Genome-wide association study of the fatty liver index in the Taiwanese population reveals shared and population-specific genetic risk factors across ethnicities by Pei Pei Lau, Chun-Yu Wei, Min-Rou Lin, Wan-Hsuan Chou, Yu-Jui Yvonne Wan, Wei-Chiao Chang

“…Results In this study, a total of 145,356 Taiwan Biobank participants were included in the discovery analysis. Subjects with elevated FLI were found to have a significantly greater risk of developing FLD, as confirmed by imaging data (OR: 4.43; 95% CI: 3.88–5.06). …”
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The Multifaceted Contributions of Community-Based Breeding Program of Bonga Sheep to Flock Dynamics, Animal Performance, and Socio-economic Benefits of Beneficiaries in Kafa Zone,... by Metsafe Mamiru, Aberra Melesse, Aynalem Haile, Tesfaye Getachew

“…In conclusion, CBBP positively influenced sheep assets, performance, and marketability, elevating the income and livelihoods of beneficiaries. …”
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Model of Liver Fibrosis Induction by Thioacetamide in Rats for Regenerative Therapy Studies by Nathaly Enciso, José Amiel, Fredy Fabián-Domínguez, Jhon Pando, Nancy Rojas, Carlos Cisneros-Huamaní, Ernesto Nava, Javier Enciso

“…The protocol used in this work established a model of advanced hepatic fibrosis as corroborated by METAVIR tests of the histological lesions; by the high levels of the markers α-SMA, CD68, and collagen type I; by functional alterations due to elevated markers of the hepatic lesions; and by alterations of the leukocytes, lymphocytes, and platelets. …”
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Managing Post COVID-19 Patient with Breathlessness by Yen Shen Wong, Muhammad Amin Ibrahim, Mohd Arif Mohd Zim, Mohd Fauzi Abdul Rani

“…Corticosteroid inhaler should be cautioned in this case, in view of recent pneumonia and non-elevated serum eosinophil count. These groups of patients should be closely followed up to unmask interstitial lung disease that may present prior to COVID-19 and worsen post-infection. …”
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DGAT1 Expression Promotes Ovarian Cancer Progression and Is Associated with Poor Prognosis by Leilei Xia, Ye Wang, Shengyun Cai, Mingjuan Xu

“…The expression of DGAT1 was elevated in advanced (p=0.0432), poorly differentiated (p=0.0148), and vascular invaded (p=0.0002) ovarian cancer specimens. …”
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Can Obesity Prevalence Explain COVID-19 Indicators (Cases, Mortality, and Recovery)? A Comparative Study in OECD Countries by Yuval Arbel, Chaim Fialkoff, Amichai Kerner, Miryam Kerner

“…Indeed, there is a linear increase in mortality rate from SARS-CoV-2 virus with an elevated prevalence of obesity. Yet, other indicators, such as the number of infected per 10,00,000 persons, rates of severe SARS-CoV-2 virus cases, rates of recovered SARS-CoV-2 virus patients, and SARS-CoV-2 virus, as the cause of death exhibit quadratic, rather than linear, patterns. …”
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T-2 toxin triggers depression-like behaviors via upregulation of dopamine transporter in nucleus accumbens of male mice by Zhigang Chen, Shaoyi Duan, Jialu Li, Jianming Su, Hongyu Lei

“…In addition, the reduced dopamine (DA) level and elevated dopamine transporter (DAT) level were found in reward center nucleus accumbens (NAc) receiving DAergic projection from ventral tegmental area (VTA) in brain after T-2 toxin administration, while there was no significant alteration in DA synthesis-related tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) in VTA and DA storage-related vesicle monoamine transporter 2 (VMAT2) in NAc. …”
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ICD Pocket-Site Infection Secondary to Gonococcal Bacteremia: The First Reported Case by Sardar Hassan Ijaz, Ali Haider Jafry, Areeba Shahnawaz, Mark Allee

“…Physical exam showed a 5 cm × 6 cm pocket-site swelling with overlying erythema. Labs revealed elevated ESR and CRP levels. Transthoracic and transesophageal echocardiography was concerning for infective endocarditis and lead vegetations. …”
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Experimental dataset of a model-scale ship in calm water and wavesUniversity of Southampton Institutional Repository by Saeed Hosseinzadeh, Stephen Turnock, Haesol Lee, Rodolfo Olvera

“…Despite notable advancements in numerical models, there exists a corresponding imperative to elevate the precision of measurements and insights obtained from towing tank tests. …”
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Laxative Effect of Lacticaseibacillus rhamnosus Glory LG12: from the Perspective of the Stem Cell Factor/C-kit Signaling Pathway by XIANG Fangqin, LI Yuxing, LI Bailiang

“…In addition, both treatments elevated the serum levels of motilin (MTL), gastrin (Gas), substance P (SP), and interleukin 10 (IL-10), reduced the levels of endothelin-1 (ET-1), somatostatin (SS), vasoactive intestinal peptide (VIP), and IL-6, up-regulated the relative mRNA expression of SCF and C-kit in colonic tissue was (P < 0.01, P < 0.001), and restored damaged colonic barrier. …”
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Level measurement, regional variations, and the dynamic evolution of active aging in China—analysis based on CHARLS tracking data by Jiru Guo, Xiaoli Zhang, Xiaoli Zhang, Longyin Chen, Hong Yang

