Harnessing the Power of Machine Learning Guided Discovery of NLRP3 Inhibitors Towards the Effective Treatment of Rheumatoid Arthritis by Sidra Ilyas, Abdul Manan, Chanyoon Park, Hee-Geun Jo, Donghun Lee

“…The models were evaluated, and a comparative analysis revealed that the ensemble Random Forest (RF) model (PubChem fingerprints) with RMSE (0.731), R² (0.622), and MAPE (8.988) and bootstrap aggregating model (MACCS fingerprints) with RMSE (0.687), R² (0.666), and MAPE (9.216) on the testing set performed well, in accordance with the Organization for Economic Cooperation and Development (OECD) guidelines. …”
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Effects of Interplanting Medicinal Herbs on Runoff, Sediment and Nitrogen and Phosphorus Losses in Young Oil Tea Plantation on Red Soil Sloping Field by YAN Shijie, DUAN Jian, SHEN Faxing, XIE Dongjie, ZHENG Haijin

“…[Conclusion] Below-ground harvesting of medicinal herb Yujin + plant hedge mode is the most economical and effective management measure to control soil erosion and nutrient losses of young oil tea plantation on red soil slope in this experiment. …”
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Hydrogenolysis of furfuryl alcohol to 1,2-pentanediol catalyzed by first row transition metal salts by Muhammad Rafi Pratama, Istifhamy Irnanda, Hendra Julius Situmorang, Yessi Permana, Siti Hartinah Qurbayni, Husni Wahyu Wijaya, Ubed Sonai Fahruddin Arrozi

“…The growing and relatively large market share of 1,2-pentanediol (1,2-PeD) has attracted attention of researchers to find effective and economically viable catalysts. One type of catalyst that can be used for synthesizing this compound is transition-metal-based catalysts, employed in the hydrogenolysis of furfuryl alcohol (FOL). …”
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Evolution and effectiveness of bilateral and multilateral development assistance for health: a mixed-methods review of trends and strategic shifts (1990–2022) by Yan Luo, Ying Chen, Beibei Yuan, Ming Xu, Shuduo Zhou, Zhijie Zheng, Siwei Xie, Sijin Du, Yuxin Huang

“…However, DAH allocation did not show any substantial shift towards health system strengthening during this period. Economic evaluations calculated the median incremental cost-effectiveness ratio of DAH interventions,Conclusions This study reviews DAH trends from 1990 to 2022, showing a predominant focus on HIV/AIDS and maternal and child health, with insufficient attention to NCDs and health system strengthening. …”
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Synergistic effect of mulch and nitrogen management on growth and essential oil yield of Salvia sclarea L. by Diksha Dhiman, Sakshi Vishvamitera, Sidharth Baghla, Sanatsujat Singh, Dinesh Kumar, Ashok Kumar, Ramesh Chauhan

“…Considering the soil health and without compromising the EO yield much, the present study suggested replacing 25% of recommended chemical N with organic manures under mulch for sustainable and economical production of S. sclarea.…”
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Life cycle assessment of agricultural waste recycling for sustainable environmental impact by S. Sumiyati, B.P. Samadikun, A. Widiyanti, M.A. Budihardjo, S. Al Qadar, A.S. Puspita

“…These findings indicate potential environmental advantages in terms of decreased greenhouse gas emissions and fossil fuel consumption, leading to a circular economic approach for agriculture. When integrating agricultural waste, including composting, anaerobic digestion, and pyrolysis, biochar is highlighted as a waste recycling method that is promising for sustainable waste management. …”
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Biogenic Waste from Two Varieties of Plantain in Ghana Contain Pectin with Potential Binding Properties in Conventional Tablets by Desmond Asamoah Bruce Otu, Frederick William Akuffo Owusu, Mariam El Boakye-Gyasi, Raphael Johnson, Prince George Jnr Acquah, Yayra Edzor-Agbo, Marcel Tunkumgnen Bayor, Mary-Ann Archer

“…Fascinatingly, these wastes, often discarded, possess significant economic potential and can be recycled into valuable raw materials or products. …”
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Predicting egg production rate and egg weight of broiler breeders based on machine learning and Shapley additive explanations by Hengyi Ji, Yidan Xu, Ganghui Teng

“…The accurate prediction of these indicators can significantly enhance farm economic efficiency and can provide a basis for future production strategies. …”
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Standardized Outcomes for Randomized Controlled Trials Targeting Early Interventions in Patients With Moderate-to-Severe Traumatic Brain Injury: Protocol for the Development of a C... by Raphael Cinotti, Yvan Derouin, Amandine Chenet, Lydia Oujamaa, Bertrand Glize, Yoann Launey, Claire Dahyot-Fizelier, Emmanuelle Cartron, Melodie Renvoise, Benedicte Sautenet, Veronique Sebille

“…Managing TBI is a major human, social, and economic concern. In the last 20 years, there has been an increase in clinical trials in neurocritical care, leading mostly to negative results. …”
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The viability of treated piggery wastewater for reuse in agricultural irrigation by Viviane F Velho, Rodrigo A Mohedano, Paulo Belli Filho, Rejane HR Costa

“…Background: The swine production is a very important economic matter, occupying prominent position in the worldwide market. …”
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Optimised extraction of antioxidant components from Calophyllum inophyllum L. seeds using response surface methodology by L. Fitriyana, M.D. Supardan, Y. Aisyah, Irfan .

