Alterations in physicochemical parameters of water and the growth performance of juvenile beluga Huso huso in earthen ponds by Hashem Noferesti, Hojatollah Jafaryan, Rahman Patimar, Hossein Adineh

“…There was a significant elevation in total length and weight over time, demonstrating effective growth conditions during the study period. …”
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The natural immune molecules urinary Tamm–Horsfall protein and pentraxin 3 as predictors for recurrent urinary tract infection severity: a single-center self-control study by Zongping Li, Yingru Xu, Qian Wang, Gang Yuan, Jing Shu, Shiwei Liu, Xuezhong Gong

“…Descriptive analysis was performed on the RUTI cohort.Results Urinary THP levels were significantly lower in RUTI patients (TLF and CLAT groups) compared to the non-RUTI, whereas PTX3 levels showed a tendency toward elevation. After treatment, urinary THP levels were markedly higher in the TLF group (27.43 ± 7.07) compared to pretreatment levels (10.00 ± 2.79), while levels remained lower in the CLAT group (8.91 ± 2.23) than in the TLF group. …”
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An Arctic sea ice concentration data record on a 6.25 km polar stereographic grid from 3 years of Landsat-8 imagery by H.-S. Jung, S.-M. Lee, S.-M. Lee, J.-H. Kim, K. Lee

“…In order to collect relatively bright and clear scenes, thresholds of solar elevation <span class="inline-formula"><i>&gt;</i>15</span>° and cloud cover <span class="inline-formula"><i>&lt;</i>10</span> % were applied in this study. …”
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Spatiotemporal range dynamics and conservation optimization for endangered medicinal plants in the Himalaya by Fu-Lv Liu, Winnie Wanjiku Mambo, Jie Liu, Guang-Fu Zhu, Raees Khan, Abdullah, Shujaul Mulk Khan, Lu Lu

“…Six species migrated northwards towards high elevation, while four species migrated southwards. …”
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Aerobic exercise alleviates statin-induced PCSK9 upregulation by increasing epoxyeicosatrienoic acid levels through the FoxO3a–Sirt6 axis by Jiahui Hu, Hao Lei, Jingyuan Chen, Leiling Liu, Yajun Gui, Kaijun Sun, Danyan Xu

“…Background: Statins are the cornerstone of low-density lipoprotein cholesterol (LDL-C)-lowering therapy; however, the therapeutic efficacy of statins in countering atherosclerotic cardiovascular disease (ASCVD) is compromised by the concurrent elevation of proprotein convertase subtilisin/kexin type 9 (PCSK9), a pivotal molecule that increases LDL-C levels. …”
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Placental trophoblast aging in advanced maternal age is related to increased oxidative damage and decreased YAP by Song Guo, Song Guo, Qihao Pan, Qihao Pan, Baokang Chen, Baokang Chen, Yijuan Huang, Yijuan Huang, Si Li, Si Li, Chenyu Gou, Chenyu Gou, Yu Gao, Yu Gao

“…YAP expression in HTR8/SVneo cells was manipulated to investigate its role in trophoblastic senescence and oxidative damage.ResultsCompared with the control group, the AMA placenta exhibits increased aging biomarkers, which is coupled with an elevation in oxidative damage within placental trophoblast cells and a notable decline in YAP levels. …”
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Vulnerability, Resilience and Adaptation of Lagos Coastal Communities to Flooding by Prince Emeka Ndimele, Akinloye Emmanuel Ojewole, Gabriel Olarinde Mekuleyi, Lateef Akorede Badmos, Christopher Monday Agosu, Emmanuel Sunday Olatunbosun, Oluseyi Olaide Lawal, Jamiu Adebayo Shittu, Olufemi Olabode Joseph, Kehinde Moyosola Ositimehin, Felix Chinsom Ndimele, Catherine Oluwalopeye Ojewole, Iman Olawunmi Abdulganiy, Odunayo Temitope Ayodele

“…All these factors have contributed to the instability of Lagos ecosystems, but the impact of flooding is particularly significant because Lagos is surrounded by aquatic ecosystems and its low elevation and topography increase its susceptibility to flooding. …”
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Population structure, floral diversity, habitat geography, and conservation status of Himalayan horse chestnut (Aesculus indica) in western Himalayan moist temperate forest ecosyst... by Urwa Irfan, Hamayun Shaheen, Muhammad Manzoor, Muhammad Manzoor, Sidra Nasar, Raja Waqar Ahmed Khan, Syed Waseem Gillani, Syed Waseem Gillani, Abdulwahed Fahad Alrefaei, Arbaz Attique, Asif Kamal, Sarah Abdul Razak, Malik Talha Riaz

