Impact of PM2.5, relative humidity, and temperature on sleep quality: a cross-sectional study in Taipei by Nguyen Thanh Tung, Yueh-Lun Lee, Wen-Te Liu, Yuan-Chien Lin, Jer-Hwa Chang, Huynh Nguyen Xuan Thao, Hoang Ba Dung, Lam Viet Trung, Tran Phan Chung Thuy, Nguyen Thi Hien, Cheng-Yu Tsai, Chen-Chen Lo, Kang Lo, Kin Fai Ho, Kai-Jen Chuang, Hsiao-Chi Chuang

“…We found PM2.5 levels mediated relationships between RH, temperature, and various sleep stages, particularly in cold season.Conclusions Lower RH and temperature, contributing to deep sleep reduction and increased arousal, were influenced by elevated PM2.5 exposure, especially during colder months. …”
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Risk factors for multidrug resistance in pulmonary tuberculosis patients with diabetes mellitus by Lianpeng Wu, Lianpeng Wu, Na Chen, Na Chen, Dandan Xia, Dandan Xia, Xiangao Jiang, Xiangao Jiang

“…Significant independent predictors of MDR included a history of TB treatment, smoking, and elevated hemoglobin A1c (HbA1c) levels. ROC curve analysis showed that the combination of TB treatment history, smoking history, and HbA1c levels had an area under the curve (AUC) of 0.809, with 64.62% sensitivity and 82.61% specificity. …”
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Integrated multiomics approach and pathological analyses provide new insights into hepatic injury and metabolic alterations in Saanen goats after dietary exposure to aflatoxin B1 by Donghua Su, Jing Peng, Jingjing Hao, Xi Wang, Peiqiang Yu, Shengli Li, Haitao Shi

“…Results showed that the liver tissue was enlarged and the relative organ index of the liver was linearly increased with elevated AFB1 levels. The hepatocyte apoptosis rate was significantly increased after AFB1 exposure, and the western blotting results revealed that both the external apoptotic pathway and mitochondrial-mediated intrinsic apoptotic pathway might be involved in AFB1-induced hepatocyte apoptosis. …”
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Aberrant Expression of miR-362 Promotes Lung Cancer Metastasis through Downregulation of Sema3A by Dan Luo, Zheng Zhang, Zhao Zhang, Jia-Yue Li, Jian Cui, Wen-Pu Shi, Xi-Wen Dong, Lin Yuan, Peng Lin, Zhi-Nan Chen, Hui-Jie Bian, Zi-Ling Wang

“…In this study, we found that the level of miR-362 was higher in NSCLC tissues than in adjacent normal tissues and that the level of miR-362 expression was also elevated in five NSCLC cell lines (A549, 95-D, H1299, H292, and H460) relative to a human normal lung epithelial cell line (BEAS2B). …”
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A novel strategy for the protective effect of ginsenoside Rg1 against ovarian reserve decline by the PINK1 pathway by Pengdi Yang, Meiling Fan, Ying Chen, Dan Yang, Lu Zhai, Baoyu Fu, Lili Zhang, Yanping Wang, Rui Ma, Liwei Sun

“…Protein expression levels in the PINK1/Parkin pathway were assessed, and molecular docking and PINK1 mutant analyses were conducted to identify potential targets.Results Ginsenoside Rg1 significantly mitigated ovarian reserve decline, enhancing offspring quantity and quality, increasing the levels of ecdysteroids, preventing ovarian atrophy, and elevating germline stem cell numbers in aged Drosophila. …”
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Causal association between matrix metalloproteinases and diabetic neuropathy: a two-sample Mendelian randomization study by Chao Bai, Chao Bai, Wenwen Yang, Guangwei Qi, Liuyu Yang, Qingrui Wu, Jieguang Peng, Ning Wang, Tao Liu

“…To evaluate the analysis’ heterogeneity and potential pleiotropy, sensitivity examinations including MR-PRESSO analysis, Cochran’s Q test, and the leave-one-out test were conducted.ResultsIVW analysis revealed that genetically decreased serum MMP-2 level were causally associated with a high risk of DN (OR = 0.88, 95% CI: 0.79-0.99, P = 0.026). Genetically elevated serum MMP-16 level were causally associated with a high risk of DN (OR = 1.15, 95% CI: 1.01-1.32, P = 0.038). …”
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A single-cell transcriptome analysis reveals astrocyte heterogeneity and identifies CHI3L1 as a diagnostic biomarker in Parkinson's disease by Zhongying Gong, Dan Guo, Yufeng Lin, Zhiwei Liu, Mengdi Lv, Xinxin Liu, Yang Yao, Sijia Wang, Yuan Wang, Zhiyun Wang

