Exploring the Effects of Sub-Dissociative Doses of Ketamine on Sedation Quality in Bronchoscopy: A Double-Blind Clinical Study by Hamidreza Shetabi, Samira Rostami

“…Additionally, the amount of propofol administered to the SDK3 cohort was less than that given to the SDK2, and both cohort received lower doses than the SDK1 cohort (P>0.001). Conclusion: Elevating the SDK from 0.2 mg/kg to 0.5 mg/kg when administered alongside propofol correlates with a rise in the score of sedation, increasing patient and bronchoscopist satisfaction, and decreasing propofol consumption in FFB in adults. …”
Get full text

An in silico analysis of heart rate impact on wall shear stress hemodynamic parameters in aortic coarctation by Jie Wang, Emily Manchester, Alex Skillen, Malebogo Ngoepe, Bernard Keavney, Alistair Revell

“…Simulations occur at 100, 120, and 160 beats per minute, representing reduced, resting, and elevated HR levels. Turbulence was analyzed over time and space using turbulence-resolving and pulsatile large-eddy simulations. …”
Get full text

Association between blood–urea–nitrogen-to-albumin ratio and in-hospital mortality in patients diagnosed with coronavirus disease 2019: a retrospective cohort study by Ruoqing Zhou, Dianzhu Pan

“…Subsequent to adjustment for confounding variables, patients in the highest BAR tertile exhibited an elevated risk for in-hospital mortality relative to those in the lowest tertile (hazard ratio [HR] 2.44 [95% confidence interval CI 1.24–4.79]) when BAR was treated as a categorical variable. …”
Get full text

In vitro sperm generation from immature mouse testicular tissue using plasma rich in growth factors by Seyyed Amir Moradian, Mansoureh Movahedin

“…Real-time PCR analysis revealed that transcript levels of Plzf, Tekt1, and Tnp1 were significantly elevated in 5% PRGF compared to 10% KSR. Immunofluorescence and quantitative analysis confirmed enhanced spermatogenesis progression in 5% PRGF media, with significantly increased numbers of PLZF + spermatogonia, SYCP3 + spermatocytes, ACRBP + spermatids, and Ki67 + proliferating cells per tubule compared to 10% KSR. …”
Get full text

Diabetes mellitus risk in post-myocardial infarction patients: FINDRISC versus self-assessment—a cross sectional study by Karianne Nölken, Jakob Linseisen, Philip Raake, Christine Meisinger, Timo Schmitz

“…This underestimation was significantly associated with older age, higher BMI, greater waist circumference, elevated blood glucose levels, use of antihypertensive medication and a family history of diabetes. …”
Get full text

Assessment of blood lead and haemoglobin levels among battery technicians and local government office workers in South-western Nigeria by Ebenezer Adeiza Ozomata, Babatunde Ogunnowo

“…A switch to repair of non-lead batteries, changing the work process by enclosing the battery during repairs, more trainings on lead exposure reduction, use of personal protective devices and regular biological monitoring of lead may control elevated lead level among battery technicians.  …”
Get full text

Effects of COVID-19 on short-term outcomes of hip arthroplasty: a multicenter, retrospective, propensity score matched study by Shih-Hui Peng, Yu-Chih Lin, Chih-Hsiang Chang, Chih-Chien Hu, Lan-Yan Yang, Yuhan Chang

“…Conclusion Our findings suggest that COVID-19 only elevated risks of postoperative pneumonia and UTI after hip arthroplasty. …”
Get full text

Thymosin β4 Protects against Cardiac Damage and Subsequent Cardiac Fibrosis in Mice with Myocardial Infarction by Fei Wang, Yajuan He, Naijuan Yao, Litao Ruan, Zhen Tian

“…Tβ4 was shown to be significantly elevated in mice AMI cardiac tissues. In mice, AAV-Tβ4 induced exogenous expression of Tβ4 significantly reduced oxidative damage, inflammation, cardiac dysfunction, and fibrosis. …”
Get full text

miR-486-5p Restrains Extracellular Matrix Production and Oxidative Damage in Human Trabecular Meshwork Cells by Targeting TGF-β/SMAD2 Pathway by Le Xu, Yiming Zhang, Hua Long, Bo Zhou, Haibo Jiang

“…Glaucoma is characterized by elevated intraocular pressure caused by aqueous outflow dysfunction. …”
Get full text

SUBCUTANEOUS ADIPOSE TISSUE IN FEMALE PATIENTS WITH IRON DEFICIENCY ANEMIA AND OBESE WOMEN DOES NOT DIFFER IN THE EXPRESSION OF IKBΑ* by V.M. Nedoborenko, O.А. Shlykova, O.V. Izmailova, K.E. Ishcheikin, I.P. Kaidashev

“…Its expression increases with elevated level of pro-inflammatory cytokines, as a result of which the concentration of iron in the blood plasma decreases, which reliably results in the activation of NF-kB. …”
Get full text

