Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy by Elena Bernasconi, Deborah Amstutz, Alberto Averna, Petra Fischer, Mario Sousa, Ines Debove, Katrin Petermann, Laura Alva, Andreia D. Magalhães, M. Lenard Lachenmayer, Thuy-Anh K. Nguyen, Michael Schuepbach, Andreas Nowacki, Claudio Pollo, Paul Krack, Gerd Tinkhauser

“…We could evidence a STN power gradient that holds most of the spectral information between 5 and 30 Hz spanning along the dorsal-ventral axis. It shows elevated power in the sub-beta range (8-12 Hz) toward the ventral STN, and elevated dorsal beta power (16–24 Hz) indicative for the hemispheres contralateral to the more affected hemi-body side. …”
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Improvement of Lumbar Bone Mass after Infliximab Therapy in Crohn’s Disease Patients by Marina Mauro, Vladimir Radovic, David Armstrong

“…BACKGROUND: Patients with Crohn’s disease (CD) have a high risk of developing osteoporosis, but the mechanisms underlying bone mass loss are unclear. Elevated proinflammatory cytokines, such as tumour necrosis factor-alpha (TNFα), have been implicated in the pathogenesis of bone resorption.…”
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Characteristic and Prognostic Value of Serum Bone Turnover Markers in Pregnant Women With Pre-Eclampsia: A Prospective Cohort Study by Fan Yu, Xiaocui Huang, Yuanting Tang, Yiduo Zhang, Qing Li, Yongmei Jiang

“…Pre-eclampsia patients with elevated bone resorptive marker ß-CTX should pay more attention to the risk of disease aggravation and adverse pregnancy outcomes.…”
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Associations between local COVID-19 policies and anxiety in the USA: a longitudinal digital cohort study by Jeffrey E Olgin, Gregory M Marcus, Rita Hamad, John Kornak, Carmen R Isasi, Ana Sanchez-Birkhead, Mark Pletcher, Soo Park, Natasha Williams, Thomas Carton, Aaron E Cozen, Madelaine Faulkner Modrow, Amy Chiang, Matthew Brandner, Jaime H Orozco, Kristen Azar, Sylvia E K Sudat, Pelin Ozluk, Heather Kitzman, Sara J Knight

“…More comprehensive containment policies were associated with elevated anxiety among people working in strongly affected sectors, and more comprehensive public health policies were associated with elevated anxiety among people vulnerable to racial discrimination.…”
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The prediction value of serum anion gap for short-term mortality in pulmonary hypertension patients with sepsis: a retrospective cohort study by Jinhua Zhu, Zeying Zhang, Yefei Lei, Zhenrong Ouyang, Shelby Kutty, Qiming Liu, Yunbin Xiao, Yunbin Xiao

“…The relationship between elevated AG and in-hospital mortality remains stable after subgroup analyses.ConclusionElevated serum AG is associated with increased risk-adjusted short-term mortality in PH patients with sepsis, and it may aid clinicians in identifying patients with poor prognosis as early as possible.…”
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Renal Transplantation Dramatically Reduces IgA Anti-beta-2-glycoprotein I Antibodies in Patients with Endstage Renal Disease by Manuel Serrano, Jose Angel Martínez-Flores, Maria José Castro, Florencio García, David Lora, Dolores Pérez, Esther Gonzalez, Estela Paz-Artal, Jose M. Morales, Antonio Serrano

“…Pretransplant IgA aB2GPI levels were elevated 31.7±4.2 U/mL without differences in age or type of dialysis. …”
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Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter by Parveen Goyal, KanagaVijayan Dhanabalan, Mariafrancesca Scalise, Rosmarie Friemann, Cesare Indiveri, Renwick CJ Dobson, Kutti R Vinothkumar, Subramanian Ramaswamy

“…Neu5Ac primarily interacts with residues in the elevator domain of the protein, thereby supporting the elevator with an operator mechanism. …”
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Non-contact tracking of shoulder bones using ultrasound and stereophotogrammetry by Ahmed Sewify, Ahmed Sewify, Maxence Lavaill, Maxence Lavaill, Dermot O’Rourke, Dermot O’Rourke, Maria Antico, Maria Antico, Peter Pivonka, Peter Pivonka, Davide Fontanarosa, Davide Fontanarosa, Saulo Martelli, Saulo Martelli

“…The RMSE errors were <1 mm for the humerus and scapula at all elevations. Ex-vivo, the CPD registration errors were (Humerus = 2 mm and Scapula = 13.9 mm) (Humerus = 7.2 mm and Scapula = 16.8 mm) and (Humerus = 14.28 mm and Scapula = 27.5 mm), for low, medium and high elevations respectively.ConclusionIn summary, we demonstrated the feasibility and accuracy of tracking shoulder bones with 3D US in a simulation and a cadaveric experiment. …”
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Correlation and diagnostic significance of CD4 T cell subsets and NLRP3 inflammasome in ulcerative colitis: the role of the NLRP3/T-bet/GATA3 axis by Yingnan Hu, Jingyi Tang, Dian Yu, Shuo Su, Jintao Fang, Linying Xia, Wenjun Xu, Weihan Zhu, Ninping Song, Fengyong Wang, Dechang Diao, Wei Zhang

“…Additionally, Th1 and Th2 cytokines (IL-2 and IL-4) were significantly elevated in severe UC, while Treg markers (FOXP3, IL-10, TGF-β1) were elevated only in mild-to-moderate UC. …”
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Role of Arg1+ ILC2s and ILCregs in gestational diabetes progression by Zhangyun Gong, Haixing Yi, Jie Zhang, Wan Li, Hao Wang, Peipei Guo, Caihua Li, Anan Pan, Yunxia Cao, Zhimin Lu, Huanhuan Jiang

