Mechanical behavior and micro-crack propagation mode of fault stick–slip under various roughness conditions by Qianbai Zhao, Yong Zhao, Tianhong Yang, Shuhong Wang

“…Abstract Characterized by depressions and elevations, the rough surfaces of faults are prone to stress concentration and energy accumulation, leading to localized rupture in the upper and lower blocks. …”
Get full text

Identification of Two Novel Mutations of ABCD1 Gene in Pedigrees with X-Linked Adrenoleukodystrophy and Review of the Literature by Bingzi Dong, Wenshan Lv, Lili Xu, Yuhang Zhao, Xiaofang Sun, Zhongchao Wang, Bingfei Cheng, Zhengju Fu, Yangang Wang

“…However, both of the cases progressed as neurological symptoms and signs after decades. Elevated VLCFAs level, brain MRI scan, and genetic analysis confirmed final diagnosis. …”
Get full text

Carpolobia lutea methanol root extract reinstates androgenesis and testicular function in cadmium- challenged rats by Ejike, Daniel Eze, Okpa, Precious Nwaka, Igbokwe, Ugochukwu Vincent, Moses, Dele Adams, Karimah, Mohammed Rabiu, Ayikobua, Emmanuel Tiyo

“…However, Carpolobia lutea and its co-administration notably (p<0.05) elevated the activity of testicular 17β-HSD and levels of serum testosterone, LH and FSH. …”
Get full text

Anti-Malarial Effects of Five Traditional Nigerian Medicinal Plant Extracts on Plasmodium Berghei-Infected Rats by Ugochukwu Vincent, Igbokwe, Ejike, Daniel Eze, Moses Dele, Adams, Karimah Mohammed, Rabiu, Iliya, Ezekiel, Prisca Ojochogu, Ajeka, Peace Ogechukwu, Okpara

“…AST and ALT activities was substantively (p<0.05) elevated in group B-E when matched with group A. Plasmodium berghei induction notably (p<0.05) lowered white blood cell (WBC) and monocyte (Mono) levels at all groups. …”
Get full text

An analysis of heavy metals contamination and estimating the daily intakes of vegetables from Uganda by Keneth Iceland, Kasozi, Eric, Oloya Otim

“…Environmental contamination with elevated levels of copper (Cu), cobalt (Co), iron (Fe), zinc (Zn), lead (Pb), chromium (Cr6þ), cadmium (Cd), and nickel (Ni)—all states of which are found in Uganda—raises health risk to the public. …”
Get full text

Preferences for and drivers of adult vaccination clinic site selection: A cross-sectional study in 30 provinces in China by Yuxi Liu, Yanlin Cao, Yugang Li, Siyuan Liu, Yunshao Xu, Weizhong Yang, Luzhao Feng

“…Our results suggest that public health strategies should concentrate on enhancing site convenience, service quality, and information transparency to elevate adult vaccination rates. Future initiatives should aim to increase public trust in vaccines, improve the selection and quality of vaccination sites, and effectively utilize digital technology for spreading vaccination information.…”
Get full text

Visceral Adipose Tissue Inflammation and Vascular Complications in a Rat Model with Severe Dyslipidemia: Sex Differences and PAI-1 Tissue Involvement by Irena Markova, Martina Hüttl, Natalie Gayova, Denisa Miklankova, Kristyna Cerna, Martina Kavanova, Petra Skaroupkova, Sona Cacanyiova, Hana Malinska

“…Both sexes had increased circulating plasminogen activator inhibitor-1 (PAI-1), higher PAI-1 gene expression in VAT and PVAT, and elevated intercellular adhesion molecule-1 (ICAM-1) gene expression in the aorta, contributing to endothelial dysfunction in the HHTg strain. …”
Get full text

The impact of creatine supplementation on the development of kidney disease – literature review by Mateusz Matczak, Karol Jasiński, Aleksandra Broda, Kacper Hoksa, Krzysztof Jodłowski, Ewa Dubniewicz, Paula Majewska, Alicja Staszek, Wiktoria Łoskot, Jan Szwech

“…However, case reports highlight potential risks for individuals with pre-existing kidney conditions, especially without monitoring. Elevated serum creatinine levels caused by creatine can mislead eGFR-based renal function tests, warranting cautious interpretation. …”
Get full text

IL-5 and IL-6 are increased in the frontal recess of eosinophilic chronic rhinosinusitis patients by Kazunori Kubota, Sachio Takeno, Takayuki Taruya, Atsushi Sasaki, Takashi Ishino, Katsuhiro Hirakawa

“…Results The expression of IL-5 was significantly elevated in all sinonasal regions tested in the ECRS group, but absent in non-ECRS patients. …”
Get full text

Enhancing pediatric congenital heart disease detection using customized 1D CNN algorithm and phonocardiogram signals by Ihtisham Ul Haq, Ghassan Husnain, Yazeed Yasin Ghadi, Nisreen Innab, Masoud Alajmi, Hanan Aljuaid

“…This study represents a significant advancement in accessible, automated CHD diagnoses, enhancing clinical competence to elevate pediatric treatment.…”
Get full text

Effects of Diverting Stoma Creation in Minimally Invasive Surgery for Rectal Cancer by Hirotaka Momose, Makoto Takahashi, Masaya Kawai, Kiichi Sugimoto, Hiromitsu Takahashi, Shunsuke Motegi, Kumpei Honjo, Yu Okazawa, Rina Takahashi, Shun Ishiyama, Yuichi Tomiki, Kazuhiro Sakamoto

