Effectively alleviate rheumatoid arthritis via maintaining redox balance, inducing macrophage repolarization and restoring homeostasis of fibroblast-like synoviocytes by metformin-... by Rui Zhang, Xingyu Lin, Rongjie Lin, Zhenbin Chen, Chenfang Miao, Yao Wang, Xiaoqin Deng, Jianlong Lin, Shishui Lin, Shaohuang Weng, Min Chen

“…Abstract Overproduction of reactive oxygen species (ROS), elevated synovial inflammation, synovial hyperplasia and fibrosis are the main characteristic of microenvironment in rheumatoid arthritis (RA). …”
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Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice by Kamila Borowczyk, Jacek Wróblewski, Joanna Suliburska, Noriyuki Akahoshi, Isao Ishii, Hieronim Jakubowski

“…Genetic hyperhomocysteinemia significantly increased N-Hcy-keratin levels in the mouse pelage. N-Hcy-keratin was elevated 3.5-, 6.3-, and 11.7-fold in hair from Mthfr−/−, Cse−/−, or Cbs−/− mice, respectively. …”
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Optimization of Protein Hydrolysate from Earthworms (<i>Perionyx excavatus</i>) of Angiotensin-I-Converting Enzyme Inhibitory Activity by One Variable at a Time by Phong Thanh Bui, Truc Anh Hoang, My Thi Thuy Pham, Linh Le Phuong Tran, Oanh Kim Nguyen

“…Hypertension, characterized by elevated blood pressure, is commonly treated with angiotensin-I-converting enzyme (ACE) inhibitors. …”
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Predicting Traffic Accident Risk in Seoul Metropolitan City: A Dataset Construction Approach by Ji-Woong Yang, Hyeon-Jin Jung, Tae-Wook Kim, Han-Jin Lee, Ellen J. Hong

“…In contemporary society, the rapid progression of urbanization and technological advancements has led to a substantial increase in the number of vehicles, consequently elevating the rate of traffic accidents. To minimize the human and economic losses resulting from these accidents, extensive research has been conducted over the past decades. …”
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FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restriction by Zhukai Chen, Jiacheng Xu, Kang Fang, Hanyu Jiang, Zhuyun Leng, Hao Wu, Zehua Zhang, Zeyu Wang, Zhaoxing Li, Mingchuang Sun, Ziying Zhao, Anqi Feng, Shihan Zhang, Yuan Chu, Lechi Ye, Meidong Xu, Lingnan He, Tao Chen

“…Serine deprivation activate the ERK1/2-p-ELK1 signaling axis, leading to upregulated FOXC1 expression in CRC cells. Elevated FOXC1 emerged as a critical element, promoting the transcription of serine metabolism enzymes PHGDH, PSAT1, and PSPH, which in turn facilitated serine production, supporting CRC growth. …”
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Neurocognitive Impairment in HIV-Infected Naïve Patients with Advanced Disease: The Role of Virus and Intrathecal Immune Activation by Monica Airoldi, Alessandra Bandera, Daria Trabattoni, Benedetta Tagliabue, Beatrice Arosio, Alessandro Soria, Veronica Rainone, Giuseppe Lapadula, Giorgio Annoni, Mario Clerici, Andrea Gori

“…Nevertheless, IL-6 and MIP-1β remained elevated after 12 weeks of therapy in HAND patients, in whom CSF HIV RNA decay was slower than the plasmatic one as well. …”
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Insulin-Like Growth Factor I Prevents Cellular Aging via Activation of Mitophagy by Xuwei Hou, Zhaohui Li, Yusuke Higashi, Patrice Delafontaine, Sergiy Sukhanov

“…IGF-1 increased mitophagy in aged cells, and this was associated with decreased expression of cyclin-dependent kinase inhibitors p16 and p21 and elevated levels of Nrf2 and Sirt3, regulators of mitophagy and mitochondrial biogenesis. …”
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General obesity, abdominal obesity, and the risk of cardiovascular disease including stroke in 5-year breast cancer survivors by Ji Soo Kim, Jihun Song, Seulggie Choi, Sang Min Park

“…Conclusions: Breast cancer survivors with higher BMI and/or abdominal obesity were associated with an elevated risk of CVD, including stroke.…”
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Climatic Trends in Hail Precipitation in France: Spatial, Altitudinal, and Temporal Variability by Lucía Hermida, José Luis Sánchez, Laura López, Claude Berthet, Jean Dessens, Eduardo García-Ortega, Andrés Merino

“…The remainder of the study area showed an elevated spatial variability with no pattern, even between relatively close hailpads. …”
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Comparative Effectiveness of Bone Grafting Using Xenograft Freeze-Dried Cortical Bovine, Allograft Freeze-Dried Cortical New Zealand White Rabbit, Xenograft Hydroxyapatite Bovine,... by Ferdiansyah Mahyudin, Dwikora Novembri Utomo, Heri Suroto, Tri Wahyu Martanto, Mouli Edward, Imelda Lumban Gaol

