Langerhans Cells Directly Interact with Resident T Cells in the Human Epidermis by Tomonori Oka, Tatsuya Hasegawa, Truelian Lee, Valeria S. Oliver-Garcia, Mahsa Mortaja, Marjan Azin, Satoshi Horiba, Sabrina S. Smith, Sara Khattab, Kathryn E. Trerice, Steven T. Chen, Yevgeniy R. Semenov, Shadmehr Demehri

“…Using normal human skin samples, we find that Langerhans cells (LCs) contact T cells in the epidermis of the elderly. LCs with high HLA-II, CD86, and PD-L2 expression directly contacted PD-1+ tissue-resident memory T cells and CTLA-4+ regulatory T cells in the epidermis, indicating an axis of peripheral tolerance in a steady state. …”
Get full text

Food insecurity and the risk of HIV acquisition: findings from population-based surveys in six sub-Saharan African countries (2016–2017) by Danielle Barradas, Nicholus Mutenda, Hetal Patel, Avi J Hakim, Lloyd Mulenga, Sally Findley, Andrea Low, George Rutherford, Sarah Ayton, Elizabeth Gummerson, Amee Schwitters, Rogerio Bonifacio, Mekleet Teferi, James Juma, Claudia Ahpoe, Choice Ginindza, Samuel Biraro, Karam Sachathep, Ahmed Saadani Hassani, Willford Kirungi, Keisha Jackson, Leah Goeke, Neena Philips, Jennifer Ward, Steven Hong

Get full text

KEAP1 mutations as key crucial prognostic biomarkers for resistance to KRAS-G12C inhibitors by Linyan Tian, Chengming Liu, Sufei Zheng, Huiyang Shi, Fang Wei, Wenxin Jiang, Yucheng Dong, Haiyan Xu, Enzhi Yin, Nan Sun, Jie He, Yan Wang

“…Results Analysis of 13 studies involving 1132 patients highlighted the significant efficacy of KRAS-G12C inhibitor monotherapy, particularly among elderly and female patients. Treatment response was notably affected by liver and brain metastases, with KEAP1 mutations identified as a primary negative prognostic factor, closely associated with early resistance to treatment. …”
Get full text

Association of quality of life in older patients with breast cancer: a cross-sectional study from China by Xi Chen, Qing Li, Xiang Wang, Lei Ji, Jintao Zhang, Qiao Li, Min Xiao, Shanshan Chen, Pin Zhang, Jiani Wang, Heng Cao, Xiaoyan Qian, Meng Xiu, Zhuoran Li, Yiqun Li, Xiaojuan Zheng

“…Interventions targeting these symptoms may lead to an overall improvement in gQoL.Trial registration number ChiCTR2200056070; Public title: Frailty and Comorbidity in the Elderly Study (FACE Study).…”
Get full text

New Horizons In The Treatment Of Metastatic Castrate Resistant Prostate Cancer by Zein El Amir

“…The subject deals with the learning of the structure of the human body from the gross external features down to the microscopic level, at all stages of development, from the embryo to the elderly. This knowledge is essential for a physician to understand the functioning of the body, disease pathophysiology, and treatment modalities.  …”
Get full text

Anatomy In The Undergraduate Medical Curriculum; Blending The Old And New by Ayesha Yousaf

“…The subject deals with the learning of the structure of the human body from the gross external features down to the microscopic level, at all stages of development, from the embryo to the elderly. This knowledge is essential for a physician in order to understand the functioning of the body, disease pathophysiology and treatment modalities.…”
Get full text

The increasing burden of group B Streptococcus from 2013 to 2023: a retrospective cohort study in Beijing, China by Yingxing Li, Wenhang Yang, Yi Li, Kexin Hua, Ying Zhao, Taie Wang, Lingli Liu, Yali Liu, Yao Wang, Wenjing Liu, Li Zhang, Renyuan Zhu, Shuying Yu, Hongli Sun, Hongtao Dou, Qiwen Yang, Yingchun Xu, Lina Guo

“…This study highlights the importance of continuous screening and monitoring for GBS, especially given the concerning antibiotic resistance rates of GBS.IMPORTANCEGroup B Streptococcus (GBS) is an important pathogen that commonly causes infections in newborns and the elderly. This retrospective study provides a comprehensive analysis of GBS strains isolated from a large tertiary hospital in Beijing between 2013 and 2023, revealing an increasing colonization rate of GBS in both pregnant and non-pregnant women. …”
Get full text

