ORCHAMP: an observation network for monitoring biodiversity and ecosystem functioning across space and time in mountainous regions by Thuiller, Wilfried, Saillard, Amélie, Abdulhak, Sylvain, Augé, Vincent,  Birck, Carole, Bonet, Richard, Choler, Philippe, Delestrade, Anne,  Kunstler, Georges, Leccia, Marie-France, Lienard, Bertrand, Poulenard, Jérome, Valay, Jean-Gabriel, Bayle, Arthur, Bonfanti, Nicolas, Brousset, Lenka,  Bizard, Léa,  Calderón-Sanou, Irene, Dentant, Cédric, Desjonquères, Camille, Gielly, Ludovic, Guéguen, Maya, Guiter, Frédéric, Hedde, Mickael,  Hustache, Eric, Kedhim, Norine, Lapenu, Pierre, Le Guillarme, Nicolas,  Marchal, Lise, Mahieu, Chloé, Martin, Gabrielle, Martinez-Almoyna, Camille,  Miele, Vincent, Murienne, Jérôme, Paillet, Yoan, Rome, Maxime,  Renaud, Julien, The Orchamp Consortium

“…Leveraging the natural elevational gradients of mountain environments, the ORCHAMP program was established in 2016 as a comprehensive initiative to monitor, understand, and predict the repercussions of environmental changes on biodiversity and associated ecosystem functions in the French Alps and Pyrenees.Beyond its monitoring role, ORCHAMP has catalyzed the development of tools for data integration, statistical analyses, visualization, and AI-based automated data processing and predictions. …”
Get full text

One-pot low-temperature preparation of thermo-responsive self-ceramifiable glass fiber insulation tiles with exceptional mechanical and ablative properties by Fengchun Ji, Zhihang Peng, Xin Yang, Jian Feng, Yang Xiang, Zeyu Liu

“…Interestingly, it can spontaneously transform into high-strength semi-crystalline ceramics at elevated temperatures. The self-ceramization mechanism of GFRIT is elaborated in considerable detail. …”
Get full text

Activation of PPAR𝛾 by Rosiglitazone Does Not Negatively Impact Male Sex Steroid Hormones in Diabetic Rats by Mahmoud Mansour, Elaine Coleman, John Dennis, Benson Akingbemi, Dean Schwartz, Tim Braden, Robert Judd, Eric Plaisance, Laura Ken Stewart, Edward Morrison

“…Treatment for eight weeks increased PPAR𝛾 mRNA and protein in the testis and elevated serum adiponectin, an adipokine marker for PPAR𝛾 activation. …”
Get full text

Tumor Necrosis Factor-α and Interleukin-6: Potential Interorgan Inflammatory Mediators Contributing to Destructive Periodontal Disease in Obesity or Metabolic Syndrome by Roozbeh Khosravi, Khady Ka, Ting Huang, Saeed Khalili, Bich Hong Nguyen, Belinda Nicolau, Simon D. Tran

“…Specifically, we suggest that elevated levels of tumor necrosis factor-α (TNF-α) or interleukin 6 (IL-6)—both adipokines and known risk factors for destructive periodontal disease—in obesity and metabolic syndrome contribute to the onset and development of destructive periodontal disease. …”
Get full text

T-2 toxin induces senescence in human neuroblastoma SH-SY5Y cells by regulating the HIF-1α/p53/p21 pathway by Yating Wang, Xu Wang, Qinghua Wu

“…T-2 toxin also transiently elevated HIF-1α levels. Notably, HIF-1α regulated the expression of cell cycle inhibitory proteins (p16, p21, p53) and senescence-associated secretory phenotype factors (IL-8, IL-6, CCL2), along with the expression of senescence-associated β-galactosidase, thereby exacerbating T-2 toxin-induced cellular senescence. …”
Get full text

Acoustic Trauma Changes the Parvalbumin-Positive Neurons in Rat Auditory Cortex by Congli Liu, Tao Xu, Xiaopeng Liu, Yina Huang, Haitao Wang, Bin Luo, Jingwu Sun

“…The present study investigated how auditory cortical PV neurons change following unilateral 1 hour noise exposure (left ear, one octave band noise centered at 16 kHz, 116 dB SPL). Noise exposure elevated the auditory brainstem response threshold of the exposed ear when examined 7 days later. …”
Get full text

Increased Nuclear Transporter KPNA2 Contributes to Tumor Immune Evasion by Enhancing PD-L1 Expression in PDAC by Kai-Xia Zhou, Shan Huang, Li-Peng Hu, Xue-Li Zhang, Wei-Ting Qin, Yan-Li Zhang, Lin-Li Yao, Yanqiu Yu, Yao-Qi Zhou, Lei Zhu, Jianguang Ji, Zhi-Gang Zhang

“…Karyopherin alpha 2 (KPNA2), a member of the nuclear transporter family, is elevated in multiple human cancers and accelerates carcinogenesis. …”
Get full text

Antihyperglycemic Activity of Houttuynia cordata Thunb. in Streptozotocin-Induced Diabetic Rats by Manish Kumar, Satyendra K. Prasad, Sairam Krishnamurthy, Siva Hemalatha

“…Oral administration of extract at 200 and 400 mg/kg dose level daily for 21 days showed a significant (P<0.05) decrease in fasting plasma glucose and also elevated insulin level in streptozotocin-induced diabetic rats. …”
Get full text

Oxidative Stress, Glutathione Insufficiency, and Inflammatory Pathways in Type 2 Diabetes Mellitus: Implications for Therapeutic Interventions by John Dawi, Yura Misakyan, Stephen Affa, Samuel Kades, Ananya Narasimhan, Fouad Hajjar, Max Besser, Kevin Tumanyan, Vishwanath Venketaraman

