Hepatic Fat Content and Liver Enzymes Are Associated with Circulating Free and Protein-Bound Advanced Glycation End Products, Which Are Associated with Low-Grade Inflammation: The... by Mitchell Bijnen, Marleen M. J. van Greevenbroek, Carla J. H. van der Kallen, Jean L. Scheijen, Marjo P. H. van de Waarenburg, Coen D. A. Stehouwer, Kristiaan Wouters, Casper G. Schalkwijk

“…It is unknown if the AGE accumulation in fatty livers results in elevated circulating AGEs. In a cohort study, we investigated the association of liver fat and hepatocellular damage with circulating AGEs and soluble RAGE (sRAGE) and subsequently the association of circulating AGEs and sRAGE with LGI. …”
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Analysis of Metabolic Risk Factors for Microcirculation Disorders Post-Percutaneous Coronary Intervention and Predictive Model Construction: A Study on Patients with Unstable Angin... by Kangming Li, Shuang Liu, Jing Wang, Zhen Liu, Chunmei Qi

“…Logistic regression analysis identified HbA1c, TG, LDL-C, and Lp(a) as independent predictors of elevated AMR post-PCI after adjusting for confounders. …”
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Combined metabolomic and transcriptomic analysis to reveal the response of rice to Mn toxicity stress by Feng Li, Yushuang Yao, Jiapeng Ma, Zhengwei Wu, Dianfeng Zheng, Yingbin Xue, Ying Liu

“…In rice leaves, the proline content increased by 632.45 %, whereas the enzymatic activities of POD, SOD, CAT, and APX were elevated by 167.17 %, 14.08 %, 103.60 %, and 146.74 %, respectively. …”
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The relationship between complete blood cell count-derived inflammatory biomarkers and erectile dysfunction in the United States by Yi Zhang, Tingzhen Li, Qixin Chen, Maobiao Shen, Xinyang Fu, Changjin Liu

“…Following adjustment for all confounding variables, it was observed that elevated levels of NLR(OR = 1.09, 95%CI 1.00–1.19, p = 0.021), MLR (OR = 2.97, 95% CI 1.18–7.50, p = 0.01), NMLR(OR = 1.10, 95% CI 1.01–1.11, p = 0.006), and SIRI(OR = 1.11, 95% CI 1.01–1.22, p = 0.017) were associated with an increased prevalence of ED. …”
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Adipose Tissue-Derived Stromal Cells Induce a Highly Trophic Environment While Reducing Maturation of Monocyte-Derived Dendritic Cells by Morten Juhl, Bjarke Follin, Monika Gad, Jesper Larsen, Jens Kastrup, Annette Ekblond

“…Interestingly, the expression of CD83 was elevated. Escalating ratios of ASC did not affect the concentration of IL-10 considerably, whereas the presence of IL-12 was reduced in a dose-dependent manner. …”
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Role of hypothalamic-pituitary-adrenal axis and catecholamine factors in independent and primary multiple types of tumor growth by E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, E. I. Surikova, Yu. A. Pogorelova, N. D. Cheryarina, L. K. Trepitaki, I. V. Neskubina, A. A. Vereskunova, I. M. Kotieva, K. A. Shumarin, A. I. Shikhlyarova, I. V. Goroshinskaya

“…All tumor-bearing females showed elevated corticotropin releasing in the hypothalamus together with an increase of all stress-characterizing parameters: cortisol, the cortisol/DHEA-S ratio, and noradrenaline. …”
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The combined effects of cardiometabolic index and high-sensitivity C-reactive protein on the risk of new onset stroke in a Chinese national prospective longitudinal cohort study by Fangfang Li, Yu He, Ali Yang, Mingrong Xia, Weizhou Zang, Jiewen Zhang

“…The risk for stroke increased with each elevating quartile of baseline CMI levels, with adjusted HRs and 95% CIs being 1.27 (0.98–1.66), 1.41 (1.08–1.83), and 1.46 (1.09–1.96) for Q2, Q3, and Q4, respectively. …”
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Conversion from clinically isolated syndrome to multiple sclerosis: what paraclinical tests findings are the most characteristic? by M. Malciūtė, I. Čelpačenko, R. Stankevičiūtė, R. Balnytė

“…The results indicate that pathological CSF findings (positive OCBs, elevated IgG levels) and prolonged BAEP latency are characteristic in patients with CIS who later progress to MS. …”
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Association of CSF soluble TREM1 levels with hippocampal atrophy in cognitively impaired older adults by Hao Shu, Gangyu Ding, Xiaona Xu, Xuerong Huang, Ruqian He

“…BackgroundRecent studies have shown that cerebrospinal fluid (CSF) levels of soluble triggering receptor expressed on myeloid cells 1 (sTREM1) are elevated in individuals with Alzheimer’s disease (AD), though the relationship between CSF sTREM1 and hippocampal atrophy remains to be elucidated. …”
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Effect of trace elements and nutrients on 21 autoimmune diseases: a Mendelian randomization study by Ming-Jie Jia, Hua-Fang Yin, Ying-Chao Liang, Feng Jiang, Hui-Lin Li, Hui-Lin Li

