A Simplified Method for Evaluating Chitin-Binding Activity Applied to YKL-40 (HC-gp39, CHI3L1) and Chitotriosidase by Keita Suzuki, Hidetoshi Suzuki, Ami Tanaka, Miwa Tanaka, Kairi Takase, Hiromu Takei, Tomoki Kanaizumi, Kazuaki Okawa, Peter O. Bauer, Fumitaka Oyama

“…YKL-40 is structurally similar to chitotriosidase (CHIT1), an active chitinase, but it lacks chitin-degrading activity while retaining chitin-binding capability. Elevated YKL-40 levels are associated with inflammatory diseases and cancers, making it a valuable biomarker. …”
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Snap diagnosis of fulminant type 1 diabetes by the normalized glucose/HbA1c ratio by Jun-Ichiro Mori, Takahiro Miyakoshi, Hanae Yuzuriha, Teruki Kondo, Eita Nishimori, Motoji Naka, Ai Sato, Mitsuhisa Komatsu, Koh Yamashita, Toru Aizawa

“…Elevated Fulminant Index (FI), [plasma glucose (PG)/glycosylated hemoglobin A1c (HbA1c)], was reportedly a sensitive index to differentiate fulminant type 1 diabetes (FT1D) from non-fulminant T1D (nFT1D). …”
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Impact of Different Sugar Syrups on the Development of the Fat Body in Worker Bees (<i>Apis mellifera macedonica</i>) by Svilen B. Lazarov, Petya M. Veleva, Atanas Z. Atanasov, Ivaylo S. Hristakov, Zlatko Puškadija

“…Apiinvert and honey/water syrup promoted higher fat body stages, while Isosweet led to elevated fifth degrees of development but raised concerns about potential toxicity due to the hydroxymethylfurfural (HMF) formation of improperly stored syrups. …”
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Exploratory analysis of a Novel RACK1 mutation and its potential role in epileptic seizures via Microglia activation by Sai Zhang, Zhaofei Dong, Jing Guo, Ze Li, Hong Wu, Linming Zhang, Fuli Min, Tao Zeng

“…Additionally, excitatory synapse density and size in the hippocampal CA1 region of mutant mice were significantly elevated, accompanied by increased expression of VGLUT1 and PSD95 within microglia. …”
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Association between atherogenic index of plasma and type 2 diabetic complications: a cross-sectional study by Yue-Yang Zhang, Yue-Yang Zhang, Yue-Yang Zhang, Yue-Yang Zhang, Yue-Yang Zhang, Xiao-Yu Yang, Xiao-Yu Yang, Xiao-Yu Yang, Xiao-Yu Yang, Xiao-Yu Yang, Qin Wan, Qin Wan, Qin Wan, Qin Wan, Qin Wan

“…In this study, logistic regression, restricted cubic splines, and subgroup analyses were employed to evaluate the association between the AIP and four major complications of type 2 diabetes, namely, type 2 diabetes with carotid atherosclerosis (DA), diabetic kidney disease (DKD), diabetic retinopathy (DR), and diabetic peripheral neuropathy (DPN).ResultsThe logistic regression results demonstrate that in the fully adjusted model, each SD increase in AIP correlates with an elevated risk of type 2 diabetic kidney disease (DKD), with the risk of kidney damage intensifying alongside higher AIP groupings. …”
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Lymphoid Progenitor Cells from Childhood Acute Lymphoblastic Leukemia Are Functionally Deficient and Express High Levels of the Transcriptional Repressor Gfi-1 by Jessica Purizaca, Adriana Contreras-Quiroz, Elisa Dorantes-Acosta, Eduardo Vadillo, Lourdes Arriaga-Pizano, Silvestre Fuentes-Figueroa, Horacio Villagomez-Barragán, Patricia Flores-Guzmán, Antonio Alvarado-Moreno, Hector Mayani, Isaura Meza, Rosaura Hernandez, Sara Huerta-Yepez, Rosana Pelayo

“…Interestingly, a number of quiescence-associated transcription factors were elevated, including the transcriptional repressor Gfi-1, which was highly expressed in primitive CD34+ cells. …”
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Proportions of Proinflammatory Monocytes Are Important Predictors of Mortality Risk in Hemodialysis Patients by Yachung Jeng, Paik Seong Lim, Ming Ying Wu, Tien-Yu Tseng, Chang Hsu Chen, Hung Ping Chen, Tsai-Kun Wu

