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77441
Prevalence and determinants of post-neonatal mortality in East Africa: a multilevel analysis of the recent demographic and health survey
Published 2025-01-01“…The multilevel mixed-effects logistic regression model was applied to determine the factors associated with post-neonatal mortality. …”
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77442
Comparative end-of-life communication and support in hospitalised decedents before and during the COVID-19 pandemic: a retrospective regional cohort study in Ottawa, Canada
Published 2022-06-01“…End-of-life (last 5 days) rates of in-person and telephone team–family communication encounters were examined using mixed-effects negative binomial models with incidence rate ratios (IRRs) and 95% CIs.Results End-of-life in-person family presence decreased progressively across pre-COVID (90.6%), COVID-ve (79.4%) and COVID+ve (47.1%) groups: adjusted ORs=0.38 (0.2–0.73) and 0.09 (0.04–0.17) for COVID-ve and COVID+ve groups, respectively. …”
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77443
Autoinducer-2 enhances the defense of Vibrio furnissii against oxidative stress and DNA damage by modulation of c-di-GMP signaling via a two-component system
Published 2025-02-01“…In contrast with another well-known AI-2 receptor LuxP that recognizes the borated form of AI-2, AsrK is found to show higher affinity with AI-2 under borate-depleted conditions, and thus boron has a negative effect on AI-2 sensing by AsrK in regulation of the biofilm and motility phenotypes. …”
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77444
Impact of antiparasitic therapy on cardiovascular outcomes in chronic Chagas disease. A systematic review and meta-analysisResearch in context
Published 2025-01-01“…A customized risk of bias scale assessed the methodological quality of studies, and a random-effects model estimated the pooled risk ratios. This investigation was registered in PROSPERO (CRD42023495755). …”
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77445
Canopy structure modulates the sensitivity of subalpine forest stands to interannual snowpack and precipitation variability
Published 2025-02-01“…<p>A declining spring snowpack is expected to have widespread effects on montane and subalpine forests in western North America and across the globe. …”
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77446
Efficacy of an avocado-based Mediterranean diet on serum lipids for secondary prevention after ischemic stroke: a randomized phase 2 controlled pilot trial
Published 2025-02-01“…Avocados also reduce metabolic syndrome and LDL-C levels but are not part of the traditional MeDi diet. The effects of an avocado-based Mediterranean diet on LDL-C were investigated and compared to those of a low-fat diet in patients with previous IS. …”
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77447
The Importance of Dose Escalation in the Treatment of Pulmonary Arterial Hypertension with Treprostinil
Published 2025-01-01“…<b>Conclusions</b>: The clinical effect of treatment is critically dependent on the rapid escalation of the treprostinil dose during the first three months of treatment.…”
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77448
Dynamic conditioning of porcine kidney grafts with extracellular vesicles derived from urine progenitor cells: A proof‐of‐concept study
Published 2024-12-01“…·pUPC‐EVs injection during HMP and NMP decreases cell damage markers and has an immunomodulatory effect. ·pUPC‐EVs‐treated kidneys have distinct biochemical, metabolic, and transcriptomic profiles highlighting targets of interest. …”
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77449
Polygonatum kingianum polysaccharide alleviated intestinal injuries by mediating antioxidant ability and microbiota
Published 2025-01-01“…IntroductionPolygonatum kingianum is a well-known medicinal herb with proven bioactivities; however, little is known about the effects of its polysaccharide on intestinal injuries in animals induced by lipopolysaccharide (LPS).MethodsA total of 30 Institute of Cancer Research (ICR) mice were divided into control (CH), induced (MH), and treated (H) groups. …”
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77450
RETRACTED: Mechanism of action of Asparagus officinalis extract against multiple myeloma using bioinformatics tools, in silico and in vitro study
Published 2023-05-01“…Its main components have tumor-prevention, immune system-enhancement, and anti-inflammation effects. Network pharmacology is a powerful approach that is being applied increasingly to research of herbal medicines. …”
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77451
Exploring the potential mediating role of systemic antibiotics in the association between early-life lower respiratory tract infections and asthma at age 5 in the CHILD study
Published 2025-01-01“…However, a significant direct effect of moderate-to-severe LRTIs on asthma risk remained in adjusted mediation models (p = .014).ConclusionThrough mediation modeling we estimate that the increased risk of asthma at age 5 that is associated with moderate-severe LRTIs in infancy may be partially mediated by systemic antibiotics taken during the first 18 months of life. …”
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77452
Efficacy and safety of SHR8554 on postoperative pain in subjects with moderate to severe acute pain following orthopedic surgery: A multicenter, randomized, double-blind, dose-expl...
