Gall bladder wall thickness and C-reactive protein as a predictor of difficult laparoscopic cholecystectomy by Nair A, Appukuttan A, Mathew J, Oommen AN, Joseph A

“…In this study, we hypothesized that increased gallbladder wall thickness and elevated preoperative C-reactive protein (CRP) levels, which are objective markers of inflammation or fibrosis, would be linked to increased difficulty in laparoscopic cholecystectomy. …”
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Risk factors for the mortality of hemodialysis patients with COVID-19 in northern Hunan province, China by Zhangxiu He, Zhong Peng, Ning Gao, Shuzhu Zhong, Fengyi Yu, Zixu Tang, Zihao Liao, Song Zhao, Gloria Umwiza, Ming Chen, Wei Long

“…Independent predictors of mortality in our cohort were: age (hazard ratio [HR] 1.09; 95% confidence interval [CI], 1.05–1.14; P < 0.001), elevated procalcitonin (PCT) levels (HR 1.02; 95%CI, 1.01–1.03; P < 0.001), and higher white blood cell-neutrophil ratio (NWR) (HR 1.04; 95%CI, 1.04–1.07; P = 0.004). …”
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Substrate curvature influences cytoskeletal rearrangement and modulates macrophage phenotype by Austin Sovar, Matthew D. Patrick, Ramkumar T. Annamalai

“…., Tnf, Nos2) in high-curvature conditions, while anti-inflammatory markers (e.g., Arg1) were elevated in low-curvature conditions. Lat-A treatment reduced F-actin density and modulated gene expression patterns, confirming the cytoskeletal regulation of macrophage phenotype.DiscussionThese findings demonstrate that substrate curvature influences macrophage behavior by modulating cytoskeletal dynamics and associated immunophenotypic markers through actin-mediated transcriptional pathways. …”
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Postural stability measures as diagnostic tools for chronic ankle instability: a comprehensive assessment by Makan Piri, Kazem Malmir, Khadijeh Otadi, Azadeh Shadmehr

“…Nonlinear analysis revealed elevated ApEn and reduced CD in CAI participants, indicating greater postural irregularity and reduced dynamic stability. …”
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Immunoglobulin G4-related disease with pleural involvement in an 80-year-old female patient: A case report and literature review by Liying Zhang, Li Mo

“…The most common manifestations were pleural effusion (37, 90.2 %) and dyspnea (26, 63.4 %). Elevated serum IgG4 levels were observed in 38 patients (92.7 %), with a median value of 398.2 mg/dL. …”
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MEG3 Alleviated LPS-Induced Intestinal Injury in Sepsis by Modulating miR-129-5p and Surfactant Protein D by Xianjin Du, Dan Tian, Jie Wei, Chen Yan, Peng Hu, Xu Wu, Wenbin Yang

“…Moreover, TNF-α and IL-6 expression was elevated in intestinal tissues compared to the control groups. …”
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Exploring molecular determinants and pharmacokinetic properties of IgG1-scFv bispecific antibodies by Kristina M.J. Aertker, Minu Ravindra Pilvankar, Tobias M. Prass, Michaela Blech, Fabian Higel, Srinath Kasturirangan

“…Our study indicated that high levels of nonspecific interactions, elevated isoelectric point (pI), and increased number of positively charged patches contributed to the fast clearance of IgG1-scFv. …”
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Thiazolo-pyridopyrimidines: An in silico evaluation as a lead for CDK4/6 inhibition, synthesis and cytotoxicity screening against breast cancer cell lines by Chaithra R Shetty, C. S. Shastry, Parasuraman P, Srinivas Hebbar

“…Furthermore, molecular dynamics simulation studies uncovered an elevated level of stability within the 4c- 6OQO complex. …”
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Protective mechanisms of exogenous melatonin on chlorophyll metabolism and photosynthesis in tomato seedlings under heat stress by Wangwang An, Guangzheng Wang, Jianhua Dou, Yonghai Zhang, Qing Yang, Yongmei He, Zhongqi Tang, Jihua Yu, Jihua Yu

“…Elevated temperatures severely affect plant growth, reducing yield and quality. …”
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Ecological and human health implications of mercury contamination in the coastal water by A. Mallongi, A.U. Rauf, R.D.P. Astuti, S. Palutturi, H. Ishak

“…Furthermore, polymer sulfur was used as a promising technique for capturing and reducing the level of mercury in the water column.FINDINGS: The results showed that the mean concentration of mercury was very high and exceeded the values established by the World Health Organization, United States of Environmental Protection Agency, and Indonesian National Standards, indicating elevated risks to the ecosystem and human health in the future. …”
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Assessment of lipid peroxidation and total antioxidant capacity in patients with breast cancer by Abdullatif Taha Babakr, Mohamed Mahmoud Nour Eldein