“…IntroductionGiven the world’s largest and increasingly serious aging population, China has elevated “positively responding to aging of population” to a national strategy. …”
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Repeated ionizing radiation exposure induces TRIP13 expression, conferring radioresistance in lung cancer cells by Wenqing Liu, Qijing Lei, Ans M. M. van Pelt, Geert Hamer

“…This effect of radioresistance could be enhanced or abrogated by overexpressing or knocking out TRIP13. Elevated TRIP13 is also correlated with enhanced repair of radiation-induced DNA damage. …”
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Advective Heat Transport and the Salt Chimney Effect: A Numerical Analysis by David P. Canova, Mark P. Fischer, Richard S. Jayne, Ryan M. Pollyea

“…Results show that decreasing the dip of the diapir induces advective heat transfer up the side of the diapir, elevating temperatures in the basin. Depth-dependent permeability causes upwelling of warm waters in the basin, which we show to be more sensitive to basal heat flux than brine concentration. …”
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Hypericum Perforatum-Derived Exosomes-Like Nanovesicles: A Novel Natural Photosensitizer for Effective Tumor Photodynamic Therapy by Ma X, Chen N, Zeng P, He Y, Zhang T, Lu Y, Li Z, Xu J, You J, Zheng Y, Wang L, Luo M, Wu J

“…In vitro, HPDENs showed light dose-dependent cytotoxicity against human melanoma cells, characterized by elevated ROS production and apoptosis induction. In vivo, HPDEN-mediated PDT significantly suppressed tumor growth and induced extensive tumor necrosis, with no observable toxicity to major organs.Conclusion: HPDENs represent a novel plant-derived photosensitizer with dual ROS generation pathways and significant therapeutic efficacy, providing a promising platform for enhancing photodynamic therapy.Keywords: Hypericum perforatum-derived exosomes-like nanovesicles, photosensitizer, photodynamic therapy, reactive oxygen species, apoptosis…”
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Long-Term Treatment with Atypical Antipsychotic Iloperidone Modulates Cytochrome P450 2D (CYP2D) Expression and Activity in the Liver and Brain via Different Mechanisms by Przemysław J. Danek, Władysława A. Daniel

“…In conclusion, by affecting CYP2D activity in the brain, iloperidone may modify its pharmacological effect, via influencing the rate of dopamine and serotonin synthesis or the metabolism of neurosteroids. By elevating the CYP2D expression/activity in the substantia nigra and striatum (i.e., in the dopaminergic nigrostriatal pathway), iloperidone may attenuate extrapyramidal symptoms, while by decreasing the CYP2D activity and metabolism of neurosteroiods in the frontal cortex and cerebellum, iloperidone can have beneficial effects in the treatment of schizophrenia. …”
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Decreased Choroidal Vascular Index in Idiopathic Intracranial Hypertension by Hang Wang, Rui Wang, Le Cao, William Robert Kwapong, Ruishan Liu, Fayun Hu, Bo Wu

“…We also explored the ability of the choroidal parameters to reflect elevated intracranial pressure (ICP) in patients with IIH. …”
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Selected Metabolic Markers in Girls with Turner Syndrome: A Pilot Study by E. Błaszczyk, M. Lorek, T. Francuz, J. Gieburowska, A. Gawlik

“…Our pilot study showed that MMP-1 may be a potential indicator of a higher risk of cardiometabolic complications in girls with TS. The elevated concentrations of BDNF in normal-weight girls with TS need to be studied further, taking into consideration the influence of estrogen-androgen imbalance.…”
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Tobacco prevalence among adults in the urban slums of Delhi: results from a cross-sectional survey by Shyam Kanhaiya Saroj, Tushti Bhardwaj, Archana Kaushik

“… Slum areas exhibited a marked prevalence of elevated tobacco consumption rates, prompting the investigation to assess the extent and perspectives of tobacco usage among the residents in these regions. …”
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Measuring the Impact of COVID-19 on Young Adult Functional Capacity: A Comparative Study of Walking and Step Endurance Tests by Patchareeya Amput, Arunrat Srithawong, Sinthuporn Maharan, Puttipong Poncumhak, Patcharin Phrompao, Eakarach Wongsaya, Tichanon Promsrisuk, Sahachat Aueyingsak

“…The study revealed an increase in heart rate and leg fatigue after the 6MWT compared to the 2MST, whereas systolic blood pressure was elevated following the 2MST compared to the 6MWT. The 6MWT showed a significant positive correlation with the 2MST (r = 0.350, p = 0.043). …”
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Measurement and Numerical Simulation of Ground and Subgrade Vibrations of Beijing Urban Rail Line 13 by Futong Wang, Leilei Yan, Qi Jiang, Xiaxin Tao

“…Long-lasting vibrations result in disturbance to people’s sleep, malfunction of sensitive equipment, and even damage to heritage buildings. Compared with elevated and tunnel sections, ground surface urban railway generates vibrations and propagates to the surroundings via a more direct path in the form of surface waves, which makes the environmental problem more prominent. …”
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