Comprehensive Metabolomic Profiling in Adults with X-Linked Hypophosphatemia: A Case-Control Study by Luis Carlos López-Romero, José Jesús Broseta, Marta Roca-Marugán, Noemí Máñez Ramírez, Julio Hernández-Jaras

“…Background: X-linked hypophosphatemia (XLH) is a rare disorder characterized by elevated levels of fibroblast growth factor 23 (FGF-23), leading to hypophosphatemia and complications in diagnosis due to its clinical heterogeneity. …”
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The influence of previous preterm birth with singleton pregnancy on the risk of recurrence in subsequent twin pregnancy: a meta-analysis by Pinghua Shen, Wenjun Wu, Yehui Jiang

“…Our results revealed a significantly elevated risk of subsequent preterm twin births associated with prior preterm singleton births at <37 weeks (OR, 2.94; 95% CI, 1.99–4.33; p < .001), <34 weeks (OR, 1.89; 95% CI, 1.67–2.14; p < .001) and <32 weeks (OR, 2.51; 95% CI, 1.58–3.99; p < .001), without heterogeneity in the included studies.Conclusions Our systematic analysis indicates a consistent and statistically significant association between a history of preterm singleton births and preterm twin births at various gestational ages. …”
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An in-vivo herb-drug interaction study of IME-9 and glimepiride in nicotinamide-STZ-induced diabetic rats by Archana K. Thikekar, Asha B. Thomas, Sohan S. Chitlange

“…Results: Concurrent administration of GP and IME-9 in diabetic rats resulted in elevated Cmax and AUC0-48hrs of GP, while no alteration in Tmax was noticed. …”
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Impact of Saharan dust on particulate matter characteristics in an urban and a natural locality in Central Europe by Jan Loskot, Daniel Jezbera, Martina Nalezinková, Adéla Holubová Šmejkalová, Danilo Fernandes, Jan Komárek

“…Notably, its carbon content was lower compared with the usual local PM10. The elevated PM10 concentrations appear to be the most relevant risk associated with this Saharan dust event in Central Europe. …”
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RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling by Megan A. Palmer, Rebecca Kirchhoff, Claudia Buerger, Yvonne Benatzy, Nils Helge Schebb, Bernhard Brüne

“…In addition to CCL2, secretion of CCL5 and CXCL10 were elevated in skin equivalents treated with lipoxygenase inhibitor ML351. …”
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Clinical significance of PCT, CRP, IL-6, NLR, and TyG Index in early diagnosis and severity assessment of acute pancreatitis: A retrospective analysis by Xu Xinyu, Zhou Jiang, Ai Qing, Li Lihua, Liu Xiehong, Zhou Lin

“…PCT, CRP, IL-6, NLR, and TyG index levels were significantly elevated in AP patients compared to controls (P < 0.001) and correlated with disease severity (P < 0.05). …”
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Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms by Ali Mohammadkhanizadeh, Mohammad Sheibani, Soroush Taherkhani, Davood Nourabadi, Seyed Mahdi Mohamadi-Zarch, Farnaz Nikbakht, Yaser Azizi

“…Apigenin has been shown to inhibit the production of pro-inflammatory cytokines, such as TNF-α and IL-1β, which are elevated in neurodegenerative diseases. Moreover, apigenin has been demonstrated to suppress the activation of microglia, the resident immune cells in the brain, which are thought to contribute to neuroinflammation. …”
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Conditional cash transfers and mortality in people hospitalised with psychiatric disorders: A cohort study of the Brazilian Bolsa Família Programme. by Camila Bonfim, Flávia Alves, Érika Fialho, John A Naslund, Maurício L Barreto, Vikram Patel, Daiane Borges Machado

“…While not designed to address elevated mortality risk in this population, this study highlights the potential for poverty alleviation programmes to mitigate mortality rates in one of the highest-risk population subgroups.…”
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Causal Association Between Skin Microbiota and Malignant Melanoma: Genetic Insights From Mendelian Randomization by Li X, Wu S, Pan Y, Wu Z, Du Z, Xie W, Zhou Q

“….], and ASV021 [Micrococcus (unc).]) related with an elevated risk of MM. Conversely, genus: Finegoldia and class: Alphaproteobacteria were shown to inhibit the occurrence of MM. …”
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Association of Visceral Adipose Tissue With Hypertension: Results From the NHANES 2011–2018 and Mendelian Randomization Analyses by Jia Liao, Miaohan Qiu, Jing Li, Yi Li, Yaling Han

