Mitochondrial DNA oxidation and content in different metabolic phenotypes of women with polycystic ovary syndrome by Mailén Rojo, Mailén Rojo, Hernán Pérez, Hernán Pérez, Andrea Liliana Millán, Andrea Liliana Millán, María Constanza Pautasso, Alejandra Duarte, Alejandra Duarte, Giselle Adriana Abruzzese, Alicia Beatriz Motta, Alicia Beatriz Motta, Gustavo Daniel Frechtel, Gustavo Daniel Frechtel, Gustavo Daniel Frechtel, Gloria Edith Cerrone, Gloria Edith Cerrone

“…Insulin resistance (IR) is common in PCOS with consequent elevated risks of metabolic disorders and cardiovascular mortality. …”
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Serious Bacterial Infections and Hepatitis C Virus Among People Who Inject Drugs: A Syndemic or Intertwined Epidemics? by Thomas J. Stopka, Robin M. Nance, L. Sarah Mixson, Hunter Spencer, Judith I. Tsui, Judith M. Leahy, Mai T. Pho, Jean DeJace, Judith Feinberg, April M. Young, Wei-Teng Yang, Amelia Baltes, Eric Romo, Randall T. Brown, Kerry Nolte, William C. Miller, William A. Zule, Wiley D. Jenkins, Joseph A. Delaney, Peter D. Friedmann

“…We examined whether syndemic interactions existed between SBI, HCV, and substance-use-related factors in rural communities, hypothesizing that injection-mediated risks elevated the likelihood for both SBIs and HCV infections, which could be exacerbated by synergistic biological–biological or biological and social interactions. …”
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Association of Circulating Neprilysin with BMI, Cardiovascular Health, and Kidney Function in High-Risk Pregnancies: A Pilot Study by Kaltrina Kutllovci Hasani, Azra Kulovic-Sissawo, Adam Saloň, Christina Stern, Karoline Mayer-Pickel, Mila Cervar-Zivkovic, Nandu Goswami, Herbert Fluhr, Ursula Hiden

“…Women with GH exhibited elevated sNEP, while former smokers had lower sNEP levels in early pregnancy. …”
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Experimental assessment of condition monitoring techniques for an OWC electrical generator operating at overload by Joseba Lopez-Mendia, Iker Erkiaga, Pablo Ruiz-Minguela, Ivan Ruibal, Eider Robles, Salvador Ceballos

“…Enhancing the operational speed may result in increased vibrations, while boosting the torque can elevate the temperature of the stator winding. This temperature rise can eventually compromise the insulation of the stator winding, leading to potential failure.At the present work, an overload operational regime of a generator, under the special operation mode of the MARMOK-Idom Oscillating Water Column (OWC) Wave Energy Converter (WEC), will be evaluated at overload till the end of its life. …”
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Inflammation severity, rather than respiratory failure, is strongly associated with mortality of ARDS patients in high-altitude ICUs by Daniel Molano-Franco, Daniel Molano-Franco, Daniel Molano-Franco, Daniel Molano-Franco, Daniel Molano-Franco, Joan Ramon Masclans Enviz, Joan Ramon Masclans Enviz, Antonio Viruez-Soto, Antonio Viruez-Soto, Antonio Viruez-Soto, Antonio Viruez-Soto, Mario Gomez, Harvey Rojas, Edgar Beltran, Victor Nieto, Fernanda Aliaga-Raduan, Fernanda Aliaga-Raduan, Pablo Iturri, Christian Arias-Reyes, Christian Arias-Reyes, Christian Arias-Reyes, Jorge Soliz, Jorge Soliz

“…IntroductionIn high-altitude cities located above 2,500 m, hospitals face a concerning mortality rate of over 50% among intensive care unit (ICU) patients with acute respiratory distress syndrome (ARDS). This elevated mortality rate is largely due to the absence of altitude-specific medical protocols that consider the unique physiological adaptations of high-altitude residents to hypoxic conditions. …”
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Cytomegalovirus infection in an immunocompetent host presenting as haemophagocytic lymphohistiocytosis by Inês Matias-Lopes, Henrique Atalaia Barbacena, Margarida Guiomar, Raquel Soares, Catarina Barão, Ana Rita Ferreira, Federica Parlato, Patrícia Howell-Monteiro

