The association between body roundness index and new-onset hyperuricemia in Chinese population: the Kailuan cohort study by Xi Cai, Naihui Zhao, Xuemei Yang, Jiajia Ma, Yajing Liang, Yicheng Liao, Ruiyue Liu, Xinran Wen, Shuohua Chen, Guodong Wang, Na Li, Shouling Wu, Liufu Cui

“…Conclusion We found that elevated BRI increased the risk of developing new-onset hyperuricaemia. …”
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A systematic investigation on microstructure evolution, phase transformation and dynamic recrystallization mechanisms of hot isostatic pressed Ti–45Al–2Mn–2Nb–1B alloy during hot d... by Meiyi Ba, Hongkui Tang, Lianxi Hu, Yu Sun, Fei Gao

“…Thermal simulation compression were carried out at an elevated temperature of 1100–1250 °C, strain rate between 0.001 and 1 s−1, and a reduction in height of 50%. …”
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Serum uric acid level and subclinical left ventricular dysfunction: a community‐based cohort study by Koki Nakanishi, Masao Daimon, Yuriko Yoshida, Jumpei Ishiwata, Naoko Sawada, Megumi Hirokawa, Hidehiro Kaneko, Tomoko Nakao, Yoshiko Mizuno, Hiroyuki Morita, Marco R. Di Tullio, Shunichi Homma, Issei Komuro

“…Conclusions In a sample of the general population, an elevated SUA was independently associated with subclinical LV dysfunction. …”
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Impact of Systolic Blood Pressure Trajectories and Variability on Unexplained Early Neurological Deterioration Post‐Endovascular Treatment in Acute Ischemic Stroke Patients by Xuxuan Gao, Qiheng Wu, Yu Ma, Yueran Ren, Jiaying Chen, Xiaofei Lin, Lianghao Ye, Wei Song, Jiajia Zhu, Jia Yin

“…These findings suggest that increased SBPV, particularly when combined with elevated mean SBP, significantly heightens the risk of unexplained END post‐EVT. …”
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Polypropylene/myristic acid assisted electrodeposition of eco-friendly micro-engineered copper superhydrophobic coating for enhancing hydrophobicity and anti-corrosion efficiency o... by Himanshu Prasad Mamgain, Krishna Kanta Samanta, Rajeev Gupta, Ranjeet Brajpuriya, Pravat Ranjan Pati, Jitendra Kumar Pandey, Abhijit Bhowmik, Abdulaziz AlHazaa

“…Electrodeposition of copper on aluminium substrate resulted in a distinctive rose flower-like micro-order rough structure, elevating the contact angle from 58° to 140° (highly hydrophobic) when voltage varying up to 10 V, with the highest hydrophobicity observed at 8 V. …”
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Implication of fibroblast growth factor 7 in ovarian cancer metastases and patient survival by Laura F. Mortan, Laura F. Mortan, Brooke A. Meelheim, Justin Garland, Justin Garland, Jacqueline A. Bohn, Zitha Redempta Isingizwe, Doris M. Benbrook, Doris M. Benbrook

“…Serum FGF7 protein levels above the median of 25 patients with ovarian cancer were associated with worse progression-free and overall survival (p = 0.005 and 0.019, respectively) independent of patient and tumor characteristics.ConclusionsIn comparison to ascites, tumors exhibit different transcriptomic profiles that identify candidate biomarkers and drug targets for predicting and preventing recurrence. Among these, elevated tumoral FGF7 validated at the protein level and elevated serum FGF7 were significantly associated with worse patient survival. …”
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Unique pharmacological properties of etrasimod among S1P receptor modulators by Ibragim Gaidarov, H. Kiyomi Komori, Dariusz T. Stepniak, Karin Bruinsma, Huong Dang, Xiaohua Chen, Todd Anthony, Joel Gatlin, Lisa Karimi‐Naser, Anh‐Tuan Ton, Tim Indersmitten, Paul E. Miller, Andre Ghetti, Najah Abi‐Gerges, David Unett, Hussien Al‐Shamma, Christopher J. Rabbat, Catherine Crosby, John W. Adams

“…Together with pharmacokinetic properties, this pharmacologic profile of etrasimod may contribute to the positive benefit risk profile of etrasimod observed during the phase III ELEVATE UC 52 and ELEVATE UC 12 trials in patients with moderately to severely active ulcerative colitis.…”
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Longitudinal maternal glycemia during pregnancy and placental epigenetic age acceleration by Tesfa Dejenie Habtewold, Prabhavi Wijesiriwardhana, Richard J. Biedrzycki, Cuilin Zhang, Katherine L. Grantz, Jagteshwar Grewal, Fasil Tekola-Ayele

“…Placental epigenetic aging may be altered by maternal elevated glycemia and may in part underlie early programming of health outcomes in pregnancy and childhood health outcomes.…”
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Dysregulated T Cell Activation and Aberrant Cytokine Expression Profile in Systemic Lupus Erythematosus by Haiyan Zhou, Bojiang Li, Jing Li, Tongqian Wu, Xiaoqian Jin, Rui Yuan, Ping Shi, Yan Zhou, Long Li, Fang Yu

“…In addition, patients with hematologic manifestations displayed elevated frequencies of HLA-DR+ T cells and ICOS+ T cells. …”
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Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon by Menglu Chen, Lei Gao, Pan Chen, Dandan Feng, Yalin Jiang, Yongchao Chang, Jianjun Jin, Fong-Fong Chu, Qiang Gao

