Hypergammaglobulinemia in Hidradenitis Suppurativa Patients: A New Emerging Association by Martora F, Battista T, Giordano A, Potestio L, Megna M

“…Fabrizio Martora,* Teresa Battista,* Antonella Giordano, Luca Potestio, Matteo Megna Dermatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy*These authors contributed equally to this workCorrespondence: Fabrizio Martora, Section of Dermatology - Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Pansini 5, Napoli, 80131, Italy, Tel +39 - 081 – 7462457, Fax +39 - 081 – 7462442, Email fabriziomartora92@libero.itAbstract: Hypergammaglobulinemia is a sign of B cell and plasma cell hyperactivity marked by elevated levels of gamma globulins, proteins within the gamma fraction of serum electrophoresis, linked to diseases like acute hepatitis, Hodgkin’s lymphoma, autoimmune conditions, and neoplasms. …”
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Targeting the IKZF1/BCL-2 axis as a novel therapeutic strategy for treating acute T-cell lymphoblastic leukemia by Juan Li, Chunmei Ye, Hui Li, Jun Li

“…Functional assays demonstrated that IKZF1 overexpression reduced BCL-2 mRNA levels and increased repressive histone marks at the BCL-2 promoter, while IKZF1 knockdown led to elevated BCL-2 expression. CX-4945, a CK2 inhibitor, could reduced BCL-2 levels in T-ALL cells. …”
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Weight cycling exacerbates glucose intolerance and hepatic triglyceride storage in mice with a history of chronic high fat diet exposure by Miriam Bernecker, Anna Lin, Annette Feuchtinger, Anna Molenaar, Sonja C. Schriever, Paul T. Pfluger

“…Despite weight loss, adipose tissue inflammation persisted with elevated pro-inflammatory markers, macrophage infiltration, and impaired Glut4 expression. …”
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Expression of some circulating microRNAs as predictive biomarkers for prognosis and treatment response in glioblastoma by Elham Ali, Marwa Adel Ahmed, May A. Shawki, Lobna R. Ezz El Arab, Mohamed K. Khalifa, Menha Swellam

“…All investigated miRs were significantly elevated in GBM patients with non-frontal lesions. …”
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Effects of butyric acid and Protoxin probiotic in the feeding of Siberian sturgeon (Acipenser baerii) by Rasool Zare, Abdolmohammad Abedian Kenari

“…Adding organic acid to the fish diet dropped pH and elevated intestinal lactic acid bacteria (P<0.05). …”
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Increased Serum Angiotensin II Is a Risk Factor of Nonalcoholic Fatty Liver Disease: A Prospective Pilot Study by Yue Li, Feng Xiong, Wen Xu, Side Liu

“…Ang II levels of NAFLD patients significantly increased, and elevated Ang II level is an independent risk factor of NAFLD. …”
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Role of Regulatory B Cells in the Progression of Cervical Cancer by Zhifang Chen, Yuejie Zhu, Rong Du, Nannan Pang, Fengbo Zhang, Di Dong, Jianbing Ding, Yan Ding

“…After coculture with Bregs, the quantity of CD8+ T cells to secrete perforin and Granzyme B was significantly decreased, and this effect was reversed after blocking IL-10 by a specific antibody. Breg cells are elevated in cervical cancer and associated with disease progression and metastasis. …”
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Restoring riparian habitats for benefits to biodiversity and human livelihoods: a systematic map protocol for riparian restoration approaches in the tropics by Sheena Davis, Matthew Grainger, Marion Pfeifer, Zarah Pattison, Philip Stephens, Roy Sanderson

“…Abstract Background Riparian zones are vital transitional habitats that bridge the gap between terrestrial and aquatic ecosystems. They support elevated levels of biodiversity and provide an array of important regulatory and provisioning ecosystem services, of which, many are fundamentally important to human well-being, such as the maintenance of water quality and the mitigation of flood risk along waterways. …”
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Exploring knowledge, attitudes, practices, and determinants regarding emergency contraception use among female university students in Goma, Democratic Republic of the Congo: a cros... by Patricia Lukusa Mishika, Olivier Mukuku, Amos Kamundu, Kaymarlin Govender, Stanislas Okitotsho Wembonyama, André Kabamba Mutombo

“…It is crucial to enhance educational campaigns within universities to mitigate the elevated risk of unsafe abortions.…”
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Differentiation of Isolated Small Bowel Crohn’s Disease from Other Small Bowel Ulcerative Diseases: Clinical Features and Double-Balloon Enteroscopy Characteristics by Meng Niu, Zheng-Hao Chen, Meng Li, Xing Zhang, Chun-Xiao Chen

“…Abdominal pain was more common in ISBCD (OR 4.986, 95% CI 2.539-9.792, p<0.001). Elevated fibrinogen levels (OR 1.431, 95% CI 1.022-2.003, p=0.037) and lower levels of D-dimer (OR 0.999, 95% CI 0.999-1.000, p=0.017) were also more supportive of the diagnosis of ISBCD. …”
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Targeted Plasma Bile Acid Metabolomic Analysis in Metabolic Dysfunction-Associated Steatohepatitis and Alcoholic Hepatitis by Yuta Hirata, Yasunaru Sakuma, Hideo Ogiso, Ryozo Nagai, Kenichi Aizawa