“…Carotene was found to have a negative causal relationship with adult-onset Still’s disease (AOSD). Elevated levels of copper and selenium were associated with an increased risk of autoimmune hyperthyroidism. …”
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Dietary insulin load and index in relation to incident gestational diabetes mellitus: a prospective cohort study by Azadeh Aminianfar, Hamid Zolfaghari, Sanaz Soltani, Hossein Hajianfar, Leila Azadbakht, Zahra Shahshahan, Ahmad Esmaillzadeh

“…Women with the greatest DII had a 23% non-significant elevated risk of GDM (95% CI 0.84, 1.82; P-trend = 0.55) compared to those with the lowest DII. …”
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Alu insertion polymorphisms and susceptibility to metabolic syndrome in a Moroccan population by Hamid Farhane, Majida Motrane, Karchali Soufaine, Fatima-Ezzahra Anaibar, Aïcha Motrane, Said Nassor Abeid, Abderraouf Hilali, Nourdin Harich

“…Abstract Background Metabolic syndrome (MetS) is a multifaceted disorder that significantly elevates the cardiovascular disease risk. The diversity of the combination of its main components, conditioned by genetics and environmental risk factors, contributes to the complexity of this health condition and increases the difficulty of its diagnosis and treatment. …”
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Circulating CD3+CD8+ T Lymphocytes as Indicators of Disease Status in Patients With Early Breast Cancer by Han‐Kun Chen, Yi‐Ling Chen, Wei‐Pang Chung, Zhu‐Jun Loh, Kuo‐Ting Lee, Hui‐Ping Hsu

“…Elevated plasma chemokine (C–C motif) ligand 2 (CCL2) levels distinguished patients with breast cancer from healthy controls. …”
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C-Reactive Protein Levels in Children with Acute Bronchiolitis by Hasan M. Isa, Abdulrahman D. Mohroofi, Fatema N. Alkhan, Asma Z. Hasan, Mariam M. Alkubisi, Sana S. Alhewaizem, Sara I. Khalifa, Noora G. Alromaihi

“…Most children with acute bronchiolitis had high rate of elevated CRP values that did not correlate with the rate of bacterial coinfection. …”
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Effects of chronic exposure of specific water quality parameters in poultry drinking water on dietary amino acid digestibility and early broiler performance by Rabin Raut, Biswajit Kumar Biswas, Thyneice Taylor-Bowden, Agnes Kilonzo-Nthenge, Bharat Pokharel, Tom Tabler, Samuel N. Nahashon, Pramir Maharjan

“…This study aimed to explore the impacts of poultry drinking water pH, TDS (total dissolved solids), and elevated levels of certain minerals on the early phase of broiler performance. …”
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Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice by Mansi Dahalia, Sparsh Gupta, Haya Majid, Divya Vohora, Nidhi

“…Pirfenidone significantly reduced pro-inflammatory cytokines including interleukin-6, interleukin-1β, transforming growth factor-β, tumor necrosis factor- α, high-mobility group box-1, and toll-like receptor-4, elevated gamma-aminobutyric acid, decreased glutamate levels, modulated aspartate aminotransferase and alanine aminotransferase levels. …”
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Effect and Mechanism of Catalpol on Behavior in Rats with Post-stroke Depression by WANG Xiangyu, ZHOU Xia, LIU Ju, LIU Fuhong, ZHANG Jiale, SUN Liping, LI Wanbin

“…The behavior of the rats was evaluated by elevated plus maze measurement. TTC staining was used to detect cerebral infarction volume. …”
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Impact of invasive infections on clinical outcomes in acute pancreatitis: early predictive factors and implications for prophylactic anti-infective therapy by Fabienne Bender, Theresa König, Matthias Hecker, Moritz Fritzenwanker, Jacqueline Braun, Joern Pons-Kühnemann, Matthias Wolff, Andreas Hecker, Martin Reichert

“…The presence of ascites and elevated white blood cell count at onset of acute pancreatitis are significant predictive factors indicating the risk of invasive infection with relevant bacterial load. …”
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Effects of dietary chlorogenic acid supplementation on laying performance, egg quality, antioxidant capacity, and liver lipid metabolism in late-peak laying hens by Haitong Zhao, Lianxiang Guo, Ming Yan, Yue Sun, Yan Hong, Mingkun Zhu

“…Egg production rate and average egg weight were significantly elevated with 600 and 800 mg/kg CGA relative to the control group. …”
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Relationship Between Serum HMGB1 and RAGE Levels and Restenosis in Type 2 Diabetes Mellitus Patients Complicated With Lower Extremity Vascular Disease: A Retrospective Study by Jia T, Zhang X, Li L, Jiang X, Wang M

“…The receiver operating characteristic (ROC) curve analysis evaluated the predictive value of serum RAGE and HMGB1 for restenosis post-intervention.Results: The ISR group exhibited statistically significant elevations in HbA1c, hs-CRP, HMGB1, and RAGE levels compared to the NISR group (P< 0.05). …”
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