Genetic and peripheral biomarkers of comorbid posttraumatic stress disorder and traumatic brain injury: a systematic review by Kiriana Cowansage, Reshmi Nair, Jose M. Lara-Ruiz, Daniel E. Berman, Courtney C. Boyd, Tiffany L. Milligan, Daniel Kotzab, Dawn M. Bellanti, Lisa M. Shank, Maria A. Morgan, Derek J. Smolenski, Ida Babakhanyan, Nancy A. Skopp, Daniel P. Evatt, Marija S. Kelber

“…The results suggest that multiple gene variants are likely to contribute to the cumulative risk of PTSD comorbid with TBI. An elevated circulating level of the pro-inflammatory cytokine IL-6 was the most consistently replicated blood-based indicator of comorbid illness, compared to mTBI alone.ConclusionSeveral genetic and protein markers of cellular injury and inflammation appear to be promising indicators of chronic pathology in comorbid TBI and PTSD. …”
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Natriuretic Peptide System Activation in Acute Heart Failure Patients with Diabetes by Filipe M. Cunha, Joana Pereira, Pedro Marques, Helena Moreira, Pedro Rodrigues, Maria João Pinto, Patrícia Lourenço, Paulo Bettencourt

“…Background. Elevated B-type natriuretic peptide (BNP) is a hallmark in heart failure (HF). …”
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Age-Dependent Effects of Butyl Benzyl Phthalate Exposure on Lipid Metabolism and Hepatic Fibrosis in Mice by Min-Seo Park, Seonhwa Hwang, Hyun-Bon Kang, Minjeong Ha, Juyeon Park, So-Youn Park, Yong-Joo Park, Min-Hi Park

“…Young mice exposed to BBP showed fatty liver, with downregulation of key fatty acid oxidation genes (CPT1A, CPT1B, CPT2, and Acox1) and elevated pro-inflammatory cytokines (TNF-α and IL-6). …”
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Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells by Jung-Eun Park, Tae-Sung Kim, Yan Zeng, Melissa Mikolaj, Jong Il Ahn, Muhammad S. Alam, Christina M. Monnie, Victoria Shi, Ming Zhou, Tae-Wook Chun, Frank Maldarelli, Kedar Narayan, Jinwoo Ahn, Jonathan D. Ashwell, Klaus Strebel, Kyung S. Lee

“…Abstract HIV-1 infection elevates the risk of developing various cancers, including T-cell lymphoma. …”
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Unravelling Lithium Interactions in Non-Flammable Gel Polymer Electrolytes: A Density Functional Theory and Molecular Dynamics Study by Nasser AL-Hamdani, Paula V. Saravia, Javier Luque Di Salvo, Sergio A. Paz, Giorgio De Luca

“…Lithium metal batteries (LiMBs) have emerged as extremely viable options for next-generation energy storage owing to their elevated energy density and improved theoretical specific capacity relative to traditional lithium batteries. …”
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Associations of serum and tissue TIMP1 with host response and survival in colorectal cancer by Akseli Kehusmaa, Anne Tuomisto, Päivi Sirniö, Henna Karjalainen, Meeri Kastinen, Vilja V. Tapiainen, Ville K. Äijälä, Taina Tervahartiala, Timo Sorsa, Jukka Rintala, Sanna Meriläinen, Juha Saarnio, Tero Rautio, Markus J. Mäkinen, Juha P. Väyrynen

“…Abstract Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) is a multifaceted, cytokine-like bioactive molecule whose levels are elevated in a wide range of inflammatory diseases and are associated with prognosis. …”
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SICKLE CELL TRAIT, CLINICAL MANIFESTATIONS AND OUTCOMES: A CROSS-SECTIONAL STUDY by Diego A Vargas-Hernández, Adriana Catalina Uscategui-Ruiz, Andrés Jesus Prada-Rueda, Consuelo Romero-Sánchez

“…We found significant elevations in leukocytes, bilirubin, LDH, and CRP. Eighteen patients (66.7%) received medical management, five patients (18.5%) required splenectomy, and only 5.9% of patients were sent for genetic counseling. …”
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Study of Corrosion Behavior of Mg–Gd-Based Soluble Magnesium Alloys by Qinghua Wang, Zhiquan Huang, Yanchun Zhu, Ling Qin, Jingfeng Zou, Lifeng Ma

“…The results demonstrated that corrosion rates increased with higher Cl⁻ concentrations and elevated temperatures, albeit in a nonlinear manner. …”
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A distinct metabolomic pattern revealed intestinal microenvironment factor-mediated food allergy in a BALB/c mouse model by Qiang Xie, Chenglong Liu, Wenhui Fu, Chen Chen, Dan Luo, Shimin Gu, Wentong Xue

“…Our results showed that gluten sensitization induced severe allergic responses in BALB/c mice, characterized by exacerbated clinical allergic and diarrheal symptoms, increased histamine, elevated gluten-specific immunoglobulin (Ig)E and IgG2a levels, and increased mast cell degranulation. …”
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The Bullseye: HST, Keck/KCWI, and Dragonfly Characterization of a Giant Nine-ringed Galaxy by Imad Pasha, Pieter G. van Dokkum, Qing Liu, William P. Bowman, Steven R. Janssens, Michael A. Keim, Chloe Neufeld, Roberto Abraham