“…Primary vegetation data and geographic features were collected via systematic quadrat-based sampling from 14 sites in the moist temperate ecosystem of Kashmir, ranging in elevation from 1,400 to 2,800 m. Population structure analysis revealed an average density of 435.85 stems/ha for A. indica, with a significant variation ranging from 220 to 1,100 stems/ha. …”
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Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes by Kazuhiro Kakimi, Hirokazu Matsushita, Masaaki Komatsu, Eiryo Kawakami, Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Katsuyuki Shiroguchi, Heiichiro Udono

“…Consequently, Glut-1 is elevated in CD8TILs, together with the expansion of activated dendritic cells. …”
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Real-world, feasibility study to investigate the use of a multidisciplinary app (Pulsara) to improve prehospital communication and timelines for acute stroke/STEMI care by Joosup Kim, Dominique A Cadilhac, Karen Smith, Ramesh Sahathevan, Stephen Bernard, Dion Stub, Voltaire Nadurata, Ernesto Oqueli, Thomas Kraemer, Chris F Bladin, Kathleen L Bagot, Michelle Vu, Grant Hocking, Tessa Coupland, Debra Pearce, Diane Badcock, Marc Budge, Wayne Pearce, Howard Hall, Ben Kelly, Angie Spencer, Pauline Chapman, Casey Hair

“…Objectives To determine if a digital communication app improves care timelines for patients with suspected acute stroke/ST-elevation myocardial infarction (STEMI).Design Real-world feasibility study, quasi-experimental design.Setting Prehospital (25 Ambulance Victoria branches) and within-hospital (2 hospitals) in regional Victoria, Australia.Participants Paramedics or emergency department (ED) clinicians identified patients with suspected acute stroke (onset &lt;4.5 hours; n=604) or STEMI (n=247).Intervention The Pulsara communication app provides secure, two-way, real-time communication. …”
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Sex Differences in the Prognostic Value of Circulating Biomarkers in Patients Presenting With Acute Chest Pain by Gard Mikael Sæle Myrmel, MD, Nasir Saeed, Ole Thomas Steiro, MD, Hilde Lunde Tjora, MD, PhD, Jørund Langørgen, MD, PhD, Rune Oskar Bjørneklett, MD, PhD, Øyvind Skadberg, MD, Vernon Vijay Singha Bonarjee, MD, PhD, Øistein Rønneberg Mjelva, MD, Eva Ringdal Pedersen, MD, PhD, Kjell Vikenes, MD, PhD, Torbjørn Omland, MD, PhD, Kristin Moberg Aakre, MD, PhD

“…Objectives: This study investigated whether there are sex differences in the long-term prognostic value of biomarkers in patients presenting with suspected non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Methods: High-sensitivity cardiac troponin (hs-cTn), hs-cTnI, N-terminal pro-B-type natriuretic peptide (NT-proBNP), growth differentiation factor (GDF)-15, and C-reactive protein (CRP) concentrations were measured in 1,476 patients admitted with suspected NSTE-ACS. …”
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The spatiotemporal changes and influencing mechanisms of the coastline in the Yellow River Delta, China by Zhuo Yang, Wei Gao, Wei Gao, Wenjie Yu, Jie Liu, Jie Liu, Jun Du, Jun Du, Ping Li, Ping Li, Yuanqin Xu, Yuanqin Xu, Ping Li, Ping Li

“…Additionally, factors such as sea-level rise due to global climate change and delta subsidence caused by sediment compaction have lowered the relative elevation of the coastline, further accelerating its erosion and retreat. …”
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L’aqueduc de Fontanières : un cinquième aqueduc romain à Lyon ? by Jean-Yves Barbier

“…At mid-slope, downstream from the Narbonne road, at an estimated invert elevation of 223 m, the canal had to negotiate the contours of the steep terrain of the Balme de Fontanières, without resorting to the aerial installations required by its four large and prestigious counterparts supplying the city’s highest districts from the west. …”
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Dietary Solid-state-fermentation product of Bacillus velezensis T23 alleviate hepatic steatosis, oxidative stress, gut barrier damage, and microbiota dysbiosis in juvenile genetica... by Qiang Hao, Rolf Erik Olsen, Einar Ringø, Qianwen Ding, Tsegay Teame, Yuanyuan Yao, Chao Ran, Yalin Yang, Zhen Zhang, Zhigang Zhou

