Exploring potential biomarkers for acute myocardial infarction by combining circadian rhythm gene expression and immune cell infiltration by Xiao Yu, Xiaopeng Zhang, Hazrat Bilal, Chang Shi, Lei Sun

“…Immune infiltration assessments using ssGSEA indicated elevated levels of neutrophils, macrophages, and eosinophils in AMI patients. …”
Get full text

Drivers of high rates of carbon burial in a riverine-influenced freshwater marsh in the Long Point Walsingham Priority Place of southern Ontario by Amanda L. Loder, Adam Gillespie, Omid Haeri Ardakani, Cecilia Cordero Oviedo, Sarah A. Finkelstein

“…We demonstrate that elevated recent rates of SOC accumulation are largely explained by more labile carbon in surficial soils, and are sustained for less than a century before transitioning to slower burial rates of predominantly recalcitrant organic matter. …”
Get full text

Stimulation of MMP-1 and CCL2 by NAMPT in PDL Cells by Marjan Nokhbehsaim, Sigrun Eick, Andressa Vilas Boas Nogueira, Per Hoffmann, Stefan Herms, Holger Fröhlich, Søren Jepsen, Andreas Jäger, Joni Augusto Cirelli, James Deschner

“…Obese individuals have an increased risk of periodontitis, and elevated circulating levels of adipokines, such as nicotinamide phosphoribosyltransferase (NAMPT), may be a pathomechanistic link between both diseases. …”
Get full text

In Vitro Acid Resistance of Pathogenic Candida Species in Simulated Gastric Fluid by Eri Ikeda, Masaya Yamaguchi, Masayuki Ono, Shigetada Kawabata

“…Moreover, dimorphic Candida species, namely, C. albicans, C. parapsilosis, and C. tropicalis, exhibited yeast–hyphal transition in simulated gastric fluid with elevated pH. Pathogenic filamentous cells had lower acid resistance than yeast cells. …”
Get full text

Differential Effects of Alcoholic and Non-Alcoholic Beer Intake on Renin–Angiotensin System Modulation in Spontaneous Hypertensive Rats by María Dolores Mayas, Cristina Cueto-Ureña, María Jesús Ramírez-Expósito, José Manuel Martínez-Martos

“…Moderate beer consumption did not elevate blood pressure in WKY or SHRs. Nevertheless, beer modulated RAS-regulating enzyme activities, indicating potential impacts on cardiovascular homeostasis.…”
Get full text

Emicizumab in two patients with acquired haemophilia A – case report by Zhao Milly, Kartika Thomas, Witenko Corey, Snead Jessica, DeSancho Maria T, Ciolek Alana

“…After a month of intermittent bleeding at the site and immunosuppression, the inhibitor level remained elevated and he was placed on emicizumab. While on therapy, debridement of the wound required activated factor VII therapy, which was complicated by a venous thromboembolism (VTE). …”
Get full text

Gain-of-Function Mutations in STAT1: A Recently Defined Cause for Chronic Mucocutaneous Candidiasis Disease Mimicking Combined Immunodeficiencies by Sanem Eren Akarcan, Ezgi Ulusoy Severcan, Neslihan Edeer Karaca, Esra Isik, Guzide Aksu, Mélanie Migaud, Ferda Evin Gurkan, Elif Azarsiz, Anne Puel, Jean-Laurent Casanova, Necil Kutukculer

“…CMV and EBV DNA titers were elevated. She had hypergammaglobulinemia; IgE level, percentages of lymphocyte subgroups, and in vitro T-cell proliferation responses were normal. …”
Get full text

Partially hydrolyzed guar gum attenuates symptoms and modulates the gut microbiota in a model of SARS-CoV-2 infection by Jiayue Yang, Isaiah Song, Misa Saito, Tenagy Hartanto, Takeshi Ichinohe, Shinji Fukuda

“…PHGG altered the gut microbiome composition and increased the relative abundances of Ileibacterium, Bifidobacterium, and Prevotella. Furthermore, it elevated the concentrations of faecal valeric acid, propionic acid, ursodeoxycholic acid, and serum deoxycholic acid. …”
Get full text

Systemic Lupus Erythematosus (SLE) with Acute Nephritis, Antineutrophil Cytoplasmic Antibody- (ANCA-) Associated Vasculitis, and Thrombotic Thrombocytopenic Purpura (TTP): A Rare C... by Sohail Farshad, Christopher Kanaan, Solomiia Savedchuk, Dillon S. Karmo, Alexandra Halalau, Abhishek Swami

“…Diagnostic work-up revealed active urine sediment with proteinuria and hematuria and elevated creatinine, anemia, and thrombocytopenia. …”
Get full text

Rational Design of Biocompatible Ir(III) Photosensitizer to Overcome Drug‐Resistant Cancer via Oxidative Autophagy Inhibition by Mingyu Park, Jung Seung Nam, Taehyun Kim, Gwangsu Yoon, Seoyoon Kim, Chaiheon Lee, Chae Gyu Lee, Sungjin Park, Kochan S. Bejoymohandas, Jihyeon Yang, Yoon Hee Kwon, Yoo Jin Lee, Jeong Kon Seo, Duyoung Min, Taiho Park, Tae‐Hyuk Kwon

“…Abstract Autophagy is a crucial quality control mechanism that degrades damaged cellular components through lysosomal fusion with autophagosomes. However, elevated autophagy levels can promote drug resistance in cancer cells, enhancing their survival. …”
Get full text