Genealogy of the Arab tribes living in Syria during the Caliphate of Imam Ali (AS)Typology of the Arab Tribes Living in the Levant during the Caliphate of Imam Ali (AS) Typology... by Akram sadat Hoseini, Yahya Mirhoseini

“…In one report, a man from the Abbas tribe brought news of the alleged slaughter of 60,000 elderly Levantine men to the Iraqi army in an effort to create anxiety and shake the resolve of Imam Ali's forces. …”
Get full text

Die ouderling in twee kerkordes in die Dordtse tradisie by P. J. Strauss

“… This article concentrates on what the mandate or task of the church elder in the tradition of the church order of Dordt (DCO) is. …”
Get full text

Evaluation of Nursing Homes Using a Novel PROMETHEE Method for Probabilistic Linguistic Term Sets by Peng Li, Zhiwei Xu

“…Traditional informal long-term care is hard to sustain because of the reduction in family size and elders’ children migration to big cities. The institution offering services for the disabled elders has been a tendency. …”
Get full text

Konsep Diri LANSIA di Panti Jompo by Yiyit Yentika

“…Based on the interview to these three elders that has been nursed in this dwelling, one elder says happy although living far away from the family and the brother feels grateful, 2 elders say that they feel sad and yearning of their family. …”
Get full text

Trompeuses séductions. La Chute d’Icare des Musées royaux des Beaux-Arts de Belgique by Dominique Allart, Christina Currie

“…Under the worn and retouched paint layer, camouflaged by a yellowed varnish, the infrared reflectogram reveals a studious and clumsy underdrawing that is neither characteristic of Pieter Bruegel the Elder nor of Pieter Brueghel the Younger, his elder son and primary copyist. …”
Get full text

Brain Hemodynamic Intermediate Phenotype Links Vitamin B12 to Cognitive Profile of Healthy and Mild Cognitive Impaired Subjects by Luca Cecchetti, Giada Lettieri, Giacomo Handjaras, Andrea Leo, Emiliano Ricciardi, Pietro Pietrini, Silvia Pellegrini, The Train the Brain Consortium

“…Despite this, no previous study directly investigated whether vitamin B12, folate, and homocysteine levels are sufficient to explain individual neuropsychological profiles or, alternatively, whether the activity of brain regions modulated by these compounds better predicts cognition in elders. Here, we measured the relationship between vitamin blood concentrations, scores at seventeen neuropsychological tests, and brain activity of sixty-five elders spanning from normal to Mild Cognitive Impairment. …”
Get full text

Vida Saludable: La Diabetes by Linda B. Bobroff, Karla P. Shelnutt, Paulina Wittkowsky

“…Shelnutt, and Paulina Wittkowsky, is the Spanish language version of Healthy Living for Elders: Diabetes. It answers several frequently asked questions about diabetes. …”
Get full text

Vida Saludable: La Diabetes by Linda B. Bobroff, Karla P. Shelnutt, Paulina Wittkowsky

“…Shelnutt, and Paulina Wittkowsky, is the Spanish language version of Healthy Living for Elders: Diabetes. It answers several frequently asked questions about diabetes. …”
Get full text

Why Are Native Hawaiians Underrepresented in Hawai‘i's Older Adult Population? Exploring Social and Behavioral Factors of Longevity by Lana Sue Ka‘opua, Kathryn L. Braun, Colette V. Browne, Noreen Mokuau, Chai-Bin Park

“…Few published studies have compared health indicators across ethnicities for the state's older adult population or focused on disparities of Native Hawaiian elders. The current study examines data from two state surveillance programs, with attention to cause of death and social-behavioral factors relevant to elders. …”
Get full text

Political Awakenings by Claudia Franziska Brühwiler

“…However, both experience only a partial initiation, since the elder brother will have to recognize his errors and the younger one will first have to learn how to go beyond the mere questioning of authority.…”
Get full text

Suggestions and Propositions for Successful Aging by María Guillermina Yanes García

“…Themes that have been identified by elderlies as part of their health problems are also included. …”
Get full text

The Impact of Physical Activity on Disability Incidence among Older Adults in Mexico and the United States by Kerstin Gerst, Alejandra Michaels-Obregon, Rebeca Wong

“…However, little is known about the potential benefit of physical activity in preventing disability among elders in countries at different stages of epidemiological transition. …”
Get full text

Healthy Eating: Smart Snacking by Jennifer Hillan, Linda B. Bobroff

“…Bobroff, provides smart snacking tips for elders in an easy-to-read format. Published by the UF Department of Family Youth and Community Sciences, March 2010.   …”
Get full text