Clinical Characteristics and Outcome of Kidney Transplant Recipients Infected with COVID-19: A Retrospective Observational Study by Manzoor Ahmad Parry, Rayees Yousuf Sheikh, Raja Kaamil Qadri, Muzafar Maqsood Wani, Imtiyaz Wani, Mohammad Ashraf Bhat

“…Advanced age, lymphopenia, elevated CRP levels, and acute graft dysfunction are associated with disease severity. …”
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Explainable Machine Learning for Efficient Diabetes Prediction Using Hyperparameter Tuning, SHAP Analysis, Partial Dependency, and LIME by Md. Manowarul Islam, Habibur Rahman Rifat, Md. Shamim Bin Shahid, Arnisha Akhter, Md Ashraf Uddin, Khandaker Mohammad Mohi Uddin

“…ABSTRACT Diabetes is a chronic metabolic disease characterized by elevated blood glucose levels and poses significant health risks, such as cardiovascular disease and cognitive damage. …”
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Association between 5-item modified frailty index and clinical outcomes in elderly rectal cancer patients after radical surgery by Hong Wu, Feiyu Shi, Chenhao Hu, Lei Zhang, Penghong Qu, Junjun She

“…Comparisons among these groups revealed that higher 5-item mFI scores were associated with an increased incidence of both overall and severe postoperative morbidity, prolonged recovery times, and elevated total medical costs. Multivariate logistic regression analysis indicated that an mFI score of ≥ 2 [odds ratio = 2.856, 95% confidence interval (CI): 1.542–5.290, P < 0.001] was an independent risk factor for severe postoperative complications. …”
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Indoor Black Carbon Concentrations and their Sources in Residential Environments: Validation of an Input-adaptive Proxy Model by Jiangyue Zhao, Pak Lun Fung, Martha Arbayani Zaidan, Birgit Wehner, Kay Weinhold, Alfred Wiedensohler, Tareq Hussein

“…Abstract Exposure to black carbon (BC) in the residential environment was found to be positively associated with elevated blood pressure and cardiovascular disease. …”
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Effects of Super Nutritional Hepatic Copper Accumulation on Hepatocyte Health and Oxidative Stress in Dairy Cows by Jaimie M. Strickland, Doug Lyman, Lorraine M. Sordillo, Thomas H. Herdt, John P. Buchweitz

“…These results demonstrate that cows with elevated hepatic copper concentrations had no evidence of active liver disease but had increased hepatic oxidative stress.…”
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Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease by Mi-Rae Shin, Sung Ho Shin, Seong-Soo Roh

“…Continuously, the activation of PPARα significantly elevated carnitine palmitoyltransferase 1 (CPT-1), a key enzyme in fatty acid β-oxidation, and mitochondrial uncoupling protein 2 (UCP-2), thermogenic regulatory genes, in PCM-treated mice compared with those of HFD control mice. …”
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Impact of fluoxetine exposure on Lymnaea stagnalis and its developing eggs: integrating untargeted lipidomics, targeted metabolomics, and classical risk assessment by Diana Ilyaskina, Yumi Nakadera, Yumi Nakadera, Marja H. Lamoree, Joris M. Koene, Pim E. G. Leonards

“…Molecular analysis revealed several neurochemical and lipidomic alterations. In the CNS, elevated levels of catecholamines, phosphatidylcholines (PC), and ceramides were linked to disruptions in neurotransmission, membrane integrity, and impaired embryo development. …”
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Association of Triglyceride‐Glucose Index, Triglyceride to High‐Density Lipoprotein Cholesterol Ratio, and Related Parameters With Prehypertension and Hypertension by Shijie Yang, Yuqing Zhang, Zhanyang Zhou, Xiaochun Duan

“…Furthermore, when comparing the fourth quartile to the first quartile of TG/HDL‐c, TyG index, and related parameters, respectively, both corresponding ORs of hypertension were higher than prehypertension. Elevated TyG, TyG‐BMI, TyG‐WC index, and TG/HDL‐c ratio levels were associated with hypertension in individuals over 45 years. …”
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Graves’ disease diagnosed nearly six months after microwave ablation of benign thyroid nodules: a case report by Yunru Gu, Rui Chen, Mingming Chen, Xiaohong Jiang, Long Wang, Xiaolin Huang

“…The patient’s thyroid ultrasound suggested bilateral diffuse thyroid lesions, with a moderately echogenic mass observed on the right side of the thyroid gland, potentially indicative of thyroid nodule ablation. The patient had elevated serum thyroid hormone levels, decreased thyroid-stimulating hormone levels and positive associated thyroid antibodies. …”
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Determination of the effect of danofloxacin on 8-hydroxy-2-deoxyguanosine level by Devran Coşkun, Rahmi Canbar, Yasemin Korkmaz, Burak Dik, Ayşe Er, Enver Yazar

“…<p> <b>Results:</b> In this study, 8-OHDG levels did not change (P>0,05) statistically, while temporal elevations in troponin I, CK-MB isoenzyme and AST levels were determined (P<0,05). …”
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Perspectives on AI-based recommendations for mask-wearing and COVID-19 vaccination for transplant recipients in the post-COVID-19 era by Oscar A. Garcia Valencia, Charat Thongprayoon, Jing Miao, Jackrapong Bruminhent, Iasmina M. Craici, Wisit Cheungpasitporn

