Inactivation of glutathione S-transferase alpha 4 blocks Enterococcus faecalis-induced bystander effect by promoting macrophage ferroptosis by Yuanyuan Ju, Chunhua Ma, Lin Huang, Yumei Tao, Tianqi Li, Haibo Li, Mark M. Huycke, Yonghong Yang, Xingmin Wang

“…Finally, Mapk8, as a ferroptosis driver, was remarkably elevated in E. faecalis-infected Gsta4-deficient macrophages. …”
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Ancient and contemporary shellfish cultivation practices bolster bivalve communities and diversity‐biomass relationships by Kieran D. Cox, Hailey L. Davies, Ben Millard‐Martin, Morgan Black, Margot Hessing‐Lewis, Nicole F. Smith, Francis Juanes, Sarah E. Dudas

“…We propose that an ecosystem‐wide management approach that considers multiple bivalve species, ecological processes and socio‐cultural practices will elevate the conservation and cultivation of marine resources. …”
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Secretory phospholipase A2 inhibitory activity in Tragia hispida: A novel and promising therapeutic agent for dengue fever by D.V. Dayangi Hemalika, U.G. Chandrika, Ajita M. Abeysekera, Sameera R. Samarakoon, Ananda Wijewickrama, Gathsaurie Neelika Malavige

“…Secretory phospholipase A2 (sPLA2), an inflammatory enzyme, plays a critical role in producing platelet-activating factor (PAF), a key mediator of vascular leak. Elevated sPLA2 activity has been linked to the progression of DHF. …”
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Soil organic carbon increase on conversion of native savanna to improved pasture in two regions of Colombia by Sandra Loaiza, Ciniro Costa Jr, Mayesse A. daSilva, Ngonidzashe Chirinda, Idupulapati Rao, Jacobo Arango, Jeimar Tapasco, Glenn Hyman

“…IP adoption led to SOC accumulation at depth (0–60 cm) after 10 years in CAS1. Elevated clay content in CAS2 favored SOC storage, while poorly drained areas hindered accumulation in CAS1. …”
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Risk assessment for non-carcinogenic effect posed by sulfates in water on the health of residents around The Sumpur River, West Sumatra-Indonesia by Sukarjo, Rahmah Dewi Yustika, Cicik Oktasari Handayani, Triyani Dewi, Yustiawati, Delvi Yanti, Ai Dariah

“…The extensive agricultural activity contributes to runoff and plays a significant role in elevated sulfate concentrations in many global water bodies. …”
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Toll-like receptor upregulation in liver and peripheral blood mononuclear cells of patients with amoebic liver abscess by Sandhya Khunger, Abhishek Mewara, Upninder Kaur, Ajay Duseja, Pallab Ray, Naveen Kalra, Navneet Sharma, Rakesh Sehgal

“…A total of 7 TLR genes (TLR1, TLR2, TLR4, TLR6, TLR7, TLR8 and TLR9) and 6 TLR genes (TLR1, TLR2, TLR3, TLR4, TLR5 and TLR8) were found to be elevated in liver aspirates and PBMCs respectively. …”
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Mitotane-Induced Hyperlipidemia: A Retrospective Cohort Study by Hassan Shawa, Ferhat Deniz, Hadil Bazerbashi, Mike Hernandez, Rena Vassilopoulou-Sellin, Camilo Jimenez, Mouhammed Amir Habra

“…Understanding the mechanism of HDL change may lead to the discovery of novel HDL-c-elevating drugs.…”
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Impact of copper stress in the intestinal barriers and gut microbiota of Chinese stripe-necked turtle (Mauremys sinensis) by Zeeshan Ali, Ijaz Khan, Muhammad Shahid Iqbal, Haitao Shi, Li Ding, Meiling Hong

“…Furthermore, This study found that copper exposure increases gut permeability by suppressing tight junction genes and triggers an inflammatory response in the gut, as indicated by elevated inflammatory cytokines. At the phylum level, Firmicutes exhibited a significant decrease, whereas Bacteroidota displayed a notable increase, and Fusobacteriota showed a substantial reduction in relative abundance in copper-treated groups. …”
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Association of the Interleukin-10-592C/A Polymorphism and Cervical Cancer Risk: A Meta-Analysis by Brehima Diakite, Yaya Kassogue, Mamoudou Maiga, Guimogo Dolo, Oumar Kassogue, Jonah Musa, Imran Morhason-Bello, Ban Traore, Cheick Bougadari Traore, Bakarou Kamate, Aissata Coulibaly, Sekou Bah, Sellama Nadifi, Robert Murphy, Jane L. Holl, Lifang Hou

“…Regarding ethnicity, a significant association of the -592C/A polymorphism of the IL-10 gene was linked to an elevated risk of cervical cancer for all genetic models (recessive, dominant, and additive) in the Asian populations and for the recessive and additive models in Caucasians with P<0.05. …”
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Association between remnant cholesterol and depression in middle-aged and older Chinese adults: a population-based cohort study by Yang Zhou, Yan Lin, Yanhui Yang, Wang Lei, Juan Xu, Yuanzeng Zhu

“…And the subgroup analysis yielded results consistent with the primary findings.ConclusionThis study revealed that in China, in middle-aged and older individuals, elevated RC levels were associated with a higher depression risk, suggesting RC is a promising target for depression prevention and treatment.…”
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Comprehensive analyses reveal the promising value of gasdermins as prognostic biomarkers and immunotherapeutic targets in head and neck squamous cell carcinoma by Huageng Huang, Jingjing Ge, Shunzhen Lu, Xinyi Deng, Ying Tian, He Huang, Zhao Wang, Yuyi Yao, Huangming Hong, Tongyu Lin