“…Further evaluation showed the presence of haemolytic anaemia; lymphocytosis and monocytosis; thrombocytosis; elevated C-reactive protein; hypertriglyceridemia and hyperferritinaemia; peripheral blood immunophenotyping with a 44% population of T cells and diminished CD4/CD8 ratio. …”
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Assessing the suitability of sites near Pine Island Glacier for subglacial bedrock drilling aimed at detecting Holocene retreat–readvance by J. S. Johnson, J. Woodward, I. Nesbitt, K. Winter, S. Campbell, K. A. Nichols, R. A. Venturelli, S. Braddock, B. M. Goehring, B. Hall, D. H. Rood, G. Balco, G. Balco

“…Furthermore, the ridge is strewn with glacial erratics at all elevations, providing valuable constraints on its early Holocene deglacial history. …”
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A novel CUL4B gene variant activating Wnt4/β-catenin signal pathway to karyotype 46, XY female with disorders of sex development by Chunlin Wang, Hong Chen, Qingqing Chen, Yangbin Qu, Ke Yuan, Li Liang, Qingfeng Yan

“…In KGN ovarian cells of the mutant group, the mRNA and protein levels for WNT4 and CTNNB1 were elevated. Damaged testicular vasculature and underdeveloped seminal vesicles were observed in Cul4b L337M mice. …”
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Association between exposure to 35 environmental pollutants and mortality from cerebrovascular diseases: A long-term prospective study by Lingjun Yan, Bingqin Xie, Zilin Liu, Yu Huang, Chenyu Ding, Wenhua Fang, Fuxin Lin, Yuanxiang Lin, Dezhi Kang, Fa Chen

“…Furthermore, the composite environmental index derived from these six pollutants also demonstrated a significant correlation with elevated cerebrovascular disease mortality risk. This prospective study provides evidence of an association between certain environmental pollutant exposure (especially for organochlorine pesticides) and risk of cerebrovascular disease mortality. …”
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Adult hypophosphatasia presenting with recurrent acute joint pain by Hayao Yoshida, Takaaki Murakami, Atsubumi Ogawa, Takashi Sunouchi, Naoko Hidaka, Nobuaki Ito, Hiromi Murakami, Hidenori Kawasaki, Tomoyuki Akiyama, Katsumi Nakajima, Daisuke Yabe, Taizo Yamamoto

“…Blood biochemical tests revealed a remarkably low serum ALP level, and repeated examination confirmed a sustained low ALP level; urine phosphoethanolamine, plasma inorganic pyrophosphate and plasma pyridoxal-5′-phosphate levels were elevated, raising concern for HPP. While the patient had no history of premature loss of primary teeth, fragility fractures, muscle weakness or abnormalities in growth, genetic testing revealed a likely pathogenic and a pathogenic heterozygous variant in the ALPL gene, i.e., c.979T>C (p.Phe327Leu) and c.1559del (p.Leu520Argfs), confirming HPP. …”
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FOSL2 activates TGF‐β1‐mediated GLUT1/mTOR signaling to promote diabetic kidney disease by Xuelin He, Min Xia, Guanghui Ying, Qien He, Zhaogui Chen, Li Liu, Qiao Zhang, Jianxin Cai

“…ChIP‐qPCR was performed on MCs to detect the binding of FOSL2 on the TGF‐β1 promoter and a dual‐luciferase assay to detect the impact of FOSL2 on the transcription of the TGF‐β1 promoter. Results FOSL2 was elevated in the kidney tissues of DKD mice. Knockdown of FOSL2 reduced the mRNA expression of TGF‐β1 to decrease the protein expression of GLUT1 and mTOR in the kidney tissues of DKD mice, and TGF‐β1 reversed the effects caused by knockdown of FOSL2. …”
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The Potency of Essential Oils in Combating Stored-Product Pests: From Nature to Nemesis by Nickolas G. Kavallieratos, Nikoleta Eleftheriadou, Constantin S. Filintas, Maria C. Boukouvala, Demeter Lorentha S. Gidari, Anna Skourti, Dionysios Ntinokas, Marta Ferrati, Eleonora Spinozzi, Riccardo Petrelli, Filippo Maggi

