Global, regional, and national burden of ischemic heart disease attributable to secondhand smoke from 1990 to 2019 by Xinyue Yang, Zhiqiang Zhang, Jiayi Sun, Wenjuan Zhang

“…Despite a declining trend in ASMR and ASDR, regional disparities persist. The elderly and middle-aged populations bore the most significant burden. …”
Get full text

Specific types of male infertility are correlated with T cell exhaustion or senescence signatures by Giada Amodio, Giorgia Giacomini, Luca Boeri, Massimiliano Raffo, Simone Cilio, Edoardo Pozzi, Federico Belladelli, Fausto Negri, Anna Maria Ferrara, Alessia d’Arma, Francesca Romana Santoni de Sio, Luca Pagliardini, Enrico Papaleo, Eugenio Ventimiglia, Massimo Alfano, Francesco Montorsi, Andrea Salonia, Silvia Gregori

“…We first observe that young infertile men have a pro-inflammatory milieu with increased frequency of myeloid cells and inflammatory mediators in the seminal fluid and the peripheral blood, which are immune alterations typically observed in healthy elderly men. Transcriptomic profiling confirms the upregulation of genes associated with the interferon-gamma and -alpha responses in peripheral blood T cells of infertile men with oligo-astheno-teratozoospermia or non-obstructive azoospermia, with distinct T cell signatures of exhaustion and senescence discriminating the two infertile conditions. …”
Get full text

Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease by Caterina Oriana Aragona, Egidio Imbalzano, Federica Mamone, Valentina Cairo, Alberto Lo Gullo, Angela D’Ascola, Maria Adriana Sardo, Michele Scuruchi, Giorgio Basile, Antonino Saitta, Giuseppe Mandraffino

“…MEDLINE was searched using keywords related to “endothelial progenitor cells” and “endothelium” and, for the different categories, respectively, “smoking”; “blood pressure”; “diabetes mellitus” or “insulin resistance”; “dyslipidemia”; “aging” or “elderly”; “angina pectoris” or “myocardial infarction”; “stroke” or “cerebrovascular disease”; “homocysteine”; “C-reactive protein”; “vitamin D”. …”
Get full text

THE OCCURRENCE OF CONTRACTURE AND THE SEVERITY OF BURN INJURIES AMONG BURN PATIENTS TREATED AT DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA (2020-2022) by Gifta Marshanda Qanitah Hamiseno, Iswinarno Doso Saputro, Diah Mira Indramaya, Lobredia Zarasade

“…Highlights: • A robust association was observed between total body surface area (TBSA) and burn injuries, except in the case of elderly individuals. • The duration of hospitalization is significantly associated with the occurrence of contracture. …”
Get full text

Evaluation of intranasal TLR2/6 agonist INNA-051: safety, tolerability and proof of pharmacology by Francesca A. Mercuri, Scott White, Hayley A. McQuilten, Charlotte Lemech, Stephan Mynhardt, Rana Hari, Ping Zhang, Nicole Kruger, Grant McLachlan, Bruce E. Miller, Nicholas P. West, Ruth Tal-Singer, Christophe Demaison

“…Background Local priming of the innate immune system with a Toll-like receptor (TLR)2/6 agonist may reduce morbidity and mortality associated with viral respiratory tract infections, particularly for the elderly and those with chronic diseases. The objectives of the present study were to understand the potential of prophylactic treatment with a TLR2/6 agonist as an enhancer of innate immunity pathways leading to accelerated respiratory virus clearance from the upper airways. …”
Get full text

Epidemiology and Antimicrobial Resistance of Stenotrophomonas maltophilia in China, 2014–2021 by Hanli Wang, Shirong Li, Haoyu Ji, Yixin Hu, Susheng Zhou, Xingwu Chen, Zhiwei Lu, Qinghai You, Yusheng Cheng, Lei Zha

“…The overall prevalence of S. maltophilia among all clinical bacterial isolates remained stable at approximately 2.1%, with higher rates observed in intensive care units and elderly patients. Resistance rates to sulfamethoxazole-trimethoprim decreased from 9.8% in 2014 to 7.5% in 2021. …”
Get full text

Prevalence and associated factors of healthy aging among community-dwelling older adults in Lishui city, China: a cross-sectional study by Jian-Hua Chen, Norhasmah Mohd Zain, Azlina Yusuf, Bi-He Ying

“…Abstract Background Identifying the level of healthy aging and exploring its associated factors are prerequisites in the planning of effective measures among the elderly population. Thus, this study aimed to investigate the prevalence of healthy aging and determine its associated factors among community-dwelling older adults from mountain areas in Lishui, China. …”
Get full text

Unravelling the transcriptomic symphony of muscle ageing: key pathways and hub genes altered by ageing and caloric restriction in rat muscle revealed by RNA sequencing by Gulam Altab, Brian J. Merry, Charles W. Beckett, Priyanka Raina, Inês Lopes, Katarzyna Goljanek-Whysall, João Pedro de Magalhães

“…Abstract Age-related muscle wasting, sarcopenia is an extensive loss of muscle mass and strength with age and a major cause of disability and accidents in the elderly. Mechanisms purported to be involved in muscle ageing and sarcopenia are numerous but poorly understood, necessitating deeper study. …”
Get full text

