The emergence of DNAM-1 as the facilitator of NK cell-mediated killing in ovarian cancer by Rachel Pounds, Rachel Pounds, Wayne Croft, Hayden Pearce, Tasnia Hossain, Kavita Singh, Janos Balega, David N. Jeevan, Sudha Sundar, Sudha Sundar, Sean Kehoe, Jason Yap, Jason Yap, Paul Moss, Jianmin Zuo

“…In contrast, NK cell numbers in primary tumour and metastasis were substantially reduced, with downregulation of activatory receptors together with elevated PD-1 expression. scRNA-Seq identified 5 NK cell subpopulations along with increased exhausted and immature NK cells within tumour tissue compared to normal tissue. …”
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Associations between night-time sleep duration and fasting glucose and ratio of triglyceride to high-density lipoprotein cholesterol among adults free of type 2 diabetes or without... by Rong Zhang, Li Zhang, Qiang Li, Minying Zhang, Feng Liu, Shuo Chen, Yu-Jie Niu, Xin Qi, Chunjun Li, Jiangshan He, Chenglin Hong, Yuxue Wang, Yaqi Fan, Pei Guo, Binbin Zhang, Shitao Ma, Mianzhi Zhang

“…BMI mediated a U-shaped association of sleep duration with TG/HDL-C (β1=−0.040, p=0.017; β2=0.003, p=0.023).Conclusions Both short and long night-time sleep was associated with elevated FG, and short sleep duration was associated with increased BMI. …”
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Comparative Analysis of 95 Patients with Different Severity in the Early Outbreak of COVID-19 in Wuhan, China by Fang He, Xue-feng Ding, Meng Cao, Hai-ying Gong, Xiang-zhen Fu, Jie Luo, Kui Liu, Zhou-zhou Tian, Lin Luo, Yu-yuan Fan, Ting Li, Qian-Jing Yao, Xiao-ju Chen, Xiang-lin Duan, Li Chen, Li Jiang

“…Laboratory findings showed that the most common abnormalities were lymphopenia (75 (78.9%)), elevated D-dimer (60 (63.2%)), and elevated C-reactive protein (56 (58.9%)) on admission. …”
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Topographical mapping of metabolic abnormalities in multiple sclerosis using rapid echo-less 3D-MR spectroscopic imaging at 7T by Eva Niess, Assunta Dal-Bianco, Bernhard Strasser, Fabian Niess, Lukas Hingerl, Beata Bachrata, Stanislav Motyka, Paulus Rommer, Siegfried Trattnig, Wolfgang Bogner

“…Conclusions: This study highlights the ability of 3D-MRSI at 7T to map widespread metabolic abnormalities in MS, with NAA reductions in prefrontal, motor, and sensory areas, linked to neuroaxonal damage and disability progression, and elevated mI in periventricular regions, reflecting gliosis.…”
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Increased dicentric chromosome in peripheral lymphocytes is related to acute skin toxicity induced by radiotherapy in cancer patients by Minjie Li, Yu Gao, Lin Han, Ping Wang, Jie Li, Junhua Song, Shasha Du, Yunfei Zhang, Yumin Lyu

“…Results: After RT, the mean counts of white blood cells (WBCs), lymphocytes, and platelets significantly decreased, while the red blood cells (RBCs) and hemoglobin notably increased (P ​< ​0.001), while the dic frequency was elevated remarkably, significantly higher in patients with higher-grade (>1) acute skin toxicities compared to those with lower-grade (=1) acute skin toxicities (Z ​= ​−1.985, P ​= ​0.047). …”
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Mental health phenotypes of well-controlled HIV in Uganda by Leah H. Rubin, Leah H. Rubin, Leah H. Rubin, Leah H. Rubin, Kyu Cho, Jacob Bolzenius, Julie Mannarino, Rebecca E. Easter, Raha M. Dastgheyb, Aggrey Anok, Stephen Tomusange, Deanna Saylor, Maria J. Wawer, Noeline Nakasujja, Gertrude Nakigozi, Robert Paul

“…Clusters 2 (n = 32; anxiety phenotype) and 3 (n = 130; mixed anxiety/depression phenotype) reported minimal PTSD symptoms, with modest BAI (Cluster 2) and PHQ-9 (Cluster 3) elevations. Cluster 4 (n = 39; minimal symptom phenotype) reported no clinical MH symptom elevations. …”
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Genetically predicted brain cortical structure mediates the causality between insulin resistance and cognitive impairment by Chaojuan Huang, Yuyang Zhang, Mingxu Li, Qiuju Gong, Siqi Yu, Zhiwei Li, Mengmeng Ren, Xia Zhou, Xiaoqun Zhu, Zhongwu Sun

“…No evidence of heterogeneity, pleiotropy, or reverse causality was observed.ConclusionsBriefly, our study noticed that elevated level of insulin resistance adversely affected cognition, with a partial mediation effect through alterations in brain cortical structure.…”
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TGF-β3 Induces Autophagic Activity by Increasing ROS Generation in a NOX4-Dependent Pathway by Yun Zhang, Hong-Mei Tang, Chun-Feng Liu, Xie-Fang Yuan, Xiao-Yun Wang, Ning Ma, Guo-Feng Xu, Song-Ping Wang, Jun Deng, Xing Wang

