Abcb1 is involved in the efflux of trivalent inorganic arsenic from brain microvascular endothelial cells by Man Lv, Ziqiao Guan, Jia Cui, Xinbo Ma, Kunyu Zhang, Xinhua Shao, Meichen Zhang, Yanhui Gao, Yanmei Yang, Xiaona Liu

“…Increased arsenic levels were observed in mice exposed to 25 mg/L or 50 mg/L of sodium arsenite (NaAsO2) in drinking water, and both arsenic uptake and efflux were detected in bEnd.3 cells treated with 16 μmol/L NaAsO2. Elevated levels of Abcb1 protein were found in the NaAsO2-exposed mouse brain microvascular endothelium and in NaAsO2-treated bEnd.3 cells. …”
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Best1 mitigates ER stress induced by the increased cellular microenvironment stiffness in epilepsy by Hao Wu, Yicong Dong, Qiang Meng, Jingyi Jiang, Bojian Gao, Yutao Ren, Yong Liu, Huanfa Li, Changhe Wang, Hua Zhang

“…The expression levels of ECM and ER stress-related proteins were elevated in tissues with higher stiffness. Polypropionamide hydrogels were used to simulate extracellular matrix (ECM) with varying stiffness levels. …”
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Anxiety and neurometabolite levels in the hippocampus and amygdala after prolonged exposure to predator-scent stress by O. B. Shevelev, V. E. Tseilikman, N. V. Khotskin, А. S. Khotskina, G. V. Kontsevaya, M. S. Lapshin, M. P. Moshkin, M. V. Komelkova, I. V. Feklicheva, O. B. Tseilikman, E. B. Manukhina, H. F Downey, E. L. Zavjalov

“…Animals of the second phenotype showed elevated levels of lactate in the hippocampus compared to animals of the first phenotype, and the lowest N-acetylaspartate levels significantly differed from those in the control and the first phenotype animals. …”
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Autophagy is involved in the toxicity of the biocontrol agent GC16 against Tetranychus pueraricola (Acari: Tetranychidae) based on transcriptomic and proteomic analyses by Yanyan He, Guangzu Du, Guang Wang, Huiming Guan, Shusheng Zhu, Bin Chen, Xiahong He, Youyong Zhu

“…Conclusions Autophagy is involved in the toxicity of GC16 against T. pueraricola and may be activated by elevated Ca2+ levels. This study reveals the molecular insecticidal mechanisms of GC16 and provides rationale for the field application of GC16 to control pest mites.…”
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Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis by Wan-fu Lin, Mao-feng Zhong, Yu-ren Zhang, Huan Wang, He-tong Zhao, Bin-bin Cheng, Chang-quan Ling

“…A total of 297 potential studies were initially identified, and 9 studies comprising 2449 patients were finally enrolled to evaluate the association between the pretreatment PLR and clinical outcomes of overall survival (OS), disease-free survival (DFS), and event occurrence in patients with HCC in different BCLC stages. An elevated pretreatment PLR indicated unfavorable worse OS (HR = 1.73; 95% CI: (1.46, 2.04); P<0.00001) and DFS (HR = 1.30; 95% CI: (1.06, 1.60); P=0.01). …”
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Peripheral mitochondrial transplantation alleviates diabetes-associated cognitive dysfunction by suppressing cuproptosis by Juan Hu, Qiao Li, Shiqiu Jiang, Yingying Deng, Lan Yang, Mengyu Du, Shuxuan He, Fuxing Xu, Chaoying Yan, Wei Gao, Yansong Li, Yaomin Zhu

“…The findings revealed that in primary neurons exposed to HG/Pal, the expression of copper levels was elevated, and the levels of FDX1, LIAS, and DLAT were reduced. …”
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Selenium’s Role in Plant Secondary Metabolism: Regulation and Mechanistic Insights by Yan Zhou, Kaiqin Nie, Lulu Geng, Yixin Wang, Linling Li, Hua Cheng

