Barriers to orthodox medical care of prostate cancer in Ghana by Patrick Opoku Manu Maison, Prince Arkoh, Ahmed Sani, Emmanuel Ekow Mensah-Baidoo, Gifty Owusu, Esther Yeboah Danso, Nana Benyin Koufie, Susanna Andzie, Perez Gyamfi, Emmanuel Omane, Sylvester Antwi, Nallasivam Palanisamy, Clara Hwang, Eleanor Walker, Valerie Ofori Aboah, Evelyn Mawunyo Jiagge

“…Of the community-recruited patients who underwent PSA testing, 26% had elevated PSA levels and underwent further diagnostic procedures. …”
Get full text

Intestinal obstruction caused by disseminated mycobacterium avium complex disease following solid organ transplantation: a case report by Akane Mita, Sho Nakakubo, Yusuke Nishimura, Hideki Shima, Masaaki Watanabe, Tsuyoshi Shimamura, Satoshi Konno

“…Endoscopy revealed an elevated lesion with circumferential ulcers, leading to a suspicion of primary malignant lymphoma. …”
Get full text

Exploring the predictive power of antinuclear antibodies and Rheumatoid factor correlations in anticipating therapeutic outcomes for female patients with coexisting Sjögren's syndr... by Anitha Krishnan Pandarathodiyil, Hema Shree K, Pratibha Ramani, B. Sivapathasundharam, Ramya Ramadoss

“…Conclusion: Age showed a significant correlation with ANA levels, indicating that older patients may have elevated ANA. The neural network model demonstrated strong predictive power for treatment response, although further refinement is needed to improve its ability to distinguish between all response categories. …”
Get full text

Serum Exosomes miR-122-5P Induces Hepatic and Renal Injury in Septic Rats by Regulating TAK1/SIRT1 Pathway by Wang J, Jiang Y, Yuan Y, Ma X, Li T, Lv Y, Zhang J, Chen L, Zhou J, Meng Y, Zhang B, Dong X, Ma L

“…Furthermore, big data analysis was utilized to screen potential targets of miR-122-5p in vivo.Key Findings: Serum exosomal levels of miR-122-5p were significantly elevated in septic patients as well as in LPS-induced septic rats. …”
Get full text

Association between Serum Uric Acid Levels and Perinatal Outcome in Women with Preeclampsia by Robinson Uchenna Ugwuanyi, Irozuruike Munachiso Chiege, Felix Eke Agwu, George Uchenna Eleje, Nonso Martin Ifediorah

“…Women with preeclampsia had significantly high serum uric acid level versus controls (6.08 ± 0.49 mg/dL vs. 5.20 ± 0.19; P<0.001). Women with elevated serum uric acid levels (˃6 mg/dL) were found to be 4 times more likely to have severe preeclampsia (P=0.022, OR = 4.00, 95% CI = 1.225–13.056), 66 times more likely to have APGAR score ˂7 in the first minute (P<0.001, OR = 66.00, 95% CI = 6.991–623.128), and 3 times more likely to have lower birth weight (P=0.038, OR = 3.400, 95% CI = 1.073–10.775) than those with normal serum uric acid levels. …”
Get full text

Circulating (CD3−CD19+CD20−IgD−CD27highCD38high) Plasmablasts: A Promising Cellular Biomarker for Immune Activity for Anti-PLA2R1 Related Membranous Nephropathy? by Agnieszka Pozdzik, Ingrid Beukinga, Chunyan Gu-Trantien, Karen Willard-Gallo, Joëlle Nortier, Olivier Pradier

“…During the follow-up, plasmablasts decreased more rapidly than memory B cells but still remained elevated as compared to day 0 of RTX. Concomitantly, anti-PLA2R1 Ab increased progressively. …”
Get full text

Association of Breastfeeding with Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis in mothers: A cross sectional survey by Muhammad Zafar Majeed Babar, Ghulam Mustafa, Manzur Ahmad Manzur, Hafiz Haseeb Ahsan

“…Out of 140 patients who did not breastfeed their children 56 (40.0%) developed NAFLD, contrary to 140 patients who breastfed their children only 20 (14.3%) (P value = 0.00) got NAFLD. Elevated ALT and AST levels are significant for NAFLD and NASH. …”
Get full text

Correlation analysis between epicardial adipose tissue and acute coronary syndrome by Gao Zhihong, Zuo Yuqiang, Jia Linyi, Yin Yuling, Yang Xu, Xu Lei, Hao Zengfang

“…Systolic blood pressure, EATV, EATD, fasting blood glucose, triglycerides, and high-sensitivity C-reactive protein were significantly elevated in the ACS group compared with the non-ACS group (all p < 0.05). …”
Get full text

Effect of PCSK9 inhibitor on early neurological deterioration in acute ischemic stroke patients with a history of coronary heart disease: a study protocol for a randomized controll... by Xing Gong, Xinting Yu, Lanlan Pu, Yang Jiao, Lin Liu, Hua Cao, Xiaofei Ji

“…Shared risk factors between CHD and AIS, especially elevated low-density lipoprotein cholesterol (LDL-C), contribute to atherosclerosis and inflammation, which worsen brain tissue damage. …”
Get full text

Oxyberberine alleviates lipopolysaccharide-induced intestinal barrier disruption and inflammation in human colonic Caco-2 cells in vitro by Cailan Li, Cailan Li, Cailan Li, Jiahao Wang, Hongmei Yang, Shuang Luo, Qiang Lu

“…In addition, OBB treatment effectively inhibited LPS-induced increases in ROS, apoptosis, and Keap1 and decreases in Nrf2 and HO-1. LPS-induced elevations in nuclear NF-κB p65 and p-IκBα were suppressed by OBB. …”
Get full text