“…Compared to the control group with normal pregnancy, significantly elevated levels of ILC2s, Arg1+ILC2s, and ILCregs were detected in the PB, CB, and placental tissues of the GDM group. …”
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Prognostic significance of CDK1 expression in diffuse large B-Cell lymphoma by Qiuni Chen, Lei Xu, Chuanyang Lu, Yujie Xue, Xue Gong, Yuye Shi, Chunling Wang, Liang Yu

“…The inhibitor Ro-3306 curtails DLBCL cell growth and enhances cell death in vitro. Conclusions Elevated CDK1 levels are correlated with poor prognosis in patients with DLBCL.…”
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Narrative Review of Free Radicals and Reactive Oxygen Species in Otitis Media by Jeongmin Lee, Seok Min Hong, Yong Sung Choi, Jinseok Lee, Joon Hyung Yeo, Sung Soo Kim, Jae Min Lee, Dong Keon Yon, Seung Geun Yeo

“…A review of their findings showed that the concentrations of hydrogen peroxide (H₂O₂), lipid hydroperoxide (LPO), and myeloperoxidase (MPO) were elevated in patients with acute OM; that the concentrations of H₂O₂, LPO, MPO, xanthine oxidase (XO), superoxide dismutase (SOD), glutathione peroxidase (GPX), malondialdehyde (MDA), hydroxyl radical (·OH), and nitrotyrosine were elevated in patients with OM with effusion; and that the levels of nitric oxide (NO), MPO, 4-hydroxynonenal (4-HNE), and malondialdehyde (MDA) were elevated in patients with chronic OM. …”
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Clinical characteristics of and growth hormone treatment effects on short stature with type 1 insulin-like growth factor receptor (IGF1R) gene alteration by Yuki Kawashima-Sonoyama, Keisuke Wada, Kei Yamamoto, Masanobu Fujimoto, Noriyuki Namba, Takeshi Taketani

“…Short stature with IGF-1 receptor (IGF1R) gene alteration is known as small-for-gestational-age (SGA) short stature with elevated serum IGF1 levels. Its prevalence and clinical characteristics remain unclear. …”
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Evaluation of Melatonin and Antioxidant Levels in the Serum of Breast Cancer Patients by Amjad Mahmood Qadir, Arzu Karatepe, Ayşegül Yazici, Rzgar Farooq Rashid, Pelin Koparir, Rebaz A. Omer, Shamal R. Hama

“…The elevated levels of melatonin and total antioxidants in the control group indicate a healthy status. …”
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Decorin, an exercise-induced secretory protein, is associated with improved prognosis in breast cancer patients but does not mediate anti-tumorigenic tissue crosstalk in mice by Marit Hjorth, Casey L. Egan, Guilherme D. Telles, Martin Pal, David Gallego-Ortega, Oliver K. Fuller, Emma D. McLennan, Ryan D. Gillis, Tae Gyu Oh, George E.O. Muscat, Surafel Tegegne, Michael S.M. Mah, Joanna Skhinas, Emma Estevez, Timothy E. Adams, Matthew J. McKay, Mark Molloy, Kevin I. Watt, Hongwei Qian, Paul Gregorevic, Thomas R. Cox, Pernille Hojman, Julie Midtgaard, Jesper F. Christensen, Martin Friedrichsen, Renato V. Iozzo, Erica K. Sloan, Brian G. Drew, Jørgen F.P. Wojtaszewski, Martin Whitham, Mark A. Febbraio

“…The hypothesis that elevated plasma decorin is a mechanism by which exercise training improves breast cancer progression in humans is not, however, supported by our pre-clinical data since elevated circulating decorin did not increase tumor decorin levels in these models.…”
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Facial wrinkles correction through autologous fat microinjection. by Heriberto Cháves Sánchez, Liliana Espinosa Chang

“…<strong>Background:</strong> autologous fat microinjection is a technique which allows the correction of different dispositions that appear in the face in a very fast, effective and simple way compared to other procedures implying more pain, incisions, and elevated doses of anesthesia. <strong><br />Objective:</strong> to show the effectiveness of the autologous fat microinjection in the correction of facial wrinkles. …”
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Poor fixation stability does not account for motion perception deficits in amblyopia by Kimberly Meier, Simon Warner, Miriam Spering, Deborah Giaschi

“…Fixation stability was elevated in the amblyopic eye relative to controls across all motion stimuli, and not selective for conditions on which perceptual deficits were observed. …”
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Pratique des anciennes instructions et nouveaux programmes de collège : réflexions, propositions by Sandrine Legrand

“…Il convient à l’enseignant de sensibiliser les élèves à la variété et à l’étrangeté de la littérature médiévale en prenant comme support des textes authentiques qui susciteront la curiosité des jeunes. …”
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Delayed Diagnosis of Congenital Hypothyroidism in a Child with Trisomy 21 and Biotinidase Deficiency and Successful Use of Levothyroxine Sodium Oral Solution by Matthew M. Feldt

“…However, biotin can interfere with endocrine laboratory assays and cause falsely low thyroid-stimulating hormone (TSH) and elevated free thyroxine (FT4) levels. This can interfere with the timely diagnosis and subsequent treatment of congenital hypothyroidism (CH). …”
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The Loss of HIF1α Leads to Increased Susceptibility to Cadmium-Chloride-Induced Toxicity in Mouse Embryonic Fibroblasts by Ajith Vengellur, Elizabeth Grier, John J. LaPres

“…Increased cell death in the HIF1α −/− cells was correlated with lower metallothionein protein, elevated levels of reactive oxygen species, and decreased superoxide dismutase enzyme activity. …”
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