A select inhibitor of MORC2 encapsulated by chimeric membranecoated DNA nanocage target alleviation TNBC progression by Xiaohan Su, Yunbo Luo, Yali Wang, Peng Qu, Jun Liu, Shiqi Han, Cui Ma, Shishan Deng, Qi Liang, Xiaowei Qi, Panke Cheng, Lingmi Hou

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Efficacy of Wenxin Keli Plus Amiodarone versus Amiodarone Monotherapy in Treating Recent-Onset Atrial Fibrillation by Nixiao Zhang, Gary Tse, Shristi Dahal, Yajuan Yang, Mengqi Gong, Calista Zhuo Yi Chan, Enzhao Liu, Gang Xu, Konstantinos P. Letsas, Panagiotis Korantzopoulos, Guangping Li, Tong Liu

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Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy by Yu Feng, Keziah S. Diego, Zhe Dong, Zoé Christenson Wick, Lucia Page-Harley, Veronica Page-Harley, Julia Schnipper, Sophia I. Lamsifer, Zachary T. Pennington, Lauren M. Vetere, Paul A. Philipsberg, Ivan Soler, Albert Jurkowski, Christin J. Rosado, Nadia N. Khan, Denise J. Cai, Tristan Shuman

“…To investigate how hippocampal-entorhinal dysfunction contributes to progressive memory deficits in epilepsy, we performed simultaneous in vivo electrophysiology in the hippocampus (HPC) and medial entorhinal cortex (MEC) of control and epileptic mice 3 or 8 weeks after pilocarpine-induced status epilepticus (Pilo-SE). …”
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Clinical characteristics, etiology, and treatment of young adult‐onset epilepsy: A 24‐year retrospective study by Xu Zhang, Feng Xiang, Ziyu Wang, Yang Li, Chenjing Shao, Xiaoyang Lan, Senyang Lang, Xiangqing Wang

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Risk factors for thromboembolic and bleeding events in anticoagulated patients with atrial fibrillation: the prospective, multicentre observational PREvention oF thromboembolic eve... by Raffaele De Caterina, Kurt Huber, Richard Schilling, Miklos Rohla, Thomas W Weiss, Ladislav Pecen, Giuseppe Patti, Jolanta M Siller-Matula, Renate B Schnabel, Dipak Kotecha, Markus Lucerna, Paulus Kirchhof

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Simulator training in focus assessed transthoracic echocardiography (FATE) for undergraduate medical students: results from the FateSim randomized controlled trial by Johannes Matthias Weimer, Franziska Marietta Sprengart, Thomas Vieth, Sebastian Göbel, Anna Dionysopoulou, Rebecca Krüger, Jan Beer, Andreas Michael Weimer, Holger Buggenhagen, Roman Kloeckner, Lukas Pillong, Johanna Helfrich, Elias Waezsada, Philipp Wand, Julia Weinmann-Menke

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Developmental dysfunction in a preclinical model of Kcnq2 developmental and epileptic encephalopathy by Miaomiao Mao, Nikola Jancovski, Yafit Kushner, Lucas Teasdale, Phan Truong, Kun Zhou, Samuel Reid, Linghan Jia, Ye Htet Aung, Melody Li, Christopher A. Reid, Sean Byars, Ingrid Scheffer, Steven Petrou, Snezana Maljevic

“…Conclusions: Our study reports on a novel Kcnq2 DEE mouse model recapitulating aspects of the disease phenotype with the electrophysiological and transcriptome analysis providing insights into KCNQ2 DEE mechanisms that can be leveraged for future therapy development.…”
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Trends in stroke-related mortality in atrial fibrillation patients in the United States: Insights from the CDC WONDER database by Muhammad Abdullah Naveed, Sivaram Neppala, Himaja Dutt Chigurupati, Muhammad Omer Rehan, Ahila Ali, Hamza Naveed, Bazil Azeem, Rabia Iqbal, Manahil Mubeen, Mashood Ahmed, Ayman R. Fath, Timir Paul, Bilal Munir

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Exome sequencing reveals a rare damaging variant in GRIN2C in familial late-onset Alzheimer's disease by Elisa Rubino, Maria Italia, Elisa Giorgio, Silvia Boschi, Paola Dimartino, Tommaso Pippucci, Fausto Roveta, Clara Maria Cambria, Gabriella Elia, Andrea Marcinnò, Salvatore Gallone, Ekaterina Rogaeva, Flavia Antonucci, Alfredo Brusco, Fabrizio Gardoni, Innocenzo Rainero

“…Functional analysis was performed using primary neuronal cultures, and the impact of the variant was assessed through immunocytochemistry and electrophysiology. Results Pathogenic variants were not identified in APP, PSEN1, or PSEN2, nor in the 77 genes in NeuroX array assay. …”
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State-of-the-art of loading and unloading tests for glaucoma: potentialities and informative value by O.S. Myakonkaya, A.S. Sarkisyan, A.V. Seleznev, A.V. Kuroyedov, I.R. Gazizova

“…Visual changes accompanying loading and unloading tests are recorded by visual acuity measurement, IOP measurement (tono metry and tonography, visual field testing (campimetry, angioscotometry), adaptometry, retinal tomography, and electrophysiology (visually evoked potentials). Studies are currently underway to develop novel modifications of diagnostic tests using modern high-tech controlling tools. …”
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Is intense exercise bad for your mind? Subjective, behavioral and physiological responses to a cognitive effort to failure by Darías Holgado, Ludovic Leubaz, Paolo Ruggeri, Guillermo Borragan, Antonio Luque-Casado, Tristan Bekinschtein, Daniel Sanabria, Nicolas Place