“…Compared to the reference group (CD16+ monocytes within [15.6–18.6], the first and second quartile), patients with CD16+ monocytes above the highest quartile level (>21.5) had an adjusted hazard ratio (HR) of 30.85 (95% confidence interval [CI]: 7.12–133.8) for CVD mortality and 5.28 (2.07–13.49) for all-cause mortality, and those with CD16+ monocytes below the lowest quartile ≤15.6), had significantly elevated death risks after 3.5-year follow-up (HR [95% CI]: 10.9 [2.42–48.96] and 4.38 [1.45–13.24] for CV and all-cause mortalities, respectively). …”
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Epsin3 promotes non-small cell lung cancer progression via modulating EGFR stability by Huiling Su, Jie Shen, Chenzi Gao, Yue Zhao, Wanyu Deng, Bo Qin, Xin Zhang, Juan Lai, Qian Wang, Jie Dou, Min Guo

“…Results Our findings revealed that the expression of EPN3 is significantly up-regulated in NSCLC patients. Elevated EPN3 expression was proportional to shorter overall survival in patients with NSCLC. …”
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Geochemical evolution and mechanisms controlling groundwater chemistry in the transboundary Komadugu–Yobe Basin, Lake Chad region: An integrated approach of chemometric analysis an... by Abdulrahman Shuaibu, Robert M. Kalin, Vernon Phoenix, Ibrahim Mohammed Lawal

“…Groundwater in the basin is predominantly of Ca–HCO₃ and Na–Cl types and is significantly undersaturated with calcite, dolomite, and fluorite, though seasonal variations show saturation in some samples. Elevated partial pressures of CO₂ (pCO₂) above atmospheric pCO₂ in nearly all samples suggests active biogeochemical processes. …”
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Pharmaceutical orientation and applications of silver/zinc oxide nanoparticles developed from various fruit peel extracts: an emerging sustainable approach by Mahima Chaudhary, Priyvart Choudhary, Anjali Tripathi, Vinay Kumar Pandey, Rohit Sharma, Seema Singh, Sarvesh Rustagi, Amritanshu Pathak

“…The controlled release of zinc from nanoparticles opens avenues for agricultural applications, enhancing nutrient availability for plants and elevating crop yields. The customization of nanoparticles for catalysis, sensing, and optoelectronics highlights their versatility and adaptability for diverse industrial applications. …”
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Semiclassical Estimates of Pressure-induced Line Widths for Infrared Absorption in Hot (Exo)planetary Atmospheres by Jeanna Buldyreva, Kathleen Stehlin, Sergei N. Yurchenko, Elizabeth R. Guest, Jonathan Tennyson

“…Because of elevated temperatures and high fluxes of stellar radiation irreproducible in laboratory conditions, molecules and molecular ions found or expected in exoplanetary atmospheres are generally poorly characterized from the viewpoint of their spectroscopic line-shape parameters; in many cases, there are no data at all. …”
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Concentration-dependent effect of norfloxacin on iron toxicity in the intestine of large yellow croaker Larimichthys crocea (Richardson, 1846) by Lin Zeng, Yong-Hong Wang, Chun-Xiang Ai, Bin Liu, Bin Liu, Min-Hui Yu, Hui Zhang, Fei Li

“…Compared to Fe alone exposure, Fe plus HNOR exposure elevated MDA, PC, and mortality rate, and deteriorated intestinal malformations by inhibiting Fe excretion, energy metabolism, anti-inflammatory response, and protein folding protective effect, and enhancing pro-inflammatory response, indicating a synergetic effect between HNOR and Fe stress. …”
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Relationships of Insulin Action to Age, Gender, Body Mass Index, and Waist Circumference Present Diversely in Different Glycemic Statuses among Chinese Population by Shao-jie Pang, Qing-Qing Man, Shuang Song, Peng-Kun Song, Zhen Liu, Yu-Qian Li, Shan-Shan Jia, Jing-Zhong Wang, Wen-Hua Zhao, Jian Zhang

