Low IL-6, IL-10, and TNF-α and High IL-13 Cytokine Levels Are Associated with Severe Hepatic Fibrosis in Schistosoma mansoni Chronically Exposed Individuals by Mable M. Mutengo, Takafira Mduluza, Paul Kelly, James C. L. Mwansa, Geoffrey Kwenda, Patrick Musonda, James Chipeta

“…On the other hand, IL-13 was significantly elevated in this group compared to the nonfibrotic group (p<0.001). …”
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Comprehensive analysis of proteomic and biochemical responses of Daphnia magna to short-term exposure to polystyrene microplastic particles by Young Sang Kwon, Chang-Beom Park, Seung-Min Lee, Jin-Woo Park, Yeong-Jin Kim, Jong-Hwan Kim, Jong-Su Seo

“…Notably, proteins involved in energy metabolism, including glycolysis and the tricarboxylic acid (TCA) cycle, were downregulated, suggesting a metabolic shift away from growth-related processes. Elevated levels of oxidative stress markers such as superoxide dismutase, catalase, and glutathione reductase reflected a pronounced response to reactive oxygen species. …”
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High-Fiber Crackers Supplemented with Asparagus Hard-Stem: Impacts of Supplementation Ratios and Water Amounts in Cracker Recipe on the Product Quality by Thi Thu Tra Tran, Le Hong Ngoc Ngo, Nu Minh Nguyet Ton, Thi Hong Nhung Le, Thi Thuy Le, Van Viet Man Le

“…As the AHP ratio increased from 0 to 20%, the dietary fiber and total phenolic contents of the fortified crackers were improved by 5.0 times and 3.2 times, respectively, while their ferric reducing antioxidant power and DPPH scavenging capacity were enhanced by 6.1 and 1.4 times, respectively. Besides, the elevated ratio of AHP also increased the product hardness and reduced its overall acceptability. …”
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Identification of a novel SPTB gene splicing mutation in hereditary spherocytosis: a case report and diagnostic insights by Xiaobing Li, Xiaobing Li, Xiaobing Li, Xiaobing Li, Xiaobing Li, Tingqiang Zhang, Tingqiang Zhang, Tingqiang Zhang, Tingqiang Zhang, Xuemei Li, Li Wang, Li Wang, Li Wang, Li Wang, Qian Li, Qian Li, Qian Li, Qian Li, Qianqian Liu, Qianqian Liu, Qianqian Liu, Qianqian Liu, Chengyin He, Li Zhang, Li Zhang, Li Zhang, Li Zhang, Yongsheng Liu, Yongsheng Liu, Yongsheng Liu, Yongsheng Liu, Junling Tang, Junling Tang, Junling Tang, Junling Tang

“…Laboratory investigations revealed hemolytic anemia, elevated bilirubin levels, and peripheral blood smear findings consistent with HS. …”
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Deep learning for predicting prognostic consensus molecular subtypes in cervical cancer from histology images by Ruoyu Wang, Gozde N. Gunesli, Vilde Eide Skingen, Kari-Anne Frikstad Valen, Heidi Lyng, Lawrence S. Young, Nasir Rajpoot

“…In addition, our extensive tumour microenvironment analysis reveals differences between the two CMS subtypes, with CMS-C1 tumours exhibit increased lymphocyte presence, while CMS-C2 tumours show high nuclear pleomorphism, elevated neutrophil-to-lymphocyte ratio, and higher malignancy, correlating with poor prognosis. …”
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Dissolution mechanism of Al2O3 in refining slags containing Ce2O3 by Wang L.J., Wang Q., Li J.M., Chou K.C.

“…The dissolution of Al2O3 was favored with the increasing CaO/Al2O3 ratio, elevating temperatures as well as the addition of Ce2O3. …”
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Circ_0089761 accelerates colorectal cancer metastasis and immune escape via miR‐27b‐3p/PD‐L1 axis by Qizhong Gao, Xiaowei Cheng, Xiang Gao

“…Our findings indicated that circ_0089761 expression was significantly elevated in CRC tissues and cell lines. Furthermore, the high expression of circ_0089761 was correlated with TNM stage and tumor size. …”
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Delayed Manifestation of Shunt Nephritis: A Case Report and Review of the Literature by Michael Babigumira, Benjamin Huang, Sherry Werner, Wajeh Qunibi

“…He complained of fevers, headaches, dizziness, and urticarial plaques on arms, trunks, and legs and was found to have anemia, low complement levels, elevated serum creatinine, proteinuria, and new onset microhematuria. …”
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Ischemia Elicits a Coordinated Expression of Pro-Survival Proteins in Mouse Myocardium by Deborah Lyn, Shaojia Bao, Nicole A. Bennett, Xiaowei Liu, Nerimiah L. Emmett

“…Chronic ischemia (after 2 weeks) was associated with elevated levels of other pro-survival factors such as Bcl-xL and the phosphorylated form of Akt, as part of the adaptive remodeling of the myocardium. …”
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The Impact of Sudden Commencements on Ground Magnetic Field Variability: Immediate and Delayed Consequences by Andrew W. Smith, Colin Forsyth, Jonathan Rae, Craig J. Rodger, Mervyn P. Freeman

“…Above 60°, other phenomena such as isolated substorms account for the majority of large R. Furthermore, the elevated rates of change observed during and after SCs are solely due to those classified as SSCs. …”
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Stroke in Athletes with Atrial Fibrillation: A Narrative Review by Joana Certo Pereira, Maria Rita Lima, Francisco Moscoso Costa, Daniel A. Gomes, Sérgio Maltês, Gonçalo Cunha, Hélder Dores, Pedro Adragão