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The Effect of Coronary Artery Disease on the Prognosis of Hypertrophic Cardiomyopathy: A Multi-Center Cohort Study by Guoqing Hou, Qian Liao, Huihui Ma, Yan Shu, Shengzhi Zeng, Yongmei Zhou, Liangjun Luo, Gang Zhao, Tao He, Mingjiang Liu, Jianhong Tao, Wei Hua, Xiaoping Li

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Impact of diabetes on clinical outcome of patients with heart failure undergoing ICD and CRT procedures: results from the German Device Registry by Elif Kaya, Jochen Senges, Matthias Hochadel, Lars Eckardt, Dietrich Andresen, Hüseyin Ince, Stefan G. Spitzer, Thomas Kleemann, Sebastian S.K. Maier, Werner Jung, Christoph Stellbrink, Tienush Rassaf, Reza Wakili

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Analysis of tumor-infiltrating exhausted T cells highlights IL-6 and PD1 blockade as a combined immunotherapy strategy for non-small cell lung cancer by Lulu Zhang, Lulu Zhang, Xiyuan Guo, Xiyuan Guo, Xiaoke Sun, Jue Liao, Qin Liu, Yingchun Ye, Zhihui Yang, Ratchada Cressey, Qing He, Qing Yuan, Qing Yuan

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Associations between local COVID-19 policies and anxiety in the USA: a longitudinal digital cohort study by Jeffrey E Olgin, Gregory M Marcus, Rita Hamad, John Kornak, Carmen R Isasi, Ana Sanchez-Birkhead, Mark Pletcher, Soo Park, Natasha Williams, Thomas Carton, Aaron E Cozen, Madelaine Faulkner Modrow, Amy Chiang, Matthew Brandner, Jaime H Orozco, Kristen Azar, Sylvia E K Sudat, Pelin Ozluk, Heather Kitzman, Sara J Knight

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Age-dependent phenotypes of cognitive impairment as sequelae of SARS-CoV-2 infection by Gabriela Gonzalez Aleman, George D. Vavougios, George D. Vavougios, Carmela Tartaglia, Carmela Tartaglia, Nalakath A. Uvais, Alla Guekht, Alla Guekht, Akram A. Hosseini, Akram A. Hosseini, Vincenzina Lo Re, Vincenzina Lo Re, Catterina Ferreccio, Catterina Ferreccio, Giovanni D'Avossa, Hernan P. Zamponi, Mariana Figueredo Aguiar, Agustin Yecora, Agustin Yecora, Mohammad Zia Ul Haq Katshu, Vasileios T. Stavrou, Vasileios T. Stavrou, Stylianos Boutlas, Konstantinos I. Gourgoulianis, Camila Botero, Francisco González Insúa, Santiago Perez-Lloret, Mikhail Zinchuk, Anna Gersamija, Sofya Popova, Yulia Bryzgalova, Ekaterina Sviatskaya, Giovanna Russelli, Giovanna Russelli, Federica Avorio, Federica Avorio, Sophia Wang, Sophia Wang, Paul Edison, Paul Edison, Yoshiki Niimi, Hamid R. Sohrabi, Elizabeta B. Mukaetova Ladinska, Elizabeta B. Mukaetova Ladinska, Daria Neidre, Gabriel A. de Erausquin, Gabriel A. de Erausquin, Gabriel A. de Erausquin

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Altered thermal preference by preoptic estrogen receptor alpha neurons in postpartum females by Nan Zhang, Meng Yu, Qianru Zhao, Bing Feng, Yue Deng, Jonathan C. Bean, Qingzhuo Liu, Benjamin P. Eappen, Yang He, Kristine M. Conde, Hailan Liu, Yongjie Yang, Longlong Tu, Mengjie Wang, Yongxiang Li, Na Yin, Hesong Liu, Junying Han, Darah Ave Threat, Nathan Xu, Taylor Smiley, Pingwen Xu, Lulu Chen, Tianshu Zeng, Yanlin He, Chunmei Wang

“…The number and activity of ERα-expressing POA neurons (ERαPOA) were assessed using immunohistochemistry and in vitro electrophysiology in response to temperature changes and ERα agonist. …”
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Nervous System of Periplaneta americana Cockroach as a Model in Toxinological Studies: A Short Historical and Actual View by Maria Stankiewicz, Marcin Dąbrowski, Maria Elena de Lima

“…Nervous system of Periplaneta americana cockroach is used in a wide range of pharmacological studies, including electrophysiological techniques. This paper presents its role as a preparation in the development of toxinological studies in the following electrophysiological methods: double-oil-gap technique on isolated giant axon, patch-clamp on DUM (dorsal unpaired median) neurons, microelectrode technique in situ conditions on axon in connective and DUM neurons in ganglion, and single-fiber oil-gap technique on last abdominal ganglion synapse. …”
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Hereditary Neuropathy with Liability to Pressure Palsy Presenting with Hand Drop in a Young Child by Inês Sobreira, Cátia Sousa, Ana Raposo, M. Rita Soares, Ana Soudo, Ana Isabel Dias

“…We present the case study of a six-year-old male child who presented with left hand drop that he kept for over four weeks. Electrophysiological studies suggested HNPP and genetic studies confirmed it. …”
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Lewis-Sumner syndrome: subacute bilateral lesion of brachial plexus by R. Bunevičiūtė, R. Masaitienė, A. Klimašauskienė

“…The most common clinical presentations of Lewis-Sumner syndrome are asymmetrical or multifocal sensory disturbances and weakness, electrophysiologically characterized by the presence of motor conduction blocks. …”
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