A Case of De Novo Antiglomerular Basement Membrane Disease Presenting during Pregnancy by F. A. K. Lodhi, T. Akcan, J. N. Mojarrab, S. Sajjad, R. Blonsky

“…Laboratory analysis revealed anemia, life-threatening hyperkalemia, AKI, and elevated antiglomerular basement membrane (GBM) antibodies. …”
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Clinical diagnosis of Q fever by targeted next-generation sequencing for identification of Coxiella burnetii by Shaohua Zhan, Haoyuan Jin, Hanbing Ji, Xin Hou, Jing Li, Ye Zhang, Jiajia Zheng, Liyan Cui

“…Although blood cultures were negative, elevated infection markers (CRP, PCT, and ferritin) and liver enzymes (ALT, AST, GGT, ALP, and LDH) were observed. …”
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Malignant Course of Anomalous Left Coronary Artery Causing Sudden Cardiac Arrest: A Case Report and Review of the Literature by Mahesh Anantha Narayanan, Christopher DeZorzi, Abhilash Akinapelli, Toufik Mahfood Haddad, Aiman Smer, Janani Baskaran, William P. Biddle

“…Sudden cardiac arrest secondary to congenital anomalous coronary artery disease is characterized by insufficient coronary flow by the anomalous left coronary artery to meet elevated left ventricular (LV) myocardial demand. High risk defects include those involved with the proximal coronary artery or coursing of the anomalous artery between the aorta and pulmonary trunk. …”
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Experimental and Numerical Study of Mechanical Properties of Concrete Containing Biochar by S.O Odeyemi, M.O Adisa, M.A Olawale, A.O Abdulsalam, J.A Oloba, H.A Ibrahim, B.O Sanusi, J.O Eda, F.O Obisiji

“…The numerical and experimental study revealed that elevating the proportion of biochar in concrete led to about 17% decrease in compressive strength, 40% reduction in tensile strength, and about 25% reduction in the flexural strength of concrete beams. …”
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X-linked ubiquitin-specific peptidase 11 (USP11) increases susceptibility to Cushing’s disease in women by Tao Zhang, Yanting Liu, Fang Liu, Kaiyu Guo, Runhua Tang, Jingwei Ye, Li Xue, Zhipeng Su, Zhe Bao Wu

“…Further investigation revealed that USP11 expression is markedly elevated in female functioning ACTH PitNETs, with levels significantly higher than those observed in male PitNETs and normal pituitary tissue. …”
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AbaComplex Enhances Mitochondrial Biogenesis and Adipose Tissue Browning: Implications for Obesity and Glucose Regulation by Serena Sagliocchi, Elisabetta Schiano, Lucia Acampora, Fortuna Iannuzzo, Annunziata Gaetana Cicatiello, Caterina Miro, Annarita Nappi, Federica Restolfer, Mariano Stornaiuolo, Stefano Zarrilli, Fabrizia Guerra, Gian Carlo Tenore, Monica Dentice, Ettore Novellino

“…Additionally, mitochondrial biogenesis and function were enhanced, evidenced by elevated mitochondrial DNA content and activity. The treatment also reduced the weight of WAT (both visceral and subcutaneous) and BAT and significantly improved glucose uptake in WAT via upregulation of GLUT4, suggesting enhanced insulin sensitivity. …”
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Systemic Inflammatory Response and Severe Thrombocytopenia after Endovascular Thoracic Aortic Aneurysm Repair by Valentina Silvestrin, Stefano Bonvini, Michele Antonello, Franco Grego, Roberto Vettor, Marco Rossato

“…This syndrome is characterized by fever, leukocytosis, and elevated CRP plasma levels and its pathogenetic mechanisms are still unknown. …”
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Neovascular Glaucoma as the First Symptom of Bilateral Occlusive Retinal Vasculitis in a 4-Year-Old Girl: A Case Report by Klaudia Rakusiewicz-Krasnodębska, Joanna Jędrzejczak-Młodziejewska, Krystyna Kanigowska, Wojciech Hautz

“…Clinical examination revealed significant findings, including elevated intraocular pressure, corneal edema, and iris neovascularization in the left eye. …”
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Gut Microbiome and Inflammation: A Study of Diabetic Inflammasome-Knockout Mice by Roma Pahwa, Miriam Balderas, Ishwarlal Jialal, Xinpu Chen, Ruth Ann Luna, Sridevi Devaraj

“…SAA and IL-18 levels were significantly elevated in diabetic mice (STZ) compared to control (WT) mice, and there was a significant attenuation of inflammation in diabetic NLRP3-KO mice (NLRP3-KO STZ) compared to control mice (p<0.005). …”
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Effects of the Glutamine Administration on T Helper Cell Regulation and Inflammatory Response in Obese Mice Complicated with Polymicrobial Sepsis by Chiu-Li Yeh, Li-Han Su, Jin-Ming Wu, Po-Jen Yang, Po-Chu Lee, Po-Da Chen, Chun-Chieh Huang, Der-Yirng Hsieh, Hsueh-Ju Wang, Sung-Ling Yeh, Ming-Tsan Lin

“…Also, expressions of inflammatory cytokines and macrophage infiltration markers in adipose tissues and lungs were elevated. Treatment of obese mice with GLN after sepsis reversed Th polarization and downregulated macrophage infiltration and inflammatory cytokine, whereas the tight junction-associated protein expression increased in the lungs. …”
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Exploring the mechanism of trait depression and cognitive impairment on the formation of among individuals with methamphetamine use disorder under varying degrees of social support by Wei Wang, Wei Wang, Guangsheng Sun, Guangsheng Sun, Chen Li, Chen Li, Cunxi Qiu, Junyi Fan, Yuhan Jin