“…Consequently, Se biofortification has emerged as an effective strategy to elevate Se content and nutritional quality in plants, attracting widespread attention. …”
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Chimonanthus nitens Oliv. leaves flavonoids alleviate hyperuricemia by regulating uric acid metabolism and intestinal homeostasis in mice by Wenya Meng, Lingli Chen, Kehui Ouyang, Suyun Lin, Yang Zhang, Jing He, Wenjun Wang

“…Further research showed that CLF treatment restored intestinal homeostasis mediated by improving the composition of gut microbiota and elevating the abundance of beneficial bacteria like Lactobacillus, Alistipes, Prevotellaceae_UCG-001 and Parasutterella. …”
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Proteomic Characterization of Liver Cancer Cells Treated with Clinical Targeted Drugs for Hepatocellular Carcinoma by Hezhou Long, Jiafu Zhou, Changxia Zhou, Shuyu Xie, Jingling Wang, Minjia Tan, Junyu Xu

“…These sites were associated with poor prognosis and elevated functional scores. <b>Conclusions</b>: In summary, this study conducted an in-depth analysis of the molecular alterations in proteins and phosphorylation modifications induced by clinical HCC-targeted drugs, predicting drug combination strategies and therapeutic targets.…”
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Radiation Induces Pulmonary Fibrosis by Promoting the Fibrogenic Differentiation of Alveolar Stem Cells by Lu-Kai Wang, Tsai-Jung Wu, Ji-Hong Hong, Fang-Hsin Chen, John Yu, Chun-Chieh Wang

“…Moreover, radiation drove LSCs to fibrosis as shown with the elevated levels of markers for epithelial-mesenchymal transition and myofibroblast (α-smooth muscle actin (α-SMA)) differentiation in in vitro and ex vivo studies. …”
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Multispecies occupancy models unravel reduced colonization probabilities in plants from the unique Amazonian cangas by Rafael de Fraga, Luiz Gustavo Rodrigues Oliveira Santos, Valeria da Cunha Tavares, Leonardo Carreira Trevelin, Maurício Takashi Coutinho Watanabe, Leandro Maioli, Samir Rolim, Carolina da Silva Carvalho

“…Negative equilibrium was more associated with the reduced colonization probabilities than with elevated extinction probabilities. Our results indicate that for some wide-ranging species, negative metapopulation equilibrium was restricted to mining plots, indicating sensitivity of these species to environmental changes caused by mining. …”
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Association of Glioblastoma Multiforme Stem Cell Characteristics, Differentiation, and Microglia Marker Genes with Patient Survival by Sandra Bien-Möller, Ellen Balz, Susann Herzog, Laura Plantera, Silke Vogelgesang, Kerstin Weitmann, Carolin Seifert, Matthias A. Fink, Sascha Marx, Angela Bialke, Chitra Venugopal, Sheila K. Singh, Wolfgang Hoffmann, Bernhard H. Rauch, Henry W. S. Schroeder

“…At protein level, CD44, ELF4, Nanog, Nestin, and Sparc were elevated in GBM, but only CD133 and Nestin were strongly associated with survival time. …”
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RETRACTED: The role and molecular mechanism of Trop2 induced epithelial‐mesenchymal transition through mediated β‐catenin in gastric cancer by Wei Zhao, Lizhou Jia, Xingwang kuai, Qi Tang, Xiaochen Huang, Tingting Yang, Zhenning Qiu, Jin Zhu, Jianfei Huang, Wenbin Huang, Zhenqing Feng

“…Trop2 promoted the metastasis and induces EMT in GC. Meanwhile, the elevated protein levels of Trop2 and mesenchymal markers were also found in the TGF‐β1‐induced EMT model in GC cells. …”
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The role of the STING inflammatory pathway in hepatic damage in psoriasis with type 2 diabetes mellitus by Shulin Huang, Kun Xie, Xiaohong Li, Xiangjin Xu, Pin Chen

