Oil Inclusion by Mohamed I. El‐Katcha, Mosaad A. Soltan, Heba I. Ghamry, Abeer F. El‐Nahas, Laila A. Al‐Shuraym, Ostan Mihaela, Rada Olga, Rasha E. Azab, Ahmed Abdeen, Mustafa Shukry, Set A. El‐Shobokshy

“…ABSTRACT Background The inclusion of synthetic amino acids in poultry nutrition plays a crucial role in both enhancing the synthesis of immunoglobulins and elevating the overall comprehensiveness of the amino acid profile. …”
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Identification of glutamine as a potential therapeutic target in dry eye disease by Xiaoniao Chen, Chuyue Zhang, Fei Peng, Lingling Wu, Deyi Zhuo, Liqiang Wang, Min Zhang, Zhaohui Li, Lei Tian, Ying Jie, Yifei Huang, Xinji Yang, Xiaoqi Li, Fengyang Lei, Yu Cheng

“…Clinical cases and rodent model showed elevated expression of glutaminase (GLS1), an upstream enzyme in glutamine metabolism, following dry eye injury. …”
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Synergistic toxicity of nanoplastics and Helicobacter pylori on digestive system in mice by Xiaolin Zhang, Yunqing Wang, Xiaohan Tong, Boqing Li, Sisi Liu, Yingzi Cui, Wenke Wang, Zhiqin Li, Chunlei Ma, Ying Zhang

“…These increases, accompanied by elevated TG and LDH levels, suggest aggravated inflammation, oxidative stress, and metabolic disruption. …”
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The incidence and influencing factors of recent suicide attempts in major depressive disorder patients comorbid with moderate-to-severe anxiety: a large-scale cross-sectional study by Lina Ren, Yeqing Dong, Xiaojing Zhou, Chuhao Zhang, Jiajia Gao, Lulu Li, Xiao Zhang, Min Zeng, Guoshuai Luo, Xiangyang Zhang

“…Additionally, suicide attempters had elevated levels of thyroid stimulating hormone (TSH), anti-thyroglobulin (TgAb), thyroid peroxidases antibody (TPOAb), systolic blood pressure (SBP), and diastolic blood pressure (DBP) compared to non-suicide attempters. …”
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Impact of sperm DNA fragmentation index on assisted reproductive outcomes: a retrospective analysis by Bin Yang, Leizhen Xia, Rufei Deng, Liping Wu, Zhiqin Zhang, Xingwu Wu, Tao Ding, Yan Zhao, Jialyu Huang, Jialyu Huang, Zhihui Huang

“…High DFI affected the blastocyst formation rate (56.44%, 55.32%, 53.72%, respectively; P=0.045) and the rate of transferable embryos (3.97 ± 2.71, 3.90 ± 2.7, 3.38 ± 2.4, respectively; P<0.001); however, no significant difference in pregnancy outcomes was observed among the three groups. Elevated DFI did not contribute to clinically relevant adverse maternal events during pregnancy, but it was associated with an increased risk of low birth weight (3.9%, 6.6%, 10.1%, respectively; P=0.006) in newborns.ConclusionsSperm DFI could influence embryonic development, with a higher risk of low birthweight infants in the high DFI group. …”
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Unveiling the prognostic value of ARID3A in breast cancer through bioinformatic analysis by Wen-Run Cai, Xu-Gang Sun, Yue Yu, Xin Wang, Xu-Chen Cao, Xiao-Feng Liu

“…Protein-protein interactions (PPI) were established using GeneMANIA and STRING, with validation through molecular docking using Cluspro. Results: Elevated ARID3A expression was associated with poor prognosis in breast cancer, particularly in Luminal and HER2-positive subtypes. …”
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Differences in Arrhythmia Detection Between Harvard Step Test and Maximal Exercise Testing in a Paediatric Sports Population by Massimiliano Bianco, Fabrizio Sollazzo, Riccardo Pella, Saverio Vicentini, Samuele Ciaffoni, Gloria Modica, Riccardo Monti, Michela Cammarano, Paolo Zeppilli, Vincenzo Palmieri

“…BACKGROUND: Sport practice may elevate the risk of cardiovascular events, including sudden cardiac death, in athletes with undiagnosed heart conditions. …”
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Maternal exposure to fine particulate matter before and during pregnancy, and the risk of birth defects: A population-based study by Shihan Zhen, Na Li, Yan Li, Qian Li, Lu Zheng, Zhouxin Yin, Yan Dou, Shuqi Wu, Yilin Liu, Xiaoyan Zhang, Xinyue Yang, Ye Wang, Wenxiu Ge, Xiaoyu Gao, Jing Yang, Fengchao Liang, Jiajin Hu, Ying Zhao

“…We observed a J-shaped association between maternal PM2.5 exposure during both the preconception period and pregnancy and the risk of total birth defects. Mothers exposed to elevated levels of PM2.5 during both the preconception period and pregnancy exhibited the highest risk of total birth defects (odds ratio: 4.43, 95% CI: 4.17, 4.71). …”
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Brain compensatory activation during Stroop task in patients with mild cognitive impairment: a functional near-infrared spectroscopy study by Chenyu Fan, Hanfei Li, Hanfei Li, Ke Chen, Ke Chen, Guohui Yang, Hongyu Xie, Haozheng Li, Yi Wu, Meng Li, Meng Li, Meng Li

“…We also measured participants’ behavior during the Stroop task, analyzed variations in cortical activation intensity at different experiment stages, and performed correlation analysis between Montreal Cognitive Assessment (MoCA) scores, Stroop performance, and oxygenation levels.ResultsOur analysis revealed that individuals with MCI and HC demonstrated elevated cortical activation in the dPFC, VLPFC, and PL areas while performing the Stroop task (q < 0.05, FDR-corrected). …”
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Adverse outcome pathway-based assessment of pulmonary toxicity from the in vivo mixture of biocides dinotefuran and cetylpyridinium chloride by Yoon Cho, Mi-Kyung Song, Dong Im Kim, Min-Seok Kim, Kyuhong Lee

“…Moreover, increased levels of markers associated with epithelial–mesenchymal transition (EMT) and fibrosis (TNF-α, Acta2, IL-1β, and MMP9), as well as elevated levels of TGF-β, a common downstream signaling factor of TLR4 and PPAR-γ, were identified. …”
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Rare renal proximal tubular dysfunctions in primary biliary cholangitis by Xiaoxiao Shi, Tianchen Guo, Yubing Wen, Wei Ye, Wenling Ye, Ke Zheng, Yan Qin, Xuemei Li, Fengchun Zhang, Limeng Chen

“…Most of them were asymptomatic PBC (7, 63.6%) with a high prevalence of elevated serum immunoglobulin M (IgM, 81.8%) and G (IgG, 54.5%) levels. …”
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