Polydatin-Induced Shift of Redox Balance and Its Anti-Cancer Impact on Human Osteosarcoma Cells by Alessio Cimmino, Magda Gioia, Maria Elisabetta Clementi, Isabella Faraoni, Stefano Marini, Chiara Ciaccio

“…Using cell-based biochemical assays, we found that cytotoxic doses of PD (100–200 µM) promote ROS production, deplete glutathione (GSH), and elevate levels of both total iron and intracellular malondialdehyde (MDA), which are key markers of ferroptosis. …”
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Human inborn errors of immunity underlying Talaromyces marneffei infections: a multicenter, retrospective cohort study by Huifeng Fan, Zhiyong Yang, Yuhui Wu, Xiulan Lu, Tian Li, Xuyang Lu, Gen Lu, Liming He, Guoping Lu, Li Huang

“…Three cases presented with pan-hypogammaglobulinemia, while three other cases showed heightened levels of IgM. Elevated levels of IgE were detected in five cases, and six cases exhibited decreased T lymphocyte absolute counts. …”
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Experimental Setup and Machine Learning-Based Prediction Model for Electro-Cyclone Filter Efficiency: Filtering of Ship Particulate Matter Emission by Aleksandr Šabanovič, Jonas Matijošius, Dragan Marinković, Aleksandras Chlebnikovas, Donatas Gurauskis, Johannes H. Gutheil, Artūras Kilikevičius

“…Ship emissions significantly impact air quality, particularly in coastal and port regions, contributing to elevated concentrations of PM_2.5, and PM₁₀, with varying effects observed across different locations. …”
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Silencing hepatic PCSK9 via novel chimeric AAV8 mitigates the progression of atherosclerosis by inhibiting inflammation in ApoE−/− mice by Xiaocui Chen, Minghui Sun, Xiang Ma, Yitong Ma, Bangdang Chen

“…Additionally, it decreased PCSK9 expression and elevated low-density lipoprotein receptor expression in Apolipoprotein E-deficient mice, leading to early changes in lipid profiles but lacking a sustained impact on circulating lipids. …”
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Identification of EXPA4 as a key gene in cotton salt stress adaptation through transcriptomic and coexpression network analysis of root tip protoplasts by Qiankun Liu, Pengtao Li, Muhammad Jawad Umer, Mubashir Abbas, Yongqing Zhao, Yu Chen, Yanfang Li, Aiming Zhang, Yuling Liu, Yangyang Wei, Quanwei Lu, Mengying Yang, Yiman Liu, Xiaoyan Cai, Zhongli Zhou, Shuxun Yu, Fang Liu, Renhai Peng

“…Silencing of the GaEXPA4 gene through virus-induced gene silencing heightened cotton’s sensitivity to salt stress, leading to increased wilting, elevated lipid peroxidation, and impaired antioxidant activity under salt conditions compared to controls. …”
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Evaluating the quality of care for heart failure hospitalizations in inflammatory arthritis – A population-based cohort study by Bindee Kuriya, Lihi Eder, Sahil Koppikar, Jessica Widdifield, Anna Chu, Jiming Fang, Irene Jeong, Douglas Lee, Jacob Udell

“…Background: Individuals with inflammatory arthritis (IA) face an elevated risk of heart failure (HF). However, whether the quality of HF care in IA patients differs from other high-risk groups, such as those with diabetes mellitus (DM), remains unclear. …”
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Mitochondrial ROS modulate presynaptic plasticity in the drosophila neuromuscular junction by Irina Stavrovskaya, Bethany Kristi Morin, Stephen Madamba, Cliyahnelle Alexander, Alexis Romano, Samia Alam, Lucas Pavlov, Erna Mitaishvili, Pablo M. Peixoto

“…The elevated emission of reactive oxygen species (ROS) from presynaptic mitochondria is well-documented in several inflammatory and neurodegenerative diseases. …”
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Multi-omic and machine learning analysis of mitochondrial RNA modification genes in lung adenocarcinoma for prognostic and therapeutic implications by Xiao Zhang, Jiatao Liu, Yaolin Cao, Wei Wang, Haoran Lin, Yue Yu