“…The findings demonstrated that <i>C. reticulata</i> and <i>I. verum</i> EOs had elevated insecticidal effects, especially against larval stages, resulting in 100% mortality in several species. …”
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Exploring the Impact of Citric Acid on Mitigating Sweet Potato Soft Rot and Enhancing Postharvest Quality by Yixi Chen, Linjiang Pang, Jiacheng Bai, Wenbao Yu, Yueming Zhu, Melvin Sidikie George, Zunfu Lv, Guoquan Lu

“…Moreover, CAC treatment was found to maintain elevated levels of total phenolics and flavonoids within the sweet potato tissues. …”
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The role of ferroptosis and oxidative stress in cognitive deficits among chronic schizophrenia patients: a multicenter investigation by Zhenlei Peng, Qiyu Jia, Junxiong Mao, Shijie Jiang, Qi Ma, Xiao Luo, Zhiguo An, Anqi Huang, Chuang Ma, Qizhong Yi

“…Multiple linear regression analysis revealed that decreased GSH and iron levels, along with elevated SOD levels, were significantly associated with the overall severity of psychiatric symptoms. …”
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Will Climate Change Alter the Swimming Behavior of Larval Stone Crabs?: A Guided-Inquiry Lesson by Abigail L. Smith, Jessyca LaBadie, Aly Busse, Emilie Solomon, Casie Farrell, Daniel M. Holstein, Zuo George Xue, Philip M. Gravinese

“…Environmental stressors like ocean acidification and elevated seawater temperatures may also impact the larvae’s natural response to these abiotic stimuli throughout ontogeny (development). …”
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Metallothionein 1B attenuates inflammation and hepatic steatosis in MASH by inhibiting the AKT/PI3K pathway by Canghai Guan, Xinlei Zou, Wujiang Shi, Jianjun Gao, Chengru Yang, Yifei Ge, Zhaoqiang Xu, Shaowu Bi, Xiangyu Zhong

“…In vivo experiments demonstrate that specific downregulation of hepatic MT1B expression via AAV8-shMT1B injection significantly increases triglyceride and total cholesterol levels, exacerbates lipid accumulation, and markedly elevates liver fibrosis and inflammatory factor expression. …”
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USP25 attenuates anti-GBM nephritis in mice by negative feedback regulation of Th17 cell differentiation by Ranran Xu, Fei Huang, Qingquan Liu, Yongman Lv, Liu Hu, Qian Zhang

“…Furthermore, changes in USP25 expression were monitored during Th17 differentiation, both in vivo and in vitro.Results USP25−/− mice with anti-GBM GN exhibited accelerated renal function deterioration, increased infiltration of Th1 and Th17 cells, and elevated RORγt transcription. In vitro experiments demonstrated that USP25−/− CD4+ T lymphocytes had a higher proportion for Th17 cell differentiation and exhibited higher RORγt levels upon stimulation. …”
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S1PR3-driven positive feedback loop sustains STAT3 activation and keratinocyte hyperproliferation in psoriasis by Panpan Lian, Li Li, Renwei Lu, Bin Zhang, Junaid Wazir, Chaode Gu, Bojie Ma, Wenyuan Pu, Wangsen Cao, Zhiqiang Huang, Zhonglan Su, Hongwei Wang

“…S1PR3 expression is markedly elevated in psoriatic lesions and correlates with disease severity. …”
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Radiomics analysis of thoracic vertebral bone marrow microenvironment changes before bone metastasis of breast cancer based on chest CT by Hao-Nan Zhu, Yi-Fan Guo, YingMin Lin, Zhi-Chao Sun, Xi Zhu, YuanZhe Li

“…Background: Bone metastasis from breast cancer significantly elevates patient morbidity and mortality, making early detection crucial for improving outcomes. …”
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Genetic characterization of a rare case of pheochromocytoma in a pulmonary transplant patient by Stéfanie Parisien-La Salle, Florence Perreault, Gilles Corbeil, Julie Morisset, Charles Poirier, Catherine Beauregard, Agnès Räkel, Marjorie Labrecque, Martine Tétreault, Martine Tétreault, Christian Cohade, Pasquale Ferraro, Isabelle Bourdeau

“…Initial assessments indicated elevated 24-hour urinary catecholamines. Consequently, the patient underwent laparoscopic right adrenalectomy, confirming the PCC diagnosis.Genetic studies1) Germline PPGL multigene panel: After consent, the patient underwent a panel of 14 susceptibility genes for PPGLs that revealed no pathogenic variants. 2) Somatic genetic analysis for EPAS1 gene found no variants. …”
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