“…Using C. inophyllum seeds as a source of flavonoids for natural antioxidants can increase their economic value and provide alternative compounds for cosmetics, including lotions. …”
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Structure and Expression of Two Sex-Related dmrt Genes in Oxyeleotris lineolata by Jiajia FAN, Dongmei MA, Huaping ZHU, Minghui LIN, Zaixuan ZHONG, Yuanyuan TIAN

“…Oxyeleotris lineolata is a valuable economic fish cultured in Australia and countries of Southern Asia. …”
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After neonatal care, what next? A qualitative study of mothers’ post-discharge experiences after premature birth in Kenya by Justinah Maluni, Dorothy Oluoch, Sassy Molyneux, Mwanamvua Boga, Caroline Jones, Florence Murila, Mike English, Sue Ziebland, Lisa Hinton

“…Prominent healthcare structural and socio-economic factors in SSA, for example poverty and weak health systems, amplify vulnerabilities for mothers and premature babies; often leading to poor outcomes. …”
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Sexual health and healthy relationships for Further Education (SaFE) in Wales and England: results from a pilot cluster randomised controlled trial by Fiona V Lugg-Widger, Chris Bonell, James White, Honor Young, Ruth Lewis, Rachel Brown, Jason Madan, Julia Townson, Lauren Copeland, Philip Pallmann, G J Melendez-Torres, Rhys Williams-Thomas, Muhammad Riaz, Gemma S Morgan

“…Objectives To examine the acceptability of implementing, trialling and estimating the cost of the Sexual health and healthy relationships for Further Education (SaFE) intervention.Design Two-arm repeated cross-sectional pilot cluster randomised controlled trial (cRCT) of SaFE compared with usual practice, including a process evaluation and an economic assessment.Setting Eight further education (FE) settings in South Wales and the West of England, UK.Participants FE students, staff and sexual health nurses.Intervention SaFE had three components: (1) onsite access to sexual health and relationship services provided by sexual health nurses available for 2 hours on 2 days per week; (2) publicity about onsite sexual health and relationship services and (3) FE staff training on how to promote sexual health, and recognise, prevent and respond to dating and relationship violence (DRV) and sexual harassment.Primary and secondary outcome measures The primary outcome was feasibility, assessing whether the study met progression criteria relating to: (a) FE setting and student recruitment; (b) the acceptability of the intervention and (c) qualitative data, and documentary evidence from students, staff and sexual health nurses on acceptability, fidelity of implementation and receipt. …”
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Preparation of Mo2C/MWCNT catalysts and its performance in electrocatalytic oxidation of methanol by Leixin MAO, Lin FU, Lei LIU, Zhihua GAO, Wei HUANG, Zhijun ZUO

“…With the rapid economic development, the increasing demand for fossil fuels and the growing importance of environmental issues, the energy issue has clearly become a focal point. …”
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Foliar application of 24-epibrassinolide enhances leaf nicotine content under low temperature conditions during the mature stage of flue-cured tobacco by regulating cold stress tol... by Haiyang Chen, Shuaitao Zhang, Jianbo Chang, Hongru Wei, Hongchen Li, Chaoyang Li, Junjie Yang, Zhengxiong Song, Zhaojun Wang, Jin Lun, Xuelin Zhang, Lihua Li, Xiaoquan Zhang

“…The result showed that foliar spraying of different concentrations of EBR notably improve the agronomic and economic traits of flue-cured tobacco to varying degrees, as well as increase the total nitrogen and nicotine content in the tobacco leaves. 0.2 mg·L− 1 EBR treatment showed better results, with nicotine content in the middle and upper leaves after curing increasing by 11.11% and 19.90%, respectively, compared to CK. …”
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Pooling the complex survey data across the 64 lower and middle-income countries: A study on antibiotic usage in under-five children by Md Fakrul Islam, Prosenjit Basak Arka, Mahfuzer Rohman, Md Sabbir Hossain, Md Rashed Babu, Hasin Anupama Azhari, Md Jamal Uddin

“…To analyze antibiotic exposures across countries, continents, economic levels, and the top and bottom ten countries with fever/cough, we conducted descriptive statistics. …”
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Model Predictive Control-Based Energy Management System with Load Curtailment for Standalone Microgrid by Muhammad Sharir Fathullah Mohd Yunus, Siti Hajar Yusoff, Siti Nadiah Mohd Sapihie, Mohd Shahrin Abu Hanifah, Teddy Surya Gunawan, Suriza Ahmad Zabidi

“… The standalone microgrid emerges as an economical solution for providing electricity to remote areas disconnected from the main grid. …”
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High-throughput untargeted metabolomics reveals metabolites and metabolic pathways that differentiate two divergent pig breeds by S. Bovo, M. Bolner, G. Schiavo, G. Galimberti, F. Bertolini, S. Dall’Olio, A. Ribani, P. Zambonelli, M. Gallo, L. Fontanesi

“…Metabolomics can describe the molecular phenome and may contribute to dissecting the biological processes linked to economically relevant traits in livestock species. Comparative analyses of metabolomic profiles in purebred pigs can provide insights into the basic biological mechanisms that may explain differences in production performances. …”
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Epidemiological trends and age-period-cohort effects on ischemic stroke burden across the BRICS-plus from 1992 to 2021 by Fangqun Cheng, Peiyu Cheng, Shudong Xie, Hailing Wang, Ying Tang, Ying Liu, Zhuo Xiao, Guixiang Zhang, Guangxiong Yuan, Ke Wang, Can Feng, Ying Zhou, Hong Xia, Yan Wang, Yuhang Wu

“…Its global incidence rose by 87.55% from 1990 to 2019, posing significant health and economic burdens. The BRICS-plus nations—Brazil, Russia, India, China, South Africa, and five others—represent a large global population, presenting unique public health challenges. …”
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