“…Conclusions: This study revealed that patients with BC had lower TAC and higher Ox-LDL serum levels, indicating elevated oxidative stress. These levels may serve as promising monitoring parameters in BC.…”
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Cobalt-induced oxidative stress and defense responses of Adhatoda vasica proliferated shoots by Abeer A. Radi, Fatma A. Farghaly, Fatma A. Al-Kahtany, Ahmed M. Zaher, Afaf M. Hamada

“…This ROS overproduction is believed to be the primary cause of oxidative damage, as evidenced by the elevated concentrations (18.46%-72.84%) of malondialdehyde (MDA) detected. …”
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Associations between phenol and paraben exposure and the risk of developing breast cancer in adult women: a cross-sectional study by Yao Xiong, Zhiyu Li, Xiong Xiong, Zixuan Luo, Kaixin Zhong, Jiawei Hu, Shengrong Sun, Chuang Chen

“…The results from the weighted multivariable regression models indicated that exposure to elevated concentrations of TRS increased the risk of developing BC by 2.33 (Q2: 95% CI = 1.45–3.75, p < 0.001) and 1.94 times (Q3: 95% CI = 1.21–3.09, p = 0.006), respectively. …”
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Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience by Beril Gurlek, Ali Sertac Batioglu, Mine Kanat-Pektas, Ibrahim Kale, Ozgur Onal, Nafiye Yilmaz-Karakas

“…Conclusions: Smoking, longer duration of infertility, and elevated basal progesterone are poor prognostic factors for clinical pregnancy in clomiphene citrate and recombinant follicle-stimulating hormone cycles. …”
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A New Perspective on Hydrogen Chloride Scavenging at High Temperatures for Reducing the Smoke Acidity of PVC in Fires—III: EN 60754-2 and the Species in Solution Affecting pH and C... by Iacopo Bassi, Claudia Bandinelli, Francesca Delchiaro, Gianluca Sarti

“…The findings highlight the effectiveness of ion chromatography and inductively coupled plasma–optical emission spectrometry as powerful analytical tools for developing efficient acid scavengers capable of maintaining performance at elevated temperatures. A further outcome regards the experimental demonstration of the limits and incongruencies of EN 60754-2 as an instrument for assessing the additional classification for acidity for cables. …”
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Impact of the COVID-19 pandemic on primary care for hypertension in the UK: a population-based cohort study by Christel Renoux, James M. Brophy, Kyle Johnson, Sarah Beradid, Robert W. Platt

“…However, initiation rates rebounded above expectations and remained elevated until March 2022. Blood pressure measurements fell by 69% (95% CI 65% to 72%) in April 2020, recovering in February 2021.Conclusions Hypertension diagnosis and management in UK primary care were significantly disrupted during the COVID-19 pandemic. …”
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The mechanism of enterogenous toxin methylmalonic acid aggravating calcium-phosphorus metabolic disorder in uremic rats by regulating the Wnt/β-catenin pathway by Xing Fan, Jing Li, Yan Gao, Lin Li, Haisong Zhang, Zhaoyu Bi

“…UR rat fecal transplantation caused elevated MMA concentration in the serum and renal tissues of Sham rats. …”
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HDAC Inhibition Modulates Cardiac PPARs and Fatty Acid Metabolism in Diabetic Cardiomyopathy by Ting-I Lee, Yu-Hsun Kao, Wen-Chin Tsai, Cheng-Chih Chung, Yao-Chang Chen, Yi-Jen Chen

“…Compared to control, DM and MPT0E014-treated DM rats had elevated blood glucose levels and lower body weights. …”
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Investigation of Hydro-Geochemical Characteristics of Groundwater In Port Harcourt City, Nigeria: Implication for Use and Vulnerability by HO Nwankwoala, GJ Udom

“…The average temperature of the groundwater samples is 29 oC, The water is slightly acidic with pH values between 4.28 – 7.72. Elevated Electrical Conductivity (EC) values in some coastal wells suggest possible pollution by seawater. …”
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Relationship between muscle activation and sagittal knee joint biomechanics in patients with patellofemoral pain syndrome: a cross-sectional study by Byung Sun Choi, Soon Bin Kwon, Sehyeon Jeon, Myeongjun Kim, Yunseo Ku, Du Hyun Ro, Hyuk-Soo Han

“…Conclusions Patients with PFPS exhibit elevated muscle activation, particularly in response to changes in the knee extension moment, which is likely a compensatory mechanism to manage knee joint loading during gait. …”
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