The Role of Oral Biomarkers in the Assessment of Noncommunicable Diseases by Gustavo Sáenz-Ravello, Marcela Hernández, Mauricio Baeza, Patricia Hernández-Ríos

“…These markers have demonstrated potential in diagnosing and monitoring systemic conditions. Among others, elevated levels of salivary glucose and inflammatory cytokines correlate with diabetes progression, while vascular endothelial growth factor (VEGF) and salivary C-reactive protein might be applicable as indicators for periodontal disease and cardiovascular risk. …”
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Hemophagocytic Lymphohistiocytosis in a Patient with Classical Hodgkin Lymphoma by G. Hyun, K. J. Robbins, N. Wilgus, L. Grosso, S. D. Goyal

“…Other findings included pancytopenia, splenomegaly, and elevated serum ferritin. Extensive work-up for autoimmune and infectious etiologies was unremarkable. …”
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Risk Factor for Postoperative Pneumonia after Coronary Artery Bypass Grafting by Vita Karima Fadhilah, Chaerul Achmad, Rien Afrianti, Prayudi Santoso

“…Key risk factors included elevated creatinine levels, eGFR <60 ml/min/1.73 m², and low early postoperative albumin. …”
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RETRACTED: Associations of vitamin D receptor polymorphisms with risk of Alzheimer’s disease, Parkinson’s disease, and mild cognitive impairment: a systematic review and meta-analy... by Yanjun Du, Peizhen Geng, Qunqun Chen, Laixi Han, Lu Liu, Maoquan Yang, Mingzhu Tan, Jun Meng, Xiaojuan Sun, Lidan Feng

“…Intriguingly, carriers with the BB genotype significantly decreased the MCI risk in Asian descents, and the ApaI variant elevated the predisposition to MCI in Caucasians and Asians. …”
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Injectable Autocatalytic Hydrogel Triggers Pyroptosis to Stimulate Anticancer Immune Response for Preventing Postoperative Tumor Recurrence by Zhiping Rao, Yutong Zhu, Zhuang Chen, Yi Luo, Zuo Yang, Weijing Liu, Chaoqiang Qiao, Yuqiong Xia, Peng Yang, Dong‐Man Ye, Zhongliang Wang

“…Following injection of the CP@Gel, the sustained release of CP leads to the autocatalytic generation of reactive oxygen species, resulting in caspase‐3 activation, and the pre‐administered DAC inhibits the methylation of Gsdme to elevate the GSDME protein levels, leading to intense pyroptosis and anti‐tumor immune responses. …”
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Arsenic toxicity in Antarctic krill oil and its impact on human intestinal cells by Haiyan Zhang, Yunyun Ji, Zhongquan Jiang, Guangxin Yang, Cong Kong, Zhemin Shen, Tao Yuan, Xiaosheng Shen

“…After 24 hours of exposure, cell viability in the high-concentration AKO group decreased to 63.95 %. Arsenic exposure elevated ROS levels, disrupted mitochondrial membrane potential, upregulated apoptosis-related genes such as Caspase-3, Caspase-9, and Bax, and downregulated the PI3K/AKT/mTOR signaling pathway. …”
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Combined Inositol Hexakisphosphate and Inositol Supplement Consumption Improves Serum Alpha-Amylase Activity and Hematological Parameters in Streptozotocin-Induced Type 2 Diabetic... by Shadae R. Foster, Lowell L. Dilworth, Jean Sparks, Ruby L. Alexander-Lindo, Felix O. Omoruyi

“…Pancreatic weight was significantly reduced while relative kidney and liver weights were elevated in the group treated with combined IP6 and inositol supplement compared to the nondiabetic control. …”
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Natalizumab Treatment Modulates Peroxisome Proliferator-Activated Receptors Expression in Women with Multiple Sclerosis by Véronique Ferret-Sena, Alexandra Maia e Silva, Armando Sena, Inês Cavaleiro, José Vale, Bruno Derudas, Giulia Chinetti-Gbaguidi, Bart Staels

“…Osteopontin levels were elevated in patients (p=0.002) and did not change during the follow-up period of NTZ treatment. …”
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Bidirectional effects of neutrophils on Streptococcus oralis biofilms in vitro by Basmah M. Almaarik, Rizwan Ali, Paul R. Cooper, Michael R. Milward, Josefine Hirschfeld

“…Neutrophils produced elevated total and intracellular ROS, however, no NETs in response to biofilms.Conclusion Neutrophils in vitro are not excessively activated by S. oralis biofilms but are able to reduce biofilm quantity in the short-term, possibly through interfering with eDNA.…”
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ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure by Xiuru Cui, Yawei Wang, Hanlin Lu, Lei Wang, Xianwei Xie, Shenghao Zhang, Pavel Kovarik, Shuijie Li, Shanshan Liu, Qunye Zhang, Jianmin Yang, Cheng Zhang, Jinwei Tian, Yan Liu, Wencheng Zhang

“…This study reveals that ZFP36 expression is highly elevated in the arteries of hypertensive patients and rodents. …”
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Colonic growth factors (G-CSF, GM-CSF) and chemokines (MCP-1, MIP-1β) in severe ulcerative colitis by Yevgeny A. Konovich, K. Ye. Shirokikh, M. V. Shapina, Igor L. Khalif

