β-Nicotinamide Mononucleotide Reduces Oxidative Stress and Improves Steroidogenesis in Granulosa Cells Associated with Sheep Prolificacy via Activating AMPK Pathway by Yu Cai, Hua Yang, Hui Xu, Shanglai Li, Bingru Zhao, Zhibo Wang, Xiaolei Yao, Feng Wang, Yanli Zhang

“…Here, we identified elevated nicotinamide levels in the follicular fluid of high-prolificacy sheep, correlated with oxidative stress in GCs, by an integrated analysis. …”
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MAC30 Knockdown Inhibits Proliferation and Enhance Apoptosis of Gastric Cancer by Suppressing Wnt/β-Cateninsignaling Pathway by Xiaohong Wu, Yong Zhang, Junping Guo, Xun Yan, Li Shen, Jianping Zhou, Jun Zhao, Min Zhuang, Zhihong Cao

“…The expression of MAC30 was abnormally elevated in gastric cancer tissues, while interfering of its expression could significantly inhibit the proliferation of gastric cancer BGC-823 cell line. …”
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The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms by Jing Zhang, Na Sun, Wanhao Zhang, Wenjie Yue, Xiaochen Qu, Xiaochen Qu, Zhonghai Li, Zhonghai Li, Gang Xu, Gang Xu

“…Serum urate (SU) levels are significantly elevated in conditions such as gout, type 2 diabetes (T2D), obesity, and other metabolic syndromes. …”
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Wogonin effects on the efflux transporters BCRP and MRP2, explain its effectiveness in ulcerative colitis: Implications for metabolic and transport interactions by Yuanyuan Liu, Zerong Zhang, Xiaoyan Li, Qinghong Hu, Zhangyu Jiang, Jia Lv, Jiayi Xue, Dongyu Wang, Jianxiong Cao, Lingyu Li, Xiaowen Ou, Lijun Zhu, Zhongqiu Liu, Tao Su

“…In these knockout mice, the content of wogonin was increased in the plasma but decreased in the colon tissues, suggesting that deficiencies in BCRP and MRP2 hinder the efflux of wogonin, resulting in elevated content in the plasma. Moreover, in vitro results showed that after knockout of BCRP and MRP2, the concentration of wogonin increased, and its UGT metabolite wogonoside decreased in both cells and mitochondria. …”
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Pretreatment neutrophil-to-lymphocyte ratio is associated with immunotherapy efficacy in patients with advanced cancer: a systematic review and meta-analysis by Jialin Su, Yuning Li, Shuhua Tan, Tianli Cheng, Yongzhong Luo, Lemeng Zhang

“…The quality of evidence was low, attributed to the serious risk of bias and incon¬sistency. An elevated NLR before immunotherapy was significantly associated with poor clinical outcomes in patients with advanced cancer.…”
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Detecting Genetic Associations between ATG5 and Lupus Nephritis by trans-eQTL by Yue-miao Zhang, Fa-juan Cheng, Xu-jie Zhou, Yuan-yuan Qi, Ping Hou, Ming-hui Zhao, Hong Zhang

“…Numerous loci were identified to perturb gene expression in trans. As elevated ATG5 expression was observed in systemic lupus erythematosus (SLE), the study was conducted to analyze the genome-wide genetic regulatory mechanisms associated with ATG5 expression in a Chinese population with lupus nephritis (LN). …”
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Selective Laser Sintering 3D Printing of Carvedilol Tablets: Enhancing Dissolution Through Amorphization by Nikola Pešić, Branka Ivković, Tanja Barudžija, Branka Grujić, Svetlana Ibrić, Djordje Medarević

“…When the powder mixture is exposed to elevated temperatures during SLS printing, the active ingredients can be converted from the crystalline to the amorphous state, which can be used as a strategy to improve the dissolution rate and bioavailability of poorly soluble drugs. …”
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Risk of second primary malignancies among survivors of cutaneous melanoma: A nationwide population-based study in the Republic of Korea by Joon Min Jung, Do Hyung Kim, Ye-Jee Kim, Ik Jun Moon, Woo Jin Lee, Sung Eun Chang, Mi Woo Lee, Chong Hyun Won

“…The risk of overall and specific SPMs was significantly elevated in Asian melanoma survivors, particularly among those with invasive melanoma. …”
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Concentrating Mill Wastes are the Source of Pollution of Human Environment and Natural Ecosystems with Heavy Metals: A Case Study in Primorsky Krai, Russian Federation by Irina A. Tarasenko, Alexander V. Zin’kov, Aleksei S. Kholodov, Muhammad Riaz, Valeriy I. Petukhov, Nikita Y. Popov, Aristidis Tsatsakis, Kirill S. Golokhvast

“…Elevated contents of hazardous elements in natural ecosystems are often associated with human activities. …”
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Soil health of bananas cultivated in Ribeira River Valley – the major producing region of Brazil by Cavalieri-Polizeli Karina Maria Vieira, da Silva Anderson Lucas, Cremonesi Marcus, Lima Juliana Domingues, Cipriano Patriciani Estela, Cherubin Maurício Roberto, Rozane Danilo Eduardo

“…Compared with natural forests, in general, banana crop soil showed elevated values of the chemical indicators, mainly due to the frequent fertiliser applications. …”
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Malaria exposure remodels the plasma proteome of Ghanaian children by Aisha M. Mohammed, Charles Ochieng’ Olwal, Andrea Fossati, Nancy K. Nyakoe, Jacqueline M. Fabius, Martin Gordon, Benjamin J. Polacco, Danielle L. Swaney, Gordon A. Awandare, Nevan J. Krogan, Mehdi Bouhaddou, Yaw Bediako