Thyroid function abnormalities in individuals with sickle cell disease: a meta-analysis by Sagad O. O. Mohamed, Hussein Ahmed, Mohammed A. H. Mohammednoor, Khalefa B. K. Alzubeir, Safaa Fadlelmoula, Osman O. A. Abdallah, Izzut Awad Ahmed

“…Conclusion Individuals with SCD exhibit a tendency towards elevated TSH levels compared to the general population, with a subset potentially developing thyroid abnormalities, particularly subclinical hypothyroidism. …”
Get full text

Enhancing the efficiency of the cultivation of cladocerans (Moina sp. and Diaphanosoma sp.) through dietary diversification strategies by Sadia Momota Hena, Abdul Mozid Akanda, Jinnath Rehana Ritu, Mohammad Ariful Islam Sumon, Md Mahfuzul Haque, Saleha Khan

“…These findings indicate that elevating the initial stocking density of cladocerans and increasing the concentrations of Haematococcus sp. as feed up to an optimal level can effectively enhance the population growth of cladocerans. …”
Get full text

siRNA-mediated inhibition of hTERT enhances the effects of curcumin in promoting cell death in precursor-B acute lymphoblastic leukemia cells: an in silico and in vitro study by Muhammad Hossein Ashoub, Ali Afgar, Alireza Farsinejad, Razieh Razavi, Samira Anvari, Ahmad Fatemi

“…Given that hTERT overexpression characterizes various cancer phenotypes and elevated telomerase activity is observed in early-stage and relapsed ALL, we investigated the molecular mechanisms linking hTERT regulation and ferroptosis in leukemia cells. …”
Get full text

Effects of yeast culture on growth performance, antioxidant capacity, immune function, and intestinal microbiota structure in Simmental beef cattle by Xueqiang Li, Xueqiang Li, Nan An, Nan An, Hui Chen, Hui Chen, Dacheng Liu, Dacheng Liu

“…Serum samples were collected on the 1st, 30th, and 60th days, respectively, while feces 3 days before the end of the test.ResultsResults showed that YC addition significantly elevated average daily gain and reduced feed to weight ratio of beef cattle. …”
Get full text

Development of a diagnostic multivariable prediction model of a positive SARS-CoV-2 RT-PCR result in healthcare workers with suspected SARS-CoV-2 infection in hospital settings. by Sandra Liliana Valderrama-Beltrán, Juliana Cuervo-Rojas, Martín Rondón, Juan Sebastián Montealegre-Diaz, Juan David Vera, Samuel Martinez-Vernaza, Alejandra Bonilla, Camilo Molineros, Viviana Fierro, Atilio Moreno, Leidy Villalobos, Beatriz Ariza, Carlos Álvarez-Moreno

“…<h4>Background</h4>Despite declining COVID-19 incidence, healthcare workers (HCWs) still face an elevated risk of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. …”
Get full text

The intersection of intimate partner violence with sexual reproductive health in the Pacific: findings from a Kiribati population study by Anneliese Spiteri-Staines, Luz Viviana Sastre Gomez, Jess Letch, Anna Bornemisza, Kristin Diemer

“…Conclusions This study shows women in Kiribati experience elevated rates of IPV and unmet need for family planning. …”
Get full text

Association between D-dimer to lymphocyte ratio and in hospital all-cause mortality in elderly patients with sepsis: a cohort of 1123 patients by Xinguang Long, Zhenkui Hu, Chao Song, Jinhui Zhang

“…Kaplan-Meier analysis highlighted a significantly increased risk of all-cause mortality among patients with elevated DLR values (log-rank p &lt; 0.001). ROC curve analyses revealed that DLR had a stronger ability to predict hospital mortality and ICU mortality in patients with sepsis than D-dimer or Lym. …”
Get full text

Distribution and Main Influencing Factors of Net Ecosystem Carbon Exchange in Typical Vegetation Ecosystems of Southern China by Yike Wang, Xia Liu, Weijia Lan, Shuxian Yin, Liya Fan, Boru Mai, Xuejiao Deng

“…However, a noticeable minimum value occurred around noon, mainly due to a combination of heightened photosynthesis, an elevated VPD, and an increased PBL height. (3) Near the light saturation point, decreased VPD improved light utilization, shifting the minimum light use efficiency (LUE) toward lower radiation levels. …”
Get full text

Expression and correlation of endoglin, sEndoglin, and MMP-14 on preeclampsia placenta by Febriana Catur Iswanti, Ninik Mudjihartini, Reni Paramita, Yuditiya Purwosunu, Ani Retno Prijanti

“…Conclusion: Endoglin, sEndoglin, and MMP-14 were differentially expressed in preeclampsia placentas, with sEndoglin and MMP-14 significantly elevated. These findings highlight their potential role in angiogenic imbalance and may provide insight into the pathophysiology of preeclampsia. …”
Get full text

Genetic insight into dissecting the immunophenotypes and inflammatory profiles in the pathogenesis of Sjogren syndrome by Jingyi Xu, Shucheng Si, Yijun Han, Lin Zeng, Jinxia Zhao

“…Results We demonstrated that an elevated level of CD27 on IgD + CD24 + B cell, a subset of B cells expressing both IgD and CD24, was associated with a higher risk of SS (OR = 1.119, 95% CI: 1.061–1.179, P < 0.001), while CD3 on CD45RA + CD4 + Treg was a protective factor (OR = 0.917, 95%CI: 0.877–0.959, P < 0.001). …”
Get full text