“…Our findings reveal that ChatGPT 4.0 consistently recommends mask-wearing in crowded and indoor environments for transplant recipients, underscoring their elevated risk. In contrast, for settings with fewer transmission risks, such as outdoor areas where social distancing is possible, the AI suggests that mask-wearing might be less imperative. …”
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Combination of inflammatory proteins in serum can be used to diagnose papillary thyroid carcinoma with lymph node metastasis by Yongqin Pan, Guanghao Wang, Delin Chen, Zhihui Wu, Yimwing Kei, Mingxi Xu

“…Results Five proteins, including IL-22RA1, IL-12B, CCL4, CCL3, and IL-1α, were significantly elevated in the serum of patients with LNM. The combined diagnosis of these five proteins demonstrated excellent diagnostic performance in distinguishing patients with PTC-LNM (area under the curve = 0.967, sensitivity = 0.941, and specificity = 0.889). …”
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Exploring the Causal Relationship and Molecular Mechanisms Between Fasting Insulin and Androgenetic Alopecia: A Mendelian Randomization Study with Bioinformatics Analysis by Ding X, Bai Z, Wang W, Gu Y, Li Z, Fan Y

“…FI-associated genes were identified through expression quantitative trait loci (eQTL) analysis, with enrichment analysis and a protein-protein interaction (PPI) network used to explore potential pathways and core genes.Results: Forward MR analysis revealed a significant causal relationship between elevated FI levels and AGA (P=0.027, OR=43.944). Reverse MR analysis found no causal effect of AGA on FI (P=0.808, OR=1.0001). …”
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Frameshift variation in the HMG-CoA reductase gene and unresponsiveness to cholesterol-lowering drugs in type 2 diabetes mellitus patients by Esmat Khaleqsefat, Khder Hussein Rasul, Ramiar Kamal Kheder, Sonia Baban, Jamil Baban

“…However, both control and responsive groups significantly differed from the non-responsive group, which had markedly elevated cholesterol levels (> 240 mg/dl). Genetic analysis revealed a cytosine nucleotide insertion in the catalytic domain of the HMGCR gene in only two non-responsive participants to atorvastatin 40 mg therapy. …”
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Multi-stage structure-based virtual screening approach combining 3D pharmacophore, docking and molecular dynamic simulation towards the identification of potential selective PARP-1... by Mahmoud A. El Hassab, Wagdy M. Eldehna, Ghaneya S. Hassan, Sahar M. Abou-Seri

“…PARP-1 and, to a lesser extent, PARP-2 display above 90% activity in response to DNA damage, thereby distinguishing them apart from other members of the PARP family. Elevated levels of PARP-1 were observed in many types of tumor cells, such as breast, lung, ovarian, prostate, and melanomas. …”
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Identification of multicohort-based predictive signature for NMIBC recurrence reveals SDCBP as a novel oncogene in bladder cancer by Chen Zhang, Hubin Yin, Tinghao Li, Junrui Chen, Weiyang He, Ke Ren, Bo Li, Xudong Liu

“…Immunohistochemical testing revealed elevated levels of ACTN4 and SDCBP in recurrent NMIBC tissues. …”
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Vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2: A scoping review. by Lemi Belay Tolu, Alex Ezeh, Garumma Tolu Feyissa

“…Among neonates with throat swab SARS-CoV-2 positive only five (33.3%) had concomitant placenta, amniotic fluid, and cord blood samples tested, of which only one amniotic fluid sample is positive for RT PCR. Five neonates had elevated IgG and IgM but without intrauterine tissue tested. …”
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Pyrroloquinoline Quinone Improved Boar Sperm Quality via Maintaining Mitochondrial Function During Cryopreservation by Shanpeng Wang, Qi Wang, Lingjiang Min, Hailiang Cao, Adedeji O. Adetunji, Kaifeng Zhou, Zhendong Zhu

“…Furthermore, the levels of mitochondrial-encoded proteins were significantly elevated in the 1000 nM PQQ group compared to the control (<i>p</i> < 0.05). …”
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Expression Analysis and Functional Validation of DcTPSb1 in Terpene Synthesis of <i>Dendrobium chrysotoxum</i> by Yuxuan Jin, Shuting Zhou, Zhihui Du, Weize Wang, Zhilin Chen

“…<i>DcTPSb1</i> exhibited elevated expression levels in flowers among four organs (roots, stems, leaves, flowers) of <i>D. chrysotoxum</i>, with the highest expression observed during the blooming phase, which aligned with the accumulation of volatile terpenes during flowering. …”
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Barriers to Adherence to Standard of Care in Appalachia: A Qualitative Assessment in Gastrointestinal Cancers by Levy BE, Castle JT, Bardhan R, Dignan M, Bhakta A

“…Brittany E Levy,1 Jennifer T Castle,1 Roshmita Bardhan,2 Mark Dignan,3 Avinash Bhakta1 1Division of Colorectal Surgery, University of Kentucky College of Medicine, Lexington, KY, USA; 2Mercy Health – The Jewish Hospital, Cincinnati, OH, USA; 3Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY, USACorrespondence: Mark Dignan, Department of Internal Medicine, University of Kentucky College of Medicine, 760 Press Avenue, Room 335, Lexington, KY, 40536-0679, USA, Tel +1 859 913 0207, Email Mark.dignan@uky.eduPurpose: Appalachian Kentucky, a 32-county region in the eastern part of the state, has elevated colon cancer mortality rates. While recommended as the standard of care, access to adjuvant chemotherapy treatment is limited in this region due to scarce health services and significant social and geographical barriers. …”
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