Heightened expression of type I interferon signaling genes in CD4+ T cells from acutely HIV-1–infected women is associated with lower viral loads by Elina El-Badry, Luxiao Chen, Khader Ghneim, Ziyi Li, Kelsie Brooks, Jake Rhodes, Rafick Sekaly, William Kilembe, Susan Allen, Susan Allen, Susan Allen, Hao Wu, Eric Hunter, Eric Hunter

“…In a univariate analysis, we have identified a number of differentially expressed genes in naïve, central memory, and effector memory CD4 T cells of women with consistent elevated expression of genes linked to type 1 interferon (IFN) signaling. …”
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Residential Indoor and Outdoor PM Measured Using Low-cost Monitors during the Heating Season in Monroe County, NY by Andrea R. Ferro, Naděžda Zíková, Mauro Masiol, Gursumeeran P. Satsangi, Thomas Twomey, David C. Chalupa, David Q. Rich, Philip K. Hopke

“…The mean I/O PM2.5 ratio was 1.1 for all homes and increased to 1.7 when a combustion source was in use as indicated by an elevated CO concentration whereas most prior studies have found this ratio to be < 1. …”
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Detection and quantification of pathogens in saliva of adolescents with cerebral palsy: a cross-sectional study by Rosemeire Arai Yoshida, Tiago Bertola Lobato, Renata Gorjão, Lucas Santiago França, Lívia Araujo Alves, Maria Teresa Botti Rodrigues Santos

“…BackgroundElevated levels of inflammatory mediators in saliva have been described in individuals with cerebral palsy (CP).ObjectiveThe aim of this study was to detect and quantify the pathogens Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum and Prevotella intermedia in the saliva of adolescents with CP.MethodsThis is a cross-sectional study with adolescents with CP to detect periodontopathogens from saliva samples. …”
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A Cell-Based Evaluation of the Tyrosinase-Mediated Metabolic Activation of Leukoderma-Inducing Phenols, II: The Depletion of <i>Nrf2</i> Augments the Cytotoxic Effect Evoked by Tyr... by Tomoko Nishimaki-Mogami, Shosuke Ito, Kazumasa Wakamatsu, Takumi Akiyama, Norimasa Tamehiro, Norihito Shibata

“…Additionally, the knockdown of the NRF2-target <i>Slc7a11</i> elevated the cytotoxicity of three out of the six compounds, indicating the involvement of cystine transport in cellular protection. …”
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Clinical Traits of SARS-CoV-2 Infection by O. Yu. Zolnikova, N. L. Dzhakhaya, N. D. Potskherashvili, K. B. Puzakov, O. Yu. Кiseleva, N. I. Kokina, E. R. Buklis, T. V. Roshchina, I. I. Коmkova

“…Patients infected with SARS-CoV-2 usually exhibit lymphopenia (p ≤ 0.001), leucocytosis, the elevated neutrophils (p ≤ 0.05), neutrophil-lymphocyte ratio (p ≤0,05), C-reactive protein (p ≤ 0.05), ferritin (p ≤ 0.05), D-dimer (p ≤ 0.05) and fibrinogen (p ≤ 0.05), altered prothrombin time (p ≤ 0.05) and INR (p ≤ 0.05). …”
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Spatial analysis of teen births near the New Bedford Harbor Superfund site by Nicole V DeVille, Carolina Villanueva, Susan A Korrick, Verónica M Vieira

“…However, both the strength of associations and areas of elevated risk were attenuated after adjustment. The highest risk was observed north and northeast of the harbor (OR: 95% CI—3.19: 2.08, 4.88 and 2.93: 1.47, 5.82), which aligns with the prevailing wind direction from the harbor. …”
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Microstructure evolution and recrystallization behavior of two nickel-based single crystal superalloys by XU Fuze, LIN Yongcheng, MA Dexin, HE Daoguang, ZHAO Yunxing, LI Lyu, CHENG Bowen, DENG Yangpi

“…Conversely， no RX was detected in the DD5 SC test plate post-treatment at 1300 ℃. Elevating the solution temperature to 1310 ℃ results in only a minor area of RX on the outer platform of the fourth stage in the DD5 SC test plate. …”
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The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies by Liyuan Han, Lina Zhang, Wenhua Xing, Renjie Zhuo, XiaLu Lin, Yanhua Hao, Qunhong Wu, Jinshun Zhao

“…Our meta-analysis demonstrates that +936C/T (rs3025039) is likely to be associated with susceptibility to DR in Asian populations, and the recessive model of –460T/C (rs833061) is associated with elevated DR susceptibility.…”
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Comparative impact of synthetic and natural animal-derived carotenoids on growth, feed utilization, and pigment enhancement in Amphiprion ocellaris by Dung Van Tran, Trang Le Thi Tran, Nam Xuan Doan, Thanh Trung Dang, Nhan Thai Hua, Hung Quoc Pham

“…This research highlights that supplementing with natural carotenoids from shrimp shells and copepods is a viable and effective method to augment growth and coloration in clownfish, suggesting a potential alternative to synthetic astaxanthin to elevate the quality and commercial value of farmed marine ornamental fish. …”
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A sterol panel for rare lipid disorders: sitosterolemia, cerebrotendinous xanthomatosis and Smith-Lemli-Opitz syndrome by Alexander Bauer Westbye, Lili L. Dizdarevic, Sandra R. Dahl, Emil Andreas Asprusten, Yngve Thomas Bliksrud, Anita Lövgren Sandblom, Ulf Diczfalusy, Per M. Thorsby, Kjetil Retterstøl