“…Using an allergic inflammation mouse model induced by house dust mite (HDM), we observed elevated lung amounts of TGF-β3 accompanied by increased ROS levels. …”
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Examining future spatiotemporal changes in blue and green water using an enhanced SWAT model: A Jialing River basin case study by Mingyan Wu, Fuquan Ni, Yu Deng, Nan Jiang, Mengyu Zhu, Huazhun Ren, Ziying Yue, Yuxuan Wang

“…Despite the suppression of vegetation activity due to elevated CO2 and high temperatures in future scenarios, increased vegetation growth demands in agricultural areas exacerbate soil water shortages and elevate future risks to water and food security. …”
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A Rare Case of Metastatic Choriocarcinoma of Lung Origin by Parth Rali, Jianwu Xie, Grishma Rali, Mayur Rali, Jan Silverman, Khalid Malik

“…To diagnose primary pulmonary choriocarcinoma, the patient should have no previous gynecologic malignancy, have elevated human chorionic gonadotropin, and have pathological confirmation of the disease excluding gonadal primary site of the tumor. …”
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Someone is to blame: the impact of suicide on the mind of the bereaved (including clinicians) by Rachel Gibbons

“…These narratives have a profound impact on well-being, increase the risk of mental illness and elevate the likelihood of death by suicide. They not only cause harm to the bereaved but also permeate and distort our systemic and societal responses. …”
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A Rare Case of Deep Pelvic Endometriosis Presenting with Serous Ascites and Infertility by Türkan Gürsu, Güldeniz Desteli, Hulusi Bülent Zeyneloğlu

“…Literature search revealed sporadic cases of endometriosis presenting with bloody or brownish ascites, some had also pleural effusion and CA-125 levels were elevated in all cases. Our case had normal CA-125 level and normal looking ovaries. …”
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1,25-Vitamin D-mediated hypercalcaemia in the setting of immune therapy-related sarcoid-like reaction by R K Dharmaputra, N Sheriff, S Ravichandran

“…Further investigations demonstrated hilar lymphadenopathy, which was not present in previous imaging, and subsequent hypercalcaemia work-up demonstrated a significantly elevated serum calcitriol level as high as 429 pmol/L. …”
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DYSOXYLUM MOLLISSIMUM (SPRENG.) BLUME EX G. DON (MELIACEAE), A NEW RECORD FOR THE FLORA OF VIETNAM by Van Dung Luong, Ngoc Trieu Le, Tan Dat Nguyen, Van Ket Nguyen, Thanh Truong Hoang

“…This species is distributed in primary and secondary forests in scattered populations at elevations of 800–1200 m above sea level in the provinces of Gia Lai and Lam Dong in the Central Highlands of Vietnam. …”
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Primary Hyperparathyroidism in Pregnancy: A Two-Case Report and Literature Review by A. D. Herrera-Martínez, R. Bahamondes-Opazo, R. Palomares-Ortega, C. Muñoz-Jiménez, M. A. Gálvez-Moreno, J. M. Quesada Gómez

“…It could be easily misdiagnosed because of physiologic changes during pregnancy; in some cases, patients could remain asymptomatic maintaining elevated calcium serum levels, and this situation represents a threat to the health of both mother and fetus. …”
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Primary Biliary Cirrhosis and Type II Autoimmune Polyglandular Syndrome by Mark Ram Borgaonkar, David Geoffrey Morgan

“…At that time, her antimitochondrial antibody (AMA) level was elevated at 1:32. She subsequently developed premature ovarian failure and type I diabetes mellitus. …”
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Perrault Syndrome Diagnosis in a Patient Presenting to Her Primary Care Provider with Secondary Amenorrhea by Leah May Roberts, Bruce Carnivale

“…After multiple negative pregnancy tests done with primary care physicians, a further evaluation by an internal medicine specialist showed an elevated FSH and LH as well as a small uterus and streak ovaries on transabdominal and transvaginal ultrasound. …”
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The Nature of Hyperactivity in Children and Adolescents With Hydrocephalus: A Test of the Dual Pathway Model by Jim Stevenson, Ineke Pit-ten Cate

“…This association was not just part of a general elevated rate of behavior problems and was not affected by sex or age. …”
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Exploring inconsistencies in environmental impact assessments of organic farming by Hikaru Komatsu, Jeremy Rappleye

“…A 2017 meta-analysis suggested elevated acidification and eutrophication potentials per unit of agricultural production for organic farming relative to conventional farming. …”
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Tumour necrosis factor-α and adenosine in endotoxin shockleading related cardiovascular symptoms by S. Sipka, T. Seres, Z. Dinya, Z. Szekanecz, J. Szentmiklósi, E. Bodolay, G. Szegedi

“…The diagnosis of SIRS was based on the demonstration of endotoxinaemia, and highly elevated plasma levels of tumour necrosis factor (TNF)-α, and interleukin (IL)-10. …”
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