Comparative analysis of salivary cytokine profiles in newly diagnosed pediatric patients with cancer and healthy children by Alina Paganini, Nora Fritschi, Cornelia Filippi, Nicole Ritz, Urs Simmen, Katrin Scheinemann, Andreas Filippi, Tamara Diesch-Furlanetto

“…At diagnosis, patients with leukemia and solid tumors showed elevated levels of interferon-γ, interleukin (IL)-1α, IL-1β, IL-4, IL-5, IL-8, IL-10, and tumor necrosis factor. …”
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Numerical investigation on heat transfer and flow mechanism in microchannel heat sink having V shape ribs by Naushad Ali, Injamamul Haque, Tabish Alam, Tauseef Uddin Siddiqui, Mushtaq Ahmad Ansari, Jagmohan Yadav, Shivam Srivastava, Erdem Cuce, Intesaaf Ashraf, Dan Dobrotă

“…This research offers a novel perspective that while elevated rib angles (approaching 90°) mitigate hydraulic resistance, they concurrently reduce the enhancement of heat transfer, thereby accentuating the necessity for an optimized rib angle to achieve equilibrium between thermal and hydraulic performance.…”
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New Optic Nerve Sonography Quality Criteria in the Diagnostic Evaluation of Traumatic Brain Injury by Ibrahim Soliman, Garrett G. R. J. Johnson, Lawrence M. Gillman, Frederick A. Zeiler, Fahad Faqihi, Waleed Tharwat Aletreby, Abdullah Balhamar, Nasir Nasim Mahmood, Shahzad Ahmad Mumtaz, Abdulrahman Alharthy, Christos Lazaridis, Dimitrios Karakitsos

“…The latter were correlated to elevated intracranial pressure (ICP) in traumatic brain injury (TBI). …”
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USP4-mediated CENPF deubiquitylation regulated tumor metastasis in colorectal cancer by Zhongdong Xie, Hanbin Lin, Yuecheng Wu, Yanan Yu, Xintong Liu, Yating Zheng, Xiaojie Wang, Jiashu Wu, Meifang Xu, Yuting Han, Qiongying Zhang, Yu Deng, Lin Lin, Yan Linzhu, Li Qingyun, Xinjian Lin, Ying Huang, Pan Chi

“…We found that CENPF expression was preferentially elevated in CRC tissues compared to adjacent normal tissues, with significantly higher levels in CRC patients with tumor recurrence. …”
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Maternal Cardiac Function after Normal Delivery, Preeclampsia, and Eclampsia: A Prospective Study by Elena Timokhina, Tatiana Kuzmina, Alexander Strizhakov, Elena Pitskhelauri, Irina Ignatko, Vera Belousova

“…The indicator of vascular resistance, SVR, is elevated for both mild and severe PE. With mild PE, a significant increase in SVR is observed up to 5 days of postpartum period, with severe PE/E up to 9 days. …”
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Nε-carboxyethyl-lysin influences atherosclerotic plaque stability through ZKSCAN3 acetylation-regulated macrophage autophagy via the RAGE/LKB1/AMPK1/SIRT1 pathway by Zhongwei Liu, Jing Liu, Xiqiang Wang, Yong Zhang, Yanpeng Ma, Gongchang Guan, Ya Yuwen, Ni He, Hanxiu Liu, Xingfeng Yu, Sen Ma, Junkui Wang, Jin Zhang, Ling Zhu, Yulian Zhang

“…Our findings revealed that elevated serum CEL levels are independently associated with increased ACS incidence. …”
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Polyethylene microplastic exposure adversely affects oocyte quality in human and mouse by Qiaoling Wang, Fengli Chi, Yingdong Liu, Qiurong Chang, Siyu Chen, Pengcheng Kong, Wanli Yang, Wenqiang Liu, Xiaoming Teng, Yan Zhao, Yi Guo

“…In conclusion, PE exposure impairs oocyte quality possibly by disrupting follicular fluid metabolism, elevating inflammation-related gene expression, and increasing ROS production in oocytes.…”
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Effects of a flavonoid-enriched orange peel extract against type 2 diabetes in the obese ZDF rat model by Alexander Gosslau, Emmanuel Zachariah, Shiming Li, Chi-Tang Ho

“…However, OPE did not improve glucose tolerance but showed significantly elevated glucose levels. Furthermore, OPE treatment caused an increase of free fatty acids in a dose-responsive manner as well as elevated levels of cholesterol and LDL. …”
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Combined effects of global DNA methylation, blood lead and total urinary arsenic levels on developmental delay in preschool children by Yuu-Hueih Hsu, Chih-Yin Wu, Hui-Ling Lee, Ru-Lan Hsieh, Ya-Li Huang, Horng-Sheng Shiue, Ying-Chin Lin, Mei-Chieh Chen, Yu-Mei Hsueh

“…A notable multiplicative interaction was observed between low 5mdC (%) and elevated blood lead levels to increase OR of DD, with OR and 95% CI was 9.51 (4.18 – 21.64). …”
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Mapping the forests and their spatiotemporal changes in the Yellow River Basin (Gansu section) in China from 2008 to 2018 by Quanfu Niu, Mingzhi Liu, Bo Liu, Gang Wang, Zhenyu Wang, Xiujie Liu, Weiming Cheng, Kegong Li