“…Methamphetamine Use Disorder not only impairs the physical and mental wellbeing of addicts but also elevates their risk of suicide. Despite the high suicide rate among individuals with methamphetamine use disorder, research on their clinical characteristics and suicide risk factors remains scarce. …”
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Modulation of Second Messenger Signaling in the Brain Through PDE4 and PDE5 Inhibition: Therapeutic Implications for Neurological Disorders by Min Kyu Park, Hyun Wook Yang, Seo Young Woo, Dong Yeon Kim, Dae-Soon Son, Bo Young Choi, Sang Won Suh

“…This review synthesizes current evidence on the roles of PDE4 and PDE5 in neurological health and disease, focusing on their regulation of second messenger pathways and their implications for brain function. Elevated PDE4 activity impairs synaptic plasticity by reducing cAMP levels and protein kinase A (PKA) activity, contributing to cognitive decline, acute brain injuries, and neuropsychiatric conditions such as bipolar disorder and schizophrenia. …”
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Pancreatic cancer cells infiltrate nerves through TGFbeta1-driven perineural epithelial-to-mesenchymal-like transdifferentiation by Theresa Krauss, Ibrahim Halil Gürcinar, Ulrike Bourquain, Maren Hieber, Evelyn N. Krohmer, Nan Wu, Sergey Tokalov, Rüdiger Goess, Carmen Mota Reyes, Dieter Saur, Helmut Friess, Güralp O. Ceyhan, Ihsan Ekin Demir, Okan Safak

“…In an autochthonous mouse model with elevated endogenous TGFbeta1 levels in addition to oncogenic Kras activation (Ptf1aCre/+, LSL-KrasG12D/+, LSL-R26Tgfβ/+), decreased perineural integrity could be reproduced in vivo.Collectively, these findings underscore the role played by TGFbeta1-overexpressing pancreatic cancer cells in the dismantling of perineural barriers during neural invasion.…”
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Natural and anthropogenic factors controlling organic carbon storage in riverine wetlands along South Korea’s four rivers by Sang-Leen Yun, Terrence A. McCloskey, Marcelo C. L. Cohen, Kam-biu Liu, Hae-Seon Shin, Junghyung Ryu

“…Geomorphological features at different elevations significantly influence soil carbon storage, with finer sediments contributing to higher carbon retention in low-energy environments. …”
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Ethanolic Extract of Red Okra Pods Induces Aberrant Spindle Segregation and Apoptotic Cell Death by Disrupting the Wnt Signaling Pathway in Colon Cancer Cells by Firli Rahmah Primula Dewi, Sri Puji Astuti Wahyuningsih, Vuanghao Lim, Lionel Lian Aun In, Alfiah Hayati

“…Results: EEROP treatment induced apoptosis in SW480 cells, marked by elevated levels of active caspase-3 (P<0.001) and cleaved poly-(ADP-ribose) polymerase (PARP)-1. …”
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Analysis of Long-Range Transport of Carbon Dioxide and Its High Concentration Events over East Asian Region Using GOSAT Data and GEOS-Chem Modeling by Seung-Yeon Kim, Sang-Deok Lee, Jae-Bum Lee, Deok-Rae Kim, Jin-Seok Han, Kwang-Ho Choi, Chang-Keun Song

“…We can find out with GEOS-Chem tagging simulation that more than 45% of the elevated CO2 concentration over central/eastern China, Korea, and Japan on high concentration days can be explained by emission sources of East Asia mainland.…”
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Intrinsic interaction inferred oxidative stress and apoptosis by Biosurfactant-microplastic hybrid reduces coordinated in vivo biotoxicity in zebrafish (Danio rerio) by Utsa Saha, Aishee Ghosh, Adrija Sinha, Aditya Nandi, Sudakshya S. Lenka, Abha Gupta, Shalini Kumari, Anu Yadav, Mrutyunjay Suar, Nagendra Kumar Kaushik, Vishakha Raina, Suresh K. Verma

“…Exposure of zebrafish embryos to μP resulted in increased oxidative stress markers, including elevated levels of reactive oxygen species and induced apoptosis, as evidenced by increased expression of apoptotic markers and morphological changes in embryonic zebrafish. …”
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Supplemented with Astragalus dregs improves growth performance, immunity, and antioxidant capacity in fattening pigs by Qi Guo, Jiayi Wang, Xuhan Wang, Hongyi Zhang, Jiajiao Xing

“…The antioxidant capacity was significantly promoted by elevated T-AOC, GSH-px, and SOD activities and reduced malondialdehyde levels (p < 0.05). …”
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Involvement of Toll -like receptor 9 signaling in neutrophil extracellular traps-induced epithelial-to-mesenchymal transition in myositis-associated interstitial lung disease by Feng Yingyue, Zhuo Cui, Su Qiyan, Cui Xi, Guo Jin, Zhu Jiarui, Zhang Sigong

“…Notably, TLR9 gene expression was significantly elevated, and the use of a TLR9 inhibitor alleviated EMT. …”
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Effects of Low-Level Autonomic Stimulation on Prevention of Atrial Fibrillation Induced by Acute Electrical Remodeling by Yubi Lin, Ning Bian, Hairui Li, Jia Chen, Huijie Xing, Hong Li, Dandan Huang, Xianwu Lan, Bojun Gong, Li Zhou, Ruijie Liu, Min Guan, Dongdong Zhang, Gang Du, Zhengyi Huang, Xiaoming Chen, Tao Zhang, Jianyi Feng, Shaorong Wu, Liwei Wang, Aidong Zhang, Zicheng Li

“…RAP induced a significant decrease in effective refractory period (ERP) and increase in the window of vulnerability at all sites, characterized by descending and elevated gradient differences towards the ganglionic plexi (GP) sites, respectively. …”
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