“…As compared with participants with a BMI from 18.5 to 19.9, those in the lowest BMI category (<18.5) had a significantly elevated risk of IR (OR, 1.96; 95% CI, 1.01–3.80), as did those in the higher BMI categories among NFG participants. …”
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The effect of NLRP3 inflammasome on cardiovascular prognosis in patients with acute coronary syndrome by De-Gang Mo, Ming-Ting Liang, Li Xu, Tai Li, Qian-Feng Han, Chen Chen, Heng-Chen Yao

“…Multivariate Cox regression identified NLRP3 inflammasome content as an independent risk factor for MACEs (hazard ratio 1.104, p = 0.001; area under the curve: 0.780 [95% confidence interval 0.721–0.840], p < 0.001). Elevated plasma NLRP3 inflammasome levels correlated with ACS severity and were associated with poorer short-term outcomes in patients with ACS.…”
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Sustainability-driven fertilizer recommender system for coffee crops using case-based reasoning approach by Edinson David León Chilito, Juan Fernando Casanova Olaya, Juan Fernando Casanova Olaya, Juan Carlos Corrales, Cristhian Figueroa

“…In Colombia, coffee cultivation plays a fundamental role in the economy, thus creating a recognized demand to elevate its production while minimizing its environmental impact sustainably.MethodologyThe study follows the CRISP-DM methodology (Cross-Industry Standard Process for Data Mining) developing of a fertilizer recommender system (FRS) for coffee crops. …”
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Renal Evaluation in Common Variable Immunodeficiency by Giovany Gomes Capistrano, Gdayllon Cavalcante Meneses, Fernanda Macedo de Oliveira Neves, Renata de Almeida Leitão, Alice Maria Costa Martins, Alexandre Braga Libório

“…Patients showed a trend towards an elevated prevalence of tubular dysfunction, mainly related to urinary acidification and concentration capacities.…”
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Rapamycin Improves Palmitate-Induced ER Stress/NF κ B Pathways Associated with Stimulating Autophagy in Adipocytes by Jiajing Yin, Liping Gu, Yufan Wang, Nengguang Fan, Yuhang Ma, Yongde Peng

“…An in vitro model was used in which 3T3-L1 adipocytes were preloaded with palmitate (PA) to generate artificial hypertrophy mature adipocytes. Elevated autophagy flux and increased number of autophagosomes were observed in response to PA and rapamycin treatment. …”
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Upregulation of HSP90α in the lungs and circulation in sarcoidosis by Takuma Isshiki, Takuma Isshiki, Takuma Isshiki, Motoko Sunakawa, Megan Vierhout, Megan Vierhout, Anmar Ayoub, Anmar Ayoub, Pareesa Ali, Pareesa Ali, Safaa Naiel, Safaa Naiel, Shion Miyoshi, Asghar Naqvi, Nathan Hambly, Kazuma Kishi, Kjetil Ask, Kjetil Ask, Martin R. J. Kolb

“…Serum HSP90α levels were elevated in sarcoidosis patients compared with controls and correlated with BALF HSP90α levels. …”
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Unraveling Abnormal Thermal Quenching of Sub‐Gap Emission in β‐Ga2O3 by Zhengpeng Wang, Fei Tang, Fang‐Fang Ren, Hongwei Liang, Xiangyuan Cui, Shijie Xu, Shulin Gu, Rong Zhang, Youdou Zheng, Jiandong Ye

“…The semi‐classical quantum theory models fitting proves the transition from green to UV emissions with elevated temperature. The enhanced STEs emission with distinguished NTQ effect strengthens evidence that the stable polarons inherently limit the transport of holes in Ga2O3, and also support the potential of Ga2O3 materials for the development of UV optoelectronics.…”
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Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment by Qiuming Zou, Xiaofeng Zhou, Jianqin Lai, Haixia Zhou, Jinxuan Su, Zhijing Zhang, Xiaosong Zhuang, Lili Liu, Ruijie Yuan, Sijia Li, Siyu Yang, Xinyi Qu, Jiezhu Feng, Yongqi Liu, Zisheng Li, Shiting Huang, Zhi Shi, Yu Yan, Zhiming Zheng, Wencai Ye, Qi Qi

“…The SFN-induced ferroptotic cell death was characterized by elevated ROS levels, lipid peroxidation, and GSH depletion, which was dependent on decreased levels of SLC7A11. …”
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