Downmodulation of Vaccine-Induced Immunity and Protection against the Intracellular Bacterium Francisella tularensis by the Inhibitory Receptor FcγRIIB by Brian J. Franz, Ying Li, Constantine Bitsaktsis, Bibiana V. Iglesias, Giang Pham, Raju Sunagar, Sudeep Kumar, Edmund J. Gosselin

“…Ft-specific IgA in serum and bronchial alveolar lavage, as well as IFN-γ, IL-10, and TNF-α production by splenocytes harvested from iFt-immunized FcγRIIB KO, were also significantly elevated. In addition, iFt-immunized FcγRIIB KO mice exhibited a reduction in proinflammatory cytokine levels in vivo at 5 days after challenge, which correlates with increased survival following Ft-LVS challenge in published studies. …”
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Bronchoalveolar Lavage Fluid IFN-γ+ Th17 Cells and Regulatory T Cells in Pulmonary Sarcoidosis by Anders Tøndell, Torolf Moen, Magne Børset, Øyvind Salvesen, Anne Dorthea Rø, Malcolm Sue-Chu

“…In sarcoidosis, increased Th17 cell fractions have been reported in bronchoalveolar lavage fluid, and elevated numbers of Th17 cells producing IFN-γ have been observed in peripheral blood. …”
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Experiences and perceptions of respectful maternity care among mothers during childbirth in health facilities of Eastern province of Rwanda: An appreciative inquiry. by Alice Muhayimana, Irene Josephine Kearns, Darius Gishoma, Olive Tengera, Thierry Claudien Uhawenimana

“…There is a need to build on the progress made in delivering RMC to strengthen community trust and elevate expectations. Given the sensitive nature of RMC, we recommend conducting further studies using the Appreciative Inquiry approach.…”
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Spatial and Temporal Relationships Between Roe and Red Deer in an Alpine Area by Valerio Donini, Luca Pedrotti, Francesco Ferretti, Elisa Iacona, Lucrezia Lorenzetti, Francesca Cozzi, Luca Corlatti

“…Spatial analysis suggested a higher probability of roe deer presence in forested habitats, at lower elevations, and in areas with gentler slopes. Diel activity patterns of roe deer were consistent across sites with higher and lower red deer relative abundance, with moderate to high interspecific overlap, suggesting moderate temporal partitioning and no major support for temporal avoidance of the latter by the former. …”
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m6A-modified lncRNA GAS5 promotes M1-polarization of microglia in alcohol use disorder by Shuang Zhu, Peng Wang, Jian Hu

“…Additionally, we discovered that GAS5 acts as a sponge for miR-136–5p, leading to the upregulation of ATF2. Elevated levels of ATF2 are associated with M1 microglial polarization. …”
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Smoking Induces the Circulating Levels of Matrix Metalloproteinase-9 and Its Association with Cardiovascular Risk in Young Smokers by Dinesh NATH, Meera SHIVASEKAR, V. M. VINODHINI

“…As a result, smoking-induced elevated serum MMP-9 levels, particularly at a younger age, raise the risk of coronary heart disease (CHD). …”
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Identification of GPD1L as a Potential Prognosis Biomarker and Associated with Immune Infiltrates in Lung Adenocarcinoma by Zhengyang Fan, Song Wu, Hongyang Sang, Qianping Li, Shaofei Cheng, Hongling Zhu

“…Moreover, based on the findings of a Kaplan-Meier survival study, elevated GPD1L expression was a strong indicator of considerably improved overall survival (OS) and disease-specific survival (DSS). …”
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NADPH Oxidase 2-Mediated Insult in the Auditory Cortex of Zucker Diabetic Fatty Rats by Zheng-De Du, Wei Wei, Shukui Yu, Qing-Ling Song, Ke Liu, Shu-Sheng Gong

“…The auditory brainstem response (ABR) of ZDF rats was found to be markedly elevated in low (8 kHz) and high (32 kHz) frequencies. …”
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The prognostic and immunomodulatory role of the MMR system in patients with stomach adenocarcinoma by Zhihui Tian, Lili Yang, Rong Yang, Wenhui Yang

“…The immune infiltration levels of most immune cells were upregulated in the high-risk group with elevated expression of PDCD1 and low TMB score. Finally, we found that MLH1 was an independent predictor of STAD prognosis among the four MMR genes. …”
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Implementation of carceral medicaid suspension and enrollment programs: perspectives of carceral and medicaid leaders by Sachini Bandara, Brendan Saloner, Hannah Maniates, Minna Song, Noa Krawczyk

“…In addition to investing in the ability to newly enroll and suspend Medicaid benefits, attention towards improving timely reactivation practices is needed, particularly given the highly elevated risk of mortality immediately after release. …”
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Factors Affecting the Presence of Renal Cortical Cysts in Kidney Donors by Sevim Nuran Kuşlu Çiçek, Amil Huseynov