“…All seven sitosterolemia patients had greatly elevated levels of free plant sterols (sitosterol, campesterol, and stigmasterol) compared to the controls. …”
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Network of Mediators for Vascular Inflammation and Leakage Is Dysbalanced during Cytoreductive Surgery for Late-Stage Ovarian Cancer by Sven Klaschik, Jennifer Gehlen, Claudia Neumann, Mignon-Denise Keyver-Paik, Martin Soehle, Stilla Frede, Markus Velten, Andreas Hoeft, Tobias Hilbert

“…The proinflammatory cytokines and chemokines IL-6, IL-8, and CCL2 were significantly elevated after 24 hrs compared to the baseline values, with IL-6 and IL-8 being most prominently increased. …”
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Small RNA sequencing highlights potential functions of tsRNAs in regulating pyroptosis in trigeminal neuralgia by Mizhen Qiu, Fei Zeng, Yi Yan, Mu Xu, Xuexue Zhang, Zhijian Wang, Yutong Wang, Daying Zhang, Shibiao Chen

“…Mechanical hyperalgesia was significantly elevated by constriction injury. Immunofluorescence revealed that expression of GSDMD and NLRP3 were significantly enhanced in TN rats. …”
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Evaluation of antidiabetic potential, cardio, pancreatic, nephroprotective effect, and herb-herb-drug interaction of Madhukiran formulations in T2 diabetic rats by Vrushabh S. Kondalkar, Pranali P. Polshettiwar, Ganesh B. Choudhari, Anil T. Pawar, Vishnu P. Choudhari

“…Results and conclusion: MFs alone, concomitantly, and with ME combination significantly decreased elevated plasma glucose level, urine volume, and urinating frequency. …”
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The diagnostic and prognostic value of serum miR-199a-5p combined with echocardiography in acute myocardial infarction by Lixin Xu, Jianfeng Lin, Jianke Xia, Deng Chen, Guohan He

“…Results Serum miR-199a-5p was elevated in AMI, positively correlated with cTnI and negatively correlated with LVEF. …”
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Untargeted Metabolomics Reveals Key Differences Between Yak, Buffalo, and Cow Colostrum Based on UHPLC-ESI-MS/MS by Yuzhuo Wang, Changhui Li, Jiaxiang Huang, Qingkun Zeng, Ling Li, Pan Yang, Pengjie Wang, Min Chu, Jie Luo, Fazheng Ren, Hao Zhang

“…In comparison to CC, both YC and BC shared common features, including reduced choline levels and elevated O-acetylcarnitine. Moreover, metabolites such as 2-hydroxy-6-pentadecylbenzoic acid, DL-glycerol-1-phosphate, thiamine, L-carnitine, methyl β-D-galactoside, and uridine diphosphate (UDP) were identified as potential biomarkers for YC, while 21-deoxycortisol, D-synephrine, uridine, mannitol-1-phosphate, nonadecanoic acid, and perillic acid were specific to BC. …”
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Dietary glycemic and insulin indices with the risk of osteoporosis: results from the Iranian teachers cohort study by Anahita HoushiarRad, Danial Fotros, Mina Esmaili, Mohammad Hassan Sohouli, Marjan Ajami, Morteza Abdollahi, Motahare Hatami Marbini

“…BackgroundOsteoporosis is a chronic condition characterized by reduced bone strength and an elevated risk of fractures. The influence of diet and glucose metabolism on bone health and the development of osteoporosis has been an area of interest. …”
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Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Peripheral Blood Leukocytes and Plasma of Children with Nonalcoholic Fatty Liver Disease by Joanna B. Trojanek, Jacek Michałkiewicz, Renata Grzywa-Czuba, Wojciech Jańczyk, Lidia Gackowska, Izabela Kubiszewska, Anna Helmin-Basa, Aldona Wierzbicka-Rucińska, Mieczysław Szalecki, Piotr Socha

“…Concentrations of AST, ALT, GGT, and leptin were elevated in serum patients with NAFLD, while concentration of other inflammatory or liver injury markers was unchanged. …”
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Association of Structural Maintenance of Chromosome-1A Phosphorylation with Progression of Breast Cancer by Sushma Yadav, Claudia M. Kowolik, Daniel Schmolze, Yuan Yuan, Min Lin, Arthur D. Riggs, David A. Horne

“…Approximately 40% of breast cancer tissue exhibited cytoplasmic/membranous localization of p-SMC1A, whereas nuclear expression was observed in normal breast tissues. Moreover, elevated phosphorylation levels were significantly associated with higher tumor grade and metastasis.…”
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Evolution of Functional and Paraclinical Markers as Predictive Factors in Pediatric Late-Onset SMA Under Nusinersen Treatment: The Role of CSF pNF-H by Mihaela Badina, Gabriel Cristian Bejan, Corina Sporea, Andrada Mirea

“…We assessed pNF-H levels in CSF and serum—neuronal proteins associated with neurodegeneration—as well as serum creatinine levels, a marker of muscle activity, and motor skill scores to evaluate pNF-H’s potential as a predictor of motor development. Elevated pNF-H levels were associated with a lower SMN2 gene copy number and more recent disease onset. …”
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In-flight Electrocardiography Monitoring in a Pilot During Cross Country Flight by William D. Kim, Sang-Wook Kim, Seong-Kyu Cho, Ju Hyeon Byeon, GunYoung Lee, WooSeok Hyun, JoungSoon Jang

“…Conclusion: We observed the relative increase of mean HR and change of HRV in the landing phase, indicating elevated sympathetic nervous tone. Further studies should be considered to evaluate specific changes of ECG signals in flight phases and confirm the clinical use of the MATLAB signal analysis tools.…”