Surveillance of SARS-CoV-2 variants in Henan, China from 2023 to 2024 by Yun Song, Bicong Wu, Hongxia Ma, Yafei Li, Su Yan, Jingjing Pan, Haifeng Wang, Ying Ye, Xueyong Huang, Wanshen Guo

“…The XBB variant exhibited a significantly lower rate of severe cases, with most infections being mild (P < 0.05). Male patients, the elderly, and certain variants (e.g., BA.5.2) were associated with more severe outcomes, while XBB and BA.2.86 showed lower pathogenicity, with a marked reduction in severe and fatal cases (P < 0.05).ConclusionAs SARS-CoV-2 variants evolve, the incidence of severe cases has progressively decreased. …”
Get full text

Age-stratified trends and outcomes of inpatient cholecystectomy for acute cholecystitis in the United States by Ayesha P. Ng, Joseph E. Hadaya, Sara Sakowitz, Zihan Gao, James Wu, Peyman Benharash

“…Background: The elderly population in the United States is rapidly expanding. …”
Get full text

Patients’ satisfaction and efficacy of modern conventional hearing aids: A comprehensive analysis of the self-reported user experiences in adult people by Daniele Portelli, Cosimo Galletti, Sabrina Loteta, Leonard Freni, Francesco Ciodaro, Angela Alibrandi, Giuseppe Alberti

“…The Mann Whitney test was applied with references to numerical parameters (APHAB and SADL) to assess differences between male vs female subjects and adults vs elderly. The Spearman correlation test was applied to assess the possible correlation between APHAB and SADL. …”
Get full text

A Rare Case of Arteriovenous Hemangioma Clinically Mimicking Pigmented Nevus by Sri Lestari, Tofrizal ., Yenny Raflis

“…Arteriovenous hemangioma is a tumor of middle-age to elderly adults with a peak incidence in the fourth and fifth decades of life. …”
Get full text

Comparing indoor and outdoor temperature and air pollution at an urban cooling center: a multiyear case study by Daniel L Mendoza, Erik T Crosman, Corbin Anderson, Mamta Chaudhari, Shawn A Gonzales

“…This is a particularly urgent issue for sensitive groups that are most subject to these hazards, such as the elderly, children, health compromised, and homeless populations. …”
Get full text

The mediating role of aging attitudes between social isolation and self-neglect: a cross-sectional study of older adults living alone in rural China by Yuling Jia, Yuexue Yue, Yu Sheng

“…Data were gathered using the General Information Questionnaire, Attitudes to Ageing Questionnaire, Lubben Social Network Scale-6, and Scale of the Elderly Self-Neglect. Data were analyzed using SPSS 27.0 and the PROCESS macro tool. …”
Get full text

Two rare cases of primary clear cell adenocarcinoma of the urethra: clinical experience, case report and literature review by Bohao Jiang, Jiyuan Hu, Benqiao Wang, Xujia Liu, Ling Tong, Yitong Xu, Hao Zhang

“…Primary symptoms include hematuria and changes in voiding habits. Middle-aged and elderly females are more susceptible to primary clear-cell adenocarcinoma of the urethra. …”
Get full text

Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF by Lijun Song, Jianjun Ying, Min Li, Lan Ying, Chenliang Zhao

“…Magnesium supplementation has illustrated a significant potential for mitigating the mortality rate in the HFpEF patient, particularly among the elderly, female, and individuals with hypertension. …”
Get full text

Advancing Alzheimer’s disease risk prediction: development and validation of a machine learning-based preclinical screening model in a cross-sectional study by Yanfei Chen, Bing Wang, Yankai Shi, Wenhao Qi, Shihua Cao, Bingsheng Wang, Ruihan Xie, Jiani Yao, Xiajing Lou, Chaoqun Dong, Xiaohong Zhu, Danni He

“…The most influential predictors were educational level, total medication count, age, sbp and BMI.Conclusions The proposed classifier can help guide preclinical screening of AD in the elderly population.…”
Get full text

A meta-analysis of risk factors for cardiovascular adverse events with anthracycline based chemotherapy in lymphoma patients by Bo Dai, Jingjing Xu, Baiyan Wang

“…Conclusions Our research findings indicate that patients with a history of hypertension, radiation therapy, diabetes, smoking, and elderly individuals are at an elevated risk of cardiovascular disease in the process of administration of anthracycline drugs. …”
Get full text

Assessing the Risk Factors of Violent and Non-violent Suicide Attempt Methods: A Population-based Cross-sectional Study by Amin Moradi, Ehsan Mosafarkhani, Fateme Nikbakht, Zahra Amiri, Ali Vafaee Najar

“…Meanwhile, women, the elderly, and those with higher education levels showed a preference for non-violent methods.…”
Get full text

Ambient pollution at hip fracture units and impact on mortality and post-operative delirium: A hormetic effect? by Chika Edward Uzoigwe, Rana Muhammad Anss Bin Qadir, Ahmed Daoub

“…This is particularly so for elderly patients who are theoretically most vulnerable to the adverse sequel of pollutant exposure. …”
Get full text