“…These analyses provide additional support for both the positive association and causal relationship between elevated VAT and the risk of developing hypertension, suggesting that targeted interventions for VAT may be beneficial in preventing hypertension.…”
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Examining the mental health of siblings of children with a mental disorder: A scoping review protocol. by John E Krzeczkowski, Terrance J Wade, Brendan F Andrade, Dillon Browne, Busra Yalcinoz-Ucan, Negin A Riazi, Elizabeth Yates, Andrea Tagalakis, Karen A Patte

“…Indeed, the siblings of these children are not insulated from these consequences and may experience elevated levels of psychological distress, placing them at increased risk for developing mental disorders. …”
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Clinical Significance of the Peripheral Blood Neutrophil-to-Lymphocyte Ratio in Predicting Chemotherapy Outcomes for Small Cell Lung Cancer by Gao L, Liu B

“…Fasting venous blood samples were collected in the morning within one week before the initiation of chemotherapy, and a complete blood cell count was performed to calculate the NLR.Results: The NLR in the plasma of patients with SCLC was significantly elevated compared to that of healthy individuals (P < 0.01). …”
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Acute Coronary Syndrome in Acute Myeloid Leukemia with Maturation Accompanying Megakaryocytic Differentiation by Kentaro Odani, Junya Abe, Yoshiaki Tsuyuki, Soshi Yanagita, Kazuya Shiogama, Mitsuhiro Tachibana, Yutaka Tsutsumi

“…The final white blood cell count reached 291,700/μL, and the platelet count was elevated to 510,000/μL. No cytogenetic studies were performed. …”
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Effects of modified reverse sural neurocutaneous flap repair on wound healing in patients with soft tissue defects of the foot and ankle by Shun Hong Luo, Yong Ping Li, Man Hua Liu, Yu Xie, Jian Li, Hao Yu, Chun Hua He

“…Island fasciocutaneous flaps were designed along the sural nerve and lesser saphenous vein, elevated subfascially, rotated 180 degrees, and inset without tension. …”
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Novel insights into immunopathogenesis and crucial biomarkers between primary open‐angle glaucoma and systemic lupus erythematosus by Yixian Liu, Mengling You, Zhou Zeng, Jing Wang, Rong Rong, Xiaobo Xia

“…Immune infiltration analysis indicated an elevated presence of immune cells, including macrophages, T cells, and B cells, in both conditions. …”
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The clinical features and outcomes of diabetes patients infected with COVID-19: a systematic review and meta-analysis comprising 192,693 patients by Kai Liu, Shu Liu, Ting-ting Xu, Hong Qiao

“…Our findings will help identify elevated risk factors in diabetics, which will benefit early prediction.…”
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Confronting the anxiety of Generation Z: electroacupuncture therapy regulates oxidative stress and microglia activity in amygdala-basolateral of socially isolated mice by Tong Yin, Junyun Yuan, Lu Liu, Yinxin Wang, Yuanfang Lin, Kangwen Ming, Hang Lv

“…This study aims to elucidate the role of microglial cells in anxiety, specifically examining how EA modulates microglial morphology and function within the basolateral amygdala (BLA) in the context of anxiety induced by social isolation.MethodsUtilizing a mouse model of social isolation-induced anxiety, we evaluated anxiety-like behaviors through the Elevated Plus Maze (EPM) and Open Field Test (OFT). …”
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Central Serous Chorioretinopathy Associated with Corticosteroid Use in a Patient with Leber Hereditary Optic Neuropathy: A Case Report by Lepsa Zoric, Aleksandra Petrovic, Vladimir Milutinovic

“…Depending on the disease stage and initial presentation, it is often diagnosed as optic neuritis. Elevated levels of endogenous and exogenous glucocorticoids have been associated with the onset of central serous chorioretinopathy (CSCR). …”
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Interventions that prevent or reduce perinatal loneliness and its proximal determinants: a restricted scoping review by Ruth Naughton-Doe, Rebecca Nowland, Stephanie Tierney, Martin Webber, Anja Wittkowski

“…The perinatal period carries an increased risk of loneliness for mothers and fathers which is elevated by intersectional inequalities, such as having a low income, being LGBTQ+, or being from a minoritised community. …”
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A thorny pathway of macrophage activating factor (GcMAF): from bench to bedside by A. A. Ostanin, S. S. Kirikovich, E. V. Dolgova, А. S. Proskurina, E. R. Chernykh, S. S. Bogachev

“…Activation results in elevated expression of the specific macrophageal surface receptors involved in the recognition of tumor-associated antigens, as well as in the implementation of direct anticancer activity by inducing the apoptosis or necrosis of tumor cells. …”
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