“…The prevalence of aortic atherosclerosis was notably elevated in donors with cysts (47.74%) compared to those without (23.57%, P < .001). …”
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Impact of blastocyst biopsy for preimplantation genetic testing on maternal and neonatal outcomes following single frozen embryo transfer cycles by Tingting He, Wenhao Shi, Xia Xue, Juanzi Shi

“…Therefore, the aim of this study was to investigate whether blastocyst biopsy is associated with an elevated risk of hypertensive disorders of pregnancy (HDP) and other adverse perinatal outcomes during frozen embryo transfer (FET) cycles in singleton live births resulting from intracytoplasmic sperm injection (ICSI) in women aged ≤ 35 years. …”
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Therapeutic reduction of neurocan in murine intracerebral hemorrhage lesions promotes oligodendrogenesis and functional recovery by Hongmin Li, Samira Ghorbani, Olayinka Oladosu, Ping Zhang, Frank Visser, Jeff Dunn, Yunyan Zhang, Chang-Chun Ling, V. Wee Yong, Mengzhou Xue

“…The small molecule inhibitor of CSPG synthesis, difluorosamine, lowered neurocan levels in lesions and elevated numbers of oligodendrocyte precursor cells, mature oligodendrocytes, and SOX2+ nestin+ neuroblasts in the perihematomal area. …”
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Persistence with Early-Line Abatacept versus Tumor Necrosis Factor-Inhibitors for Rheumatoid Arthritis Complicated by Poor Prognostic Factors by Xue Han, Francis Lobo, Michael S. Broder, Eunice Chang, Sarah N. Gibbs, David J. Ridley, Irina Yermilov

“…Poor prognostic factors included ACPA+, RF+, increased C-reactive protein levels, elevated erythrocyte sedimentation rate levels, or presence of joint erosions. …”
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Evaluating lead leaching from uPVC pipes into drinking water: Characterization with SEM-EDX and ICP-OES by Yassin T.H. Mehdar

“…Furthermore, there are many studies about lead exposure and its damage to the kidneys and reproductive system, as well as contributing to elevated blood pressure and hypertension.This study investigates the presence of lead and its leaching rate from some uPVC pipes into drinking water under different conditions of temperature and time. …”
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Non-HDL-c/TC: A Novel Lipid-Related Marker in the Assessment of Severity of Coronary Artery Lesions and Cardiovascular Outcomes by Anan Huang, Xin Qi, Liping Wei, Mingyin Zhang, Shiqi Zhou

“…The concentration of non-LDL-c differed between non-obstructive-CAD group and obstructive-CAD group (P<0.05), and non-HDL-c/TC was elevated in the obstructive-CAD group (P<0.05). Increased GS was associated with increasing non-HDL-c/TC (P<0.05). …”
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Ningxiang pig-derived Lactobacillus reuteri improves the gut health of weaned piglets by regulating intestinal barrier function and cytokine profiles by Qian Xie, Mei Yang, Qing Duanmu, Meng Kang, Jing Wang, Bi E Tan

“…However, it lowered serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels (P < 0.05) and elevated serum concentrations of Immunoglobulin A (IgA), immunoglobulin G (IgG), and secretory immunoglobulin A (sIgA) (P < 0.05). …”
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Anti-Myxovirus Resistance Protein-1 Immunoglobulin A Autoantibody in Idiopathic Pulmonary Fibrosis by Toru Arai, Masaki Hirose, Yoshimasa Hamano, Tomoko Kagawa, Akihiro Murakami, Hiroshi Kida, Atsushi Kumanogoh, Yoshikazu Inoue

“…Univariate Cox proportional hazards regression analysis did not identify an elevated anti-MX1 IgG, IgA, or IgM autoantibody level as a significant prognostic factor; however, a higher anti-MX1 IgA autoantibody level heralded significantly poorer survival after adjustment for GAP stage (p=0.030) and for percent forced vital capacity and modified Medical Research Council score (p=0.018). …”
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Cardiac manifestation of phenylketonuria in adulthood by Péter Homródi, Emese Tóth-Zsámboki, Róbert Gábor Kiss, Orsolya Lovász, Gábor Zoltán Duray

“…In 2023, he was admitted to our department due to cardiac decompensation. Hypertension, elevated LDL-cholesterol level, male gender, obesity and PKU were identified as cardiovascular risk factors. …”
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Pharmacological Inhibition of Caspase-1 Ameliorates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation in Mice by Jung-Yeon Kim, Jae-Hyung Park, Kiryeong Kim, Jungmin Jo, Jaechan Leem, Kwan-Kyu Park

“…Moreover, increased macrophage accumulation and elevated expression of cytokines and chemokines were attenuated by caspase-1 inhibition. …”
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