Enhancing precision in cancer treatment: the role of gene therapy and immune modulation in oncology by Emile Youssef, Brandon Fletcher, Dannelle Palmer

“…By integrating these innovations with combination therapies and addressing regulatory and ethical concerns, gene therapy is poised to revolutionize cancer treatment, providing durable, effective, and personalized solutions for both hematologic and solid tumors.…”
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Activated Carbon from Prickly Pear Seed Cake: Optimization of Preparation Conditions Using Experimental Design and Its Application in Dye Removal by Y. El Maguana, N. Elhadiri, M. Bouchdoug, M. Benchanaa, A. Jaouad

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Chemical reaction and Soret impacts on MHD heat and mass transfer Casson hybrid nanofluid (MoS2+ZnO) flow based on engine oil across a stretching sheet with radiation by M. Radhika, Y. Dharmendar Reddy

“…The primary objective of investigating the hybrid nano lubricant MoS2 + ZnO combined with engine oil is to further the development of more durable and efficient lubrication solutions for automotive engines, hence improving reliability, fuel efficiency, and environmental sustainability. …”
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Effects of H^{−} low beam irradiation and high field pulsing tests in different metals by C. Serafim, S. Calatroni, F. Djurabekova, R. Peacock, V. Bjelland, A. T. Perez-Fontenla, W. Wuensch, A. Grudiev, S. Sgobba, A. Lombardi, E. Sargsyan

“…This work studies the suitability of a set of different materials for manufacturing more efficient and durable radio-frequency quadrupole (RFQ) structures compared to that currently used in many linear particle accelerators, traditionally made out of copper. …”
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Impact of open femoral endarterectomy on treating multilevel iliac and common femoral artery occlusive disease by Suehyun Park, Taewan Ku, Deokbi Hwang, Woo-Sung Yun, Seung Huh, Hyung-Kee Kim

“…The severity of iliac and common femoral artery disease was not associated with PP loss of FEIA.ConclusionsDespite the challenging nature of initially classified TASC II C/D lesions, our findings highlight the effectiveness of FE in reducing TASC II classification and the durable patency achieved with FEIA. Hybrid FEIA could be a viable primary treatment option, particularly for lesions featuring severe iliac and common femoral artery disease.…”
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Resistance to viruses of potato: current status and prospects by S. S. Makarova, V. V. Makarov, M. E. Taliansky, N. O. Kalinina

“…However, these approaches have essential limitations because the acquired resistance is highly specific (against individual viruses only), is not durable, can be overcome by viruses and, finally due to regulatory bans on genetically modified organisms. …”
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Endophytic fungi related to the ash dieback causal agent encode signatures of pathogenicity on European ash by Maryam Rafiqi, Chatchai Kosawang, Jessica A. Peers, Lukas Jelonek, Hélène Yvanne, Mark McMullan, Lene R. Nielsen

“…Identifying new pathogens and including them in the screening for durable immunity of common ash trees is key to the long-term survival of ash in Europe.…”
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‘Gvardeets’: a new awnless brome (<i>Bromorsis inermis</i>) cultivar developed in Tyumen Province by N. A. Feoktistova, Yu. E. Leonidov

“…Holub) is a perennial herbaceous plant used as feed in animal husbandry, for phytomelioration, and as a component of grass mixtures to make a durable natural cover for landscaping. Studying the genetic diversity of this species and selecting the best accessions will help to develop new cultivars capable of productive longevity.Materials and methods. …”
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Epidemiology and impact of device-specific infections on patients receiving left ventricular assist devices by Amit Iyengar, MD MSE, Jason Feinman, MD, Joyce Jiang, BS, Cindy Song, BA, Spencer Kim, BA, Alvin Mathew, MD, Sophia Golec, MD, Aarti Rao, MD, Ankitha Radakrishnan, MD, Michaela Asher, MPhil, David Rekhtman, BS, John DePaolo, MD PhD, Noah Moss, MD, Shinobu Itagaki, MD, Anelechi Anyanwu, MD, Joyce Wald, DO, Marisa Cevasco, MD MPH, Aditya Parikh, MD

“…Background: Left ventricular assist device-specific infections (LSIs) remain a persistent problem facing patients with durable left-ventricular assist devices (LVADs). However, the infectious agents and associated morbidity remained poorly defined. …”
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Recycling cupola slag for manufacturing magnesium metal matrix composites with alumina for electric vehicle battery pack system housings by Andrea Sánchez-Arroyo, Mario Rodríguez-Reyes, Gerardo Daniel Olvera-Romero, José Refugio Parga-Torres, Zully Matamoros-Veloza, Brandon Osvaldo Villarreal-Fuentes, Dagoberto Vázquez-Obregón

“…These findings underscore the potential of magnesium matrix composites reinforced with cupola slag and Al₂O₃ as lightweight, durable, and sustainable materials for BPS housings, addressing both performance and environmental considerations.…”
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FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models by Timothy Weeden, Tyler Picariello, Brendan Quinn, Sean Spring, Pei-Yi Shen, Qifeng Qiu, Benjamin F. Vieira, Lydia Schlaefke, Ryan J. Russo, Ya-An Chang, Jin Cui, Monica Yao, Aiyun Wen, Nelson Hsia, Tama Evron, Katy Ovington, Pei-Ni Tsai, Nicholas Yoder, Bo Lan, Reshmii Venkatesan, John Hall, Cody A. Desjardins, Mo Qatanani, Scott Hilderbrand, John Najim, Zhenzhi Tang, Matthew K. Tanner, Romesh Subramanian, Charles A. Thornton, Oxana Ibraghimov-Beskrovnaya, Stefano Zanotti

