lncRNA PAPPA-AS1 Induces the Development of Hypertrophic Scar by Upregulating TLR4 through Interacting with TAF15 by Pengju Fan, Yongjie Wang, Jingjing Li, Man Fang

“…The expression levels of TLR4, MyD88, TGF-β1, collagen I, collagen III, and α-SMA were greatly elevated in HTsFb cells. By knocking down PAPPA-AS1, the proliferation of HTsFb cells, TLR4, and TGF-β1 signal pathway and the expression of fibrosis markers both in HTsFb cells and HTS tissues were suppressed. …”
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The Passage of Chaperonins to Extracellular Locations in <i>Legionella pneumophila</i> Requires a Functional Dot/Icm System by Peter Robertson, David S. Allan, Rafael A. Garduño

“…The analysis of periplasmic extracts and outer membrane vesicles of these mutants, where HtpB co-localized with bona fide periplasmic proteins, confirmed the elevated levels of periplasmic HtpB. Genetic complementation of the mutants recovered parent strain levels of surface-exposed and periplasmic HtpB. …”
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Case Study: Analyzing CFTR Mutations and SNPs in Pulmonary Fibrosis Patients with Unclear Symptoms by Sahar Yousaf, null Sumaira, Iqbal Bano, Atia Rehman, Samra Kousar, Muhammad Usman Ghani, Mariam Shahid

“…In this case report, a suspected patient with ambiguous respiratory symptoms underwent a comprehensive investigation revealing elevated CRP levels, TLC, and characteristic pulmonary manifestations on chest X-ray, suggesting cystic fibrosis. …”
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Crise du sport scolaire et universitaire au Sénégal : des conflits personnels et institutionnels aux carences financières, infrastructurelles et organisationnelles by Mouhamed Dit Momar Talla NDONGO, Danty Patrick DIOMPY, Souleymane DIALLO

“…Des professeurs d’EPS s’élèvent pour boycotter encore les activités du secteur posant paradoxalement des actes caractéristiques d’une prolongation de la crise dont les nouvelles fédérations créées ont pour but de résoudre. …”
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The Effect of Chronic Candesartan Therapy on the Metabolic Profile and Renal Tissue Cytokine Levels in the Obese Zucker Rat by Carolyn M. Ecelbarger, Arjun Rash, Rajesh K. Sinha, Swasti Tiwari

“…An ELISA-based cytokine array revealed that candesartan normalized elevated renal interleukin (IL) 1-β and monocyte chemoattractant protein-1 (MCP-1) levels in OZ. …”
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The modern use of hydroxyurea for children with sickle cell anemia by Charles T. Quinn, Russell E. Ware

“…From initial small proof-of-principle studies to multi-center Phase 3 controlled clinical trials and then numerous open-label studies, the consistent benefits of once-daily oral hydroxyurea have been demonstrated across the lifespan. Elevated fetal hemoglobin (HbF) serves as the most important treatment response, as HbF delays sickle hemoglobin polymerization and reduces erythrocyte sickling. …”
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Serum Uric Acid Is Associated with Poor Outcome in Black Africans in the Acute Phase of Stroke by Yacouba N. Mapoure, Chia Mark Ayeah, M. S. Doualla, H. Ba, Hugo B. Mbatchou Ngahane, Salomon Mbahe, Henry N. Luma

“…A total of 701 acute stroke patients were included and the prevalence of hyperuricemia was 46.6% with a mean SUA level of 68.625 ± 24 mg/l. Elevated SUA after stroke was associated with death (OR = 2.067; 95% CI: 1.449–2.950; p < 0.001) but did not predict this issue. …”
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Effects of Late Evening Snack on Cirrhotic Patients: A Systematic Review and Meta-Analysis by Ying-jie Guo, Zi-bin Tian, Na Jiang, Xue-li Ding, Tao Mao, Xue Jing

“…The results showed that the respiratory quotient value (MD = 11.09) and carbohydrate oxidation value (MD = 0.05) significantly elevated with one week or with up to three weeks of LES treatment in cirrhotic patients (P<0.05). …”
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Średniowieczne źródła antropocentryzmu by Anita Ganowicz-Bączyk

“…Mysticism negated both the value of nature and man as accidental entities. Nonetheless, it elevated man above other creatures. Rationalism assigned the man a central position in nature, for only human being among the accidental material entities is endowed with intellect and grace of faith., On the other hand, empiricism enhanced both nature (as the subject of cognition and exploitation) and man (as a rational being, who has some extraordinary abilities to use the environment to satisfy his needs). …”
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Identification of Individuals at Risk of Developing Type 2 Diabetes by Belkis Vicente Sánchez, Ernesto Vicente Peña, Aylín Altuna Delgado, Miriam Costa Cruz