“…Glutathione (GSH), a major antioxidant, is crucial for neutralizing ROS, but GSH levels are notably low in T2DM, exacerbating oxidative stress and inflammation. Elevated interleukin-6 (IL-6) levels further intensify inflammation and oxidative stress, disrupting insulin signaling and worsening complications such as nephropathy, retinopathy, and neuropathy. …”
Get full text

Improvement of yield and nutrient composition of orchardgrass in soils with increased nickel concentration by inoculation with Bacillus strains by Buntić Aneta, Stajković-Srbinović Olivera, Pešić Mila, Dinić Zoran, Milinković Mira, Knežević Magdalena

“…A pot experiment was conducted in soil with elevated Ni concentration, and plant dry mass, as well as the content of micro and macro elements in plant material was determined. …”
Get full text

Attenuated titin protein expression is associated with advanced stages of ovarian cancer by Harvey Sharma, Jaskaran Aujla, Asad Nawaz, Thabet Khasawneh, Ayesha Alvero, Robert T. Morris, Asma Basha, Laila Tutunji, Toshima Z. Parris, Khalil Helou, Ghassan M. Saed

“…Quantitative real-time PCR analyzed titin mRNA in cell lines, including chemosensitive, chemoresistant, and normal ovarian cells. Notably, elevated titin levels were detected in 90.9% of stage I tissues compared to only 14.3% of stage III and IV tissues. …”
Get full text

The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding by Simon Malte Lauer, Jakob Gasse, Andor Krizsan, Maren Reepmeyer, Thiemo Sprink, Rainer Nikolay, Christian M. T. Spahn, Ralf Hoffmann

“…Separation of cellular extracts derived from cells exposed to Api137 in a sucrose gradient reveals elevated levels of partially assembled and not fully matured precursors of the 50S subunit (pre-50S). …”
Get full text

N-acetylglutamate synthetase deficiency - literature review by Krystian Wdowiak, Agnieszka Maciocha, Julia Wąż, Aleksandra Witas, Justyna Drogoń, Weronika Chachaj, Natalia Szymkowiak, Ewa Gardocka

“…Key biochemical markers include elevated ammonia, glutamine, and alanine; decreased citrulline; and respiratory alkalosis. …”
Get full text

Evasion of Early Antiviral Responses by Herpes Simplex Viruses by Paula A. Suazo, Francisco J. Ibañez, Angello R. Retamal-Díaz, Marysol V. Paz-Fiblas, Susan M. Bueno, Alexis M. Kalergis, Pablo A. González

“…Besides overcoming physical constraints, such as extreme temperatures, reduced humidity, elevated pressure, and natural predators, human pathogens further need to overcome an arsenal of antimicrobial components evolved by the host to limit infection, replication and optimally, reinfection. …”
Get full text

Acute Pericarditis Occurring Three Days after Intravesical Instillation of Mitomycin C after Transurethral Bladder Tumor Resection in a 64-Year-Old Woman by Vineet Meghrajani, Arsalan Hashmi, Shuo Cheng Lin, Zvi Plawes, Shelly Brejt

“…Despite classic pericarditis symptoms, the patient underwent an urgent coronary angiogram due to elevated cardiac troponin I level, EKG changes, and wall motion abnormalities on her echocardiogram. …”
Get full text

Decreased Expression of CD14 in MSU-Mediated Inflammation May Be Associated with Spontaneous Remission of Acute Gout by Lihua Duan, Jiao Luo, Qiang Fu, Ke Shang, Yingying Wei, Youlian Wang, Yan Li, Jie Chen

“…Gout is a common metabolic disease in humans, and it is due to persistently elevated levels of uric acid in the blood. At high levels, uric acid crystallizes and the crystals deposit in joints and surrounding tissues, resulting in an attack of gout. …”
Get full text

Evolution of CpG-islands by means of tandem duplications by V. N. Babenko, Y. L. Orlov, Zh. T. Isakova, D. A. Antonov, M. I. Voevoda

“…The degenerate nature of CpG-island (elevated CG composition) implies an increase in the probability of tandem repeats and palindromes within CpG- island. …”
Get full text

TGF-β1 Induces the Dual Regulation of Hepatic Progenitor Cells with Both Anti- and Proliver Fibrosis by Ai-Ting Yang, Dou-Dou Hu, Ping Wang, Min Cong, Tian-Hui Liu, Dong Zhang, Ya-Meng Sun, Wen-Shan Zhao, Ji-Dong Jia, Hong You

“…In contrast, severe liver fibrosis and elevated collagen-1 levels were detected in the rats transplanted with HPCs pretreated with TGF-β1 for 48 hours. …”
Get full text

Effects of Irrigation with Treated Slaughterhouse Effluent and <i>Bradyrhizobium</i> spp. Inoculation on Soybean Development and Productivity: Strategies for Sustainable Management by Ana Carolina Murad Lima, Lisiane Brichi, Lucas Renato Trevisan, André Leão de Souza Dominguez, Gustavo Nocera Santiago, Tamara Maria Gomes, Fabrício Rossi

“…Foliar nitrogen concentrations were higher in the first cycle, particularly at elevated effluent doses, while foliar sodium showed a positive correlation with nitrogen and a negative correlation with magnesium. …”
Get full text

Exploring Strategies to Prevent and Treat Ovarian Cancer in Terms of Oxidative Stress and Antioxidants by Yanru Long, Houhui Shi, Jiatian Ye, Xiaorong Qi

“…In addition, chemotherapy and radiotherapy may elevate the oxidative stress in ovarian cancer cells. …”
Get full text