Case Report: Combination of sirolimus and endoscopic lauromacrogol sclerotherapy in the management of blue rubber bleb nevus syndrome with gastric tract bleeding by Lu Liu, Lu Liu, Liyuan Wang, Liyuan Wang, Fan Hu, Fan Hu

“…The combination of oral sirolimus with endoscopic lauromacrogol has demonstrated efficacy in reducing lesion size and elevating hemoglobin levels.…”
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Case Report: Surgery combined with extracorporeal membraneoxygenation for acute type A aortic dissection complicated with acute myocardial infarction by Jianming Xia, Yan Qiu, Shuo Chang, Ying Feng, Heng Zhang, Xiaoqi Wang

“…The 12-lead electrocardiogram revealed ST-segment depression, myocardial enzyme levels were significantly elevated. Emergency physicians diagnosed ATAAD with AMI, and emergency surgery was planned in collaboration with the cardiovascular surgery team. …”
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Aggregation‐based dual‐target probe for dual‐colour super‐resolution monitoring mitophagy and evaluating drugs regulating mitochondria by Xiu‐Zhi Yang, Hongbao Fang, Shumeng Li, Chengyan Chu, Yunhua Zhang, Ying Yang, Weijiang He, Yuncong Chen, Zijian Guo

“…Mitochondria dysfunction triggered by different drugs and genetic defect lead to elevated oxidative stress and higher levels of mitophagy. …”
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Discoloration Effects of High-Dose γ-Irradiation and Long-Term Thermal Aging of (U)HMW-PE by Anja Kömmling, Emmanouil Chatzigiannakis, Jörg Beckmann, Volker Wachtendorf, Kerstin von der Ehe, Ulrike Braun, Matthias Jaunich, Ulrich Schade, Dietmar Wolff

“…Therefore, the yellowing is assumed to originate from annealable color centers in the form of free radicals that are trapped in the crystalline regions of the polymer and recombine at elevated temperatures. For the antioxidant-containing HMW-PE, yellowing was observed after both irradiation and thermal aging. …”
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Characterization of Zebrafish von Willebrand Factor Reveals Conservation of Domain Structure, Multimerization, and Intracellular Storage by Arunima Ghosh, Andy Vo, Beverly K. Twiss, Colin A. Kretz, Mary A. Jozwiak, Robert R. Montgomery, Jordan A. Shavit

“…While reduced VWF is associated with bleeding, elevations in overall level or multimer size are implicated in thrombosis. …”
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Mathematical modeling of flexible printed circuit configuration: a study in deformation and optimization by Longhui Meng, Liang Ding, Aqib Mashood Khan, Mohammed Alkahtani, Yicai Shan

“…This dual-faceted strategy is pivotal in enhancing the durability and operational reliability of FPCs, particularly in contexts demanding elevated flexibility and precision. Our research offers essential insights into the refinement of FPC design, skillfully addressing the complexities associated with curvature and physical interaction. …”
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FLAIR Hyperintense Vessel Sign of Both MCAs with Severe Heart Failure by Donghee Kim, Seung-Yul Lee, Kwon-Duk Seo

“…In the baseline routine laboratory investigations, the AST, ALT, and B-type natriuretic peptide levels were elevated. Transthoracic echocardiography (TTE) showed mitral valve prolapse with severe regurgitation. …”
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Double-Blind, Placebo-Controlled, Randomized Study Comparing 0.0003% Calcitriol with 0.1% Tacrolimus Ointments for the Treatment of Endemic Pityriasis Alba by Berenice Moreno-Cruz, Bertha Torres-Álvarez, Diana Hernández-Blanco, Juan Pablo Castanedo-Cazares

“…Tacrolimus and calcitriol ointments induced a mean improvement of 68%, compared to 44% of placebo. We found an elevated TEWL in PA lesions. In the treated plaques, the reduction of the affected area was associated with improvement of pigmentation and TEWL. …”
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Shotgun metagenomics reveals the interplay between microbiome diversity and environmental gradients in the first marine protected area in the northern Arabian Gulf by Saja A. Fakhraldeen, Rakhesh Madhusoodhanan, Nazima Habibi, Sakinah Al-Haddad, Surendraraj Alagarsamy, Sabeena F. K. Habeebullah, Walid M. Al-Zakri, Fathima Thuslim, Loreta Fernandes, Faiza Al-Yamani, Turki Al-Said

“…IntroductionThe northwest Arabian Gulf encounters significant anthropogenic pressures, including nutrient enrichment from coastal development and effluent discharge.MethodsThis study presents the first shotgun metagenomics-based characterization of microbial communities in Kuwaiti waters of the northwest Arabian Gulf, focusing on Kuwait’s first Marine Protected Area (MPA) in Sulaibikhat Bay, a vital nursery ground for commercially important fish.ResultsAnalysis revealed significantly higher microbial diversity within the MPA compared to adjacent waters, with Rhodobacteraceae (27.8%) and Flavobacteriaceae (15.3%) being dominant. Elevated inorganic phosphorus, nitrogen, and salinity were key factors driving this diversity. …”
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The Late Permian Kupferschiefer Fossils and the Geological Educational Trail in the UNESCO Global Geopark TERRA.vita (NW Germany) by Tobias Fischer, Lothar Schöllmann, Johannes Haunert

