Quarantine nematode species and pathotypes potentially dangerous for domestic potato production: populations diversity and the genetics of potato resistance by N. V. Mironenko, T. A. Gavrilenko, A. V. Khiutti, O. S. Afanasenko

“…Special attention in the review is paid to the breeding of potato cultivars with durable resistance to various nematode pathotypes, because the cultivation of such varieties is the most ecologically safe and economically advantageous way to prevent epiphytoties. …”
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Immunogenicity in humans of a transdermal multipeptide melanoma vaccine administered with or without a TLR7 agonist by Craig L Slingluff, Gina R Petroni, Walter C Olson, Kimberly A Chianese-bullock, Donna Deacon, Mark Smolkin, William W Grosh, Max O Meneveau, Kevin T Lynch, Elise P Salerno, Elizabeth Woodson, James W Patterson

“…Overall, 61% of participants had CD4+ T cell immune responses to the tetanus peptide, with large, durable responses in groups 3 and 4. Five of seven participants in group 4 had a severe rash, one that was dose limiting. …”
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Prominent efficacy and good safety of sequential CD19 and CD22 CAR-T therapy in relapsed/refractory adult B-cell acute lymphoblastic leukemia by Tingting Yang, Yetian Dong, Mingming Zhang, Jingjing Feng, Shan Fu, Pingnan Xiao, Ruimin Hong, Huijun Xu, Jiazhen Cui, Simao Huang, Guoqing Wei, Delin Kong, Jia Geng, Alex H. Chang, He Huang, Yongxian Hu

“…Conclusions Sequential CAR-T cell therapy demonstrated durable efficacy and a manageable safety profile in R/R B-ALL, providing a viable option to address antigen-loss relapse and improve long-term outcomes in high-risk adult patients.…”
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Cancer vaccines compensate for the insufficient induction of protective tumor-specific immunity of CD3 bispecific antibody therapy by Sjoerd H van der Burg, Marjolein Sluijter, Thorbald van Hall, Jim Middelburg, Kristel Kemper, Janine Schuurman, Gaby Schaap, Katy Lloyd, Vitalijs Ovcinnikovs

“…Background CD3 bispecific antibody (CD3 bsAb) therapy has become an established treatment modality for some cancer types and exploits endogenous T cells irrespective of their specificity. However, durable clinical responses are hampered by immune escape through loss of tumor target antigen expression. …”
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Blood-based prognostic scores and early dynamics under immunotherapy to select patients with metastatic solid tumors for continuing immune check-point inhibition: a prospective lon... by Javier García-Corbacho, Alberto Indacochea, Iván Victoria, Débora Moreno, Laura Angelats, Azucena E. González Navarro, Laura Mezquita, Fara Brasó-Maristany, Patricia Galván, Begoña Mellado, Nuria Viñolas, Tamara Sauri, Miquel Nogué, Barbara Adamo, Joan Maurel, Estela Pineda, Lydia Gaba, Oscar Reig, Neus Basté, Esther Sanfeliu, Manel Juan, Aleix Prat, Francesco Schettini

“…The primary endpoint was identifying the best score to predict rapid PD (≤ 4 months) with ICI using logistic regressions accounting for tumor type, and receiving operators characteristics (ROC) with area under curve (AUC), accompanied by an extensive comparison of the score performances in the prediction of overall survival (OS), progression-free survival (PFS), overall response rates (ORR) and durable clinical benefit (DCB). Secondary objectives included describing study cohort outcomes and studying the association between the selected score at C1D1, C2D1 and its dynamics with OS and PFS. …”
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Evaluation of Safety and Efficacy of a Single Lorecivivint Injection in Patients with Knee Osteoarthritis: A Multicenter, Observational Extension Trial by Christopher J. Swearingen, Jeyanesh R. S. Tambiah, Ismail Simsek, Heli Ghandehari, Sarah Kennedy, Yusuf Yazici

“…Efficacy analyses on the subset of completer patients demonstrated durable symptom improvements in WOMAC pain and function for at least 12 months compared to PBO after a single injection of LOR. …”
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Green building development utilising modified fired clay bricks and eggshell waste by Wafaa Soliman, Yasser M. Z. Ahmed, Ahmed Ghitas, Abdel‑Hamid El‑Shater, M. Abdelhamid Shahat

