Noise-induced ribbon synapse loss in the mouse basal cochlear region does not reduce inner hair cell exocytosis by David Oestreicher, David Oestreicher, Alfonso Mauro Malpede, Alfonso Mauro Malpede, Annalena Reitmeier, Annalena Reitmeier, Carolin Paula Bräuer, Carolin Paula Bräuer, Laura Schoch, Laura Schoch, Nicola Strenzke, Nicola Strenzke, Tina Pangrsic, Tina Pangrsic, Tina Pangrsic

“…Two noise sound pressure levels (SPLs) were used to evoke acute hearing threshold elevations with different levels of recovery 2 weeks post-exposure. …”
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Perioperative pembrolizumab in early-stage non-small cell lung cancer (NSCLC): safety, efficacy, and exploratory biomarker analysis by Jeff Clarke, Xiaofei Wang, Thomas Stinchcombe, Scott J Antonia, Jeffrey Crawford, Neal Ready, Konstantin H Dragnev, Lin Gu, Cameron Wood, James M Isaacs, Liliana Lyniv, Kent Weinhold, Jacob M Kaufman, Eziafa I Oduah, Betty C Tong, Dennis Wigle

“…Plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels increased across our patient cohort over time from baseline until postsurgery and remained elevated at the end of treatment. There was a significant difference between mean plasma PCSK9 levels for patients with MPR versus all other patients on study when checked postoperatively.Conclusions Perioperative pembrolizumab was safe and effective with promising MPR rate, PFS, and OS.…”
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Alternative Complement Pathway in Carotid Atherosclerosis: Low Plasma Properdin Levels Associate With Long‐Term Cardiovascular Mortality by Mieke C. Louwe, Chrysostomi Gialeli, Annika E. Michelsen, Sverre Holm, Andreas Edsfeldt, Karolina Skagen, Tove Lekva, Maria Belland Olsen, Vigdis Bjerkeli, Therese Schjørlien, Kristine Stø, Xiang Yi Kong, Tuva B. Dahl, Per H. Nilsson, Peter Libby, Pål Aukrust, Tom Eirik Mollnes, Thor Ueland, Mona Skjelland, Isabel Gonçalves, Bente Halvorsen

“…Although patients with carotid atherosclerosis had elevated levels of properdin compared with controls, within these patients, low plasma levels of properdin (ie, <median levels of properdin in the patient group) were significantly associated with cardiovascular mortality. …”
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TOPBP1 as a potential predictive biomarker for enhanced combinatorial efficacy of olaparib and AZD6738 in PDAC by Xiao-Mei Tang, Min-Min Shi, Jia-Cheng Wang, Yi-Jin Gu, Yu-Ting Dai, Qin-Xin Yang, Jia Liu, Ling-Jie Ren, Xin-Yun Liu, Chun Yang, Fang-Fang Ma, Ji-Bing Liu, Hong Yu, Da Fu, Yun-Feng Wang

“…We examined the relationship between TOPBP1 expression, DDR pathway modulation, and therapeutic response in PDAC cell lines, primary cells, and subcutaneous mouse models. We found that elevated TOPBP1 expression was positively correlated with increased histologic grade and reduced patient survival in PDAC. …”
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Irisin Attenuates Hepatic Stellate Cell Activation and Liver Fibrosis in Bile Duct Ligation Mice Model and Improves Mitochondrial Dysfunction by Thuy Linh Lai, So Young Park, Giang Nguyen, Phuc Thi Minh Pham, Seon Mee Kang, Jeana Hong, Jae-Ho Lee, Seung-Soon Im, Dae-Hee Choi, Eun-Hee Cho

“…In vivo, irisin ameliorated the elevated liver-to-body weight ratio induced by BDL and alleviated liver fibrosis, as evidenced by Masson’s trichrome staining. …”
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Association of Wrist Circumference and Waist-to-Height Ratio with Cardiometabolic Risk Factors among Type II Diabetics in a Ghanaian Population by Christian Obirikorang, Yaa Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Emmanuel Toboh, Evans Adu Asamoah, Bright Amakwaa, Emmanuella Nsenbah Batu, Peter Brenya

