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2461
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of gynecologic cancer
Published 2023-06-01“…Recently, immune checkpoint inhibitors (ICIs) have been approved by the US Food and Drug Administration for the treatment of cervical cancer and endometrial cancer, offering durable responses for some patients. In addition, many immunotherapy strategies are under investigation for the treatment of earlier stages of disease or in other gynecologic cancers, such as ovarian cancer and rare gynecologic tumors. …”
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2462
Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma
Published 2025-02-01“…This approach harnesses the body's immune system to target and eliminate cancer cells, potentially resulting in durable antitumor responses. However, acquired resistance and the tumor immunosuppressive microenvironment (TIME) significantly hinder its clinical application. …”
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2463
De la « déportation-abandon » à la réintégration des « ex-koulaks » : les modulations de la répression à l’égard des paysans soviétiques (1930-1948)
Published 2012-07-01“…In 1930 and 1931, more than one million eight hundred thousand peasants were sent into internal exile, becoming Stalin’s first « special settlers ».In 1930, the Soviet Northern territory was chosen to be the laboratory of this repressive and social experimentation on human beings that obliged thousands of peasant families to extract the natural resources of these frozen hinterlands. They had to remain durably in the so-called « special villages » built for their rehabilitation.This paper, based on archival materials combined with survivors’ stories, throws new light on the fate of peasant families in the North, their survival strategies when facing the most horrific first years of repression, as well as their strategies of adaptation and rehabilitation within society from the second half of the 1930s on. …”
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2464
Urinary bacteriophage cooperation with bacterial pathogens during human urinary tract infections supports lysogenic phage therapy
Published 2025-02-01“…Abstract Despite much promise in overcoming drug-resistant infections, clinical studies of bacteriophage antibacterial therapy have failed to show durable effectiveness. Although lysogeny plays an important role in bacterial physiology, its significance in diverse microbiomes remains unclear. …”
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2465
Recent Developed Strategies for Enhancing Chondrogenic Differentiation of MSC: Impact on MSC-Based Therapy for Cartilage Regeneration
Published 2021-01-01“…Thus, there is an urgent need to develop strategies that promote MSC chondrogenic differentiation to give rise to durable and phenotypically correct regenerated cartilage. …”
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2466
Current status of immunisation for herpes zoster
Published 2025-12-01“…The vaccine offers a paradigm for successful and durable immunization in the aging and immune-compromised.…”
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2467
Suitable Friction Sliding Materials for Base Isolation of Masonry Buildings
Published 2012-01-01“…Green marble and geosynthetic are found to be better alternatives for use in friction isolation system with equal effectiveness of energy dissipation and limiting the earthquake energy transmission to super structure during strong earthquake leading to a low cost, durable solution for earthquake protection of masonry buildings.…”
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2468
Oncolytic virus OH2 extends survival in patients with PD-1 pretreated melanoma: phase Ia/Ib trial results and biomarker insights
Published 2025-02-01“…In phase Ib, 10 patients achieved immune-partial response (iPR)/partial response (PR), yielding an objective response rate (ORR) of 37.0% (95% CI, 19.4% to 57.6%), with 6 patients still responding. The rate of the durable response (PR or complete response lasting at least 6 months) was at least 29.6% (8/27). …”
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2469
Liouville Theorem for Some Elliptic Equations with Weights and Finite Morse Indices
Published 2016-01-01Get full text
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2470
Visual Perception Evaluation Of Corten Steel: ŞImal Shopping Mall
Published 2025-01-01“…Corten steel is a recyclable, energy efficient, durable, and aesthetic material in terms of sustainability. …”
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2471
Intratumor heterogeneity in KRAS signaling shapes treatment resistance
Published 2025-02-01“…Combination immunotherapy leads to durable tumor regression in preclinical models.…”
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2472
Unveiling the Core Design Elements of Bamboo Furniture
Published 2025-01-01“…Enhancing connector performance, selecting durable materials, and optimizing ergonomic design are key strategies for improving safety and extending product lifespan. …”
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2473
Nanocomposites for extrinsic self-healing polymer Materials: A comprehensive review of their repair behaviour
Published 2025-01-01“…This review concludes by highlighting the practical implications of these advancements and outlining future directions for research, underscoring their potential to revolutionize the development of durable, multifunctional materials for real-world applications.…”
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2474
T follicular helper and memory B cells in IgE recall responses
Published 2025-01-01“…This review investigates the mechanisms governing IgE production and Tfh activation in the primary and recall responses, towards the objective of identifying molecular targets for therapeutic intervention that durably inactivate the IgE recall response.…”
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2475
Predicting immunotherapy efficacy in endometrial cancer: focus on the tumor microenvironment
Published 2025-01-01“…Major question we raise here – which group of patients is the most favorable to achieve durable immunotherapy response in endometrial cancer?…”
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2476
Assessing ecosystem platforms impact on investment attractiveness of companies
Published 2025-01-01“…The Russian economy is experiencing rapid growth in real estate values, prices for durable goods, and general inflation. All these factors have led to a large-scale increase in brokerage accounts and active growth of private investors on the Moscow Interbank Currency Exchange. …”
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2477
A Review of Research on Potential Solutions for Dendrite Growth in Solid State Cells
Published 2025-01-01“…These include coating the lithium metal surface with durable layers or alloy compounds, micro-modulating the solid-state electrolyte to reduce dendrite nucleation, and managing nano-cracks in the electrolyte. …”
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2478
Real-Time Pipeline Leak Detection: A Hybrid Deep Learning Approach Using Acoustic Emission Signals
Published 2024-12-01“…This approach significantly advances smart city capabilities in pipeline monitoring and maintenance, offering a durable and scalable solution for proactive infrastructure management.…”
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2479
Design and Construction of Position Sensorless Controller of Permanent Magnet Synchronous Motor with Internal Magnet based on Improved Phase-Locked Loop
Published 2024-09-01“…These engines are cheaper, lighter, and more durable. However, to control these motors, accurate information about the position of the rotor is necessary. …”
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Delay discounting predicts COVID-19 vaccine booster willingness
Published 2025-01-01“…Abstract Developing ways to predict and encourage vaccine booster uptake are necessary for durable immunity responses. In a multi-nation sample, recruited in June–August 2021, we assessed delay discounting (one’s tendency to choose smaller immediate rewards over larger future rewards), COVID-19 vaccination status, demographics, and distress level. …”
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