“…The reduced shrinkage enhances stability, while increased pore size and porosity improve thermal insulation, making the bricks more durable and energy-efficient. In this regard, the brick containing 10% eggshell that was fired at 1100°C possessed the greatest drop in heat conductivity (i.e., 50%), thermal diffusivity (30%), and thermal effusivity (30%) as compared to the pure one. …”
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Ethical issues raised in the care of the elderly during the SARS-CoV-2 pandemic and possible solutions for the future: a systematic review of qualitative scientific literature by Mohamed Amine Bouchlaghem, Zoé Estey-Amyot, Erika Ethier, Miruna Anohim, Marie-Laurence Ouellet-Pelletier, Lyse Langlois, Félix Pageau

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Effects of Climatic Conditions and Agronomic Practices on Health, Tuber Yield, and Mineral Composition of Two Contrasting Potato Varieties Developed for High and Low Input Producti... by Gultekin Hasanaliyeva, Ourania Giannakopoulou, Juan Wang, Marcin Barański, Enas Khalid Sufar, Daryl Knutt, Jenny Gilroy, Peter Shotton, Halima Leifert, Dominika Średnicka-Tober, Ismail Cakmak, Levent Ozturk, Bingqiang Zhao, Per Ole Iversen, Nikolaos Volakakis, Paul Bilsborrow, Carlo Leifert, Leonidas Rempelos

“…It has been hypothesized that the breeding of potato varieties suitable for the organic/low-input sector should (i) focus on increasing nutrient (especially N) use efficiency, (ii) introduce durable late blight resistance, and (iii) be based on selection under low-input conditions. …”
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Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors by Romain Pacaud, Scott Thomas, Sibapriya Chaudhuri, Ann Lazar, Luika A. Timmerman, Pamela N. Munster

“…However, clinical responses are often not durable and treatment may be detrimental in advanced cancer due to excessive toxicities. …”
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Waning neutralizing antibodies through 180 days after homologous and heterologous boosters of inactivated COVID-19 vaccine by Zhifei Chen, Fangqin Xie, Hairong Zhang, Dong Li, Suhan Zhang, Mengping Zhang, Junrong Li, Jianfeng Xie, Lina Zhang, Xiuhui Yang, Dongjuan Zhang

“…Heterologous boosting with Convidecia demonstrated a more robust, durable, and broad humoral immune response compared to boosting with inactivated vaccines or Zifivax, suggesting that adenovirus vector vaccines possess a special advantage in the realm of vaccine development for preventing infectious diseases.…”
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Pilot study of a comprehensive multidisciplinary inpatient-based approach to smoking cessation in patients with vascular disease by Tanner Kim, MD, Anand Brahmandam, MBBS, Dana Alameddine, MD, Rachel Forman, MD, Amin Hardik, MD, Lisa Fucito, PhD, Carlos Mena-Hurtado, MD, Raul Guzman, MD, Cassius Iyad Ochoa Chaar, MD, MS, MPH

“…Conclusions: This pilot study demonstrates that an inpatient, multidisciplinary approach to smoking cessation is effective with a durable impact up to 1 year. Inpatient strategies leveraging multidisciplinary teams and teachable moments should be incorporated into smoking cessation programs.…”
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Acceptability of and experiences with menstrual hygiene cups among adolescent girls and young women aged 15–24 in two communities in Lusaka, Zambia: an exploratory study nested in... by Melleh Gondwe, Melvin Simuyaba, Mwelwa Phiri, Chisanga Mwansa, Albertus Schaap, Lucheka Sigande, Kwame Shanaube, Sian Floyd, Sarah Fidler, Helen Ayles, Musonda Simwinga, Bernadette Hensen

“…Use of the cup was comfortable, and cups were said to be cost-effective and durable. Advantages over pads included: the absence of odor, easy to maintain, and environmentally friendly: “it is hygienic, and it is even easy to maintain”. …”
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Restorative Neurostimulation Therapy Compared to Optimal Medical Management: A Randomized Evaluation (RESTORE) for the Treatment of Chronic Mechanical Low Back Pain due to Multifid... by Frank Schwab, Nagy Mekhail, Kiran V. Patel, Meredith Langhorst, Robert D. Heros, Jonathan Gentile, Sherif Costandi, Gregory Moore, Christopher Gilmore, Smith Manion, Krishnan Chakravarthy, S. Craig Meyer, Justin V. Bundy, Jordan L. Tate, Rebecca Sanders, Sandeep Vaid, Oszkar Szentirmai, Johnathan Goree, Vikas V. Patel, Jeff Lehmen, Mehul J. Desai, Jason E. Pope, Anthony Giuffrida, Salim Hayek, Sohrab Singh Virk, Richard Paicius, William R. Klemme, Robert Levy, Christopher Gilligan, the RESTORE investigators