“…Conclusion. 5-HT induced MMP-3 and MMP-9 expression in mouse colon; these elevated MMPs may contribute to DSS-induced colitis.…”
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Bacteroides Fragilis Exacerbates T2D Vascular Calcification by Secreting Extracellular Vesicles to Induce M2 Macrophages by Cong Chen, Zhengfeng Liang, Yuqi He, Yan Gao, Shuhui Ouyang, Lili Wang, Jianghua Liu, Jingsong Cao

“…Clinical studies have shown that Serpine1 is significantly elevated in the peripheral blood of patients with T2D VC and is closely associated with T2D VC. …”
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Gap junction intercellular communications regulates activation of SARM1 and protects against axonal degeneration by Wen Jie Zhu, Jun Liu, Wan Hua Li, Zhi Ying Zhao, Chongquan Huang, Jian Yuan Yang, Hon Cheung Lee, Yong Juan Zhao

“…This activity is blocked by elevated NAD level. Here, we verified this metabolic regulation in somatic HEK-293T cells by overexpressing NMN-adenyltransferase to elevate cellular NAD, which resulted not only in inhibition of their own SARM1 from producing cADPR but, surprisingly, also in the 5–10 neighboring wildtype cells in mixed cultures via connexin (Cx)-43. …”
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A proteomic analysis identifies higher AHSG (Alpha-2-HS-glycoprotein) in saliva of oropharyngeal cancer patients – A potential salivary biomarker by Anu Jain, Aafaque Ahmad Khan, Rajandeep Kaur, Roshan K Verma, Jaimanti Bakshi, Aditi Chatterjee, Amanjit Bal, Sushmita Ghoshal, Arnab Pal

“…Conclusions: AHSG levels are elevated in saliva of OPC cases compared to non-OPC healthy controls. …”
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Efficacy and safety of first-line nivolumab plus ipilimumab treatment in elderly patients (aged ≥ 75 years) with non-small cell lung cancer by Satoshi Endo, Hisao Imai, Atsuto Mouri, Kasumi Tsukamoto, Kenji Masaki, Kosuke Hashimoto, Yu Miura, Ayako Shiono, Ou Yamaguchi, Junichi Nakagawa, Kyoichi Kaira, Kunihiko Kobayashi, Hiroshi Kagamu

“…Common Grade ≥ 3 AEs included pneumonitis, elevated aspartate transaminase, elevated alanine transaminase, adrenal insufficiency, and colitis. …”
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Development and Evaluation of a Deep Learning–Based Pulmonary Hypertension Screening Algorithm Using a Digital Stethoscope by Ling Guo, Nivedita Khobragade, Spencer Kieu, Suleman Ilyas, Preston N. Nicely, Emmanuel K. Asiedu, Fabio V. Lima, Caroline Currie, Emileigh Lastowski, Gaurav Choudhary

“…We developed a deep learning–based method that uses phonocardiograms (PCGs) for the detection of elevated pulmonary artery systolic pressure, an indicator of pulmonary hypertension. …”
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Persistent Stapedial Artery Encountered during Cochlear Implantation by Holly Jones, Justin Hintze, Adrien Gendre, Clifton Wijaya, Fergal Glynn, Laura Viani, Peter Walshe

“…The PSA was carefully lifted off the middle ear promontory using a Hughes elevator to divide adhesions and delineate the artery. …”
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Spondyloarthritis associated with inflammatory myositis: An unusual case report by Pradip Kumar Prajapati

“…Her radiological studies showed sacroiliitis with inflammatory edema in the thigh muscle, with laboratory investigations showing elevated levels of creatine phosphokinase and inflammatory markers and positive human leukocyte antigen B27. …”
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Additional Legal Protection for Corruption Whistleblowers by Ahmad Irzal Fardiansyah, Muhammad Farid, Ramadani Fitra Diansyah P

“…Corruption represents a breach of the economic rights of society, elevating it beyond mere criminality to the status of an extraordinary offense. …”
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Vibration Response of Small-caliber Vehicular Gun Tube with Gear Backlash by Fan Chunlin, Qiu Xiaobo, Shan Dongsheng, Wang Yang

“…Aiming at the study the vibration response frequency and its displacement of small-caliber vehicular gun tube,the simplified model of elevating mechanism including gear backlash is established and the method of parameter identification of contact-impact mechanical model is given.Through the dynamics simulation by applying sinusoidal signal in ADAMS,the vibration response frequency of tube with backlash are compared with no backlash,and its displacement and velocity are obtained.The results show that the continuous multi-frequency phenomenon occurred with large range,which has a bad effect on projectile initial conditions and reduces firing accuracy.Based on this,the theoretical guidance in structure optimization of gun control and firing accuracy improvement is provided.…”
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Autoimmune Hepatitis (AIH) in Acquired Immune Deficiency Syndrome (AIDS): A Case Report and Review of Literature by Jordan Roussel, Sudha Pandit, Paul Jordan, Moheb Boktor, Kurt Knowles, Nester Dela Cruz, Hrishikesh Samant

“…Here we present a fascinating case of 32-year-old African-American man with advanced AIDS who presented with elevated transaminases. He was diagnosed with AIH before starting antiretroviral therapy and successfully treated with prednisolone and azathioprine with antiretroviral therapy despite very low CD4 count.…”
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