“…Results In HSALR mice, a surrogate FORCE conjugate achieves durable correction of spliceopathy and improves myotonia to a greater extent than unconjugated ASO. …”
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Investigation of Reinforced Concrete Column Containing Metakaolin and Fly Ash Cementitious Materials by R. Dharmaraj, Sudhir Singh Bhadauria, K. Mayilsamy, J. Thivya, Alagar Karthick, I. Baranilingesan, V. Mohanavel, M. Muhibbullah, Sameh M. Osman

“…Nowadays, high-performance concrete is employed in the building sector all over the world. For a strong and durable construction, high performance appears to be a better option. …”
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Dendritic cell maturation is induced by p53-armed oncolytic adenovirus via tumor-derived exosomes enhancing systemic antitumor immunity by Tomoko Ohtani, Shinji Kuroda, Nobuhiko Kanaya, Yoshihiko Kakiuchi, Kento Kumon, Masashi Hashimoto, Chiaki Yagi, Ryoma Sugimoto, Satoru Kikuchi, Shunsuke Kagawa, Hiroshi Tazawa, Yasuo Urata, Toshiyoshi Fujiwara

“…Intratumoral injection of OBP-702 into PAN02 subcutaneous tumors significantly increased the presence of mature DCs and CD8-positive T cells in draining lymph nodes, leading to long-lasting antitumor effects through the durable activation of systemic antitumor immunity. …”
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Le diagnostic agraire : comprendre les trajectoires d’évolution de l’agriculture locale pour nourrir les prospectives sur l’eau à l’échelle territoriale by Ariane DEGROOTE, Sophie DEVIENNE, Frank MICHEL

“…Depuis 2019, les projets de territoire pour la gestion de l’eau (PTGE) sont déployés dans certains territoires pour parvenir à un équilibre durable entre les besoins et les ressources disponibles. …”
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Proximally based sural artery flap for the reconstruction of soft tissue defects around the knee and proximal third of the leg in India: a clinical study by Lakshmi Palukuri, Sreedharala Srinivas, Dharmapuri Madhulika, Sanujit Pawde, Ajo Sebastian, Swathi Sankar, Sandeep Reddy Chintha

“…This flap consistently provided a thin, pliable, stable, and durable soft tissue cover over the defect with no functional deficit and minimal donor site morbidity. …”
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S6P mutation in Delta and Omicron variant spike protein significantly enhances the efficacy of mRNA COVID-19 vaccines by Yong-Sik Bong, David Brown, Ezra Chung, Neeti Ananthaswamy, Renxiang Chen, Renxiang Chen, Evan Lewoczko, William Sabbers, Athéna C. Patterson-Orazem, Zachary Dorsey, Yiqing Zou, Xue Yu, Jiening Liang, Jiaxi He, Steven Long, Dong Shen

“…Additionally, the effectiveness of RV-1730 as a heterologous booster following primary vaccination with BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna-NIAID) was assessed.ResultsRV-1730 elicited significantly stronger B and T cell responses and more durable neutralizing antibodies compared to S2P-based vaccines. …”
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MRD-driven phase 2 study of daratumumab, carfilzomib, lenalidomide, and dexamethasone in newly diagnosed multiple myeloma by Manisha Bhutani, Myra Robinson, David Foureau, Shebli Atrash, Barry Paul, Fei Guo, Jason M. Grayson, Anna Ivanina-Foureau, Mauricio Pineda-Roman, Cindy Varga, Reed Friend, Christopher J. Ferreri, Xhevahire Begic, Sarah Norek, Tiffany Drennan, Michelle B. Anderson, James T. Symanowski, Peter M. Voorhees, Saad Z. Usmani

“…The post induction MRD-adapted strategy deepened responses in MRD-positive patients and maintained durable MRD control in MRD-negative patients. This trial was registered at www.clinicaltrials.gov as #NCT04113018.…”
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Space frame structures in domestic design practice and their installation methods by S. S. Potasiev

“…Modern construction demonstrates the wide use of various space frame types, because of their efficient from an engineering point of view, architecturally expressive, economical and durable. Large spans required increased frame rigidity; in such situations, space frames are more economical than classic flat trusses solutions. …”
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The Addition of Opuntia ficus-indica Ethanolic Extract to a Skimmed Milk-Based Extender Impacts Ram Sperm Quality by Larbi Allai, Xavier Druart, Pinar Terzioğlu, Noureddine Louanjli, Boubker Nasser, Mehmet Ozturk, Bouchra El Amiri

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Lieu-de-mémoiriser hydro-québec comme symbole des représentations de la nature et de la technologie : esquisses de réponse et pistes de réflexion by Stéphane Savard

“…Toutefois, vers le milieu des années 1990 et à la suite des catastrophes naturelles du déluge du Saguenay et de la Crise du verglas, l’entreprise publique devient l’instrument pour promouvoir des représentations centrées sur le respect de l’environnement et du développement durable. Quant au rapport à la technologie, la société d’État symbolise lors de la Révolution tranquille le fleuron d’un Québec francophone tourné vers la technologie, émancipé de son statut de porteur d’eau et entrant manifestement dans la « modernité »; image qui semble s’essouffler dans les années 1990 alors qu’Hydro-Québec et ses ouvrages ne sont plus perçus comme étant à la fine pointe de la technologie.…”
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