“…Using Framingham risk scores, 61% of the subjects had elevated 10-year risk of developing cardiovascular diseases (CVDs), with no significant difference in gender prevalence. …”
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Volume contracted state, mortality and functional outcomes in patients with acute ischaemic stroke due to large vessel occlusion by Risheng Xu, Max Wintermark, Gregory W Albers, Jeremy J Heit, Adam A Dmytriw, Adrien Guenego, Yasmin Aziz, Kambiz Nael, Benjamin Pulli, Victor Urrutia, Dhairya A Lakhani, Tobias D Faizy, Argye Hillis, Vivek Yedavalli, Dylan Wolman, Licia P Luna, Elisabeth B Marsh, Hamza Adel Salim, Janet Mei, Vaibhav Vagal, Aakanksha Sriwastwa, Raf Llinas, Hanzhang Lu, Mona N Bahouth

“…Background Acute ischaemic stroke (AIS) is a leading cause of mortality and disability globally, with volume contracted state (VCS), as indicated by an elevated blood urea nitrogen to creatinine (BUN/Cr) ratio, potentially influencing outcomes. …”
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Overexpression of OsDUF868.12 enhances salt tolerance in rice by Hao Chen, Jiale Wan, Jiali Zhu, Ziyi Wang, Caiyao Mao, Wanjing Xu, Juan Yang, Yijuan Kong, Xiaofei Zan, Rongjun Chen, Jianqing Zhu, Zhengjun Xu, Lihua Li, Lihua Li

“…Furthermore, overexpression of OsDUF868.12 elevated the transcription levels of positively regulated salt stress-related genes. …”
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Involvement of the posterior limb of the internal capsule independently predicts the prognosis of patients with basal ganglia and thalamic hemorrhage by Sohan Gupta, Mengxuan Xiao, Na Liu, Na Liu, Yunxiao Zhao, Xiaolin Zhao, Yunqiang Huang, Yongming Wu, Zhenzhou Lin, Zhong Ji, Haihao Xu, Minzhen Zhu, Suyue Pan, Kaibin Huang

“…When combined with the iICH, the AUC of max-ICH was significantly elevated from 0.816 to 0.866. Comparable results were found in the validation cohort.ConclusionsIncreased involvement of the posterior limb of the internal capsule is associated with a worse outcome in patients with basal ganglia and thalamic ICH.…”
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Painless Silent Chronic Fibrosing Pancreatitis Caused Complete Biliary Obstruction in a Toddler: A Case Report by Magd Ahmed Kotb, Mohamed Elbarbary, Sherif Kaddah, Martina Magdy, Rania Hamdy, Reham Osama Mahmoud, Nevian Nabil, Noha Adel Yassin, Ahmed Nabil, Ahmed El Hatw, Sayed Khedr

“…We report a 21-month-old boy who presented by jaundice, clay colored stool, elevated liver enzymes, and hepatomegaly. The mother reported that the child had no complaints otherwise. …”
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Impact of obesity on iron metabolism and the effect of intravenous iron supplementation in obese patients with absolute iron deficiency by Laura Tarancon-Diez, Marianela Iriarte-Gahete, Pilar Sanchez-Mingo, Mª Ángeles Muñoz-Fernandez, Maria Luisa Navarro-Gomez, Yolanda M. Pacheco, Manuel Leal

“…Obese group exhibited higher levels of ferritin, hemoglobin (Hb), soluble transferrin receptor (sTfR) and hepcidin compared to HW group. Elevated BMI was independently associated with increased sTfR levels. …”
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Influence of prenatal hexachlorobenzene, PCB and selenium levels on growth trajectories in the first year of life: Findings from the NEHO birth cohort by Ilaria Cosentini, Silvia Ruggieri, Paolo Colombo, Fabrizio Bianchi, Liliana Cori, Melania Casella, Elisa Eleonora Tavormina, Fabio Cibella, Gaspare Drago

“…Conversely, PCB-180 exposure was linked to higher growth only in females [higher vs normal: ORFemale = 24.10 (95 % CIFemale:1.33;438.24)]. Elevated levels of selenium in cord serum were negatively associated with excessive growth [higher vs normal: OROverall = 0.50 (95 % CIOverall: 0.26;0.97)]. …”
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Chemokine associations with blood cerebrospinal fluid (CSF) barrier permeability and delirium by Paul Denver, Lucas Tortorelli, Karen Hov, Jens Petter Berg, Lasse M. Giil, Arshed Nazmi, Ana Lopez-Rodriguez, Daire Healy, Carol Murray, Robyn Barry, Leiv Otto Watne, Colm Cunningham