“…<b>Results:</b> Concentrations of ursodeoxycholic acid (UDCA), chenodeoxycholic acid (CDCA), taurocholic acid (TCA), tauroursodeoxycholic acid (TUDCA), taurochenodeoxycholic acid (TCDCA), glycoursodeoxycholic acid (GUDCA), glycochenodeoxycholic acid (GCDCA), and glycocholic acid (GCA) were significantly elevated in the hepatitis group. Correlation analysis revealed strong positive relationships between the total and direct bilirubin levels and TUDCA and GCDCA. …”
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The quality of education of the Russian political elite by N. N. Meshcheryakova, O. V. Kryshtanovskaya

“…But in the young generation of the elite the situation is beginning to change by increasing the number of universities they graduated from and the geography of its localization.Elite and elitist education today do not coincide, which indicates the incompleteness of the period of formation of the Russian ruling class, as well as the system of social elevators in education.…”
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Long-Term Environmental Enrichment Relieves Dysfunctional Cognition and Synaptic Protein Levels Induced by Prenatal Inflammation in Older CD-1 Mice by Zhe-Zhe Zhang, Li-Ping Zeng, Jing Chen, Yong-Fang Wu, Ya-Tao Wang, Lan Xia, Qi-Gang Yang, Fang Wang, Gui-Hai Chen

“…Analysis revealed that at 15 months of age, the control mice experienced a reduction in cognitive ability and elevated expression levels of Arc and Syt1 genes when compared to control mice at 3 months of age. …”
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SMAC-armed oncolytic virotherapy enhances the anticancer activity of PD1 blockade by modulating PANoptosis by Fanghui Chen, Liwei Lang, Jianqiang Yang, Fan Yang, Sijia Tang, Zhenzhen Fu, Nabil F. Saba, Ming Luo, Yong Teng

“…Results Compared to its parental virus, VSV-S not only increases apoptosis by overexpressing SMAC during VSV infection but also triggers elevated levels of PANoptosis (pyroptosis, apoptosis, and necroptosis) in HNSCC cells via activation of caspase-1/gasdermin D (GSDMD) signaling. …”
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Unraveling the Beneficial Role of Resveratrol in Fructose-Induced Non-Alcoholic Steatohepatitis with a Focus on the AMPK/Nrf2 Signaling Axis by Soha S. Zakaria, Safaa M. Hanafy

“…Furthermore, resveratrol restored the liver architecture and the oxidative balance, as evidenced by the decreased MDA levels and improved antioxidant status via elevated GSH and SOD activities, as well as the activation of the AMPK/Nrf2 signaling axis. …”
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New epigenome players in the regulation of PCSK9-H3K4me3 and H3K9ac alterations by statin in hypercholesterolemia by Sushmitha Duddu, Yash T. Katakia, Rituparna Chakrabarti, Pooja Sharma, Praphulla Chandra Shukla

“…We observed that atorvastatin (ATS) increases the fold enrichment of H3K4me3 at the promoter of PCSK9 by elevating the expression of the SET1/COMPASS family of proteins like SET1b and MLL1 in HepG2. …”
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A strategy to increase identification of patients with Familial Hypercholesterolemia: Application of the Simon Broome lipid criteria in a large-scale retrospective analysis by James K. Fleming, Renee M. Sullivan, David Alfego, Natalia T. Leach, Tamara J. Richman, Jill Rafalko

“…Introduction: Familial Hypercholesterolemia (FH) is a primarily autosomal dominant condition characterized by markedly elevated low-density lipoprotein-cholesterol (LDL-c) and an increased risk of atherosclerosis and cardiovascular disease (CVD). …”
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Impact of ZnO nanopriming on physiological and biochemical traits of wheat (Triticum aestivum L.) seedling by Priyanka Pandya, Sushil Kumar, Ghanshyam Patil, Monil Mankad, Zarna Shah

“…Zinc oxide nanoparticles notably improved key biochemical features, including elevated levels of total chlorophyll, malondialdehyde (MDA), total protein, and the accumulation of osmolytes such as proline and glycine-betaine. …”
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Dynamics and Half-Life of Cell-Free DNA After Exercise: Insights from a Fragment Size-Specific Measurement Approach by Ryutaro Yamamoto, Hiroshi Asano, Ryo Tamaki, Yoshihiro Saito, Ami Hosokawa, Hidemichi Watari, Takeshi Umazume

“…<b>Background:</b> Cell-free DNA (cfDNA) is present in healthy individuals but is elevated in those undergoing physical exertion, trauma, sepsis, and certain cancers. …”
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Intracapsular and extracapsular fracture types and inpatient mortality in failed hemiarthroplasty by Kürşat Tuğrul Okur, Koray Özdemir, Ahmet Yesevi Sarıaslan, Fırat Ozan

“…Revisions for extracapsular fractures were associated with a higher prevalence of diabetes mellitus (p = 0.01) and elevated Almelo Hip Fracture Score (AHFS; p = 0.01). …”
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