“…Growth factor and chemokine levels were significantly elevated in colonic biopsy specimens of UC patients in comparison to that of controls: G-CSF 52,5±17,0 and 0,4±0,1 pg/10 mg (p MIP-1β - in 17 (89,4%) and 12 (63,1%) of 19 colonic biopsies of UC patients with severe inflammatory activity. …”
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Development and functional validation of a disulfidoptosis-related gene prognostic model for lung adenocarcinoma based on bioinformatics and experimental validation by Tao Shen, Tao Shen, Zhuming Lu, Sisi Yang, Dongxi Zhang, Yongwen Ke, Zhuowen Chen, Jinqiang Wu, Jinqiang Wu, Weidong Wu

“…The risk score independently predicted LUAD prognosis and correlated with immunotherapy responses. IHC showed elevated TNS4 levels in LUAD tissues, while in vitro TNS4 knockdown reduced both cell proliferation and migration.ConclusionThis study highlights the role of DRGs in LUAD, with a validated gene signature offering new avenues for targeted therapies, potentially improving LUAD treatment outcomes.…”
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CAV1 promotes epithelial-to-mesenchymal transition (EMT) and chronic renal allograft interstitial fibrosis by activating the ferroptosis pathway by Qianguang Han, Bin Ni, Wei Bao, Junqi Zhang, Ming Zheng, Jinxu Miu, Zijie Wang, Jingwen Yuan, Jun Tao, Zhijian Han, Min Gu, Xiaobing Ju, Ruoyun Tan

“…However, the mechanism by which ferroptosis contributes to the onset and progression of CAD remains unclear.MethodsThis study analyzed transcriptome data from renal transplant biopsy samples in the Gene Expression Omnibus (GEO), through clinical samples, animal models, and cell experiments, this study investigated the mechanism by which Caveolin-1 (CAV1) promotes CAD through the regulation of the ferroptosis pathway.ResultsThe elevated levels of CAV1 were found to positively correlate with CAD incidence. …”
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Enteric Methane Emission Factor for Local Kedah-Kelantan Cross Beef Cattle in Smallholder Farms of Malaysia by Ahmad Azmin Azizi, Bastami Mohd Saufi, Abu Bakar Nurul Ain, Mohammad Mardhati, Rusli Mohd Ghazali, Md Suptian Mohd Fairuz

“…Increasing the ruminant population to meet this goal could elevate greenhouse gas (GHG) emissions, especially methane (CH4) from enteric fermentation. …”
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Association of triglyceride-glucose index with Helicobacter pylori infection in the 1999–2000 NHANES cross-sectional study by Wei Liu, Jie An, Cheng Jiao, Jun Guo, Lipu Zhang, Haifeng Jin, Guangchao Liu, Yao Zhang

“…The analysis included 2984 participants. Elevated TyG index values were associated with an increased likelihood of H. pylori infection. …”
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Impact of Zootechnical Additive of the Nitrooxypropanol to Minimize Methane Emission in Cattle: A Review by Ghasaq Sami Mshary, Cristina Castillo, Joaquin Hernandez, Rodrigo Muiño

“…In conclusion, the 3-NOP is established to be a practical CH4 mitigator at elevated and intermediate dosages, recommending that it may have application as an enteric CH4 mitigator.…”
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Aberrant c-AMP signalling in richter syndrome revealed by single-cell transcriptome and 3D chromatin analysis by Heng Li, Cheng Xing, Ji Li, Yihao Zhan, Ming Luo, Peilong Wang, Yue Sheng, Hongling Peng

“…At the compartment scale, the interaction between B compartments was strengthened in DLBCL cells, while topologically associating domains (TADs) in DLBCL had elevated intra-TAD and reduced inter-TAD contacts. …”
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Effects of Sleep Deprivation on Brain Bioenergetics, Sleep, and Cognitive Performance in Cocaine-Dependent Individuals by George H. Trksak, Bethany K. Bracken, J. Eric Jensen, David T. Plante, David M. Penetar, Wendy L. Tartarini, Melissa A. Maywalt, Cynthia M. Dorsey, Perry F. Renshaw, Scott E. Lukas

“…Following recovery sleep, [31]P MRS scans revealed that cocaine-dependent participants exhibited elevated global brain β-NTP (direct measure of adenosine triphosphate), α-NTP, and total NTP levels compared to those of healthy controls. …”
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Metabolomic Profiling Reveals Potential Biomarkers and Prominent Features in HIV/AIDS Patients Co-Infected with SARS-CoV-2 by Xuan Yan, Xinyu Zhang, Wei Song, Tangkai Qi, Zhenyan Wang, Yang Tang, Jianjun Sun, Shuibao Xu, Junyang Yang, Jiangrong Wang, Jun Chen, Renfang Zhang, Li Liu, Yinzhong Shen

“…Moreover, the plasma of the pc group showed disturbances in lipid metabolism, with elevated triglycerides (TG) and phosphatidylcholine (PC) and decreased phosphatidylglycerol (PG) compared to the control group. …”
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Bi-targeting of thioredoxin 1 and telomerase by thiotert promotes cell death of myelodysplastic syndromes and lymphoma by Qiangan Jing, Yunyi Wu, Yanchun Li, Chaoting Zhou, Junyu Zhang, Jun Xia, Keyi Li, Yuhuan Shen, Hongfeng Yao, Xiangmin Tong, Jing Du, Lushan Yu, Ying Wang

“…Further studies confirmed that thiotert effectively disrupts cellular redox homeostasis, as evidenced by elevated intracellular reactive oxygen species (ROS) levels, increased MnSOD, accelerated DNA impairment, and activated apoptosis signal. …”
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