Dynamic soil columns simulate Arctic redox biogeochemistry and carbon release during changes in water saturation by Erin C. Berns-Herrboldt, Teri A. O’Meara, Elizabeth M. Herndon, Benjamin N. Sulman, Baohua Gu, Dawn M. Klingeman, Kenneth A. Lowe, David E. Graham

“…During saturation, an outflow of dissolved organic carbon from the UC soil correlated with elevated reduced iron and decreased pH; during drainage, UC carbon dioxide fluxes were 70% higher than TC fluxes. …”
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Sildenafil (Viagra) Protective Effects on Neuroinflammation: The Role of iNOS/NO System in an Inflammatory Demyelination Model by Catarina Raposo, Ana Karolina de Santana Nunes, Rayana Leal de Almeida Luna, Shyrlene Meiry da Rocha Araújo, Maria Alice da Cruz-Höfling, Christina Alves Peixoto

“…Sildenafil reduced Iba-1, IFN-γ, and IL-1β levels but had no effect on the expression of GFAP, TNF-α, and COX-2 compared to the cuprizone group. Sildenafil elevated GSTpi levels and improved the myelin structure/ultrastructure. iNOS−/− mice suffered from severe inflammation following treatment with cuprizone, while WT mice had milder inflammation, as found in the previous study. …”
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m6A Reader PRRC2A Promotes Colorectal Cancer Progression via CK1ε‐Mediated Activation of WNT and YAP Signaling Pathways by Xi Wu, Shiyang Wang, Yuwei Pan, Mengzhen Li, Manyu Song, Hanfu Zhang, Min Deng, Xu Yang, Jiuzhi Xu, Shuo Zhang, Jinhua Zhang, Fengchao Wang, Maksim V. Plikus, Cong Lv, Lu Yu, Zhengquan Yu

“…Through multiomics analysis, PRRC2A directly targeted CSNK1E (encoding CK1ε), maintaining its RNA stability in an m6A‐dependent manner, and that elevated CK1ε can concomitantly result in activation of the WNT and YAP signaling pathways. …”
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USP20 mediates malignant phenotypic changes in bladder cancer through direct interactions with YAP1 by Wensun Chen, Siqi Wu, Yifan Chen, Weijian Li, Yiqing Cao, Yingchun Liang, Xiyu Dai, Xinan Chen, Yilin Chen, Tian Chen, Shenghua Liu, Chen Yang, Haowen Jiang

“…A tissue microarray assay confirmed that USP20 expression was elevated in tumor tissues and correlated with YAP1 expression. …”
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The Expression of IL-6, TNF-α, and MCP-1 in Respiratory Viral Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease by Jingtong Zheng, Yue Shi, Lingxin Xiong, Weijie Zhang, Ying Li, Peter G. Gibson, Jodie L. Simpson, Chao Zhang, Junying Lu, Jingying Sai, Guoqiang Wang, Fang Wang

“…Circulating levels of IL-6, TNF-α, and MCP-1 were elevated in VP and coinfection subjects (p<0.05), while the levels of 37 other cytokines showed no difference, compared with virus negative groups and controls (p>0.05). …”
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Increased Susceptibility to Ethylmercury-Induced Mitochondrial Dysfunction in a Subset of Autism Lymphoblastoid Cell Lines by Shannon Rose, Rebecca Wynne, Richard E. Frye, Stepan Melnyk, S. Jill James

“…These respiratory parameters were significantly elevated at baseline in the ethylmercury-sensitive autism subgroup as compared to control LCLs. …”
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High-starchy carbohydrate diet aggravates NAFLD by increasing fatty acids influx mediated by NOX2 by Yuqi Gao, Rui Hua, Kezheng Peng, Yuemiao Yin, Chenye Zeng, Yannan Guo, Yida Wang, Liyuan Li, Xue Li, Ying Qiu, Zhao Wang

“…Our study systematically demonstrated the effect of a HCD on NAFLD. Elevated fatty acid influx is a unique molecular regulatory pathway that mediates HCD-induced NAFLD exacerbation, which is different from the effect of simple sugars. …”
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Cardiovascular disease risk in Korean patients with systemic lupus erythematosus compared to diabetes mellitus and the general population by Jung-Yong Han, Soo-Kyung Cho, Yena Jeon, Gaeun Kang, Sun-Young Jung, Eun Jin Jang, Yoon-Kyoung Sung

“…SLE patients aged 40–59 years displayed a significantly elevated CVD risk. Advanced age, male gender, and current use of glucocorticoids, immunosuppressive, and anti-platelet agents were associated with increased CVD risk in SLE patients. …”
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Resistance Exercise Reduces Skeletal Muscle Cachexia and Improves Muscle Function in Rheumatoid Arthritis by Salaheddin Sharif, James M. Thomas, David A. Donley, Diana L. Gilleland, Daniel E. Bonner, Jean L. McCrory, W. Guyton Hornsby, Hua Zhao, Mathew W. Lively, Jo Ann A. Hornsby, Stephen E. Alway

“…A 46-year-old woman was studied to determine: (i) if resistance exercise could reverse cachexia by improving muscle mass, fiber cross-sectional area, and muscle function; and (2) if elevated apoptotic signaling was involved in cachexia with RA and could be reduced by resistance training. …”
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Malignant Lymphoma in the Parasellar Region by Takao Koiso, Hiroyoshi Akutsu, Shingo Takano, Tetsuya Yamamoto, Eiichi Ishikawa, Yasushi Okoshi, Akira Matsumura