“…Analysis of the H i content in this galaxy from ALFALFA finds significantly elevated neutral hydrogen with respect to the galaxy's stellar mass, another feature in alignment with GLSB systems.…”
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Predictive value of serum procalcitonin level for the diagnosis of bloodstream infections in hematological patients by Qi Sun, Qingsong Lin, Yanxia Lv, Zhiying Tian, Qiushuang Yan, Yaqing Yu, Xue Fu, Hongjing Yao, Fujun Sun, Yonghui Xia, Guoqing Zhu, Sizhou Feng

“…Results For patients with hematological diseases, the serum PCT was slightly elevated in the BSI group. We found that most hematological patients with bloodstream infection were in the stage of severe neutropenia. …”
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Any Long-term Effect of the Beirut Port Explosion on the Airborne Particulate Matter? by Yi-Bo Zhao, Nathalie Hayeck, Najat A. Saliba, Claudia Schreiner, Markus Zennegg, Fuze Jiang, Renato Figi, Davide Bleiner, Jing Wang

“…The continuous demolition and reconstruction after the explosion are possibly the main long-term effect of the Beirut port explosion, causing an elevated concentration of PM2.5 at ground level 400% higher than the recommended concentrations (15 µg m−3 for 24-hour mean). …”
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Regulation of fibronectin and collagens type I, III and VI by TNF-α, TGF-β, IL-13, and tofacitinib by Frederik S. Gillesberg, Martin Pehrsson, Anne-Christine Bay-Jensen, Peder Frederiksen, Morten Karsdal, Bent W. Deleuran, Tue W. Kragstrup, Satoshi Kubo, Yoshiya Tanaka, Joachim H. Mortensen

“…The in vitro findings were supported by clinical observations in patients with active rheumatoid arthritis, which had elevated serum type III collagen formation, indicating ongoing fibrogenesis during inflammation. …”
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Assessment of symptoms of temporomandibular dysfunction in patients undergoing orthodontic treatment using occlusal lift by Isabella Avelar Santos, Gracia Lopes Costa, Rodrigo Bernardes Pereira, Thiago Bezerra Leite, António Sérgio Guimarães, Luciane Lacerda Franco Rocha Rodrigues

“…They were evaluated: before the start of orthodontic treatment (T0), 24 hours (T1) and 30 days (T2) after installation of the occlusal elevator. Symptom assessment was carried out by applying the DC/TMD symptom questionnaire. …”
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The impact of abandoned iron ore on the endophytic bacterial communities and functions in the root systems of three major crops in the local area by Shuyi Chen, Jie Tang, Junqiang Xu, Lianxin Peng, Peng Wu, Qiang Li

“…Interestingly, the chao1 and shannon indices of the root endophytes of the mining crop were significantly elevated compared to the contro (p < 0.05). Among them, Musa basjoo Siebold showed the highest level of community richness in the mining environment. …”
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Progression of Luminal Breast Tumors Is Promoted by Ménage à Trois between the Inflammatory Cytokine TNFα and the Hormonal and Growth-Supporting Arms of the Tumor Microenvironment... by Polina Weitzenfeld, Nurit Meron, Tal Leibovich-Rivkin, Tsipi Meshel, Adit Ben-Baruch

“…Jointly, TNFα + Estrogen + EGF had a stronger effect on breast cancer cells than each element alone, leading to the following: (1) extensive cell spreading and formation of FAK/paxillin-enriched cellular protrusions; (2) elevated proportion of tumor cells coexpressing high levels of CD44 and β1 and VLA6; (3) EMT and cell migration; (4) resistance to chemotherapy; (5) release of protumoral factors (CXCL8, CCL2, MMPs). …”
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Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentr... by Patrizia Bruzzi, Maria Francesca Messina, Alessandra Bartoli, Barbara Predieri, Laura Lucaccioni, Simona Filomena Madeo, Alberto Verrotti, Filippo De Luca, Lorenzo Iughetti

“…At diagnosis of CPP, height SDS adjusted for target height (H-TH SDS) was significantly reduced in A than in C (−0.63 ± 1.94 versus 1.56 ± 1.38), while basal LH and oestradiol levels were significantly elevated in A than in C. During follow-up, despite an effective treatment, growth impairment deteriorated in A than in C (Δ H-SDS from diagnosis of CPP to last follow-up: −0.49 ± 0.91 versus 0.21 ± 0.33, p=0.023). …”
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Integrating behavioral and neurophysiological insights: High trait anxiety enhances observational fear learning by Xianchao Ming, Ganzhong Luo, Jinxia Wang, Haoran Dou, Hong Li, Yi Lei

“…Furthermore, during the direct test phase, HTA participants reported significantly elevated fear and shock expectancy ratings for both types of stimuli, in contrast to their LTA counterparts. …”
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High levels of histone acetylation modifications promote the formation of PGCs by Ziduo Zhao, Yuhui Wu, Fufu Cheng, Zhe Wang, Qingqing Geng, Yingjie Niu, Qisheng Zuo, Yani Zhang

“…The acetate treatment group exhibited a significantly higher number of embryoid bodies and elevated expression levels of CVH, C-KIT, and NANOS3 compared to the ANAC group (P < 0.01). …”
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Targeting OAS3 for reversing M2d infiltration and restoring anti-tumor immunity in pancreatic cancer by Shaopeng Zhang, Ximo Xu, Kundong Zhang, Changzheng Lei, Yitian Xu, Pengshan Zhang, Yuan Zhang, Haitao Gu, Chen Huang, Zhengjun Qiu

“…M2d is characterized by elevated secretion of IL-10 and VEGF-A, which diminish CD8+T cells cytotoxicity and promote tumor neoangiogenesis simultaneously. …”
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