“…Differentially abundant proteins were enriched in immune response processes, including complement cascade activities and elevated platelet activation. We found IGKV3D-20 protein to be strongly associated with high malaria exposure. …”
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Examining the effect of salbutamol use in ozone air pollution by people with exercise‐induced bronchoconstriction by Bennett T. Stothers, Andy Hung, Patric E. O. Gonçalves, Lulu X. Pei, Tessa van deKerkhof, Jem I. Arnold, Owen D. Harris, Nadine Borduas‐Dedekind, Andrew W. Sheel, Michael S. Koehle

“…This evidence suggests that it is safe for people with EIB to continue to use salbutamol as prescribed when ozone levels are elevated.…”
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Disruption of Tumor Necrosis Factor Receptor-Associated Factor 5 Exacerbates Murine Experimental Colitis via Regulating T Helper Cell-Mediated Inflammation by Jian Shang, Lixia Li, Xiaobing Wang, Huaqin Pan, Shi Liu, Ruohang He, Jin Li, Qiu Zhao

“…TRAF5 deficiency significantly enhanced IFN-γ, IL-4, and IL-17a mRNA and protein levels in the colons of DSS-fed mice, and the mRNA expression of T-bet and GATA-3 was also markedly elevated. However, ROR-α and ROR-γt mRNA levels did not differ between DSS-induced KO and WT mice. …”
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AAV-KLF7 Promotes Descending Propriospinal Neuron Axonal Plasticity after Spinal Cord Injury by Wen-Yuan Li, Ying Wang, Feng-Guo Zhai, Ping Sun, Yong-Xia Cheng, Ling-Xiao Deng, Zhen-Yu Wang

“…In vitro, KLF7 and target proteins were successfully elevated and axonal outgrowth was enhanced. In vivo, young adult C57BL/6 mice received a T10 contusion followed by an AAV-KLF7 injection at the T7–9 levels above the lesion. …”
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Characterizing Radon Among Public Buildings and Small/Medium-Sized Businesses in a Canadian Province by Lily X. Yang, Tracy L. Kirkham, Laura Boksman, Anne-Marie Nicol, Paul A. Demers

“…Radon levels also varied significantly based on window-opening behavior, business access type, the presence of an elevator, air conditioning, additions to the building, and cracks and/or gaps in the foundation/wall and around drains, indicating building characteristics with some influence on air circulation may impact overall radon levels.…”
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Biopreservation of Shrimps Using Composed Edible Coatings from Chitosan Nanoparticles and Cloves Extract by Ahmed A. Tayel, Aml F. Elzahy, Shaaban H. Moussa, Mohammed S. Al-Saggaf, Amany M. Diab

“…Additionally, the sensorial attributes (appearance, odor, color, and texture) of EC-treated samples preserved their elevated qualities for storage duration. The most effective EC blend contained 1.5% from Cht/NPs and 1.0% from CLE. …”
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LIVER DISEASE & SICKLE CELL DISEASE: AUTOIMMUNE HEPATITIS MORE THAN A COINCIDENCE; A SYSTEMATIC LITERATURE REVIEW. by Kelvin Lynch, Andrea Mega, Andrea Piccin, Massimo Daves, Helen Fogarty

“…More than 50% of SCD patients have elevated liver enzymes. Common underlying aetiologies include sickle cell hepatic crisis, viral hepatitis, sickle cell intrahepatic cholestasis and hepatic sequestration in the acute setting, and cholelithiasis and iron overload in the chronic setting. …”
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Effect of Phosphate Amendment on Cadmium Accumulation in Pepper (<i>Capsicum annuum</i> L.) Grown in Geogenic Cd-Rich Soil from the Karst Region by Yuyang Li, Dan Xing, Rong Wen, Wangwang Zhou, Yongxiang Zhang, Yizhang Liu

“…High contents of total Cd (6.19 mg/kg) and bioavailable Cd (2.72 mg/kg, 44%) in the studied soils resulted in elevated Cd content in pepper, and it decreased in the order of root (8.18 mg/kg) > stem (4.89 mg/kg) > fruit (3.88 mg/kg). …”
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Traffic-related air pollution (TRAP) exposure, lung function, airway inflammation and expiratory microbiota: A randomized crossover study by Rongrong Xu, Yanping Zhang, Tingting Wu, Hao Liu, Jianhao Peng, Zhanshan Wang, Te Ba, Baorong Zhang, Zhigang Li, Yongjie Wei

“…TRAP including NO2 and CO in the road were about 1.5 times higher than that in the park except for PMs, and total VOCs also showed higher concentrations. We observed elevated difference in FeNO was associated with high TRAP exposure in the road session, but didn’t find obvious changes in lung function. …”
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Prevalence of Metabolic Syndrome One Year after Delivery in Finnish Women at Increased Risk for Gestational Diabetes Mellitus during Pregnancy by Jatta Puhkala, Tarja I. Kinnunen, Tommi Vasankari, Katriina Kukkonen-Harjula, Jani Raitanen, Riitta Luoto

“…Twenty-seven percent had elevated fasting plasma glucose (≥5.6 mmol/L), and 29% had reduced HDL cholesterol (≤1.3 mmol/L). …”
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