“…T2 hypointensity of a lesion in MR imaging in addition to an elevated serum level of soluble interleukin-2 receptor (sIL-2R) in a patient with a sellar lesion can be useful clues for the differential diagnosis of this rare disease.…”
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Effects of synergistic fermentation of tea bee pollen with bacteria and enzymes on growth and intestinal health of Apis cerana cerana by Panpan Xue, Le Xu, Yakai Tian, Mingkui Lv, Pingping Fang, Kun Dong, Qiuye Lin, Zhenhui Cao

“…Moreover, the relative abundances of Lactobacillus and Bifidobacterium were elevated, while those of Enterococcus and Bacteroides were diminished. …”
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Mouse ZGRF1 helicase facilitates DNA repair and maintains efficient fertility by Ernest Wee Kiat Lim, Smaragda Kompocholi, André Brannvoll, K. Stine V. Bagge, Jennifer R. Gruhn, Javier Martin-Gonzalez, Eliene Albers, Ian D. Hickson, Andrés López-Contreras, Michael Lisby

“…However, at a cellular level, mouse embryonic fibroblasts exhibit sensitivity to ICLs and show elevated levels of the DNA damage marker γH2AX. In the absence of ZGRF1, the rates of tumorigenesis and tumour-free survival in Eμ-Myc and Trp53 knockout mice remained largely unaffected. …”
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Establishment of reference audiometric norms for the elderly population: A community-based study on mean and median hearing thresholds by Tzong-Hann Yang, Yu-Fu Chen, Yen-Fu Cheng, Chuan-Song Wu, Yuan-Chia Chu

“…However, older age groups, particularly those over 85, presented an elevated occurrence of moderate hearing loss.…”
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The Relationship between Carotid Atherosclerosis, Inflammatory Cytokines, and Oxidative Stress in Middle-Aged and Elderly Hemodialysis Patients by Hongqi Ren, Xuan Zhou, Zhiyong Luan, Xiaomei Luo, Shujing Han, Qing Cai, Wang Rui, Yan Li

“…The hs-CRP, TNF-α, and IL-6 levels were elevated in both groups but showed no significant differences. …”
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Disappearance of the Polar Cap Ionosphere During Geomagnetic Storm on 11 May 2019 by H.‐J. Kwon, K.‐H. Kim, G. Jee, J. Seon, C. Lee, Y.‐B. Ham, J. Hong, E. Kim, T. Bullett, H.‐U. Auster, W. Magnes, S. Kraft

“…From these observations we suggest that transpolar ionospheric currents connected to the field‐aligned currents flowing on a substorm wedge‐shaped circuit act as a source of polar atmospheric heating during the moderate geomagnetic storm interval and that elevated heavy molecular gases (O2 and N2) by atmospheric heating contribute to the electron density depletion via increased recombination rate.…”
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Skeletal muscle stem cells modulate niche function in Duchenne muscular dystrophy mouse through YY1-CCL5 axis by Yang Li, Chuhan Li, Qiang Sun, Xingyuan Liu, Fengyuan Chen, Yeelo Cheung, Yu Zhao, Ting Xie, Bénédicte Chazaud, Hao Sun, Huating Wang

“…Augmented CCL5 secretion promotes MP recruitment via CCL5/C-C chemokine receptor 5 (CCR5) crosstalk, which subsequently hinders FAP clearance through elevated Transforming growth factor-β1 (TGFβ1). Maraviroc-mediated pharmacological blockade of the CCL5/CCR5 axis effectively mitigates muscle dystrophy and improves muscle performance. …”
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Meaning mindset theory: a transdiagnostic approach to mental health promotion and intervention for children by Laura Lynne Armstrong, Emmalyne Watt, Catherine Laura Potter, Brent L. Epperson

“…There is substantial overlap and comorbidity among various mental health concerns and the onset of one mental illness elevates the risk of others, underscoring the potential limitations of singular-focused mental health education or treatment. …”
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A scoping review on heat indices used to measure the effects of heat on maternal and perinatal health by Anayda Portela, Debra Jackson, Nathalie Roos, Chuansi Gao, Francesca Conway, Ijeoma Solarin, Chloe Brimicombe, Darshnika Lakhoo

“…For documents that met the inclusion criteria, we extracted 23 publications.Results We find four heat indices: heat index, apparent temperature, wet bulb globe temperature and universal thermal climate index. Exposure to elevated levels of heat stress can be associated with preterm birth. …”
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Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory Response by Binfeng He, Mingdong Hu, Zhihui Liang, Qianli Ma, Yunhai Zi, Zhiwei Dong, Qi Li, Yongjun Luo, Guisheng Qian, Liang Guo, Kexiong Lin, Zhenyu Liu, Guansong Wang

“…SPC therapy also reduced the serum levels of CK, CK-MB, LDH, IL-17A, TNF-α, and miR-155 and elevated IL-10 and miR-21 levels. We thus demonstrate that SPCs effectively ameliorated HADAS symptoms in these subjects via suppression of the hypoxia-reoxygenation injury and inflammatory response.…”
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Melting ternary hybrid nanofluid stagnation point flow with velocity slip past a stretching/shrinking sheet: Numerical simulation and validation via P2SATRA by Nur Syahirah Wahid, Nur Ezlin Zamri, Siti Zulaikha Mohd Jamaludin, Nur Hazirah Adilla Norzawary, Mohd Shareduwan Mohd Kasihmuddin, Mohd. Asyraf Mansor, Norihan Md Arifin, Ioan Pop

“…The numerical results indicate significant enhancements in heat transfer performance under conditions of elevated melting and enhanced velocity slip. Reducing the melting parameter and second-order velocity slip may expand the solution range, leading to a delay in boundary layer separation. …”
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