“…In the in vivo experiments, liver tissues from model mice exhibited significantly elevated expression of STING and its downstream inflammatory factors, including NF-κB p65, interferon-β, interleukin (IL)-17A, and IL-23 (p < 0.05). …”
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Compensatory increase in oxygen extraction fraction is associated with age-related cerebrovascular disease by John McFadden, Julian Matthews, Lauren Scott, Karl Herholz, Ben Dickie, Hamied Haroon, Oliver Sparasci, Saadat Ahmed, Natalia Kyrtata, Geoffrey J.M. Parker, Hedley C.A. Emsley, Joel Handley, Maélène Lohezic, Laura M. Parkes

“…We used a simultaneous PET-MRI protocol to measure OEF, CBF, CMRO2, and arterial transit time (ATT) in elderly people (n = 24, age 69.6 ± 5.3 years) with a range of vascular disease risk (QRisk 18.7 ± 10.8 %) and cognitive abilities (MoCA scores 26.7 ± 3.4) to determine if a) vascular disease risk (parameterised with QRisk2 score) is associated with altered CBF, ATT, OEF and CMRO2, b) if impaired blood supply and increasing transit times are associated with elevated OEF and c) if these physiological measures are associated with impaired cognition. …”
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Association of homocysteine and uric acid with type 2 diabetes mellitus: a case-control study by Xiaolong Yang, Qiuqiu Lan, Qingan Wang, Yixuan Xue, Jiaxing Zhang, Xiaoxia Li, Yi Zhao, Yuhong Zhang

“…Plasma Hcy and UA levels were significantly higher in diabetic patients compared to non-diabetic controls (p < 0.001, p = 0.002). Elevated Hcy and UA were risk factors for T2DM. Binary logistic regression analysis showed that compared with the lowest quartile of Hcy and UA, the highest quartile had a significantly increased risk of T2DM (OR = 1.629, 95% CI: 1.303, 2.035 for Hcy; OR = 1.596, 95% CI: 1.277, 1.995 for UA). …”
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Risk factors for postoperative acute kidney injury after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: a meta-analysis and systematic review by Dengzhuo Chen, Yongli Ma, Jinghui Li, Liang Wen, Linfeng Liu, Guosheng Zhang, Hongkai Hu, Chengzhi Huang, Xueqing Yao

“…In addition, the risk of postoperative AKI varied by primary tumor site, with Appendix being less prone to AKI, while mesothelioma and ovarian, two sites with a greatly elevated risk of postoperative AKI. Conclusions This meta-analysis identified a number of risk factors for postoperative AKI after CRS + HIPEC. …”
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Enhanced CATBraTS for Brain Tumour Semantic Segmentation by Rim El Badaoui, Ester Bonmati Coll, Alexandra Psarrou, Hykoush A. Asaturyan, Barbara Villarini

“…The results demonstrate that E-CATBraTS achieves both high segmentation accuracy and elevated generalisation abilities, ensuring the model is robust to dataset variation.…”
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Clinical Features and Risk Factors of Active Tuberculosis in Patients with Behçet’s Disease by Yaxu Liu, Lifan Zhang, Ziyue Zhou, Luxi Sun, Baotong Zhou, Xiaoqing Liu, Wenjie Zheng

“…Our study suggested that when BD patients have systemic symptoms with significantly elevated TB-SPOT, the diagnosis of ATB should be considered.…”
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Effect of Radiation, Organic Solvents and Vibration Occupational Exposure on the Thyroid Disease: Results from Project ELEFANT by Bibo Yuan, Citlalli Osorio-Yáñez, Junkai Fang, Lei Zhao, Ander Wilson, Marco Sanchez-Guerra, Hongbin Liu, Peng-Hui Li, Liqiong Guo

“…Our results show, for the first time, that vibration exposure is associated with an increased risk of thyroid disease and elevated TSH levels. If these findings are confirmed in other cohorts, thyroid examinations should be conducted for individuals exposed to vibration in the workplace.…”
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