“…Astrocytes exhibiting elevated CHI3L1 levels demonstrated interactions with microglia in PD patients. …”
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Effect of triple-frequency sono-germination and soaking treatments on techno-functional characteristics of barley by Tabussam Tufail, Huma Bader Ul Ain, Jawad Ashraf, Muhammad Safiullah Virk, Zahoor Ahmed, Mokhtar Dabbour, Tawfiq Alsulami, Suleiman Althawab, Bin Xu

“…Enzyme activities, such as peroxidase (POD) and polyphenol oxidase (PPO), were notably elevated, indicating enhanced defense mechanisms. The study also found increased γ-Aminobutyric Acid (GABA) levels and antidiabetic potential through inhibition of α-amylase and α-glucosidase enzymes. …”
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Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice by Ryan Brown, Donna M. Small, Declan F. Doherty, Leslie Holsinger, Robert Booth, Richard Williams, Rebecca J. Ingram, J. Stuart Elborn, Marcus A. Mall, Clifford C. Taggart, Sinéad Weldon

“…Background. Elevated levels of the cysteine protease cathepsin S (CatS) are associated with chronic mucoobstructive lung diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). …”
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Overexpression of Tear Inflammatory Cytokines as Additional Finding in Keratoconus Patients and Their First Degree Family Members by Ioana Catalina Ionescu, Catalina Gabriela Corbu, Cristiana Tanase, Gabriela Ionita, Cristina Nicula, Valeria Coviltir, Vasile Potop, Mihaela Constantin, Elena Codrici, Simona Mihai, Ionela Daniela Popescu, Ana-Maria Enciu, Dana Dascalescu, Miruna Burcel, Radu Ciuluvica, Liliana-Mary Voinea

“…In conclusion, in the case of some first degree family members, the elevated tear biomarkers may represent a supplementary risk factor.…”
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Four decades of phenology in an alpine amphibian: trends, stasis, and climatic drivers by Lenzi, Omar, Grossenbacher, Kurt, Zumbach, Silvia, Lüscher, Beatrice, Althaus, Sarah, Schmocker, Daniela, Recher, Helmut, Thoma, Marco, Ozgul, Arpat, Schmidt, Benedikt R.

“…Phenological shifts in breeding are observed in a wide number of amphibian populations, but less is known about populations living at high elevations, which are predicted to be more sensitive to climate change than lowland populations. …”
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Practice Guidelines for the Value Evaluation of Clinical Pharmacy Services (version 2) by Liuyun Wu, Ziyan Lv, Min Chen, Xingyue Zheng, Lian Li, Shan Du, Lizhu Han, Qinan Yin, Yin Wang, Xinxia Liu, Wenyuan Li, Xuefei Huang, Hulin Wang, Xiaoqing Yi, Xiaojiao Cui, Zhujun Chen, Yueyuan Wang, Yingying Hou, Xi Zheng, Yang Lei, Mengqiu Gou, Yue Wu, Fengjiao Kang, Fengqun Cai, Shuhong Liang, Yong Yang, Jinqi Li, Yuan Bian

“…Ultimately, three dimensions for evaluating the value of clinical pharmacy were identified, encompassing 15 indicators, resulting in 20 recommendations.ConclusionThis guideline presents a set of metrics to assess the quality and effectiveness of clinical pharmacy services, which is crucial for enhancing and elevating clinical pharmacy services in healthcare institutions.Systematic review registrationhttp://www.guidelines-registry.org/guide/28502a74-7038-439c-bdee-d355747e2a9d, identifier: PREPARE-2022CN756.…”
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Effects of replacing fishmeal with soybean meal on growth performance, liver antioxidant capacity and intestinal health in juvenile Asian red-tailed catfish (Hemibagrus wyckioides) by Weijia Cai, Xinping Li, Minglang Cai, Zhe Tang, Bo Zhu, Mengxi Yang, Yi Hu, Jihong Dai

“…Compared with the FM group, the SBM45 and SBM60 groups exhibited significantly elevated serum glutamate pyruvate transaminase (GPT) levels and showed evidence of liver oxidative stress injury. …”
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Reduced p63 expression is linked to unfavourable prognosis in muscle‐invasive urothelial carcinoma of the bladder by Kira Furlano, Henning Plage, Sebastian Hofbauer, Sarah Weinberger, Bernhard Ralla, Annika Fendler, Florian Roßner, Simon Schallenberg, Sefer Elezkurtaj, Martina Kluth, Maximilian Lennartz, Niclas C. Blessin, Andreas H. Marx, Henrik Samtleben, Margit Fisch, Michael Rink, Marcin Slojewski, Krystian Kaczmarek, Thorsten Ecke, Stefan Koch, Nico Adamini, Sarah Minner, Ronald Simon, Guido Sauter, Joachim Weischenfeldt, Tobias Klatte, Thorsten Schlomm, David Horst, Henrik Zecha