“…Compared with those in normal tissues, the mRNA and protein levels of GSDMs, especially GSDMD/E, were commonly elevated in HNSC (P < 0.05). Additionally, the expression of GSDMs differed significantly between the clinicopathological subgroups of HNSC patients. …”
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Modulatory Effect of 1,25-Dihydroxyvitamin D3 on IL1β-Induced RANKL, OPG, TNFα, and IL-6 Expression in Human Rheumatoid Synoviocyte MH7A by Xiaoke Feng, Chengyin Lv, Fang Wang, Ke Gan, Miaojia Zhang, Wenfeng Tan

“…MH7A cells were stimulated with IL1β and then treated with different concentrations of 1,25(OH)2D3 for 48 h. A significantly elevated OPG/RANKL ratio and markedly decreased levels of IL-6 and TNFβ mRNA expression in cells and IL-6 protein in supernatants were observed in IL1β-induced MH7A in the presence of 1,25(OH)2D3 compared with those in the absence of it. …”
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Investigating Two-dimensional Horizontal Mesh Grid Effects on the Eulerian Atmospheric Transport Model Using Artificial Neural Network by Amine Ajdour, Brahim Ydir, Houria Bouzghiba, Ishaq Dimeji Sulaymon, Anas Adnane, Dris Ben Hmamou, Kenza Khomsi, Jamal Chaoufi, Gábor Géczi, Radouane Leghrib

“…Abstract The complexity of monitoring is compounded by the environmental and health impacts linked to air pollution. The elevated expenses and intricate execution involved in measurements prompt the integration of modeling as a complementary approach alongside monitoring and surveillance efforts. …”
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Cardiac CT reveals high prevalence of coronary artery disease in esophageal cancer eligible for radiotherapy by Akinori Takada, Satoshi Nakamura, Yutaka Toyomasu, Takamitsu Mase, Tomoko Kawamura, Suguru Araki, Yoshitaka Suzuki, Masaki Ohi, Hajime Sakuma, Yoshihito Nomoto, Kakuya Kitagawa

“…Radiation therapy (RT) for esophageal cancer is associated with elevated cardiac radiation exposure. This study aimed to assess the prevalence of coronary artery disease (CAD) in patients with esophageal cancer who were eligible for RT. …”
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STAT3-Inducible Mouse ESCs: A Model to Study the Role of STAT3 in ESC Maintenance and Lineage Differentiation by Yu Qian Wong, Hongyan Xu, Qiang Wu, Xinyu Liu, Chengchen Lufei, Xiu Qin Xu, Xin-Yuan Fu

“…Western blot also showed that pSTAT3 and STAT3 protein levels were significantly reduced in InSTAT3 KO ESCs while dominantly elevated in InSTAT3 CA ECSs upon Dox stimulation. Likewise, it was found that STAT3-null ESCs would affect the differentiation of ESCs into mesoderm and cardiac lineage. …”
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Development of a prognostic model based on four genes related to exhausted CD8+ T cell in triple-negative breast cancer patients: a comprehensive analysis integrating scRNA-seq and... by Yulin Shi, Yang Yu, Jiahan Zhao, Linan Huang, Qingyang Wang, Qi Sun, Lijuan Liu, Changgang Sun

“…The model demonstrated robust predictive capability in both the TCGA cohort and an external cohort, with the low-risk group exhibiting elevated expression of immunological checkpoint molecules and immune cell infiltration, as well as better responses to immunotherapy and chemotherapy. …”
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Increased Circulating Chemerin in Relation to Chronic Microvascular Complications in Patients with Type 2 Diabetes by Ping Gu, Wei Wang, Yue Yao, Yixin Xu, Liping Wang, Pu Zang, Jian Ma, Cuihua Yang, Junya Liang, Bin Lu, Jiaqing Shao

“…Plasma levels of chemerin in diabetic subjects with microvascular complications were markedly elevated compared to those without. The number of microvascular complications increased with high plasma chemerin levels. …”
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Prevalence and clinical impact of disseminated intravascular coagulation in acute aortic dissection: a nationwide cohort study by Shuhei Murao, Yutaka Umemura, Hirotaka Mori, Yoshinobu Seki, Takayuki Ikezoe, Kohji Okamoto, Satoshi Fujimi, Kazuma Yamakawa

“…With the progression of coagulopathy, characterized by thrombocytopenia, elevated prothrombin time-international normalized ratio, prolonged activated partial thromboplastin time, increased D-dimer, and decreased fibrinogen levels, in-hospital mortality also increased. …”
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Neurotoxic Effect of Myricitrin in Copper-Induced Oxidative Stress Is Mediated by Increased Intracellular Ca²⁺ Levels and ROS/p53/p38 Axis by Ignacija Vlašić, Antonio Krstačić-Galić, Anđela Horvat, Nada Oršolić, Anja Sadžak, Lucija Mandić, Suzana Šegota, Maja Jazvinšćak Jembrek

“…This research highlights the toxic potential of myricitrin and emphasizes the need for caution when considering flavonoid supplementation in conditions with elevated copper levels.…”
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Human Chorionic Plate-Derived Mesenchymal Stem Cells Restore Hepatic Lipid Metabolism in a Rat Model of Bile Duct Ligation by Yun Bin Lee, Jong Ho Choi, Eun Nam Kim, Jin Seok, Hyun-Jung Lee, Jung-Hwan Yoon, Gi Jin Kim

“…Serum cholesterol level, which was elevated after BDL, was significantly decreased following CP-MSC transplantation. …”
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