“…Thus, DS construction should be considered in a case with an elevated preoperative GPS.…”
Get full text

Depression and Anxiety States of Patients Followed in Pituitary Polyclinic by Afruz Babayeva, Mehmet Muhittin Yalçın, Atakan Tüm, Aydın Tuncer Sel, Alev Eroğlu Altınova, Müjde Aktürk, Mehmet Ayhan Karakoç, İlhan Yetkin, Füsun Törüner

“…Conclusion: In our study, the presence of pituitary disease due to any etiology was associated with elevated levels of depression and anxiety. Our findings that patients with pituitary adenomas had increased levels of depression and anxiety may have implications for the long-term care of these patients. …”
Get full text

Identification of TUBB3 as an immunotherapy target in lung cancer by genome wide in vivo CRISPR screening by Dan Zhao, Ravindra Deshpande, Kerui Wu, Abhishek Tyagi, Sambad Sharma, Shih-Ying Wu, Fei Xing, Stacey O'Neill, Jimmy Ruiz, Feng Lyu, Kounosuke Watabe

“…We found that TUBB3 expression was significantly elevated in the non-responders compared to responders in our patient cohort that received immunotherapies. …”
Get full text

Effect of Proinflammatory Cytokines (IL-6, TNF-α, and IL-1β) on Clinical Manifestations in Indian SLE Patients by Vinod Umare, Vandana Pradhan, Milind Nadkar, Anjali Rajadhyaksha, Manisha Patwardhan, Kanjaksha K. Ghosh, Anita H. Nadkarni

“…Systemic lupus erythematosus (SLE) is an inflammatory rheumatic disease characterized by production of autoantibodies and organ damage. Elevated levels of cytokines have been reported in SLE patients. …”
Get full text

Harnessing the potential of chloroplast-derived expression elements for enhanced production of cellulases in Escherichia coli by Ayesha Siddiqui, Muhammad Mudassar Iqbal, Asad Ali, Iqra Fatima, Hazrat Ali, Aamir Shehzad, Sameer H. Qari, Ghulam Raza, Muhammad Aamer Mehmood, Peter J. Nixon, Niaz Ahmad

“…Furthermore, the activity assays confirmed that the recombinant enzymes maintained their activity at elevated temperatures. Thermostability analysis showed that recombinant enzymes retained their thermotolerance even after being expressed in a non-native host. …”
Get full text

Comparison of PM2.5 Chemical Compositions during Haze and Non-haze Days in a Heavy Industrial City in North China by Menghui Li, Liping Wu, Xiangyan Zhang, Xinwu Wang, Wenyu Bai, Jing Ming, Chunmei Geng, Wen Yang

“…The PM2.5 concentration was 76.78% higher during the haze (mean ± standard deviation [SD] = 211 ± 39 µg m−3) than before it (49 ± 38 µg m−3), and the dominant ions were NO3-, SO42- and NH4+. Additionally, an elevated TE concentration was observed during the episode (exceeding the pre- and post-haze values by 54.70% and 31.98%, respectively), with crustal elements (K, Al, Ca, Si, Na, Fe and Mg), the most abundant elemental components, accounting for 88.64%. …”
Get full text

The link between sleep bruxism and oxidative stress based on a polysomnographic study by Michal Fulek, Weronika Frosztega, Mieszko Wieckiewicz, Anna Szymanska-Chabowska, Pawel Gac, Rafal Poreba, Grzegorz Mazur, Milena Sciskalska, Marta Kepinska, Adrian Martuszewski, Helena Martynowicz

“…Sleep bruxism is related to oxidative stress markers. Elevated markers of lipid and protein peroxidation may be associated with endovascular damage and cardiovascular risk in sleep bruxers, but further research is needed in this topic.…”
Get full text

Metabolic Profiles of the Gut Microbiota in Patients with Different Stages of Metabolism Dysfunction-Associated Fatty Liver Disease by X. Cao, O. Yu. Zolnikova, R. V. Maslennikov, E. A. Poluektova, E. L. Bueverova, M. S. Reshetova, M. S. Zharkova, V. T. Ivashkin

“…Patients whose microbiota metabolism for SCFA production was high had correspondingly elevated SCFA levels. And, on the contrary, patients in whom the metabolic activity of the microbiota was reduced were characterized by a steady decrease in SCFAs and disease progression to liver cirrhosis. …”
Get full text

Lessons learned in migrating from one commercial genetics clinical decision-making tool to another: Assessment of data integrity and utilization by Calvin Le, Kevin Tatunay, Wayne Liu, Haibo Lu, Nicole-Ann Rodis, Thomas Nam, Mercy Y. Laurino, Marianne E. Dubard-Gault

“…The electronic health record often contains multiple ways to record risk factors and to identify patients at an elevated genetic risk for cancer. However, these variables exist in multiple forms and disparate locations in each commercial electronic health record solution resulting in significant variations in how family history or genetic data is codified. …”
Get full text

Efficacy and safety of an herbal galactagogue decoction versus powdered formulation in lactating rats by Pruksa Chotitham, Suksalin Booranasubkajorn, Saracha Pattanapholkornsakul, Pravit Akarasereenont, Pinpat Tripatara

“…Additionally, the traditional decoction method was effective in increasing milk production and elevating serum prolactin levels in mother rats.…”
Get full text