“…Regular physical activity prior to a first stroke appears to reduce mortality, though recurrent stroke risk in athletes with AF mirrors that of non-athletes, despite an elevated AF incidence. Management of AF in athletes is complex, with limited evidence guiding anti-thrombotic strategies. …”
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Three-dimensional direct lithography of stable quantum dots in hybrid glass by Dezhi Zhu, Shangben Jiang, Ying Wang, Dejun Liu, Weijia Bao, Liwei Liu, Junle Qu, Yiping Wang, Changrui Liao

“…Due to the encapsulated QDs within the densely silicon-oxygen molecular networks, the functional structures demonstrate good stability against ultraviolet irradiation, corrosive solutions, and elevated temperatures. Based on hybrid 3D nanolithography, bicolor multilayer micro-/nano- structures are manufactured for applications in 3D data storage and optical information encryption. …”
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Strontium Promotes the Proliferation and Osteogenic Differentiation of Human Placental Decidual Basalis- and Bone Marrow-Derived MSCs in a Dose-Dependent Manner by Yi-Zhou Huang, Cheng-Guang Wu, Hui-Qi Xie, Zhao-Yang Li, Antonietta Silini, Ornella Parolini, Yi Wu, Li Deng, Yong-Can Huang

“…Strontium at doses of 0.1 mM and 1 mM elevated several osteogenic gene expressions of PDB-MSCs, but not those of BM-MSCs at an early stage. …”
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Bone Mineral Density in Postmenopausal Women Heterozygous for the C282Y HFE Mutation by Jenny E. Gunton, Frances Gates, Greg R. Fulcher, Phillip B. Clifton-Bligh

“…Mutations in the HFE gene may be associated with increased tissue iron stores reflected in an elevated serum ferritin. With homozygous mutation C282Y, the increase in serum ferritin may be associated with tissue damage in the liver, pancreas, and pituitary and with a reduced bone mineral density. …”
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Isolated Left Main Coronary Artery Stenosis after Thoracic Radiation Therapy: To Operate or Not to Operate by Osama Alsara, Ahmad Alsarah, Jagadeesh K. Kalavakunta, Heather Laird-Fick, George S. Abela

“…However, following an indeterminate exercise nuclear stress test, she developed chest pain and elevated cardiac enzymes. Coronary angiography demonstrated 90% stenosis of the left main coronary artery ostium, without any evidence of atherosclerotic disease or stenosis in other coronary arteries. …”
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Pathogenic and periodontal bacteria may contribute to the fatal outcome of critically ill elderly COVID-19 patients by L. Johana Madroñero, Eliana P. Calvo, Carolina Coronel-Ruiz, Myriam L. Velandia-Romero, María Angélica Calderón-Peláez, Jhann A. Arturo, Adriana P. Franco-Rodríguez, Ricardo Gutiérrez-Pérez, Lady S. López, Félix G. Delgado, Sigrid J. Camacho-Ortega, Lilia J. Bernal-Cepeda, Sonia P. Bohórquez, Jaime E. Castellanos

“…Airway samples were collected and the 16 S rRNA variable regions V3-V4 were amplified and sequenced using the Illumina MiSeq platform. Elevated levels of blood urea nitrogen, creatinine and lactate dehydrogenase, and higher frequencies of cardiovascular disease, diabetes mellitus and renal disease were observed in patients with a fatal outcome. …”
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Influence of Channel Regulating Structures on the Transportation and Dissipation of Supersaturated Total Dissolved Gas by Yun Qing, Qian Ma, Ran Li, Xia Shen, XuJin Zhang, LinFeng Han

“…The dissipation of supersaturated TDG is a very slow process. Thus, the elevated TDG may remain through the water body for hundreds of kilometers downstream and lead to gas bubble disease (GBD) and even mortality in fish. …”
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Predicting exacerbation of renal function by DNA methylation clock and DNA damage of urinary shedding cells: a pilot study by Akihito Hishikawa, Erina Sugita Nishimura, Norifumi Yoshimoto, Ran Nakamichi, Eriko Yoshida Hama, Wataru Ito, Tomomi Maruki, Kengo Nagashima, Ryoko Shimizu-Hirota, Hiromasa Takaishi, Hiroshi Itoh, Kaori Hayashi

“…Moreover, in cases of advanced CKD (G4-5), the DNA damage in urinary shedding cells was significantly increased, highlighting the interplay between elevated DNA damage and eGFR decline. This study suggests the potential role of the DNA methylation clock and urinary DNA damage as predictive markers for the progression of chronic kidney disease.…”
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ZBP1-mediated PANoptosis is a crucial lethal form in diverse keratinocyte death modalities in UVB-induced skin injury by Xuechan Bi, Min Li, Yiming Guo, Mengyao Hu, Yujie Chen, Ni Lian, Sihan Chen, Min Li, Heng Gu, Xu Chen

“…We observed that the key molecules of GSDMD-mediated pyroptosis, apoptosis, and necroptosis, which are N-terminal GSDMD, cleaved caspase-3/PARP, and phosphorylated MLKL, respectively, were elevated in keratinocytes of UVB-challenged mice and human skin tissue. …”
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Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age by David T. Chao, Nilesh H. Shah, Herbert J. Zeh, Aatur D. Singhi, Nathan Bahary, Kevin M. McGrath, Kenneth E. Fasanella, Amer H. Zureikat, David C. Whitcomb, Randall E. Brand

“…No significant difference was observed in the mean age of PC diagnosis in those patients who maintained a normal BMI-18 when compared to those patients who subsequently became overweight or obese (67.0 versus 66.6; p=0.65). Conclusions. An elevated BMI at age 18 is associated with an earlier age of PC onset and should be factored into determining the optimal age of beginning screening for patients at high risk for PC.…”
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