Prevalence and clinical profile of hepatitis C virus infections in multitransfused thalassemic patients in the capital twin cities of Pakistan by Z. Z. Piracha, U. Saeed, R. Uppal, M. R. Uppal, A. Ahmad Khan, M. Abdullah, K. Mari, A. Basra, S. S. Gilani, M. N. Tariq, D. U. Ozsahin, B. Uzun, I. Ozsahin

“…Furthermore, the risk of contracting HCV infections escalates with the advancing age of thalassemic patients. Elevated ALT levels and hepatomegaly were pervasive among the majority of HCV-positive thalassemic patients. …”
Get full text

The prevalence of and the effect of global stressors on eating disorders among medical students by Muneera B. Almahmeed, Muna A. Almutawa, Yahya M. Naguib, Yahya M. Naguib

“…Data was collected from September 2022 to February 2023.ResultsThree hundred and ninety-seven students were recruited in the present study. 32.1% of the tested students demonstrated an elevated risk for developing EDs. Living situation, earlier years of study, and mental health status were significantly associated with increased risk. …”
Get full text

Thyroid Storm with Multiorgan Failure Treated with Plasmapheresis by Ann Miller, Kristi D. Silver

“…Despite maximal anti-thyroid therapy, he had not improved clinically and T4 and T3 remained markedly elevated. A 4-day course of plasmapheresis was initiated resulting in marked lowering of T4 and T3 and clinical stability. …”
Get full text

Correlations of inflammatory processes caused by cerebral stroke with the outcome of the disease by A. Vaitkus, J. Valinčiūtė, S. Gylytė

“…Nosocomial infection. Elevated inflammatory markers and other prognostic factors are directly associated with higher rates of in-hospital complications such as pneumonia, urinary tract infection, and unfavorable stroke outcomes. …”
Get full text

Analysis of the circadian rhythm of biological processes in mouse liver and kidney by I. N. Podkolodnyy, N. N. Tverdokhleb, O. A. Podkolodnaya

“…In the kidneys, the differences in the distribution of the number of genes in the phase of an elevated translation level by the time of day were less pronounced, and the maximum number of such genes was observed from the middle of the light phase of the day to the middle of the dark one. …”
Get full text

Macrophage Activation Syndrome/Secondary Hemophagocytic Lymphohistiocytosis in Adult‐Onset Still's Disease: An Uncommon Initial Presentation in a Young Nepalese Female: A Case Repo... by Kanchan Bishwakarma, Kajal Bishwakarma, Sunil Bogati, Saket Jha

“…ESR/CRP and lactate dehydrogenase (LDH) were elevated, and ferritin was 38,291 ng/mL. Tropical disease screening, blood culture, viral serologies, imaging for malignancies, and autoimmune disease panels were negative. …”
Get full text

Can Abies alba Needles Be Used as Bio-passive Samplers to Assess Air Quality? by Agnieszka Stojanowska, Maciej Górka, Anita Urszula Lewandowska, Kinga Wiśniewska, Magdalena Modelska, David Widory

“…Aerosols that were enriched in 13C, indicating the impact of human activities, were located close to inhabited areas, at highly elevated points and in places situated outside the park. …”
Get full text

Association between alkaline phosphatase levels and mortality in Chinese patients with colorectal cancer with liver metastases: a retrospective cohort study by ZhaoXi Liu, ZiQing Zhang, GuoFang Yu, MingJiang Mo, ChuanYu Xie, DangHan Xu, JieTao Lin, YuChen Zhang, Li Deng, YiChang Luo, YingFeng Huang, Cui Shao

“…After adjusting for the covariates, elevated ALP levels were significantly associated with an increased risk of mortality (hazard ratio = 1.24, 95% confidence interval: 1.08–1.43, p  = 0.0029). …”
Get full text

Assessment of Interleukin-1β in Saliva of Smoker and Non-smoker Patients with Chronic Periodontitis. by Solav Abdul-Qadir Mustafa, Haween T. Nanakaly, Hozan Wrya Azeez

“…Conclusion: Salivary IL-1β level were significantly elevated in periodontitis patients. Smokers with chronic periodontitis exhibited a highly significant increase in salivary IL-1β levels. …”
Get full text

Exploring Inflammatory Changes in the Peripheral Blood of Type 2 Diabetes Mellitus in China by Li D, Zhang Z, Li W, Zhao C, Li X, Pan Z, Li Y

“…Flow cytometry, Western Blotting and qPCR were used to analyse the apoptosis of monocytes or THP-1 cells.Results: The numbers of white blood cells, lymphocytes, and neutrophils substantially increased with elevated IL-6 levels. There was a significant decrease in monocytes due to increased cell apoptosis caused by sustained high glucose stimulation. …”
Get full text