“…Approximately 94.09% of the forest area is located at elevations up to 3,500 meters, with stable and increasing forest types predominantly found on the northern and western slopes, spanning elevations between 3,000 and 3,500 meters and slopes ranging from 20° to 35°. …”
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Integration of transcriptomics and metabolomics data revealed role of insulin resistant SNW1 gene in the pathophysiology of gestational diabetes by Ravi Bhushan, Rimjhim Trivedi, Ritu Raj, Anjali Rani, Sangeeta Rai, Anima Tripathi, Shiv Govind Rawat, Ajay Kumar, Dinesh Kumar, Pawan K. Dubey

“…This study identified SNW1 as a novel insulin-resistant gene that induces hyperglycemia by elevating gluconeogenesis and decreasing glucose uptake. …”
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Cytokine and Chemokine Profile in Patients with Multiple Myeloma Treated with Bortezomib by Paweł Robak, Edyta Węgłowska, Izabela Dróżdż, Damian Mikulski, Dariusz Jarych, Magdalena Ferlińska, Ewa Wawrzyniak, Małgorzata Misiewicz, Piotr Smolewski, Wojciech Fendler, Janusz Szemraj, Tadeusz Robak

“…The levels of IL-8, MIP-1α, and TNF-α were significantly higher in patients with renal insufficiency. Only MIP-1α was elevated in patients with hypercalcemia compared to patients with normal calcium levels. …”
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The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women by Irma B. Ancheta, Cynthia A. Battie, Dan Richard, Christine V. Ancheta, Nancy Borja-Hart, Annabelle S. Volgman, Yvette Conley

“…The Trp719Arg allele of KIF6 rs20455, a putative risk factor for CHD especially in those with elevated low-density lipoprotein cholesterol (LDL-C), was investigated in Filipino-American women (FAW, n=235) participating in health screenings in four cities. …”
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CRISPR-based epigenetic editing of Gad1 improves synaptic inhibition and cognitive behavior in a Tauopathy mouse model by Lei Wan, Ping Zhong, Pei Li, Yong Ren, Wei Wang, Mingjun Yu, Henry Y. Feng, Zhen Yan

“…Furthermore, the tauopathy mouse model with PFC injection of dCas9p300 and gRNAGad1 lentiviruses had significantly elevated GABAergic synaptic currents and improved spatial memory. …”
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Association between depression and diabetes among American adults using NHANES data from 2005 to 2020 by Chuanjie Zheng, Jianming Yin, Linyue Wu, Zhanhui Hu, Yikai Zhang, Lingyong Cao, Yiqian Qu

“…Abstract Depression impairs self-management in diabetic patients, exacerbates insulin resistance, and elevates glycated hemoglobin (HbA1c) levels, thereby increasing diabetes risk. …”
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Evaluating atherogenic index of plasma as a predictor for metabolic syndrome: a cross-sectional analysis from Northern Taiwan by Liang-Sien Chen, Liang-Sien Chen, Liang-Sien Chen, Liang-Sien Chen, Yu-Rui Chen, Yu-Rui Chen, Yi-Hsiu Lin, Yi-Hsiu Lin, Hung-Keng Wu, Hung-Keng Wu, Yan Wen Lee, Jau-Yuan Chen, Jau-Yuan Chen

“…We hypothesize that an elevated atherogenic index of plasma (AIP) predicts MetS risk through lipid imbalance, but population-specific variations in its predictive strength remain unexplored. …”
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The modulating effect of circulating carbohydrate antigen 125 on ST2 and long-term recurrent morbidity burden by Elena Revuelta-López, Rafael de la Espriella, Gema Miñana, Enrique Santas, Sandra Villar, Juan Sanchis, Antoni Bayés-Genís, Julio Núñez

“…In heart failure (HF), elevated levels of sST2 are associated with a higher risk of adverse clinical outcomes. …”
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Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection by Michal Holub, David A. Lawrence, Nancy Andersen, Alžběta Davidová, Ondřej Beran, Vilma Marešová, Pavel Chalupa

“…Bacterial etiology of infection was associated with significantly (P<0.001) elevated serum concentrations of IL-1Ra, IL-2, IL-6, and TNF-α in comparison to levels observed in the sera of patients with viral infections. …”
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Impact of Obesity-Associated SARS-CoV-2 Mutations on COVID-19 Severity and Clinical Outcomes by Ana B. Martínez-Martinez, Alexander Tristancho-Baró, Beatriz Garcia-Rodriguez, Marina Clavel-Millan, Maria Pilar Palacian, Ana Milagro, Antonio Rezusta, Jose M. Arbones-Mainar

“…Our findings revealed three key mutations—C14599T, A20268G, and C313T—that were associated with elevated BMI. Notably, C14599T appeared to be protective against hospitalization, suggesting context-dependent effects, while A20268G was linked to a 50% increase in hospitalization risk and elevated antibody levels, potentially indicating an adaptive immune response. …”
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α₁-Acid Glycoprotein with Highly Fucosylated Glycans as a Potential Diagnostic Marker for Early Detection of Hepatobiliary and Pancreatic Cancers by Mizuki Endo, Shin Yazawa, Rie Sano, Takehiko Yokobori, Ken Shirabe, Hiroshi Saeki

“…<b>Background</b>: Previously, we reported elevated levels of fucosylated α₁-acid glycoprotein (fAGP) in plasma samples from patients with diverse types of cancers. …”
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