“…The Immunoglobulin-G was elevated in control and all study groups but not significantly (p=0.07855). …”
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Merging polymers of intrinsic microporosity and porous carbon-based zinc oxide composites in novel mixed matrix membranes for efficient gas separation by Muning Chen, Jiemei Zhou, Jing Ma, Weigang Zheng, Guanying Dong, Xin Li, Zhihong Tian, Yatao Zhang, Jing Wang, Yong Wang

“…As a result, the CO2 permeability of the optimized C@ZnO/PIM-1 MMMs is elevated to 13,215 barrer, while the CO2/N2 and CO2/CH4 selectivity reached 21.5 and 14.4, respectively, substantially surpassing the 2008 Robeson upper bound. …”
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The Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population by Jae Woong Sull, Seung-Ju Yang, Soriul Kim, Sun Ha Jee

“…Elevated serum uric acid levels are associated with a variety of adverse health outcomes, including gout, hypertension, diabetes mellitus, metabolic syndrome, and cardiovascular diseases. …”
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2’-Fucosyllactose alleviate immune checkpoint blockade-associated colitis by reshaping gut microbiota and activating AHR pathway by Shikai Yan, Leilei Yu, Fengwei Tian, Jianxin Zhao, Wei Chen, Qixiao Zhai

“…In addition, administration of 2’FL increased the abundance of Bifidobacterium and Lactobacillus, and elevated the levels of microbial metabolites, such as indole-3-lactic acid (ILA), which activated the aryl hydrocarbon receptor ligands (AHR) pathway. …”
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A novel protein encoded by porcine circANKRD17 activates the PPAR pathway to regulate intramuscular fat metabolism by Xiao He, Fang Xie, Ying Nie, Xuefeng Wang, Junyi Luo, Ting Chen, Qianyun Xi, Yongliang Zhang, Jiajie Sun

“…Results We combined circRNA-seq and Ribo-seq data to screen a total of 18 circRNA candidates with coding potential, and circANKRD17 was found to be significantly elevated in the longissimus dorsi muscle of Lantang piglets, with a length of 1,844 nucleotides. …”
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The Influence of Physical Activity, Fast Food, and Body Composition on Hypercholesterolemia in Young Adults: A Step Toward SDGs - Good Health and Well-being by Sari Hesti Permata, Fadlilah Synta Haqqul, Febriani Ayu Rizky, Yasmin Alya, Fadilah Fitria Nur, Azizah Nisa Fithri

“…Hypercholesterolemia is a condition marked by elevated cholesterol levels in the blood, which can increase the risk of heart disease, hypertension, and stroke. …”
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Lachnospiraceae-bacterium alleviates ischemia-reperfusion injury in steatotic donor liver by inhibiting ferroptosis via the Foxo3-Alox15 signaling pathway by Shenghe Deng, Huan Cao, Tongxi Li, Xueling Wang, Junpeng Meng, Teng Zeng, Di Zhang, Shuhua Zhang, Guoliang Wang, Ran Liu, Tianhao Zou, Mao Cai, Ren Lang, Di Lu, Jinyang Gu

“…Multi-omics analysis revealed elevated pyruvate levels in transplanted livers after Lachn. treatment, alongside reduced Alox15 and Foxo3 expression. …”
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Investigating the Allelopathic and Bioherbicidal Potential of <i>Solidago altissima</i> with a Focus on Chemical Signaling in <i>Trifolium repens</i> by Ho-Jun Gam, Arjun Adhikari, Yosep Kang, Md. Injamum-Ul-Hoque, Shifa Shaffique, Ji-In Woo, Jin Ryeol Jeon, Byeong-Kwan An, Min Young Back, Ki-Yong Kim, Sang-Mo Kang, In-Jung Lee

“…Additionally, antioxidant activities, such as superoxide dismutase, catalase, and peroxidase enzyme activities, were significantly elevated in <i>T. repens</i> treated with SRE. Moreover, SRE treatment significantly inhibited the seed germination of all tested weed species in a concentration-dependent manner. …”
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Child Maltreatment and Medical Traumatic Stress—A Double-Edged Sword by Rony Kapel Lev-ari, Roy Aloni, Amit Shalev, Avi Elbaz, Yael L. E. Ankri, Shiri Ben-David, Naomi Kahana Levy, Fortu Benarroch, Amichai Ben-Ari

“…Parents of children who endured prior trauma and child maltreatment also exhibited elevated pre-procedure distress. Prior trauma and child maltreatment independently contributed to heightened medical distress. …”
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Codon optimized influenza H1 HA sequence but not CTLA-4 targeting of HA antigen to enhance the efficacy of DNA vaccines in an animal model by Dito Anurogo, Chia-Yuan Chen, Chu-Chi Lin, Jeanne Adiwinata Pawitan, Daniel W. Qiu, J. Timothy Qiu

“…The study findings revealed that the codon-optimized HA gene (pcHA) led to increased protein synthesis, as evidenced by elevated mRNA levels. Codon optimization also significantly bolstered both cellular and humoral immune responses. …”
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Enhancing RF Fingerprint Generation in Power Amplifiers: Unequally Spaced Multitone Design Approaches and Considerations by Chengyu Fan, Junting Deng, Ethan Chen, Vanessa Chen

“…Subsequently, time-varying unequally spaced multitone (USMT) techniques are proposed to further elevate the count of available timestamped RFFs from 4096 to 16 384. …”
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