“…Our findings uniquely link MRMS to increased tumor mutational burden, genetic instability, and an immunosuppressive tumor microenvironment characterized by reduced immune cell infiltration and elevated tumor purity. Additionally, MRMS is associated with immunotherapy-related features, suggesting its potential in predicting treatment response. …”
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Assessment of different genotyping markers and algorithms for distinguishing Plasmodium falciparum recrudescence from reinfection in Uganda by Alex Mwesigwa, Monica Golumbeanu, Sam Jones, Sara L. Cantoreggi, Benson Musinguzi, Joaniter I. Nankabirwa, Everd Maniple Bikaitwoha, Joan N Kalyango, Charles Karamagi, Mateusz Plucinski, Samuel L. Nsobya, Christian Nsanzabana, Pauline Byakika-Kibwika

“…Microsatellites 313, Poly-α, and 383 exhibited the highest diversity, while PfPK2 and Poly-α revealed elevated multiplicity of infection (MOI) across all sites. …”
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Association between vascular endothelial growth factor and atrial fibrillation: a systematic review by Nikhil Sharma, Mahalaqua Nazli Khatib, R. Roopashree, Mandeep Kaur, Manish Srivastava, Amit Barwal, G. V. Siva Prasad, Pranchal Rajput, Rukshar Syed, Kamal Kundra, Vinamra Mittal, Muhammed Shabil, Amit Kumar, Pancham Cajla, Ganesh Bushi, Rachana Mehta, Zaid Khan, Prakasini Satapathy, Shilpa Gaidhane, Afukonyo Shidoiku Daniel, Renu Sah

“…The studies show a general trend of elevated VEGF levels in AF patients compared to controls, with significant heterogeneity in findings across studies. …”
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Sewage pollution from onsite sewage disposal systems and an offshore wastewater treatment plant outfall in coastal waters of Keaukaha, Hawaiʻi Island by Shayla M.P. Waiki, Steven L. Colbert, Tracy N. Wiegner, Noelani Puniwai, Joseph W.P. Nakoa, III, Nicolas M. Storie, Craig E. Nelson, Ashlynn N. Overly, Karla J. McDermid, Devon K. Aguiar

“…Our findings suggest that Hilo’s prioritization category for OSDS removal should be elevated to Priority 1, and that the HWTP outfall should be relocated to a less culturally and ecologically sensitive area.…”
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The Neutrophil-to-Monocyte Ratio and Platelet-to-White Blood Cell Ratio Represent Novel Prognostic Markers in Patients with Pancreatic Cancer by Feng Tang, Penghui Dai, Qiongqiong Wei, Ke Gan, Zijie Wang, Huan Chen, Ting Li, Muhan Lv, Mingming Deng, Gang Luo

“…The current study demonstrated that NMR and PWR may serve as novel and promising inflammatory prognostic scores for patients with pancreatic cancer. Elevated NMR (>48) and depressed PWR (<6) were independently associated with poor prognosis in patients with pancreatic cancer.…”
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Cost-effectiveness of metacognitive therapy for cardiac rehabilitation participants with symptoms of anxiety and/or depression: analysis of a randomised controlled trial by David Reeves, Calvin Heal, Patrick Joseph Doherty, Gemma E Shields, Adrian Wells, Lora Capobianco, Anthony Heagerty, Deborah Buck, Linda M Davies, Elizabeth Camacho

“…The objective of this within-trial economic evaluation was to compare the cost-effectiveness of metacognitive therapy (MCT) plus usual care (UC) to UC, from a health and social care perspective in the UK.Methods A multicentre, single-blind, randomised controlled trial (ISRCTN74643496) was conducted in the UK involving 332 patients with CR with elevated symptoms of anxiety and/or depression and compared group-based MCT with UC. …”
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Professional experiences on use of the mental health act in ethnically diverse populations: a photovoice study by Roisin Mooney, Paul McCrone, Rose McCabe, Kamaldeep Bhui, Brian Brown, Colin King, Andrew Molodynski, Nusrat Husain, Jacqueline Sin, Karen Newbigging, Michael Larkin, Neil Caton, Raghu Raghavan, Doreen Joseph, Anthony Zigmond, Michelle Yeung, Julie Carr, Phuong Hua, Frank Keating, Tara Morey, Claire Dempsey, Rahul Battacharya, Nuwan Dissanyake, Rochelle Ramkisson, Laura Dixon, Kopal Tandon, Gary Roberts, Paul Illingworth, Jo White, Karen Persaud, Sayeeda Basharat, Tripti Kandia, Sandra Griffiths, Michael Molete