Published 2025-02-01“…Biased µ-opioid receptor (MOR) agonists enhance pain relief by selectively activating G protein-coupled receptor signaling and minimizing β-arrestin-2 activation, resulting in fewer side effects. This multicenter Phase II/III trial evaluated the optimal dosage, efficacy, and safety of SHR8554, a biased MOR agonist, for postoperative pain management following orthopedic surgery. …”
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77453
Dose-dependent serological profiling of AdCLD-CoV19-1 vaccine in adults
Published 2025-01-01“…These findings underscore the importance of considering diverse humoral immune responses when evaluating vaccine efficacy and provide insights for optimizing adenovirus vector-based SARS-CoV-2 vaccine doses.IMPORTANCEOptimization of vaccine dose is crucial for eliciting effective immune responses. In addition to neutralizing antibodies, non-neutralizing antibodies that mediate Fc-dependent effector functions play a key role in protection against various infectious diseases, including coronavirus disease 2019. …”
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77454
Towards person-centred maternal and newborn care in Ethiopia: a mixed method study of satisfaction and experiences of care
Published 2025-01-01“…Independent variables: [1] person-centred care (1A: receipt of information; 1B: perceived adequacy of health worker responses) and [2] unmet psychosocial needs (2A: Patient Health Questionnaire for depressive symptoms; 2B: screening questionnaire for intimate partner violence (IPV)). Linear mixed effect regression assessed hypothesized associations between person-centred care/unmet psychosocial needs and service satisfaction, accounting for clustering at the health centre level. …”
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77455
Factors associated with physical fitness and disparities in population segments among older adults: A cross-sectional study
Published 2025-01-01“…Furthermore, greater marginal effects on achieving higher physical fitness test scores were observed among individuals classified as inactive when engaging in more moderate-to-vigorous activities and exercise. …”
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77456
Neoadjuvant immunotherapy for DNA mismatch repair proficient/microsatellite stable non-metastatic rectal cancer: a systematic review and meta-analysis
Published 2025-01-01“…Non-metastatic pMMR/MSS RC receiving the short-course radiotherapy (SCRT) in neoadjuvant setting exhibited superior pooled pCR and MPR than long-course radiotherapy (LCRT) without upregulating the incidence of adverse effects. Furthermore, patients with MSS RC underwent neoadjuvant treatment with anti-PD-1 inhibitors demonstrated higher pooled pCR, MPR, cCR compared to those receiving PD-L1 inhibitors. …”
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77457
Climate change policies reduce air pollution and increase physical activity: Benefits, costs, inequalities, and indoor exposures
Published 2025-01-01“…By 2040 under BNZP, relative to BAU, the buildings sector was predicted to be three times more effective at reducing PM2.5 than road transport. To help reduce the inequality gap the NZ building transition was tailored toward those most in need. …”
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77458
Development of a framework to structure decision-making in environmental and occupational health: A systematic review and Delphi study
Published 2025-01-01“…Background: Environmental and occupational health (EOH) assessments increasingly utilize systematic review methods and structured frameworks for evaluating evidence about the human health effects of exposures. However, there is no prevailing approach for how to integrate this evidence into decisions or recommendations. …”
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77459
Development and interpretation of a pathomics-driven ensemble model for predicting the response to immunotherapy in gastric cancer
Published 2024-05-01“…Pathogenomics analysis was employed to explain the molecular mechanisms underlying the model’s predictions.Results Our pathomics-driven ensemble model effectively stratified the response to ICIs in training cohort (AUC 0.985 (95% CI 0.971 to 0.999)), which was further validated in internal validation cohort (AUC 0.921 (95% CI 0.839 to 0.999)), as well as in external validation cohort 1 (AUC 0.914 (95% CI 0.837 to 0.990)), and external validation cohort 2 (0.927 (95% CI 0.802 to 0.999)). …”
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77460