“…However, markedly downregulation of the mRNA level of pro-inflammatory cytokine il-1β (p < 0.05) was observed in 0.05 and 0.3T23 groups, compared with the control. 16S rRNA sequencing analysis data on gut microbiota indicated that supplementation of T23 at lower levels (0.05, 0.1 and 0.2) resulted in a remarkable elevation of the abundance of phylum Firmicutes and reduced the abundance of Proteobacteria, and the ratio of (Firmicutes +Bacteroidota +Fusobacteria) /Proteobacteria. …”
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Virological and serological outcomes in people with HIV-HBV coinfection who had discontinued tenofovir-containing antiretroviral therapy: Results from a prospective cohort study by Amir M. Mohareb, Patrick Miailhes, Julie Bottero, Caroline Lascoux-Combe, Julie Chas, Sarah Maylin, Audrey Gabassi, Hayette Rougier, Emily P. Hyle, Constance Delaugerre, Karine Lacombe, Anders Boyd

“…Determinants of HBV DNA >2000 IU/mL while people were off tenofovir were detectable HIV RNA (p = 0.041), lower CD4+ T-cell count (p = 0.027), HBeAg positive serology (p = 0.004) and positive hepatitis D serology (p = 0.001). ALT elevation was associated with positive hepatitis C antibody serology (p = 0.012). …”
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Estimation of mangrove carbon stocks using unmanned aerial vehicle over coastal vegetation by S.H. Larekeng, M. Nursaputra, M.F. Mappiasse, S. Ishak, M. Basyuni, E. Sumarga, V.B. Arifanti, A.A. Aznawi, Y.I. Rahmila, M. Yulianti, R. Rahmania, A. Mubaraq, S.G. Salmo III, H. Ali, I. Yenny

“…Drones equipped with multispectral sensors enable the collection of precise and comprehensive data on vegetation and elevation in many ecological systems. The survey and subsequent analysis highlighted the wide variation in the density of mangrove forests in the Lantebung mangrove ecosystem. …”
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Palmitic Acid Accelerates Endothelial Cell Injury and Cardiovascular Dysfunction via Palmitoylation of PKM2 by Yu He, Senlin Li, Lujing Jiang, Kejue Wu, Shanshan Chen, Linjie Su, Cui Liu, Peiqing Liu, Wenwei Luo, Shilong Zhong, Zhuoming Li

“…In ApoE−/−mice, 10 mg/kg−1 PA treatment induces blood pressure elevation, cardiac contractile dysfunction, endothelial dysfunction and atherosclerotic plaqueformation. …”
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Profil glucido-lipidique et risque cardiovasculaire chez les diabétiques de type 2 by Mourad Nachi, Ibtissem Kihel, Abdessamad Dali-Ali, Mouna Gourine, Fouzia Benrahal

“…Conclusion - this study showed a high frequency of micro and macrovascular complications, lipid abnormalities and a very poor glycemic control. The elevation of HbA1c level, the high blood pressure and dyslipidemia are the most associated factors with a high cardiovascular risk. …”
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Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice by Ali Yousefian-Jazi, Suhyun Kim, Jiyeon Chu, Seung-Hye Choi, Phuong Thi Thanh Nguyen, Uiyeol Park, Min-gyeong Kim, Hongik Hwang, Kyungeun Lee, Yeyun Kim, Seung Jae Hyeon, Hyewhon Rhim, Hannah L. Ryu, Grewo Lim, Thor D. Stein, Kayeong Lim, Hoon Ryu, Junghee Lee

“…Moreover, MEF2C mutant cells show reduction of mitochondrial membrane potential, ATP level but elevation of oxidative stress. MEF2C deficiency in the upper and lower motor neurons of mice impairs mitochondria-encoded genes, and leads to mitochondrial metabolic disruption and progressive motor behavioral deficits. …”
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Temporal trends in characteristics and outcome of heart failure patients with and without significant coronary artery disease by Entela Bollano, Björn Redfors, Araz Rawshani, Dimitrios Venetsanos, Sebastian Völz, Oskar Angerås, Charlotta Ljungman, Joakim Alfredsson, Tomas Jernberg, Truls Råmunddal, Petur Petursson, J. Gustav Smith, Oscar Braun, Henrik Hagström, Ole Fröbert, David Erlinge, Elmir Omerovic

“…No such increase was seen for indications angina pectoris and ST‐elevation myocardial infarction. A normal CAG or non‐obstructive CAD was reported in 63.2% (HF‐NCAD), and 36.8% had >50% diameter stenosis in one or more coronary arteries (HF‐CAD). …”
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