“…Results Nuclear p63 staining was seen in all cells of normal urothelium and at elevated levels in pTaG2 tumours. The rate of p63 positive cases and the staining intensity was lower in pTaG3 tumours (93.2%, p < 0.0001 for pTaG3 vs. pTaG2) and markedly lower in pT2‐4 carcinomas (83.5%, p = 0.0120 for pT2‐4 vs. pTaG3). …”
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Newly identified single-nucleotide polymorphism associated with the transition from nonalcoholic fatty liver disease to liver fibrosis: results from a nested case-control study in... by Yitong Ling, Yu Xuan Yang, Yan Chun Chen, Jing Hao Wang, Dong Ge Feng, Shi Jian Xiang, Xiaoyu Zhang, Jun Lyu, Sha Sha Li

“…Oxidative stress markers like elevated malondialdehyde (MDA) and reduced catalase (CAT) and superoxide dismutase (SOD) levels indicated liver damage in the TGF-β group. …”
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IgG4-mediated M2 macrophage polarization in tertiary lymphoid structures of esophageal cancer: implications for immunosuppression by Hui Wang, Hui Wang, Jirui Li, Yinghai Wang, Yang Chen, Yang Chen, Weifeng Zhang, Xinyan Pan, Xinyan Pan, Chanjuan Su, Ziteng Li, Li Wang, Li Wang, Jiang Gu, Jiang Gu

“…Serum analysis revealed that both IgG4 (P&lt;0.01, **) and IL-10 (P&lt;0.0001, ****) were significantly elevated and positively correlated in tumor patients compared to controls (P&lt;0.01, **). …”
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Improving serum redox balance, inflammatory status, physical function, and cognitive ability through dual-task resistance training and detraining in nursing home residents by Erivaldo Machado Araújo, Hélio José Coelho-Júnior, Caio Victor Sousa, Thiago dos Santos Rosa, Ivo Vieira Sousa Neto, Emanuele Marzetti, Octávio Luiz Franco, Samuel da Silva Aguiar

“…The CAT/TBARS ratio increased significantly post-training (p < 0.001) and remained elevated post-detraining. Nitric Oxide levels increased post-training (p < 0.05) and stayed higher post-detraining. …”
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CAVIN-2 positively correlates with diabetic PAD and promotes LDL transcytosis by inhibiting eNOS activation by Li Wang, Yi Song, Yan Shu, Baorui Xue, Fangyang Yu, Yao Yin, Ziyun Feng, Xiang Ma, Yulin Yao, Yangze Pan, Si Jin

“…Cellular experiments were used to investigate the effect and mechanism of CAVIN-2 on LDL transcytosis.Results Elevated CAV1 and CAVIN-2 levels were observed in T2DM and DM-PAD groups, with a positive correlation to DM-PAD and PAD severity. …”
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Photoreduction of CO2 to Formic Acid in Aquatic Phase Using Layer Double Hydroxide (LDH) Catalyst by Jenny Rizkiana, Dzaky Auliardi, Aghietyas Choirun Az Zahra, Francesco Thadeo, Wibawa Hendra Saputera, Tatang Hernas Soerawidjaja, Hary Devianto

“…In contrast, 0.3Cu2O@Zn-CrLDH showed a decreased activity at the elevated temperatures. This discrepancy attributed to the self-oxidation mechanism of Cu and Cu2O; while the oxidation of 0.3Cu@Zn-CrLDH results in Cu2O which retains photocatalytic activity, the oxidation of 0.3Cu2O@Zn-CrLDH leads to inactive CuO. …”
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Classification of Wheezing Children in Rural Bangladesh by Intensity of Ascaris Infection, Total and Specific IgE Levels, History of Pneumonia, and Other Risk Factors by Haruko Takeuchi, Md Alfazal Khan, Khalequz Zaman, Sayaka Takanashi, S. M. Tafsir Hasan, Mohammad Yunus, Tsutomu Iwata

“…Childhood wheezing in rural Bangladesh could be divided into three groups, with 26% of wheezing attributable to anti-Ascaris IgE and 16% to history of pneumonia during early childhood, and 58% might have been due to Ascaris infection without elevated anti-Ascaris IgE.…”
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