“…<strong><br />Conclusions:</strong> low and slightly elevated risk of developing type 2 diabetes predominated in the study population according to the results of the score applied. …”
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46, XY Complete Gonadal Dysgenesis (Swyer Syndrome) Presenting as Primary Amenorrhea in a Normomorphic Adult Female From Kakamega, Kenya by Christian Omoaghe

“…Swyer syndrome is a rare disorder of sex development, characterized by unambiguous female genitalia, bilateral streak gonads, and elevated gonadotropin levels in individuals with a 46, XY karyotype. …”
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Mechanisms Mediating the Effects of γ-Tocotrienol When Used in Combination with PPARγ Agonists or Antagonists on MCF-7 and MDA-MB-231 Breast Cancer Cells by Abhita Malaviya, Paul W. Sylvester

“…These findings suggest that elevations in PPARγ are correlated with increased breast cancer growth and survival, and treatment that decreases PPARγ expression may provide benefit in the treatment of breast cancer.…”
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Network Pharmacology Analysis of the Therapeutic Potential of Colchicine in Acute Lung Injury by Fei Sun, Lijuan Zhang, Lulu Shen, Chunman Wang

“…In vivo studies showed that colchicine significantly reduced elevated CXCL12 and CXCR4 levels in ALI mice. Conclusion. …”
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THE RELATIONSHIP BETWEEN WORK DEMANDS AND SOCIAL SUPPORT ON WORK STRESS DURING THE PANDEMIC by Nisrina Tiara Sani, Noeroel Widajati, Afrian Eskartya Harjono

“…Result: The findings of the study indicated that: 1) UPT Keselamatan Kerja Surabaya employees fell into elevated work demands, 2) UPT Keselamatan Kerja Surabaya employees obtained a high level of social support, 3) Work demands and social support simultaneously affected employees’ work stress at UPT Keselamatan Kerja Surabaya. …”
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Cardiovascular complications in vascular connective tissue disorders after COVID-19 infection and vaccination. by Anthony L Guerrerio, Allyson Mateja, Gretchen MacCarrick, Jonathan Fintzi, Erica Brittain, Pamela A Frischmeyer-Guerrerio, Harry C Dietz

“…<h4>Background</h4>COVID-19 infection and vaccination have been reported to confer an elevated risk for cardiovascular events (CVE). We sought to determine whether individuals with an underlying vascular connective tissue disorder including Marfan syndrome (MFS), Loeys-Dietz syndrome (LDS), or vascular Ehlers Danlos syndrome (vEDS) are at increased risk for cardiac events after COVID-19 infection or vaccination.…”
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La résilience : facteurs de risque et facteurs de protection dans l’environnement social et scolaire du jeune enfant by Bernard Terrisse, François Larose, Marie-Louise Lefebvre

“…Ils présentent ensuite les résultats d’une étude de résilience réalisée auprès d’un échantillon de 134 élèves provenant de milieux socio-économiquement faibles et ayant bénéficié de mesures d’intervention éducative précoce en 1992-1993. …”
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Mapping evidence on cryptococcal antigen infection among HIV-infected persons in sub-Saharan Africa- A scoping review protocol. by Khululiwe Dlamini, Boitumelo Moetlhoa, Astrid Turner, Kuhlula Maluleke, Tivani Mashamba-Thompson

“…Discoveries from previous studies prelude to the mortality of cryptococcal antigen positive, which persisted to be elevated than in cryptococcal antigen negative persons. …”
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Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil by Mariam Charkviani, Natia Murvelashvili, Francisco Barrera, Alisha Sharma, Randa Sharag Eldin, Nur Un Nisa Nabil

“…In the ED, his ECG had ischemic changes, troponin was elevated, and echocardiogram showed anterior wall hypokinesis. …”
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Inside the impulsive brain: a narrative review on the role of neurobiological, hormonal and genetic factors influencing impulsivity in psychiatric disorders by Hannah Raji, Susha Dinesh, Sameer Sharma

“…The intricate interplay of hormonal influences, specifically cortisol, adrenaline, and testosterone, is meticulously examined, unveiling associations between elevated cortisol levels, excessive adrenaline release, and heightened impulsivity. …”
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Rheumatoid Arthritis Effects on Kidney and Liver and their Correlations with CDAI by Tamara Salman Mohammed, Raya Ezat Maroof, Ali Hussein Al-Hafidh

“…The study showed that the levels of urea, creatinine, GPT, and GOT were either normal or slightly elevated and they are non-significantly associated with RA disease activity, the little effect of RA on kidney and liver may be related to the low doses of methotrexate and corticosteroid therapy which used mostly for these patients and didn’t reach to toxicity. …”
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