“…Chemokines were not associated with delirium in univariate analysis or when stratified on dementia status, but exploratory analyses showed that elevated Eotaxin (CCL11) and MIP1α (CCL3) were associated with prevalent delirium. …”
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The Development of a Novel Broad-Spectrum Influenza Polypeptide Vaccine Based on Multi-Epitope Tandem Sequences by Song Zhao, Junhao Luo, Wenhui Guo, Li Li, Siyu Pu, Libo Dong, Wenfei Zhu, Rongbao Gao

“…IFN-γ production was significantly elevated in spleen lymphocytes upon stimulation with the vaccine. …”
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Are Trace Elements Provided for Children on Long-Term Parenteral Nutrition Adequate to Meet Their Needs? by Hanna Romanowska, Mikołaj Danko, Anna Borkowska, Katarzyna Popińska, Marta Sibilska, Joanna Żydak, Joanna Wielopolska, Klaudia Bartoszewicz, Agnieszka Szlagatys-Sidorkiewicz, Janusz Książyk

“…Children with signs of infection or elevated C-reactive protein levels were excluded. Elemental analysis was performed using inductively coupled plasma mass spectrometry (ICP-MS). …”
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Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development by Yue-Wei Chen, Qiu-Rong Du, Yu-Juan He, Wen-Shu Chen, Wen-Yang Jiang, Qi Gui, Cheng-Cheng Xu, Wei Wang, Hong-Yun Cheng

“…Recently, we observed that circ_0044516 expression levels were obviously elevated in lung cancer tissues and cells. A549 and SPCA1 cells were transfected with circ_0044516 siRNA. …”
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Dose-Dependent Hemodynamic, Biochemical, and Tissue Oxygen Effects of OC99 following Severe Oxygen Debt Produced by Hemorrhagic Shock in Dogs by William W. Muir, Carlos L. del Rio, Yukie Ueyama, Bradley L. Youngblood, Robert S. George, Carl W. Rausch, Billy S. H. Lau, Robert L. Hamlin

“…The administration of 0.65 g/kg OC99 significantly elevated pulmonary artery pressure. Plasma hemoglobin concentrations of OC99 ranging from 0.3 to 1.1 g/dL, in conjunction with colloid based fluid resuscitation, normalized clinical surrogates of tissue oxygen debt, improved tPO2, and avoided clinically relevant increases in pulmonary artery pressure.…”
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Assessing Electricity Supply Reliability by Detection of Anomalies in Daily Nighttime Light by Miaoying Chen, Yang Hu, Xin Cao, Shijie Li, Luling Liu

“…Moreover, the electricity anomaly rate in Johannesburg increased from 36&#x0025; to 51&#x0025; between 2020 and 2023, with elevated areas mainly in densely residential areas and commercial centers. …”
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Influence of sacroiliac joint variation on clinical features of axial spondyloarthritis: a comparative analysis by Denis Poddubnyy, Torsten Diekhoff, Sevtap Tugce Ulas, Fabian Proft, Valeria Rios Rodriguez, Judith Rademacher, Juliane Greese, Katharina Ziegeler, Carolina Dominguez Aleixo, Maximilian Lindholz

“…Classification of back pain as inflammatory (=IBP), human leucocyte antigen-B27 positivity, family history, disease activity according to Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), symptom duration, elevated acute phase reactants, peripheral and extramusculoskeletal manifestations were evaluated. …”
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Changes in the intestinal microbiota induced by the postnatal environment and their association with hypertension by Patrizia Dardi, Camille Perella Coutinho, Sarah de Oliveira, Simone Aparecida Teixeira, Renaide Rodrigues Ferreira Gacek, Eduardo Purgatto, Marco Aurélio Ramirez Vinolo, Marcelo Nicolás Muscará, Luciana Venturini Rossoni

“…Wistar (WW) rats, even before hypertension onset, characterized by a reduction of the “low-abundance” bacterial genera, a diminished availability of fecal butyrate and elevated hydrogen sulfide (H2S) production by the SS gut microbiota. …”
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