“…We undertook a thematic analysis.Results Ineffective communications between inpatient and community services, insufficient staff capacity, a lack of continuity of care and language and cultural constraints meant MHA assessments were lacking information, leading to elevated perceptions of risk. Practitioners felt helpless at times of staff shortages and often felt CAT could have been prevented. …”
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Clinical Features and Dynamics of T Cells-Related Markers in Immunocompetent Patients with Cytomegalovirus Hepatitis by Takuya Komura, Takashi Kagaya, Hideo Takayama, Masahiro Yanagi, Takatoshi Yoshio, Saiho Sugimoto, Michiko Nishino, Noriaki Orita, Yoshiro Asahina, Masashi Nishikawa, Shuichi Kaneko, Masashi Unoura

“…The serum sIL-2R level, which reflects T-cell activation, was transiently elevated and correlated with the extent of hepatic inflammation. …”
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Evaluating Dose- and Time-Dependent Effects of Vitamin C Treatment on a Parkinson’s Disease Fly Model by Huynh Man Anh, Dao My Linh, Vuu My Dung, Dang Thi Phuong Thao

“…Moreover, knockdown of dUCH led to elevated level of ROS. Thus, dUCH knockdown flies can be used as a model for screening of potential antioxidants for treating PD. …”
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Pharmacological Effects of Antioxidant Mycosporine-Glycine in Alleviating Ultraviolet B-Induced Skin Photodamage: Insights from Metabolomic and Transcriptomic Analyses by Kai Wang, Ling Qin, Huan Lin, Mengke Yao, Junhan Cao, Qing Zhang, Changfeng Qu, Yingying He, Jinlai Miao, Ming Liu

“…M-Gly treatment improved skin appearance and reduced mast cell numbers, while also elevating antioxidant levels, including superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). …”
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Exploring the Variability in Acute Glycemic Responses to Exercise in Type 2 Diabetes by Tasuku Terada, Alanna Friesen, Baljot S. Chahal, Gordon J. Bell, Linda J. McCargar, Normand G. Boulé

“…The greater reduction in CapBG seen in individuals with higher preexercise CapBG may suggest the importance of exercise in the population with elevated glycemia. Lower blood glucose can be achieved with moderate intensity exercise, but prolonging exercise duration and/or including brief bouts of intense exercise accentuate the reduction, which can further be magnified by performing exercise after meals and antihyperglycemic medication. …”
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Prosaposin – A plausible biomarker in head and neck squamous cell carcinoma by Avradeep Datta, Rajandeep Kaur, Anshika Chauhan, Geeta Singh Boora, Himanshu Garg, Debajyoti Chatterjee, Jaimanti Bakshi, Sushmita Ghoshal, Arnab Pal

“…Results: Serum PSAP levels of cases at baseline (median: 2.736 ng/mL) were found to be significantly elevated when compared to healthy controls (median: 2.129 ng/mL) (p = 0.0297*). …”
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Cardiovascular Risk and Metabolic Syndrome Characteristics in Patients with Nonfunctional Pituitary Macroadenoma by Guadalupe Vargas-Ortega, Baldomero González-Virla, Lourdes Balcázar-Hernández, Oriana Nieto-Guzmán, Ana Pamela Garrido-Mendoza, Marco Antonio Flores-Maya, Victoria Mendoza-Zubieta

“…Context. An elevated incidence of type 2 diabetes and cardiovascular disease (CVD) has been reported in patients with nonfunctional pituitary macroadenoma (NFPMA). …”
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