Efficacy and safety of the metformin-mazindol anorectic combination in rat by Argüelles-Tello Federico, Roa-Coria José Eduardo, Zúñiga-Romero Ángel, Huerta-Cruz Juan Carlos, Quiñonez-Bastidas Geovanna Nalley, Flores-Murrieta Francisco Javier, Rocha-González Héctor Isaac, Reyes-García Juan Gerardo

“…A single oral dose of ED40e mazindol-metformin mixture induced anxiolysis in the elevated plus-maze test. Moreover, oral administration of mazindol-metformin combination for 3 months significantly decreased glycemia, but not blood pressure nor other parameters of hematic biometry and blood chemistry. …”
Get full text

Integrated Transcriptomic and Proteomic Analyses Reveal Molecular Mechanism of Response to Heat Shock in <i>Morchella sextelata</i> by Jiexiong Zhang, Yanxia Li, Yifan Mao, Yesheng Zhang, Botong Zhou, Wei Liu, Wen Wang, Chen Zhang

“…Morel cultivation is highly sensitive to elevated temperatures; however, the mechanisms of their response to heat shock remain poorly understood. …”
Get full text

Circulatory Support with Venoarterial ECMO Unsuccessful in Aiding Endogenous Diltiazem Clearance after Overdose by Erin N. Frazee, Sarah J. Lee, Ejaaz A. Kalimullah, Heather A. Personett, Darlene R. Nelson

“…The peak diltiazem level was 13150 ng/mL (normal 100–200 ng/mL) and it remained elevated at 6340 ng/mL at hour 90. Unfortunately, the patient developed multiple complications which resulted in her death on ICU day 9. …”
Get full text

Climatic variability as a principal driver of primary production in the southernmost subalpine Rocky Mountain lake by Anna Shampain, Jill S. Baron, Peter R. Leavitt, Sarah A. Spaulding

“…The abundance of cyanobacteria, purple sulfur-reducing bacteria, and diatom pigments were elevated during the stable conditions of the Little Ice Age; these phototrophic groups declined in the late 1800s and reached a minimum by 1950. …”
Get full text

Effects of Renal Denervation on Insulin Sensitivity and Inflammatory Markers in Nondiabetic Patients with Treatment-Resistant Hypertension by Ulla Kampmann, Ole N. Mathiassen, Kent L. Christensen, Niels H. Buus, Mette Bjerre, Henrik Vase, Niels Møller, Anne Kaltoft, Per L. Poulsen

“…Afferent signaling from the kidneys elevates the central sympathetic drive. We investigated the effect of catheter-based renal sympathetic denervation (RDN) on glucose metabolism, inflammatory markers, and blood pressure in nondiabetic patients with treatment-resistant hypertension. …”
Get full text

Tumor-associated neutrophils and macrophages interaction contributes to intrahepatic cholangiocarcinoma progression by activating STAT3 by Jian Zhou, Jia Fan, Zhiqiang Hu, Jia Li, Zhengjun Zhou, Pengcheng Wang, Rongqi Sun, Haoyang Xin, Chubin Luo, Shaolai Zhou

“…In tumor samples from patients with ICC, increased TAN and TAM levels were correlated with elevated p-STAT3 expression. All three of those factors were independent predictors of patient outcomes.Conclusions TANs and TAMs interact to promote ICC progression by activating STAT3.…”
Get full text

Corneal Backscatters as an Objective Index for Assessing Fuchs’ Endothelial Corneal Dystrophy: A Pilot Study by Hsueh-Yen Chu, Ching-Hsi Hsiao, Phil Yeong-Fong Chen, David Hui-Kang Ma, Chee-Jen Chang, Hsin-Yuan Tan

“…Quantitatively, mean AD and DM/AD were both elevated in FECD patients as compared with normal subjects (P=0.01 and 0.025, resp.). …”
Get full text

Vertical Movement of Head, Withers, and Pelvis of High-Level Dressage Horses Trotting in Hand vs. Being Ridden by Hilary M. Clayton, Sarah Jane Hobbs, Marie Rhodin, Elin Hernlund, Mick Peterson, Rosalie Bos, Filipe Serra Bragança

“…The rider’s influence increases the horse’s impulsion and vertical ROM, which may exacerbate inherent asymmetries in muscular strength when lowering the haunches and elevating the withers.…”
Get full text

The anomalously thundery month of June 1925 in southwest Spain: description and synoptic analysis by F. J. Acero, M. Antón, A. J. P. Aparicio, A. J. P. Aparicio, N. Bravo-Paredes, V. M. S. Carrasco, M. C. Gallego, J. A. García, M. Núñez, I. Tovar, J. Vaquero-Martínez, J. M. Vaquero

“…Thereby, a combination of a negative North Atlantic Oscillation (NAO) situation, elevated convective available potential energy (CAPE) values, large-scale lifting, and abundant precipitable water availability in the region was revealed.…”
Get full text

Impact of Enzyme–Microbe Combined Fermentation on the Safety and Quality of Soy Paste Fermented with Grass Carp By-Products by Jing Yang, Zihan Li, Xinping Lin, Sufang Zhang, Chaofan Ji

“…Notably, enzyme-microbe co-fermentation harnessed the strengths of both methods, achieving improved safety and enhanced flavor profiles while elevating overall product quality. These findings suggest a promising way to transform freshwater fish by-products into high-value condiments, advancing sustainable food processing.…”
Get full text