“…In the UNESCO Global Geopark TERRA.vita, Kupferschiefer fossils have been found at three tectonically uplifted elevations: Hüggel, Schafberg, and Piesberg. Here we review not only the Kupferschiefer fossil record of the Geopark, but also the paleontological excavations and environmental education programs that have been undertaken by the LWL Museum of Natural History in Münster, the local associations Museumsverein Hüggel e.V. and Kultur- und Verkehrsverein Hasbergen e.V. in Hasbergen, and the UNESCO Global Geopark TERRA.vita over the past 40 years. …”
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Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis by Muhammad Zahoor Khan, Liangliang Li, Yandong Zhan, Huang Binjiang, Xiaotong Liu, Xiyan Kou, Adnan Khan, Abdul Qadeer, Qudrat Ullah, Khalid J. Alzahrani, Tongtong Wang, Changfa Wang, Muhammad Zahoor

“…Mastitis is a common inflammation of mammary glands that has a significantly impact on dairy production and animal health, causing considerable economic burdens worldwide. Elevated reactive oxygen species (ROS) followed by oxidative stress, apoptosis, inflammatory changes and suppressed immunity are considered the key biomarkers observed during mastitis. …”
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Regulation of Chemokine Production via Oxidative Pathway in HeLa Cells by Shinichiro Kina, Toshiyuki Nakasone, Hiroyuki Takemoto, Akira Matayoshi, Shoko Makishi, Nao Sunagawa, Feixin Liang, Thongsavanh Phonaphonh, Hajime Sunakawa

“…Enzyme-linked immunosorbent assays showed that IL-8 protein secretion was elevated in ROS-treated HeLa cells. When Fe2+ was removed from these cells, IL-8 secretion was inhibited. …”
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Influences of Rearing Season, Host Plant, and Silkworm Species on Gut Bacterial Community by Chang Chen, Yujuan Hao, Jiaqi Yang, Jingyu Zhang, Huan Wang, Yanqun Liu

“…We found that the bacterial composition and diversity of larvae reared in the autumn are elevated compared to those of larvae from the spring. …”
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The Role of IL-37 as an Anti-Inflammatory Biomarker in some Iraqi Rheumatoid Arthritis Patients and Its Correlation with DAS28 by Sattar Brissm Hassan, Hanaa N. Abdullah, Khalied Yassen Zakair

“…When compared to controls, the level of serum IL-37 was shown to be considerably elevated in RA patients. (49.16 ± 3.25pg/ml vs. 32.04 ± 2.22pg/ml; p ≤ 0.05). …”
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Probiotics fermentation enhanced the bioactive properties of Gnaphalium affine water extract and improved regulation ability of gut microbiota by Qin Zhang, Shiying Yan, YuanYuan Luo, Zixin Meng, Zhihao Yu, Jian Zhao, Xiaojuan Wu, Yiming Tian, Guzhen Cui, Zhenghong Chen, Daoyan Wu

“…Following fermentation, the concentrations of chlorogenic acid, coniferin, lactic acid, glycolic acid, and behenic acid were significantly elevated. Additionally, the G. affine fermented beverages promoted the growth of intestinal probiotics such as Lactobacillus, Bifidobacterium, while inhibiting pathogens like Clostridium, Shigella. …”
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Formononetin promotes porcine oocytes maturation and improves embryonic development by reducing oxidative stress by Na Wang, Han Yang, Yelei Chen, Hekun Wang, Chaorui Wang, Jianglin Fan, Yajie Chen, Yinghua Li, Maobi Zhu

“…It also increased mitochondrial function and ATP levels, reduced intracellular reactive oxygen species, and elevated intracellular GSH levels in both oocytes and embryos. …”
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Severe Vitamin B12 Deficiency in Pregnancy Mimicking HELLP Syndrome by Shravya Govindappagari, Michelle Nguyen, Megha Gupta, Ramy M. Hanna, Richard M. Burwick

“…Severe vitamin B12 deficiency may present with hematologic abnormalities that mimic thrombotic microangiopathy disorders such as hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. …”
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Spontaneous Regression of Metastatic Papillary Thyroid Cancer in a Lymph Node by Jien Shim, Jianyu Rao, Run Yu

“…She had persistently elevated thyroglobulin levels. Six years after her initial treatments, she had biopsy-proven cervical lymph node metastasis. …”
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Metal-organic cage crosslinked nanocomposites with enhanced high-temperature capacitive energy storage performance by Shuo Zhao, Weifeng Peng, Le Zhou, Shuqi Dai, Weibin Ren, Erxiang Xu, Yao Xiao, Mufeng Zhang, Mingjun Huang, Yang Shen, Ce-Wen Nan

“…The in-situ crosslinking by self-assembled metal-organic cages not only achieves a homogeneous distribution of inorganic components, but also constructs robust organic-inorganic interfaces, which avoids the interfacial losses of conventional nanocomposites and improves the breakdown strength at elevated temperatures. Ultimately, the developed nanocomposites exhibit exceptionally high energy densities of 7.53 J cm−3 (150 °C) and 4.55 J cm−3 (200 °C) with charge-discharge efficiency of 90%.…”
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Mammalian SLC39A13 promotes ER/Golgi iron transport and iron homeostasis in multiple compartments by Huihui Li, Yanmei Cui, Yule Hu, Mengran Zhao, Kuanyu Li, Xiaoyun Pang, Fei Sun, Bing Zhou

“…ZIP13 loss causes an iron deficiency in the ER/Golgi and other intracellular compartments, such as lysosomes and mitochondria, as well as elevating iron in the cytosol. ZIP13 overexpression has the opposite effect, increasing iron in organellar compartments. …”
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