“…Conclusion The RESTORE trial demonstrates that restorative neurostimulation is a safe, reversible, clinically effective, and highly durable option for patients suffering with nonoperative CLBP associated with multifidus dysfunction. …”
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Comment acquérir une compétence d’oral spontané en situation d’apprentissage institutionnalisée by Günter Schmale

“…Au niveau didactique, il importe, dans une perspective “constructiviste” de créer un environnement pédagogique qui permet l’apprentissage et la subséquente acquisition durable et opérationnelle des “constructions” adéquates. …”
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Discontinuation of immune checkpoint inhibitors for reasons other than disease progression and the impact on relapse and survival of advanced melanoma patients. A systematic review... by Konstantinos Lallas, Eftychia Chatziioannou, Derya Durak, Georg Frey, Lina Maria Serna-Higuita, Marie-Lena Rasch, Athanassios Kyrgidis, Eleni Timotheadou, Zoe Apalla, Ulrike Leiter, Lukas Flatz, Lukas Flatz, Aimilios Lallas, Teresa Amaral, Teresa Amaral

“…BackgroundDespite durable responses achieved with Immune Checkpoint Inhibitors (ICIs), data about optimal duration of treatment, especially in the context of adverse events, remain scarce.ObjectiveTo systematically review the evidence concerning the impact of treatment discontinuation with ICIs for reasons other than progressive disease (PD) on relapse rates and survival of melanoma patients.MethodsA systematic literature search was conducted in three electronic databases until July 2024. …”
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Anti-PD-1 amplifies costimulation in melanoma-infiltrating Th1-like Foxp3+ regulatory T cells to alleviate local immunosuppression by Fernando Alvarez, Fan Huang, Sonia V Del Rincon, Mikhaël Attias, Tho-Alfakar Al-Aubodah, Roman Istomine, Paige McCallum, Abrahim Sleiman, Tamiko Nishimura, Yasser Riazalhosseini, Ciriaco A Piccirillo

“…PD-1 blockade enhances the effector functions of melanoma-infiltrating CD8+ T cells, leading to durable tumor remissions. However, 55% of patients with melanoma do not respond to treatment. …”
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Activités alimentaires journalières de la chamelle gestante dans son milieu naturel by Khalid Mallem, Abdelmadjid Chehma, Johann Huguenin

“…Il est intéressant de surveiller les habitudes alimentaires quotidiennes du dromadaire afin de saisir comment il parvient à exploiter ses ressources limitées de manière durable pour satisfaire ses besoins. Objectif : Cette étude visait à déterminer les activités quotidiennes des chamelles gestantes dans leur milieu naturel. …”
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Scoping review of climate drivers on maternal health: current evidence and clinical implicationsAJOG Global Reports at a Glance by Claire Masters, MHP, Chuhan Wu, MS, Dara Gleeson, MPH, Michaela Serafica, RN, MSN, Jordan L. Thomas, PhD, Jeannette R. Ickovics, PhD

“…The majority of studies (146/158; 92.4%) documented statistically significant and clinically meaningful associations between climate drivers and adverse perinatal health outcomes, including risk of preterm birth, low birthweight, and stillbirth as well as preeclampsia, gestational diabetes, miscarriage, and maternal death. Among the most durable findings: extreme heat exposure in early and late pregnancy were associated with increased risk of preterm birth and stillbirth. …”
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What motivates West African cocoa farmers to value trees? Taking the 4 W approach to the heart of the field by Marie Ruth Dago, Irié Casimir Zo‐Bi, Isaac Kouamé Konan, Aimé Kouadio Kouassi, Stéphane Guei, Patrick Jagoret, Anny Estelle N'Guessan, Elsa Sanial, Chloé Tankam, Soulemane Traoré, Bruno Hérault

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